his study focused on exploring the specificity of mechanical behavior for completely weathered granite,as a special soil,by consolidated drained triaxial tests.The influences of dry density(1.60,1.70,1.80 and 1.90 g/c...his study focused on exploring the specificity of mechanical behavior for completely weathered granite,as a special soil,by consolidated drained triaxial tests.The influences of dry density(1.60,1.70,1.80 and 1.90 g/cm^(3)),confining pressure(100,200,400 and 600 kPa),and moisture content(13.0%,that is,natural moisture content)were investigated in the present work.A newly developed Duncan-Chang model was established based on the experimental data and Duncan-Chang model.The influence of each parameter on the type of the proposed model curve was also evaluated.The experimental results revealed that with varying dry density and confining pressure,the deviatoric stress–strain curves have diversified characteristics including strain-softening,strain-stabilization and strain-hardening.Under high confining pressure condition,specimens with different densities all showed strain-hardening characteristic.Whereas at the low confining pressure levels,specimens with higher densities gradually transform into softening characteristics.Except for individual compression shear failure,the deformation modes of the specimens all showed swelling deformation,and all the damaged specimens maintained good integrity.Through comparing the experiment results,the strain-softening or strain-hardening behavior of CWG specimens could be predicted following the proposed model with high accuracy.Additionally,the proposed model can accurately characterize the key mechanical indicators,such as tangent modulus,peak value and residual strength,which is simple to implement and depends on fewer parameters.展开更多
Understanding the strength characteristics and deformation behaviour of the tunnel surrounding rock in a fault zone is significant for tunnel stability evaluation.In this study,a series of unconfined compression tests...Understanding the strength characteristics and deformation behaviour of the tunnel surrounding rock in a fault zone is significant for tunnel stability evaluation.In this study,a series of unconfined compression tests were conducted to investigate the mechanical characteristics and failure behaviour of completely weathered granite(CWG)from a fault zone,considering with height-diameter(h/d)ratio,dry densities(ρd)and moisture contents(ω).Based on the experimental results,a regression mathematical model of unconfined compressive strength(UCS)for CWG was developed using the Multiple Nonlinear Regression method(MNLR).The research results indicated that the UCS of the specimen with a h/d ratio of 0.6 decreased with the increase ofω.When the h/d ratio increased to 1.0,the UCS increasedωwith up to 10.5%and then decreased.Increasingρd is conducive to the improvement of the UCS at anyω.The deformation and rupture process as well as final failure modes of the specimen are controlled by h/d ratio,ρd andω,and the h/d ratio is the dominant factor affecting the final failure mode,followed byωandρd.The specimens with different h/d ratio exhibited completely different fracture mode,i.e.,typical splitting failure(h/d=0.6)and shear failure(h/d=1.0).By comparing the experimental results,this regression model for predicting UCS is accurate and reliable,and the h/d ratio is the dominant factor affecting the UCS of CWG,followed byρd and thenω.These findings provide important references for maintenance of the tunnel crossing other fault fractured zones,especially at low confining pressure or unconfined condition.展开更多
This paper presents an electrical impedance tomography(EIT)method using a partial-differential-equationconstrained optimization approach.The forward problem in the inversion framework is described by a complete electr...This paper presents an electrical impedance tomography(EIT)method using a partial-differential-equationconstrained optimization approach.The forward problem in the inversion framework is described by a complete electrodemodel(CEM),which seeks the electric potential within the domain and at surface electrodes considering the contact impedance between them.The finite element solution of the electric potential has been validated using a commercial code.The inverse medium problem for reconstructing the unknown electrical conductivity profile is formulated as an optimization problem constrained by the CEM.The method seeks the optimal solution of the domain’s electrical conductivity to minimize a Lagrangian functional consisting of a least-squares objective functional and a regularization term.Enforcing the stationarity of the Lagrangian leads to state,adjoint,and control problems,which constitute the Karush-Kuhn-Tucker(KKT)first-order optimality conditions.Subsequently,the electrical conductivity profile of the domain is iteratively updated by solving the KKT conditions in the reduced space of the control variable.Numerical results show that the relative error of the measured and calculated electric potentials after the inversion is less than 1%,demonstrating the successful reconstruction of heterogeneous electrical conductivity profiles using the proposed EIT method.This method thus represents an application framework for nondestructive evaluation of structures and geotechnical site characterization.展开更多
