Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs

Hydrogels are soft materials consisting of a three-dimensional network of polymer chains.Over the years,hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications,ranging from cancer therapy and wound care to the treatment of neurodegenerative and inflammatory diseases.Most of these carriers,however,are designed only to deliver single agents.Carriers based on hydrogels for co-delivery of multiple agents,with the release rate of each of the co-delivered agents tunable,are lacking.This study reports a one-pot method of fabricating alginate-based complex fibers with the Janus morphology,with carboxymethyl cellulose sodium functioning as a polymeric modifier of the properties of each of the fiber compartments.By using malachite green and minocycline hydrochloride as model drugs,the generated fibers demonstrate the capacity of enabling the release profile of each of the co-delivered drugs to be precisely controlled.Along with their negligible toxicity and the retention of the activity of the loaded drugs,the complex fibers reported in this study warrant further development and optimization for applications that involve co-delivery of multiple agents.

Functionalization-Directed Stabilization of Hydrogen-Bonded Polymer Complex Fibers:Elasticity and Conductivity

Elastic,repairable and conductive fibers are desirable in the newly emerging field of soft electronic and wearable devices.Here,we design a multifunctional fiber by incorporation of different components to optimize its performance.The combination of the poly(acrylic acid)(PAA)and poly(ethylene oxide)(PEO)through hydrogen bonding endows the fiber with high elasticity and repairability.Polydopamine(PDA)significantly increases the stability of the fiber,thus the fiber will not dissolve in alkaline solutions and still keep the repairable ability.The fiber shows a reversible swelling-shrinking property as pH values go up and down.Further,the conductive component,carbon nanotube,is adsorbed at the swelling state and then is fastened with fiber shrinking.

Preparation and Properties of Eu^(3+) Rare Earth Complex and Fluorescent Fiber

A novel Eu^3＋ rare earth complex, composed of 4 - hydroxybenzolate acid and 1, 10 - phenanthroline ligands was synthesized. The apparent morphology, composition, thermal stability and fluorescent property of the rare earth complex were measured by TEM, Element analysis, IR, TG and Fluorescence spectrometer. The results indicated that this rare earth complex has sphere-like morphology and its diameter was about 100 nm. The complex has good thermal stability due to the strong coordination between the Eu^3＋ ions and the ligands. Based on the composition analysis, the complex structure formula was： Eu （HOC6 H4 COI）3 （phen） ·H2O Fluorescence spectra showed that the rare earth complex emission peaks were corresponding to the transition of ^5D0→7FJ（J=0,1,2,4）,. and the highest intensity fluorescence peak was at 617 nm. The luminescent fiber was prepared by blending melt-spinning with rare earth complex and polypropylene resin. It also has a good luminescent quality, which the strongest emission peak was at 619 nm. It could be considered suitable for industrial application.

Preparation and Properties of Poly (ethylene terephthalate) Luminescence Fibers with Multi-branched Benzoic Acid Rare Earth Complex

A new multi-branched benzoic acid rare earth complex( MBBAL-Eu( III) complex) was prepared. The advanced tested technologies were employed to characterize the composition and structure of as-prepared complex. Scanning electron microscopy( SEM) image shows that as-prepared complex has a layer structure. Transmission electron microscopy( TEM) image presents that the shape of MBBAL-Eu( III) complex is similar to oval; the size is in the range of 20-50 nm. The thermogravimetric analysis( TGA) curves of MBBAL-Eu( III) complex reveal that as-prepared complex has good thermal stability. The PET luminescence fibers with MBBAL-Eu( III) complex were prepared through meltspinning and electrospun methods. The results prove that asprepared fibers with MBBAL-Eu( III) complex have good luminescent properties and show bright red light.

深井复杂条件煤巷快速掘进网的可替代性实验研究与应用初探

通过实验研究聚酯纤维网和菱形金属网的单位质量、延伸率、单根破坏应力、网状破坏应力、网兜状压断破坏应力来验证聚酯纤维网替代菱形金属网的可行性,进一步采用数值模拟验证了实验室相关网力学试验的测试数据可靠性,并在顾桥煤矿1211(1)工作面运输顺槽开展了现场试验,替代后应用效果良好。研究结果表明,在深井复杂条件下聚酯纤维网可以替代菱形金属网进行支护,为类似复杂条件的快速掘进工程网的更新替代研究提供一定借鉴与参考。

Evaluation of peripapillary retinal nerve fiber layer, macula and ganglion cell thickness in amblyopia using spectral optical coherence tomography

