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Nontraditional energy-assisted mechanical machining of difficult-to-cut materials and components in aerospace community:a comparative analysis 被引量:2
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作者 Guolong Zhao Biao Zhao +5 位作者 Wenfeng Ding Lianjia Xin Zhiwen Nian Jianhao Peng Ning He Jiuhua Xu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期190-271,共82页
The aerospace community widely uses difficult-to-cut materials,such as titanium alloys,high-temperature alloys,metal/ceramic/polymer matrix composites,hard and brittle materials,and geometrically complex components,su... The aerospace community widely uses difficult-to-cut materials,such as titanium alloys,high-temperature alloys,metal/ceramic/polymer matrix composites,hard and brittle materials,and geometrically complex components,such as thin-walled structures,microchannels,and complex surfaces.Mechanical machining is the main material removal process for the vast majority of aerospace components.However,many problems exist,including severe and rapid tool wear,low machining efficiency,and poor surface integrity.Nontraditional energy-assisted mechanical machining is a hybrid process that uses nontraditional energies(vibration,laser,electricity,etc)to improve the machinability of local materials and decrease the burden of mechanical machining.This provides a feasible and promising method to improve the material removal rate and surface quality,reduce process forces,and prolong tool life.However,systematic reviews of this technology are lacking with respect to the current research status and development direction.This paper reviews the recent progress in the nontraditional energy-assisted mechanical machining of difficult-to-cut materials and components in the aerospace community.In addition,this paper focuses on the processing principles,material responses under nontraditional energy,resultant forces and temperatures,material removal mechanisms,and applications of these processes,including vibration-,laser-,electric-,magnetic-,chemical-,advanced coolant-,and hybrid nontraditional energy-assisted mechanical machining.Finally,a comprehensive summary of the principles,advantages,and limitations of each hybrid process is provided,and future perspectives on forward design,device development,and sustainability of nontraditional energy-assisted mechanical machining processes are discussed. 展开更多
关键词 difficult-to-cut materials geometrically complex components nontraditional energy mechanical machining aerospace community
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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library
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作者 Shi-Qi Wang Xun Zhao +10 位作者 Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第5期722-732,共11页
Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon... Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products. 展开更多
关键词 Polysorbate 20 component DATABASE DISCRIMINATION Degradation
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Multi-omics analyses provide insights into the evolutionary history and the synthesis of medicinal components of the Chinese wingnut
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作者 Zi-Yan Zhang He-Xiao Xia +5 位作者 Meng-Jie Yuan Feng Gao Wen-Hua Bao Lan Jin Min Li Yong Li 《Plant Diversity》 SCIE CAS CSCD 2024年第3期309-320,共12页
Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family Juglandaceae.However,the lack of high-quality reference genome has hindered its in-depth research.In thi... Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family Juglandaceae.However,the lack of high-quality reference genome has hindered its in-depth research.In this study,we successfully assembled its chromosome-level genome and performed multiomics analyses to address its evolutionary history and synthesis of medicinal components.A thorough examination of genomes has uncovered a significant expansion in the Lateral Organ Boundaries Domain gene family among the winged group in Juglandaceae.This notable increase may be attributed to their frequent exposure to flood-prone environments.After further differentiation between Chinese wingnut and Cyclocarya paliurus,significant positive selection occurred on the genes of NADH dehydrogenase related to mitochondrial aerobic respiration in Chinese wingnut,enhancing its ability to cope with waterlogging stress.Comparative genomic analysis revealed Chinese wingnut evolved more unique genes related to arginine synthesis,potentially endowing it with a higher capacity to purify nutrient-rich water bodies.Expansion of terpene synthase families enables the production of increased quantities of terpenoid volatiles,potentially serving as an evolved defense mechanism against herbivorous insects.Through combined transcriptomic and metabolomic analysis,we identified the candidate genes involved in the synthesis of terpenoid volatiles.Our study offers essential genetic resources for Chinese wingnut,unveiling its evolutionary history and identifying key genes linked to the production of terpenoid volatiles. 展开更多
关键词 GENOME Medicinal components METABOLOME Pterocarya stenoptera TRANSCRIPTOME
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Effects of main components on energy output characteristics of thermobaric explosive——A case study of typical formulations