An improved Gaussian mixture model (GMM)- based clustering method is proposed for the difficult case where the true distribution of data is against the assumed GMM. First, an improved model selection criterion, the ...An improved Gaussian mixture model (GMM)- based clustering method is proposed for the difficult case where the true distribution of data is against the assumed GMM. First, an improved model selection criterion, the completed likelihood minimum message length criterion, is derived. It can measure both the goodness-of-fit of the candidate GMM to the data and the goodness-of-partition of the data. Secondly, by utilizing the proposed criterion as the clustering objective function, an improved expectation- maximization (EM) algorithm is developed, which can avoid poor local optimal solutions compared to the standard EM algorithm for estimating the model parameters. The experimental results demonstrate that the proposed method can rectify the over-fitting tendency of representative GMM-based clustering approaches and can robustly provide more accurate clustering results.展开更多
Objective: In our previous work, we incorporated complete blood count (CBC) into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharynge...Objective: In our previous work, we incorporated complete blood count (CBC) into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharyngeal carcinoma (NPC). The purpose of this study was to revalidate the accuracy of the model, and its superiority to TNM stage, through data from a prospective study.Methods: CBC of 249 eligible patients from the 863 Program No. 2006AA02Z4B4 was evaluated. Prognostic index (PI) of each patient was calculated according to the score model. Then they were divided by the PI into three categories: the low-, intermediate-and high-risk patients. The 5-year disease-specific survival (DSS) of the three categories was compared by a log-rank test. The model and TNM stage (Tth edition) were compared on efficiency for predicting the 5-year DSS, through comparison of the area under curve (AUC) of their receiver-operating characteristic curves.Results: The 5-year DSS of the low-, intermediate- and high-risk patients were 96.0%, 79.1% and 62.2%, respectively. The low- and intermediate-risk patients had better DSS than the high-risk patients (P〈0.001 and P〈0.005, respectively). And there was a trend of better DSS in the low-risk patients, compared with the intermediate-risk patients (P=0.049). The AUC of the model was larger than that of TNM stage (0.726 vs. 0.661, P:0.023). Conclusions: A CBC-based prognostic score model was revalidated to be accurate and superior to TNM stage on predicting 5-year DSS of NPC.展开更多
BACKGROUND: The establishment of a rat model of complete transected spinal cord injury lacks technological specifications. The current models lack concordance and reliability, and the death rate of the experimental a...BACKGROUND: The establishment of a rat model of complete transected spinal cord injury lacks technological specifications. The current models lack concordance and reliability, and the death rate of the experimental animals is high. Therefore, there is a great need for a reliable model to apply clinical applications of therapy. OBJECTIVE: To construct a rat model of complete transected spinal cord injury characterized by stability, reproducibility, and a high animal survival rate. DESIGN: Completely randomized controlled study. SETTING: Department of Neurosurgery, Xiangya Hospital of Central South University. MATERIALS: Fifty-five healthy specific pathogen free grade adult female Sprague Dawley rats were provided by the Experimental Animal Department, Xiangya Medical College, Central South University. Olympus BX51 imaging collecting analytic system was provided by Olympus Company, Japan; and SEN-7203 Nihon-Kohden electrical stimulator by Nihon Kohden, Japan. METHODS: This study was performed at the Laboratory of Neurosurgery, Xiangya Hospital of Central South University from April to June 2006. Experimental grouping: 55 rats were randomly divided into model group (n = 40) and sham surgery group (n = 15). In the model group, a self-made sliver hook was passed through the ventral side to support the spinal cord at the T12 segment and to shear it off. A complete transected spinal cord, 2 mm in length, was resected. In the sham surgery group, the spinal cord was identically exposed. The dura mater of the spinal cord was cut open, but the spinal cord was not damaged. MAIN OUTCOME MEASURES: Histopathological changes after spinal cord injury at L2 segment were observed subsequent to hematoxylin and eosin staining under optical microscopy. Olympus BX51 imaging collecting analytic system was used to count spinal cord ventral horn neurons. Motor function of rat hindlimb was evaluated with the Basso, Beattie and Bresnahan (BBB) scale. Paraplegia was evaluated as 0 point, and complete normality as 21 points. Somatosensory-evoked potential was measured using Nihon-Kohden electric stimulator at 21 days post-operation. RESULTS: A total of 82% (33/40) rats survived longer than 30 days after modeling. Pathological changes of spinal cord tissue: degenerative and necrotic pathological changes appeared in the model group after surgery; for example, neuronal swelling, chromatinolysis, and karyopyknosis. The spinal cord in the sham surgery group displayed mild edema 24 hours after surgery, gradually recovering to normal levels. Quantification of spinal cord ventral horn neurons: the number of spinal cord ventral horn neurons in the model group was less than in the sham surgery group at 24 hours, as well as 7 and 21 days after surgery (P 〈 0.01); while, the number at 7 and 21 days after surgery decreased compared to 24 hours after surgery (P 〈 0.01). Motor function changes: Rats in the sham operation group moved lightly abnormally following anesthesia recovery and then moved normally 7 days after surgery. BBB scores in the model group were less than in the sham surgery group 21 days after surgery (P 〈 0.01). BBB scores of both lower extremities increased slightly 7 days after surgery (P 〈 0.01); however, voluntary motor function of both lower extremities was still not recovered 30 days after surgery. Changes of somatosensory-evoked potential: wave form of somatosensory-evoked potential was normal in the sham surgery group 21 days after surgery, but recovered wave form was not recorded in the model group. CONCLUSION: Results from spinal cord histopathology, cytology, motor function, and somatosensory-evoked potential suggested that the complete transected spinal cord injury model in this study was stable, reliable, and reproducible. Furthermore, the survival rate of experimental animals was high.展开更多