AIM:To investigate peripapillary retinal nerve fiber layer (RNFL), macula and ganglion cell layer thicknesses (GCC) in amblyopic eyes with spectral domain optical coherence tomography (SD-OCT). METHODS:Thirty six patients with a history of unilateral amblyopia and thirty two children who had emmetropia without amblyopia were included in this study. In this institutional study, 36 eyes of 36 patients with amblyopia (AE), 36 fellow eyes without amblyopia (FE), and 32 eyes of 32 normal subjects (NE) were included. RNFL, GCC and macular thickness measurements were performed with RS-3000 OCT Retina Scan (Nidek Inc CA. USA). RESULTS:The mean global thicknesses of the RNFL were 113.22 ±21.47, 111.57 ±18.25, 109.96 ±11.31μm in the AE, FE, and NE, respectively. There was no statistically significant difference for mean global RNFL thickness among the eyes (P =0.13). The mean thicknesses of the macula were 258.25±18.31, 258.75±19.54, 248.62±10.57μm in the AE, FE and NE, respectively. There was no statistically significant difference for thickness of macula among the eyes (P =0.06). The GCC was investigated into two parts:superior and inferior. The mean thicknesses of superior GCC were 102.57 ±13.32, 103.32 ±10.64, 100.52 ± 5.88μm in the AE, FE, and NE, respectively. The mean thicknesses of inferior GCC were 103.82 ±12.60, 107.82 ± 12.33, 105.86±10.79μm in the AE, FE and NE, respectively. There was no statistically significant difference for thickness of superior and inferior GCC between the eyes (P =0.63, P =0.46). ·CONCLUSION:The macular thicknesses of AE and FE were greater than the NE, although it was not statistically significant. Amblyopia does not seem to have a profound effect on the RNFL, macula and GCC.

Dynamics of Interaction of a Single Fiber with a Headset of a Sampling Drum

The article presents an analysis of the dynamics of interaction of a single fiber with the sampling drum of a headset during pneumomechanical spinning. The regularity is investigated and the equation of the movement of fibers on the surface of the tooth of the sampling drum headset is obtained. It was found that the dependences of the movement of fibers along the tooth at different angles of inclination, the distribution of fiber tension along the arc, and the distribution of fiber speeds in the region of the sampling arc have an increase property. As a result of the analysis of the tension and speed of the fibers, it was found that with the increase in the sampling zone, the tension force and speed of the fiber increase.

Manufacturing of High-efficiency Air Filter Paper Using Ultra-fine Fibers

In this paper,the manufacturing of high-efficiency air filter paper is reported.The air filter paper was produced using ultra-fine fibers and wateroat fibers mercerized by alkali,using an electrospinning apparatus with multiple rings.The high efficiency air filter paper has an antibacterial effect after adding a chitosan-copper complex which is harmless to humans.As a result of the measurement,the filtering efficiency of the air filter paper is approximately 99.998%and its antibacterial efficiency is approximately 99.5%.

物联网环境下复杂光纤通信传输网络节点调度

为了解决物联网环境下,光纤通信传输网络节点能耗高、调度效率低的问题,提出一种物联网环境下复杂光纤通信传输网络节点调度方法。在物联网环境下,分析光纤通信传输网络节点的分布情况,根据动态联盟理论,以最快调度速度和最小投资为目标,构建复杂光纤通信传输网络节点调度模型。通过蚁群和粒子群算法相结合的融合算法展开全部搜索,获取最佳调度方案,实现光纤通信传输网络节点调度。实验结果表明,所提方法的节点平均能耗在6.0 mJ以下,LBF值始终高于0.20,且节点调度耗时始终低于200 ms,具有良好的调度效果。

Experimental and Computational Study of the Microwave Absorption Properties of Recycled α-Fe2O3/OPEFB Fiber/PCL Multi-Layered Composites

The aim of this study was to fabricate multi-layered recycled α-Fe2O3/OPEFB fiber/PCL composites for microwave absorbing applications in the 1 - 4 GHz frequency range. The multi-layered composites were 6 mm thick and each consisted of a 2 mm thick layer of recycled α-Fe2O3/PCL composites at various loadings (5 wt% - 25 wt%) of 16.2 nm recycled α-Fe2O3 nanofiller, placed between two layers of 2 mm thick OPEFB fiber/PCL composites blended at a fixed ratio of 7:3. The real (ε') and imaginary (ε") components of the relative complex permittivity were measured using the open-ended coaxial probe technique and the values obtained were applied as inputs for the Finite Element Method to calculate the reflection coefficient magnitudes from which the reflection loss (RL) properties were determined. Both ε' and ε" increased linearly with recycled α-Fe2O3 nanofiller content and the values of ε' varied between 3.0 and 3.9 while the ε" values ranged between 0.26 and 0.64 within 1 - 4 GHz. The RL (dB) showed the most prominent values within the 1.38 - 1.46 GHz band with a minimum of -38 dB attained by the 25 wt% composite. Another batch of minimum values occurred in the 2.39 - 3.49 GHz range with the lowest of -25 dB at 2.8 GHz. The recycled α-Fe2O3/OPEFB fiber/PCL multi-layered composites are promising materials that can be engineered for solving noise problems in the 1 - 4 GHz range.