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作者 Yunfei Zhao Yaning Li +3 位作者 Zhiwei Han Peng Bao Jingyan Wang Boliang Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第8期205-216,共12页
As a kind of high-efficiency explosive with compound destructive capability, the energy output law of thermobaric explosives has been receiving great attention. In order to investigate the effects of main components o... As a kind of high-efficiency explosive with compound destructive capability, the energy output law of thermobaric explosives has been receiving great attention. In order to investigate the effects of main components on the explosive characteristics of thermobaric explosives, various high explosives and oxidants were selected to formulate five different types of thermobaric explosive. Then they were tested in both open space and closed space respectively. Pressure measurement system, high-speed camera,infrared thermal imager and multispectral temperature measurement system were used for pressure,temperature and fireball recording. The effects of different components on the explosive characteristics of thermobaric explosive were analyzed. The results showed that in open space, the overpressure is dominated by the high explosives content in the formulation. The addition of the oxidants will decrease the explosion overpressure but will increase the duration and overall brightness of the fireball. While in closed space, the quasi-static pressure formed after the explosion is positively correlated with the temperature and gas production. In addition, it was found that the differences in shell constraints can also alter the afterburning reaction of thermobaric explosives, thus affecting their energy output characteristics. PVC shell constraint obviously increases the overpressure and makes the fireball burn more violently. 展开更多
关键词 Thermobaric explosives components OVERPRESSURE FIREBALL Afterburning reaction
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Effect of Planting Date on Yield and Yield Components of Grain Sorghum Hybrids
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作者 Bandiougou Diawara Sory Diallo +2 位作者 Brahima Traore Scott Staggenbord Vara Prasad 《American Journal of Plant Sciences》 CAS 2024年第5期387-402,共16页
In Kansas, productivity of grain sorghum [Sorghum bicolor (L.) Moench] is affected by weather conditions at planting and during pollination. Planting date management and selection of hybrid maturity group can help to ... In Kansas, productivity of grain sorghum [Sorghum bicolor (L.) Moench] is affected by weather conditions at planting and during pollination. Planting date management and selection of hybrid maturity group can help to avoid severe environmental stresses during these sensitive stages. The hypothesis of the study was that late May planting improves grain sorghum yield and yield components compared with late June planting. The objectives of this research were to investigate the influence of planting dates yield and yield components of different grain sorghum hybrids, and to determine the optimal planting date and hybrid combination for maximum biomass and grains production. Three sorghum hybrids (early, medium, and late maturing) were planted in late May and late June without irrigation in Kansas at Manhattan/Ashland Bottom Research Station, and Hutchinson in 2010;and at Manhattan/North Farm and Hutchinson in 2011. Data on dry matter production, yield and yield components were collected. Grain yield and yield components were influenced by planting date depending on environmental conditions. At Manhattan (2010), greater grain yield, number of heads per plant, were obtained with late-June planting compared with late May planting, while at Hutchinson (2010) greater yield was obtained with late May planting for all hybrids. The yield component most affected at Hutchinson was the number of kernels∙panicle<sup>−1</sup> and plant density. Late-May planting was favorable for late maturing hybrid (P84G62) in all locations. However, the yield of early maturing hybrid (DKS 28-05) and medium maturing hybrid (DKS 37-07) was less affected by delayed planting. The effects of planting dates on yield and yield components of grain sorghum hybrids were found to be variable among hybrid maturity groups and locations. 展开更多
关键词 Sorghum [Sorghum bicolor (L.) Moench] Grain Yield Yield components
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Simultaneous purification of minor components in natural products using twin-column recycling chromatography with a step solvent gradient
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作者 Guangxia Jin Yuxue Wu Feng Wei 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第5期212-219,共8页