In this paper,we consider the estimates d of error variance d2=Var(ei) in the linear models Yi=x' iβ+ei(i= 1, 2, ... ). We study the complete convergence of dm2-o2 when the error {ei }is a sequence of identically...In this paper,we consider the estimates d of error variance d2=Var(ei) in the linear models Yi=x' iβ+ei(i= 1, 2, ... ). We study the complete convergence of dm2-o2 when the error {ei }is a sequence of identically distributed p-mixing variables. And we also obtain the better convergence rates when {ei} is not identically distribution展开更多
Settlement control of high-speed railways is a key technology in embankment engineering. In order to reveal the engineering characteristics of the deep, completely decomposed granite soil in the Hainan East Ring Railw...Settlement control of high-speed railways is a key technology in embankment engineering. In order to reveal the engineering characteristics of the deep, completely decomposed granite soil in the Hainan East Ring Railway, four groups of centrifuge model tests were conducted. We studied the settlement properties, under the embankment action, of untreated subsoil, subsoil treated by dynamic compaction, and subsoil reinforced with cement-mixed piles. In particular, we examined the relationship between settlement and time, including the settlement during and after construction. The results show that the Weibull model can describe the relationship between embankment settlement and time well, and that the post-construction settlements of the subsoil meet the requirements of the relevant code. Among the two foundation treatment measures, dynamic compaction is more effective than reinforcement with cement-mixed piles. The tested pressure on the contact surface between embankment and subsoil was obviously different from the commonly used calculated values.展开更多
The de Sitter special relativity on the Beltrami-de Sitter-spacetime and Snyder's model in the momentum space can be combined together with an IR-UV duality to get the complete Yang model at both classical and quantu...The de Sitter special relativity on the Beltrami-de Sitter-spacetime and Snyder's model in the momentum space can be combined together with an IR-UV duality to get the complete Yang model at both classical and quantum levels, which are related by the proposed Killing quantization. It is actually a special relativity based on the principle of relativity of three universal constants (c, ρp, R).展开更多
In stratified survey sampling, sometimes we have complete auxiliary information. One of the fundamental questions is how to effectively use the complete auxiliary information at the estimation stage. In this paper, we...In stratified survey sampling, sometimes we have complete auxiliary information. One of the fundamental questions is how to effectively use the complete auxiliary information at the estimation stage. In this paper, we extend the model-calibration method to obtain estimators of the finite population mean by using complete auxiliary information from stratified sampling survey data. We show that the resulting estimators effectively use auxiliary information at the estimation stage and possess a number of attractive features such as asymptotically design-unbiased irrespective of the working model and approximately model-unbiased under the model. When a linear working-model is used, the resulting estimators reduce to the usual calibration estimator(or GREG).展开更多
Binomial no-arbitrage price have a method is the traditional approach for derivative pricing,which is,the complete model,which makes possible the perfect replication in the market.Risk neutral pricing is an appropriat...Binomial no-arbitrage price have a method is the traditional approach for derivative pricing,which is,the complete model,which makes possible the perfect replication in the market.Risk neutral pricing is an appropriate method of asset pricing in a complete market.We have discussed an incomplete market,a non-transaction asset that produces incompleteness of the market.An effective method of asset pricing in incomplete markets is the undifferentiated pricing method.This technique was firstly introduced by Bernoulli in(1738)the sense of gambling,lottery and their expected return.It is used to command investors'preferences and better returns the results they expect.In addition,we also discuss the utility function,which is the core element of the undifferentiated pricing.We also studied some important behavior preferences of agents,and injected exponential effect of risk aversion in the model,so that the model was nonlinear in the process of claim settlement.展开更多