Temperature-induced effect on refractive index of graphene based on coated in-fiber Mach-Zehnder interferometer

The temperature-induced complex refractive index（CRI） effect of graphene is demonstrated theoretically and experimentally based on a graphene coated in-fiber MZI（Mach-Zehnder interferometer）. The relationships between real and imaginary parts of the graphene CRI and temperature are obtained through investigating the dip wavelength and intensity of the MZI interference spectrum changing with temperature, respectively. The temperature effect of CRI of the graphene is also analyzed theoretically. Both experimental and theoretical studies show that the real part and imaginary part of the CRI nonlinearly decrease and increase with temperature increasing, respectively. This graphene-coated in-fiber MZI structure also possesses the advantages of easy fabrication, miniaturization, low cost and robustness. It has potential applications in nanomaterial-based optic devices for communication and sensing.

复杂应力状态下玻璃纤维再生混凝土损伤演变及应力-应变本构关系研究

本工作旨在通过常规三轴受压试验探究玻璃纤维再生混凝土(GFRAC)在三轴受压力学方面的性能,为此以玻璃纤维体积掺量V、再生粗骨料取代率γ和侧向围压σw为参数,共设计了168个100 mm(直径)×200 mm(高度)的玻璃纤维再生混凝土圆柱体试件并进行试验。通过试验获得了GFRAC的破坏特征并分析了不同参数对峰值应力、峰值应变及弹性模量的影响规律。由试验结果分析可得,随着侧向围压的增大,GFRAC的破坏形态由纵向劈裂破坏逐步转为斜向剪切破坏,网格状裂缝逐渐增多并布满试件,在试件的中部或端部出现“腰鼓”变形现象;通过施加侧向围压可以有效地增加GFRAC的峰值应力、应变和弹性模量;玻璃纤维提高了试件的峰值应力,且提高幅度在20%以内;增加再生粗骨料的取代率会导致峰值应力和弹性模量减小,最大下降幅度分别约为19.17%和34.91%,而峰值应变会增大,最大增幅可达76.77%;侧向围压和玻璃纤维均有效延缓了试件的损伤过程;最后,基于试验数据建立了玻璃纤维再生混凝土在三轴受压状态下的应力-应变本构关系。

不同金属盐体系对锦纶66纤维结构与性能的影响

选用氯化钙、氯化锂、氯化铜及氯化锌四种金属盐,分别以去离子水和无水乙醇为溶剂配置成溶液,对锦纶66纤维进行络合改性处理,采用FTIR、DSC、XRD、SEM、单纤维拉伸研究不同金属盐及其溶剂种类对锦纶66纤维结构性能的影响。结果表明,经四种金属盐处理后,氯化铜对锦纶66纤维的结构性能影响最大、对纤维的络合作用最强,氯化锌对锦纶66纤维的结构、性能影响最小,氯化钙和氯化锂的影响程度居中,具体表现为红外光谱图中N-H振动峰向低波数移动,熔融温度下降、结晶度减小、拉伸断裂强度降低。选择氯化钙为金属盐络合剂时,以乙醇作为溶剂时对锦纶66纤维的结构、性能的影响作用大于以水为溶剂时,说明乙醇有利于金属离子与纤维之间形成络合作用。

复合酶改性玉米皮可溶性膳食纤维的工艺优化及理化特性分析

为探究玉米皮可溶性膳食纤维(Soluble Dietary Fiber,SDF)最佳提取工艺及功能特性。本研究以玉米加工副产物玉米皮为原料,采用复合酶法改性提取玉米皮可溶性膳食纤维,通过单因素实验和响应面优化确定最佳工艺参数并对其理化性质进行了研究。结果表明,当纤维素酶添加量为1.5%、木聚糖酶添加量为1%、酶解温度为55℃、酶解时间为150 min时,玉米皮SDF得率达到的最高值为16.64%±0.21%,其溶解度为87.63%±0.43%,持水力为2.87±0.16 g/g,持油力为2.30±0.12 g/g,葡萄糖吸附力为5.32±0.12 mmol/g,体外模拟胃环境(pH2.0)、肠环境(pH7.0)下胆固醇吸附性分别为11.74±0.15、42.93±0.08 mg/g,胆酸钠吸附性分别为15.43±0.17、50.67±0.10 mg/g。研究结果可为玉米皮可溶性膳食纤维的开发利用提供理论参考。