The isolation of minor components from complex natural product matrices presents a significant challenge in the field of purification science due to their low concentrations and the presence of structurally similar co... The isolation of minor components from complex natural product matrices presents a significant challenge in the field of purification science due to their low concentrations and the presence of structurally similar compounds.This study introduces an optimized twin-column recycling chromatography method for the efficient and simultaneous purification of these elusive constituents.By introducing water at a small flowing rate between the twin columns,a step solvent gradient is created,by which the leading edge of concentration band would migrate at a slower rate than the trailing edge as it flowing from the upstream to downstream column.Hence,the band broadening is counterbalanced,resulting in an enrichment effect for those minor components in separation process.Herein,two target substances,which showed similar peak position in high performance liquid chromatography(HPLC)and did not exceed 1.8%in crude paclitaxel were selected as target compounds for separation.By using the twin-column recycling chromatography with a step solvent gradient,a successful purification was achieved in getting the two with the purity almost 100%.We suggest this method is suitable for the separation of most components in natural produces,which shows higher precision and recovery rate compared with the common lab-operated separation ways for natural products(thin-layer chromatography and prep-HPLC). 展开更多
关键词 Solvent gradient Twin-column recycling chromatography PURIFICATION Minor component Natural products
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Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods
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作者 Changge Guan Zhenglin Tan +6 位作者 Shucheng Li Yi Wang Naoyuki Yamamoto Chong Zhang Songjun Wang Junjie Chen Xinhui Xing 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期166-172,共7页
Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides minin... Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence data.In this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA sequences.By functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to longevity.We have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide database.Val-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is reliable.This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences. 展开更多
关键词 Chinese giant salamander Transcriptomic analysis Bioactive components Functional peptides mining
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基于Visual Components的套筒类零件柔性制造单元的应用研究
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作者 潘文宏 《煤矿机械》 2024年第5期188-191,共4页
为实现多品种中、小批量零件的智能化加工,以套筒类零件加工为研究对象,通过对零件工艺的分析,为满足单元加工、搬运、翻转等功能需求,对数控机床和工业机器人进行选型,实现柔性制造单元的设计。利用Visual Components软件进行单元搭建... 为实现多品种中、小批量零件的智能化加工,以套筒类零件加工为研究对象,通过对零件工艺的分析,为满足单元加工、搬运、翻转等功能需求,对数控机床和工业机器人进行选型,实现柔性制造单元的设计。利用Visual Components软件进行单元搭建、仿真优化反馈以提高真实产线运行效率。利用Profinet实现制造单元真实搭建,完成单元安装调试。套筒类零件柔性制造单元的设计为生产线设计提供了新思路。 展开更多
关键词 套筒类零件 柔性制造单元 Visual components PROFINET
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Association of complement components with risk of colorectal cancer:A systematic review and meta-analysis
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作者 Xiao-Lin Zhu Lu Zhang Su-Xia Qi 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期2168-2180,共13页
BACKGROUND Complement components could contribute to the tumor microenvironment and the systemic immune response.Nevertheless,their role in colorectal cancer(CRC)remains a contentious subject.AIM To elucidate the rela... BACKGROUND Complement components could contribute to the tumor microenvironment and the systemic immune response.Nevertheless,their role in colorectal cancer(CRC)remains a contentious subject.AIM To elucidate the relationship between complement components and CRC risk and clinical characteristics.METHODS Searches were conducted in PubMed,the Cochrane Library,and the China National Knowledge Infrastructure database until June 1,2023.We included cohort studies encompassing participants aged≥18 years,investigating the association between complement components and CRC.The studies were of moderate quality or above,as determined by the Agency for Healthcare Research and Quality.The meta-analysis employed fixed-effects or random-effects models based on the I^(2)test,utilizing risk ratio(RR)and their corresponding 95%confidence interval(CI)for outcomes.Sensitivity and subgroup analyses were performed to validate the robustness of the collective estimates and identify the source of heterogeneity.RESULTS Data from 15 studies,comprising 1631 participants that met the inclusion criteria,were included in the meta-analysis.Our findings indicated that protein levels of cluster of differentiation 46(CD46)(RR=3.66,95%CI:1.75-7.64,P<0.001),CD59(RR=2.86,95%CI:1.36-6.01,P=0.005),and component 1(C1)(RR=5.88,95%CI:1.75-19.73,P=0.004)and serum levels of C3(standardized mean difference=1.82,95%CI:0.06-3.58,P=0.040)were significantly elevated in patients with CRC compared to healthy controls.Strong expression of CD55 or CD59 was associated with a higher incidence of lymph node metastasis,whereas strong CD46 expression correlated with a higher incidence of tumor differentiation compared to low CD46 expression(P<0.05 for all).Although specific pooled results demonstrated notable heterogeneity,subgroup analyses pointed to regional differences as the primary source of inconsistency among the studies.CONCLUSION Our analysis underscores that increased levels of specific complement components are associated with a heightened risk of CRC,emphasizing the potential significance of monitoring elevated complement component levels. 展开更多
关键词 Complement components Colorectal cancer Lymph node metastasis Systematic review META-ANALYSIS