In this paper, an exponential inequality for the maximal partial sums of negatively superadditive-dependent (NSD, in short) random variables is established. By uSing the exponen- tial inequality, we present some gen...In this paper, an exponential inequality for the maximal partial sums of negatively superadditive-dependent (NSD, in short) random variables is established. By uSing the exponen- tial inequality, we present some general results on the complete convergence for arrays of rowwise NSD random variables, which improve or generalize the corresponding ones of Wang et al. [28] and Chen et al. [2]. In addition, some sufficient conditions to prove the complete convergence are provided. As an application of the complete convergence that we established, we further investigate the complete consistency and convergence rate of the estimator in a nonparametric regression model based on NSD errors.展开更多
Horizontal wells are commonly used in bottom water reservoirs,which can increase contact area between wellbores and reservoirs.There are many completion methods used to control cresting,among which variable density pe...Horizontal wells are commonly used in bottom water reservoirs,which can increase contact area between wellbores and reservoirs.There are many completion methods used to control cresting,among which variable density perforation is an effective one.It is difficult to evaluate well productivity and to analyze inflow profiles of horizontal wells with quantities of unevenly distributed perforations,which are characterized by different parameters.In this paper,fluid flow in each wellbore perforation,as well as the reservoir,was analyzed.A comprehensive model,coupling the fluid flow in the reservoir and the wellbore pressure drawdown,was developed based on potential functions and solved using the numerical discrete method.Then,a bottom water cresting model was established on the basis of the piston-like displacement principle.Finally,bottom water cresting parameters and factors influencing inflow profile were analyzed.A more systematic optimization method was proposed by introducing the concept of cumulative free-water production,which could maintain a balance(or then a balance is achieved)between stabilizing oil production and controlling bottom water cresting.Results show that the inflow profile is affected by the perforation distribution.Wells with denser perforation density at the toe end and thinner density at the heel end may obtain low production,but the water breakthrough time is delayed.Taking cumulative free-water production as a parameter to evaluate perforation strategies is advisable in bottom water reservoirs.展开更多
The mechanical performance of recycled aggregate concrete (RAC) is investigated. An experiment on the complete stress-strain curve under uniaxial compression loading of RAC is carried out. The experimental results i...The mechanical performance of recycled aggregate concrete (RAC) is investigated. An experiment on the complete stress-strain curve under uniaxial compression loading of RAC is carried out. The experimental results indicate that the peak stress, peak strain, secant modulus of the peak point and original point increase with the strength grade of RAC enhanced. On the contrary, the residual stress of RAC decreases with the strength grade enhancing, and the failure of RAC is often broken at the interface between the recycled aggregate and the mortar matrix. Finally, the constitutive model of stress-strain model of RAC has been constituted, and the results from the constitutive model of stress-strain meet the experiment results very well.展开更多
The distribution of shear stress on the cross-section of plastic metal solid circular shaft under pure torsion yielding, the applicability of complete plastic model assumption and the shear stress formula were researc...The distribution of shear stress on the cross-section of plastic metal solid circular shaft under pure torsion yielding, the applicability of complete plastic model assumption and the shear stress formula were researched. Based on the shear stress formula of circular shaft under pure torsion in elastic stage, the formula of torque in elastic stage and the definition of yield, it is obtained that the yielding stage of plastic metal shaft under pure torsion is only a surface phenomenon of torque-torsion angle relationship, and the distribution of shear stress is essentially different from that of tensile stress when yielding under uniaxial tension. The pure torsion platform-torsion angle and the shape of torque-torsion angle curve cannot change the distribution of shear stress on the shaft cross-section. The distribution of shear stress is still linear with the maximum shear stress ts. The complete plasticity model assumption is not in accordance with the actual situation of shaft under torsion. The experimental strength data of nine plastic metals are consistent with the calculated results of the new limiting strain energy strength theory (LSEST). The traditional yield stress formula for plastic shaft under torsion is reasonable. The shear stress formula based on the plane assumption in material mechanics is applicable for all loaded stages of torsion shaft.展开更多
In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electric...In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electrical interactions between charged microparticles (MPs), which develop as fundamental vibrations (FVs) in ether, producing the vibrational strains εand γand the resulting stresses σand τ, as percussions of ether cells (ECs) upon the MP surface. The stresses σ?and?τproduce a resultant force FP, due to the percussions which constitute the real electric force FCC. The spatial effect of ether on FP is demonstrated by an analytical method, considering the electrical interaction between MPs through various equidistant spatial paths li of FVs, modelled on the basis of the Huygens principle for waves. For this issue, we utilized a numerical calculation, which could be generalized. But this spatial effect of the ether leads at a very slow decreasing of the FP forces ratio rF when doubling the distance l, in contrast to Coulomb’s FC forces whose ratio rF?decreases accentuate with doubling l. Accordingly, the necessity of including the term ln r in the FCC force, which is limited to 1.0 for doubling l, at long distances, was justified.展开更多