熔体静电纺丝直写技术在组织工程中的应用

背景:计算机辅助设计下,熔体静电纺丝直写技术可以精确构建具有特定形貌的3D组织工程支架,在组织工程领域已经引起越来越多的关注。目的:阐述熔体静电纺丝直写技术近年来在组织工程中的应用进展。方法:利用PubMed、中国知网数据库检索有关熔体静电纺丝直写技术应用于组织工程的文献,检索时间范围为2008年3月至2023年2月,以“melt electrowriting,melt electrospinning,electrospinning,tissue engineering,scaffold,regeneration”为英文检索词,“熔体直写,静电纺丝,组织工程”为中文检索词,通过阅读文题和摘要对文章进行初步筛选,最终纳入69篇文献进行综述。结果与结论:①相较于传统的静电纺丝技术,熔体静电纺丝直写技术可以实现纤维的逐层精确沉积,更好地模拟天然组织的复杂结构;相比于其他3D打印技术,熔体静电纺丝直写技术可以制备更小直径的纤维,形成高度有序的多孔结构;②通过与其他支架制备技术或材料相结合,如熔融沉积建模、溶液静电纺丝技术、水凝胶等,熔体静电纺丝直写技术在制备复杂组织工程支架方面表现出巨大的潜力,为实现复杂组织的再生提供了一定可能;③复杂组织再生往往同时涉及血管、神经和软硬组织,血管和神经再生对于实现组织的生理性重建具有重要意义,软硬组织因其不同的生物、力学性能,实现二者的协调再生具有一定的困难,熔体静电纺丝直写技术可制备多尺寸、高孔隙率、良好生物相容性的支架,在仿生支架构建领域具有一定的优势。

铜氨络合粘胶纤维的制备及其抗菌性能

利用铜氨溶液对粘胶纤维进行处理,制备了铜氨络合粘胶纤维。分析了铜氨溶液浓度、反应时间对Cu^(2+)结合量的影响。通过SEM、XRD和XPS表征了粘胶纤维的形貌与化学结构,测试了不同Cu^(2+)结合量下铜氨络合粘胶纤维的抑菌性及耐水洗性能。结果表明:随着铜氨溶液浓度的提高,Cu^(2+)结合量迅速增加;当溶液浓度达到25.00 mmol/L时,Cu^(2+)结合量达到最大值;反应30 min,即可达到络合平衡。铜氨溶液处理后,Cu^(2+)与粘胶纤维的羟基发生配位络合反应,纤维纵向分布着络合物小颗粒,形貌变粗糙,横向截面变化较小;纤维化学结构无明显改变。铜氨络合粘胶纤维显示出较好的抗菌性能,当铜氨溶液浓度达到0.30 mmol/L时,对大肠埃希菌和金黄葡萄球菌的抑菌率分别为97.80%和99.33%,经50次标准水洗后,抑菌率分别为83.40%和86.51%。

空化射流联合复合酶法提取豆渣中可溶性膳食纤维工艺优化

目的探究空化射流联合复合酶法对豆渣可溶性膳食纤维(soluble dietary fiber,SDF)得率、抗氧化活性及官能团的影响。方法采用单因素和响应面实验设计优化空化射流联合复合酶法提取工艺条件,测定提取后SDF的1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基清除率和红外光谱。结果豆渣SDF最佳提取条件为:空化射流处理压力0.3 MPa,复合酶添加量为6%,料液比为1:30(g/mL),豆渣SDF提取率为18.21%;此条件下得到的SDF具有较高的抗氧化活性,在SDF质量浓度为2.5 mg/mL时,对DPPH自由基抑制率为73.06%;红外光谱图显示经联合方法提取的豆渣SDF官能团成分没有发生变化。结论空化射流联合复合酶法可以有效提高豆渣SDF提取率,为提高豆渣应用价值提供理论支撑。