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Umami taste components in chicken-spices blends and potential effect of aroma on umami taste intensity
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作者 Rani Andaleeb Yiwen Zhu +5 位作者 Ninglong Zhang Danni Zhang Muzahir Hussain Yin Zhang Yingshuang Lu Yuan Liu 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1220-1230,共11页
In this study,umami taste intensity(UTI)and umami taste components in chicken breast(CB)and chickenspices blends were characterized using sensory and instrumental analysis.Our main objective was to assess the aroma-um... In this study,umami taste intensity(UTI)and umami taste components in chicken breast(CB)and chickenspices blends were characterized using sensory and instrumental analysis.Our main objective was to assess the aroma-umami taste interactions in different food matrices and reconcile the aroma-taste perception to assist future product development.The impact of key aroma,including vegetable-note"2-pentylfuran",meaty"methional",green"hexanal",and spicy-note-estragole and caryophyllene"on UTI was evaluated in monosodium glutamate and chicken extract.We found that spices significantly decreased UTI and umami taste components in CB.Interestingly,the perceptually similar odorants and tastants exhibited the potential to enhance UTI in food matrices.Methional was able to increase the UTI,whereas spicy and green-note components could reduce the UTI significantly.This information would be valuable to food engineers and formulators in aroma selection to control the UTI perceived by consumers,thus,improving the quality and acceptability of the chicken products. 展开更多
关键词 Chicken-spices blends Umami taste components Aroma-taste interactions Perceptual similarity Umami taste intensity
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A novel approach of jet polishing for interior surface of small-grooved components using three developed setups
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作者 Qinming Gu Zhenyu Zhang +6 位作者 Hongxiu Zhou Jiaxin Yu Dong Wang Junyuan Feng Chunjing Shi Jianjun Yang Junfeng Qi 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期428-447,共20页
It is a challenge to polish the interior surface of an additively manufactured component with complex structures and groove sizes less than 1 mm.Traditional polishing methods are disabled to polish the component,meanw... It is a challenge to polish the interior surface of an additively manufactured component with complex structures and groove sizes less than 1 mm.Traditional polishing methods are disabled to polish the component,meanwhile keeping the structure intact.To overcome this challenge,small-grooved components made of aluminum alloy with sizes less than 1 mm were fabricated by a custom-made printer.A novel approach to multi-phase jet(MPJ)polishing is proposed,utilizing a self-developed polisher that incorporates solid,liquid,and gas phases.In contrast,abrasive air jet(AAJ)polishing is recommended,employing a customized polisher that combines solid and gas phases.After jet polishing,surface roughness(Sa)on the interior surface of grooves decreases from pristine 8.596μm to 0.701μm and 0.336μm via AAJ polishing and MPJ polishing,respectively,and Sa reduces 92%and 96%,correspondingly.Furthermore,a formula defining the relationship between linear energy density and unit defect volume has been developed.The optimized parameters in additive manufacturing are that linear energy density varies from 0.135 J mm^(-1)to 0.22 J mm^(-1).The unit area defect volume achieved via the optimized parameters decreases to 1/12 of that achieved via non-optimized ones.Computational fluid dynamics simulation results reveal that material is removed by shear stress,and the alumina abrasives experience multiple collisions with the defects on the heat pipe groove,resulting in uniform material removal.This is in good agreement with the experimental results.The novel proposed setups,approach,and findings provide new insights into manufacturing complex-structured components,polishing the small-grooved structure,and keeping it unbroken. 展开更多
关键词 abrasive air jet polishing multi-phase jet polishing interior curved surface small-grooved component aluminum alloy
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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model
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作者 Ao Qier Naren Mandula +7 位作者 Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang 《Traditional Medicine Research》 2024年第2期8-17,共10页
Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treati... Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine model.Methods:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 software.For the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine model.Pre-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior tests.RNA sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal nerve.Results:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass spectrometry.We discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology database.The“compound-target-disease”network contained 163 intersection targets with the migraine state.Gene Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,etc.When Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,etc.These predictions were further demonstrated via in vivo animal model experiments.The RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreated group.Those genes were mainly involved in neuromodulation,vascular function,and hormone metabolism.Conclusion:The 55 bio-active components in Horcha-6 regulate inflammation,hormone metabolism,and neurotransmitters and have potential as a therapy to treat migraines. 展开更多