基金Project(42202318)supported by the National Natural Science Foundation of China。
文摘his study focused on exploring the specificity of mechanical behavior for completely weathered granite,as a special soil,by consolidated drained triaxial tests.The influences of dry density(1.60,1.70,1.80 and 1.90 g/cm^(3)),confining pressure(100,200,400 and 600 kPa),and moisture content(13.0%,that is,natural moisture content)were investigated in the present work.A newly developed Duncan-Chang model was established based on the experimental data and Duncan-Chang model.The influence of each parameter on the type of the proposed model curve was also evaluated.The experimental results revealed that with varying dry density and confining pressure,the deviatoric stress–strain curves have diversified characteristics including strain-softening,strain-stabilization and strain-hardening.Under high confining pressure condition,specimens with different densities all showed strain-hardening characteristic.Whereas at the low confining pressure levels,specimens with higher densities gradually transform into softening characteristics.Except for individual compression shear failure,the deformation modes of the specimens all showed swelling deformation,and all the damaged specimens maintained good integrity.Through comparing the experiment results,the strain-softening or strain-hardening behavior of CWG specimens could be predicted following the proposed model with high accuracy.Additionally,the proposed model can accurately characterize the key mechanical indicators,such as tangent modulus,peak value and residual strength,which is simple to implement and depends on fewer parameters.
基金supported by the National Natural Science Foundation of China,NSFC(No.42202318).
文摘Understanding the strength characteristics and deformation behaviour of the tunnel surrounding rock in a fault zone is significant for tunnel stability evaluation.In this study,a series of unconfined compression tests were conducted to investigate the mechanical characteristics and failure behaviour of completely weathered granite(CWG)from a fault zone,considering with height-diameter(h/d)ratio,dry densities(ρd)and moisture contents(ω).Based on the experimental results,a regression mathematical model of unconfined compressive strength(UCS)for CWG was developed using the Multiple Nonlinear Regression method(MNLR).The research results indicated that the UCS of the specimen with a h/d ratio of 0.6 decreased with the increase ofω.When the h/d ratio increased to 1.0,the UCS increasedωwith up to 10.5%and then decreased.Increasingρd is conducive to the improvement of the UCS at anyω.The deformation and rupture process as well as final failure modes of the specimen are controlled by h/d ratio,ρd andω,and the h/d ratio is the dominant factor affecting the final failure mode,followed byωandρd.The specimens with different h/d ratio exhibited completely different fracture mode,i.e.,typical splitting failure(h/d=0.6)and shear failure(h/d=1.0).By comparing the experimental results,this regression model for predicting UCS is accurate and reliable,and the h/d ratio is the dominant factor affecting the UCS of CWG,followed byρd and thenω.These findings provide important references for maintenance of the tunnel crossing other fault fractured zones,especially at low confining pressure or unconfined condition.
基金funded by the National Research Foundation of Korea,the Grant from a Basic Science and Engineering Research Project(NRF-2017R1C1B200497515)and the Grant from Basic Laboratory Support Project(NRF-2020R1A4A101882611).
文摘This paper presents an electrical impedance tomography(EIT)method using a partial-differential-equationconstrained optimization approach.The forward problem in the inversion framework is described by a complete electrodemodel(CEM),which seeks the electric potential within the domain and at surface electrodes considering the contact impedance between them.The finite element solution of the electric potential has been validated using a commercial code.The inverse medium problem for reconstructing the unknown electrical conductivity profile is formulated as an optimization problem constrained by the CEM.The method seeks the optimal solution of the domain’s electrical conductivity to minimize a Lagrangian functional consisting of a least-squares objective functional and a regularization term.Enforcing the stationarity of the Lagrangian leads to state,adjoint,and control problems,which constitute the Karush-Kuhn-Tucker(KKT)first-order optimality conditions.Subsequently,the electrical conductivity profile of the domain is iteratively updated by solving the KKT conditions in the reduced space of the control variable.Numerical results show that the relative error of the measured and calculated electric potentials after the inversion is less than 1%,demonstrating the successful reconstruction of heterogeneous electrical conductivity profiles using the proposed EIT method.This method thus represents an application framework for nondestructive evaluation of structures and geotechnical site characterization.