Bi_(2)Te_(3)/KOH/PEDOT:PSS和SiO_(2)气凝胶增强钢丝绒热电性能研究

在热电材料研究领域,一般认为金属的Seebeck系数较低,因此有关金属的热电性能的研究并不多见。但研究发现金属的物理形态对其热电性能具有影响。考察了金属纤维钢丝绒(SW)的热电性能。发现SW(主要成分为Fe)的Seebeck系数是块体铁的2倍。在此基础上,将SW与有机和无机热电材料进行复合,并在其空隙中填充SiO_(2)气凝胶,最终制备出了Bi_(2)Te_(3)/KOH/PEDOT:PSS@SW-SiO_(2)气凝胶复合材料,使其热电性能得到了进一步提升。结果表明,气凝胶的加入可使SW的导热系数降低34%。电导率(σ)、热导率(κ)和Seebeck系数(S)得到解耦。Bi_(2)Te_(3)/KOH/PEDOT:PSS@SW-SiO_(2)气凝胶的Seebeck系数、热电优值(ZT)和功率因子(PF)分别是纯SW的1.2、3.4、2.4倍。通过改变材料物理形态和添加气凝胶来提高材料热电性能的方式有望为其他热电材料的研究提供新的思路和有益参考。

木纤维重构红壤下根系特征对根土复合体抗剪特性的影响

红壤黏性重、水分变化大、抗剪性能较低,通过根系特征参数研究草本植物根土复合体的力学特性具有一定意义。为探明不同质量分数(0、0.5%、2.5%和5.0%)木纤维重构红壤下,根系特征对草本植物根土复合体抗剪特性的影响机理,该研究通过直剪试验测定白三叶和黑麦草根土复合体的抗剪强度,并采用WinRHIZO根系分析系统测定根表面积指数、根系体积比、根系长度、地下生物量4个根系特征参数,并进一步揭示其对抗剪强度影响机理及规律。结果表明:适量的木纤维添加有利于须根系草本植物的生长,木纤维质量分数较低时,黑麦草的根系特征参数值高于白三叶3~5倍,木纤维质量分数较高时,黑麦草和白三叶的根系长度分别为456.27和438.35 cm,地下生物量分别为0.410和0.150 mg;随根系特征参数增加黑麦草根土复合体的抗剪强度增幅大于白三叶根土复合体,增幅范围分别为26.55%~47.20%、26.21%~35.07%,但存在一定的变化阈值。采用摩尔-库伦模型对根土复合体的抗剪特性参数的模拟效果较好,根系特征参数达到变化阈值时,黏聚力变化差异明显,对内摩擦角影响较小。该研究对深入研究红壤区的边坡防护、植被恢复和土地整治等具有重要的理论和工程实践价值。

基于荧光猝灭原理的比率式光纤溶解氧传感器研究

溶解氧浓度的准确测定在医疗应用、海洋监测、工农业生产等领域中,起到至关重要的作用。本篇论文提出了一种比率式光纤溶解氧传感器,以四乙氧基硅烷(TEOS)和正辛基三乙氧基硅烷(Octyl-triEOS)为前驱体的有机改性硅酸盐(ORMOSILs)作为载体基质,选用三(4,7-联苯-1,10-邻菲啰啉)二氯化钌(Ru(dpp)_(3)^(2+))为氧敏感染料,选用7-氨基-4-(三氟甲基)香豆素(AFC)为参比染料。吸收光谱表明,氧敏感染料和参比染料可以被中心波长为405nm的光源激发。发射光谱表明,氧敏感染料和参考染料的发射波长没有光谱重叠,因此可以使用比率法测量溶解氧浓度。通过溶胶-凝胶工艺制备的ORMOSILs将氧敏感染料和参比染料固定在塑料光纤端部,从而形成复合氧敏感薄膜,对传感膜的厚度和疏水性进行了表征,传感膜的厚度为569μm,水接触角为81°。将该传感器在水溶液中进行了测试,在光源激发下,氧敏感染料和参考染料在605和490nm处有明显的发射峰,随着溶解氧浓度的增加,氧敏感染料的荧光强度降低,而参比染料的荧光强度稳定在某一数值,通过测量氧敏感染料与参比染料的比率,达到检测氧浓度的目的。采用Stern-Volmer方程对溶解氧浓度和荧光强度比进行线性拟合,该传感器在0~20.05mg·L^(-1)溶解氧范围内,Stern-Volmer拟合度可达98.22%,灵敏度可达0.4334/[O_(2)],从饱和氮溶液到饱和氧溶液传感器的响应时间为12s,从饱和氧溶液到饱和氮溶液传感器的恢复时间为144s,引入非对称因子ASY表明传感时间的不对称性。对传感器的光稳定性和重复性进行了测试,比率式光纤传感器可以克服光源波动,相对单荧光强度传感有更强的稳定性。