基金The National Natural Science Foundation of China(No.61105048,60972165)the Doctoral Fund of Ministry of Education of China(No.20110092120034)+2 种基金the Natural Science Foundation of Jiangsu Province(No.BK2010240)the Technology Foundation for Selected Overseas Chinese Scholar,Ministry of Human Resources and Social Security of China(No.6722000008)the Open Fund of Jiangsu Province Key Laboratory for Remote Measuring and Control(No.YCCK201005)
文摘An improved Gaussian mixture model (GMM)- based clustering method is proposed for the difficult case where the true distribution of data is against the assumed GMM. First, an improved model selection criterion, the completed likelihood minimum message length criterion, is derived. It can measure both the goodness-of-fit of the candidate GMM to the data and the goodness-of-partition of the data. Secondly, by utilizing the proposed criterion as the clustering objective function, an improved expectation- maximization (EM) algorithm is developed, which can avoid poor local optimal solutions compared to the standard EM algorithm for estimating the model parameters. The experimental results demonstrate that the proposed method can rectify the over-fitting tendency of representative GMM-based clustering approaches and can robustly provide more accurate clustering results.
基金supported by Hi-Tech Research and Development Program of China (863 Program) (No.2006AA02Z4B4)
文摘Objective: In our previous work, we incorporated complete blood count (CBC) into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharyngeal carcinoma (NPC). The purpose of this study was to revalidate the accuracy of the model, and its superiority to TNM stage, through data from a prospective study.Methods: CBC of 249 eligible patients from the 863 Program No. 2006AA02Z4B4 was evaluated. Prognostic index (PI) of each patient was calculated according to the score model. Then they were divided by the PI into three categories: the low-, intermediate-and high-risk patients. The 5-year disease-specific survival (DSS) of the three categories was compared by a log-rank test. The model and TNM stage (Tth edition) were compared on efficiency for predicting the 5-year DSS, through comparison of the area under curve (AUC) of their receiver-operating characteristic curves.Results: The 5-year DSS of the low-, intermediate- and high-risk patients were 96.0%, 79.1% and 62.2%, respectively. The low- and intermediate-risk patients had better DSS than the high-risk patients (P〈0.001 and P〈0.005, respectively). And there was a trend of better DSS in the low-risk patients, compared with the intermediate-risk patients (P=0.049). The AUC of the model was larger than that of TNM stage (0.726 vs. 0.661, P:0.023). Conclusions: A CBC-based prognostic score model was revalidated to be accurate and superior to TNM stage on predicting 5-year DSS of NPC.
基金the Scientific and Technological Foundation of Hunan Public Health Bureau, No. B2006-034
文摘BACKGROUND: The establishment of a rat model of complete transected spinal cord injury lacks technological specifications. The current models lack concordance and reliability, and the death rate of the experimental animals is high. Therefore, there is a great need for a reliable model to apply clinical applications of therapy. OBJECTIVE: To construct a rat model of complete transected spinal cord injury characterized by stability, reproducibility, and a high animal survival rate. DESIGN: Completely randomized controlled study. SETTING: Department of Neurosurgery, Xiangya Hospital of Central South University. MATERIALS: Fifty-five healthy specific pathogen free grade adult female Sprague Dawley rats were provided by the Experimental Animal Department, Xiangya Medical College, Central South University. Olympus BX51 imaging collecting analytic system was provided by Olympus Company, Japan; and SEN-7203 Nihon-Kohden electrical stimulator by Nihon Kohden, Japan. METHODS: This study was performed at the Laboratory of Neurosurgery, Xiangya Hospital of Central South University from April to June 2006. Experimental grouping: 55 rats were randomly divided into model group (n = 40) and sham surgery group (n = 15). In the model group, a self-made sliver hook was passed through the ventral side to support the spinal cord at the T12 segment and to shear it off. A complete transected spinal cord, 2 mm in length, was resected. In the sham surgery group, the spinal cord was identically exposed. The dura mater of the spinal cord was cut open, but the spinal cord was not damaged. MAIN OUTCOME MEASURES: Histopathological changes after spinal cord injury at L2 segment were observed subsequent to hematoxylin and eosin staining under optical microscopy. Olympus BX51 imaging collecting analytic system was used to count spinal cord ventral horn neurons. Motor function of rat hindlimb was evaluated with the Basso, Beattie and Bresnahan (BBB) scale. Paraplegia was evaluated as 0 point, and complete normality as 21 points. Somatosensory-evoked potential was measured using Nihon-Kohden electric stimulator at 21 days post-operation. RESULTS: A total of 82% (33/40) rats survived longer than 30 days after modeling. Pathological changes of spinal cord tissue: degenerative and necrotic pathological changes appeared in the model group after surgery; for example, neuronal swelling, chromatinolysis, and karyopyknosis. The spinal cord in the sham surgery group displayed mild edema 24 hours after surgery, gradually recovering to normal levels. Quantification of spinal cord ventral horn neurons: the number of spinal cord ventral horn neurons in the model group was less than in the sham surgery group at 24 hours, as well as 7 and 21 days after surgery (P 〈 0.01); while, the number at 7 and 21 days after surgery decreased compared to 24 hours after surgery (P 〈 0.01). Motor function changes: Rats in the sham operation group moved lightly abnormally following anesthesia recovery and then moved normally 7 days after surgery. BBB scores in the model group were less than in the sham surgery group 21 days after surgery (P 〈 0.01). BBB scores of both lower extremities increased slightly 7 days after surgery (P 〈 0.01); however, voluntary motor function of both lower extremities was still not recovered 30 days after surgery. Changes of somatosensory-evoked potential: wave form of somatosensory-evoked potential was normal in the sham surgery group 21 days after surgery, but recovered wave form was not recorded in the model group. CONCLUSION: Results from spinal cord histopathology, cytology, motor function, and somatosensory-evoked potential suggested that the complete transected spinal cord injury model in this study was stable, reliable, and reproducible. Furthermore, the survival rate of experimental animals was high.
文摘In this paper,we consider the estimates d of error variance d2=Var(ei) in the linear models Yi=x' iβ+ei(i= 1, 2, ... ). We study the complete convergence of dm2-o2 when the error {ei }is a sequence of identically distributed p-mixing variables. And we also obtain the better convergence rates when {ei} is not identically distribution
文摘Settlement control of high-speed railways is a key technology in embankment engineering. In order to reveal the engineering characteristics of the deep, completely decomposed granite soil in the Hainan East Ring Railway, four groups of centrifuge model tests were conducted. We studied the settlement properties, under the embankment action, of untreated subsoil, subsoil treated by dynamic compaction, and subsoil reinforced with cement-mixed piles. In particular, we examined the relationship between settlement and time, including the settlement during and after construction. The results show that the Weibull model can describe the relationship between embankment settlement and time well, and that the post-construction settlements of the subsoil meet the requirements of the relevant code. Among the two foundation treatment measures, dynamic compaction is more effective than reinforcement with cement-mixed piles. The tested pressure on the contact surface between embankment and subsoil was obviously different from the commonly used calculated values.
基金Supported by the National Natural Science Foundation of China under Grant Nos.10701081,10975167,and 10875129
文摘The de Sitter special relativity on the Beltrami-de Sitter-spacetime and Snyder's model in the momentum space can be combined together with an IR-UV duality to get the complete Yang model at both classical and quantum levels, which are related by the proposed Killing quantization. It is actually a special relativity based on the principle of relativity of three universal constants (c, ρp, R).
基金Supported by the National Natural Science Foundation of China(10571093)
文摘In stratified survey sampling, sometimes we have complete auxiliary information. One of the fundamental questions is how to effectively use the complete auxiliary information at the estimation stage. In this paper, we extend the model-calibration method to obtain estimators of the finite population mean by using complete auxiliary information from stratified sampling survey data. We show that the resulting estimators effectively use auxiliary information at the estimation stage and possess a number of attractive features such as asymptotically design-unbiased irrespective of the working model and approximately model-unbiased under the model. When a linear working-model is used, the resulting estimators reduce to the usual calibration estimator(or GREG).
文摘Binomial no-arbitrage price have a method is the traditional approach for derivative pricing,which is,the complete model,which makes possible the perfect replication in the market.Risk neutral pricing is an appropriate method of asset pricing in a complete market.We have discussed an incomplete market,a non-transaction asset that produces incompleteness of the market.An effective method of asset pricing in incomplete markets is the undifferentiated pricing method.This technique was firstly introduced by Bernoulli in(1738)the sense of gambling,lottery and their expected return.It is used to command investors'preferences and better returns the results they expect.In addition,we also discuss the utility function,which is the core element of the undifferentiated pricing.We also studied some important behavior preferences of agents,and injected exponential effect of risk aversion in the model,so that the model was nonlinear in the process of claim settlement.
基金Supported by the National Natural Science Foundation of China(11501004,11501005,11526033,11671012)the Natural Science Foundation of Anhui Province(1508085J06,1608085QA02)+1 种基金the Key Projects for Academic Talent of Anhui Province(gxbj ZD2016005)the Research Teaching Model Curriculum of Anhui University(xjyjkc1407)
文摘In this paper, an exponential inequality for the maximal partial sums of negatively superadditive-dependent (NSD, in short) random variables is established. By uSing the exponen- tial inequality, we present some general results on the complete convergence for arrays of rowwise NSD random variables, which improve or generalize the corresponding ones of Wang et al. [28] and Chen et al. [2]. In addition, some sufficient conditions to prove the complete convergence are provided. As an application of the complete convergence that we established, we further investigate the complete consistency and convergence rate of the estimator in a nonparametric regression model based on NSD errors.
文摘Horizontal wells are commonly used in bottom water reservoirs,which can increase contact area between wellbores and reservoirs.There are many completion methods used to control cresting,among which variable density perforation is an effective one.It is difficult to evaluate well productivity and to analyze inflow profiles of horizontal wells with quantities of unevenly distributed perforations,which are characterized by different parameters.In this paper,fluid flow in each wellbore perforation,as well as the reservoir,was analyzed.A comprehensive model,coupling the fluid flow in the reservoir and the wellbore pressure drawdown,was developed based on potential functions and solved using the numerical discrete method.Then,a bottom water cresting model was established on the basis of the piston-like displacement principle.Finally,bottom water cresting parameters and factors influencing inflow profile were analyzed.A more systematic optimization method was proposed by introducing the concept of cumulative free-water production,which could maintain a balance(or then a balance is achieved)between stabilizing oil production and controlling bottom water cresting.Results show that the inflow profile is affected by the perforation distribution.Wells with denser perforation density at the toe end and thinner density at the heel end may obtain low production,but the water breakthrough time is delayed.Taking cumulative free-water production as a parameter to evaluate perforation strategies is advisable in bottom water reservoirs.
基金Supported by the Fund of Hunan Provincial Construction Department(No.06-468-8)
文摘The mechanical performance of recycled aggregate concrete (RAC) is investigated. An experiment on the complete stress-strain curve under uniaxial compression loading of RAC is carried out. The experimental results indicate that the peak stress, peak strain, secant modulus of the peak point and original point increase with the strength grade of RAC enhanced. On the contrary, the residual stress of RAC decreases with the strength grade enhancing, and the failure of RAC is often broken at the interface between the recycled aggregate and the mortar matrix. Finally, the constitutive model of stress-strain model of RAC has been constituted, and the results from the constitutive model of stress-strain meet the experiment results very well.
文摘The distribution of shear stress on the cross-section of plastic metal solid circular shaft under pure torsion yielding, the applicability of complete plastic model assumption and the shear stress formula were researched. Based on the shear stress formula of circular shaft under pure torsion in elastic stage, the formula of torque in elastic stage and the definition of yield, it is obtained that the yielding stage of plastic metal shaft under pure torsion is only a surface phenomenon of torque-torsion angle relationship, and the distribution of shear stress is essentially different from that of tensile stress when yielding under uniaxial tension. The pure torsion platform-torsion angle and the shape of torque-torsion angle curve cannot change the distribution of shear stress on the shaft cross-section. The distribution of shear stress is still linear with the maximum shear stress ts. The complete plasticity model assumption is not in accordance with the actual situation of shaft under torsion. The experimental strength data of nine plastic metals are consistent with the calculated results of the new limiting strain energy strength theory (LSEST). The traditional yield stress formula for plastic shaft under torsion is reasonable. The shear stress formula based on the plane assumption in material mechanics is applicable for all loaded stages of torsion shaft.
文摘In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electrical interactions between charged microparticles (MPs), which develop as fundamental vibrations (FVs) in ether, producing the vibrational strains εand γand the resulting stresses σand τ, as percussions of ether cells (ECs) upon the MP surface. The stresses σ?and?τproduce a resultant force FP, due to the percussions which constitute the real electric force FCC. The spatial effect of ether on FP is demonstrated by an analytical method, considering the electrical interaction between MPs through various equidistant spatial paths li of FVs, modelled on the basis of the Huygens principle for waves. For this issue, we utilized a numerical calculation, which could be generalized. But this spatial effect of the ether leads at a very slow decreasing of the FP forces ratio rF when doubling the distance l, in contrast to Coulomb’s FC forces whose ratio rF?decreases accentuate with doubling l. Accordingly, the necessity of including the term ln r in the FCC force, which is limited to 1.0 for doubling l, at long distances, was justified.