关键词 Horcha-6 bio-active components rat migraine model inflammation hormone metabolism NEUROTRANSMITTER
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Microstructure and properties of 35 kg large aluminum alloy flywheel housing components formed by squeeze casting with local pressure compensation
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作者 Ju-fu Jiang Jing Yan +4 位作者 Ying-ze Liu Ning Ge Ying Wang Chang-jie Ding De-chao Zou 《China Foundry》 SCIE EI CAS CSCD 2024年第5期563-576,共14页
The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 kg.The numerical simulation,microstructure observation and phase characterization were ... The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 kg.The numerical simulation,microstructure observation and phase characterization were performed,and the influence of local pressure compensation on feeding of thick-wall position,microstructure and mechanical properties of the formed components were discussed.Results show that the molten metal keeps a good fluidity and the filling is complete during the filling process.Although the solidification at thick-wall positions of the mounting ports is slow,the local pressure compensation effectively realizes the local forced feeding,significantly eliminating the shrinkage cavity defects.In the microstructure of AlSi9Mg alloy,α-Al primarily consists of fragmented dendrites and rosette grains,while eutectic Si predominantly comprises needles and short rods.The impact of local pressure compensation on strength is relatively minimal,yet its influence on elongation is considerable.Following local pressure compensation,the average elongation at the compensated areas is 9.18%,which represents a 44.90%higher than that before compensation.The average tensile strength is 209.1 MPa,and the average yield strength is 100.6 MPa.The local pressure compensation can significantly reduce or even eliminate the internal defects in the 35 kg large-weight components formed by squeeze casting. 展开更多
关键词 squeeze casting local pressure compensation aluminum alloy microstructure mechanical properties large flywheel housing components
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Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control
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作者 Qi-Er Mu Yi-Sa A +1 位作者 Yan-Qiu Bai Chu-La Sa 《Traditional Medicine Research》 2024年第12期13-30,共18页
Gentiana macrophylla Pall.(G.macrophylla),whose genus and family belong to the Gentianaceae and Gentiana.The main distribution centers of G.macrophylla resources were the Loess Plateau and the eastern Qinghai-Tibet Pl... Gentiana macrophylla Pall.(G.macrophylla),whose genus and family belong to the Gentianaceae and Gentiana.The main distribution centers of G.macrophylla resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in China.G.macrophylla,as a traditional medicine,has a long history and was used in different ethnic medicines.Its roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing swelling.From previous studies,it could be found that there were more than forty components isolated and identified from G.macrophylla.The main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and alkaloids.Iridoid terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of G.macrophylla,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract activities.The flower mainly contains isoorientin and isovitexin as the representative of flavonoids.They have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of melanin.It could be seen from previous studies that the research on G.macrophylla was mainly focused on the root,and the flower was rarely studied.It was reported that the experimental data of the anti-inflammatory and anti-tumor effects of G.macrophylla flowers show that its curative effect was very good.Therefore,the flowers of the flower of G.macrophylla can be used as potential medicinal parts for research.Given that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about G.macrophylla’s potential medical benefits.Based on botanical books,Chinese classic texts,medical monographs and academic search engines(Google,Google Scholar,Web of Science,SciFinder,Pubmed,CNKI,Sci-hub,Elsevier and Wanfang),the data and information on G.macrophylla in the past 20 years are inquired and summarized comprehensively.The basic source,traditional use,chemical composition,biological activity,pharmacodynamics and quality control of G.macrophylla was systematically reviewed,in order to provide reliable basis for the subsequent development and utilization of G.macrophylla. 展开更多
关键词 Gentiana macrophylla Pall basic source chemical component pharmacological activity quality control
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Microbiomics and metabolomics insights into the microbial regulation on the formation of flavor components in the traditional fermentation process of Chinese Hongqu aged vinegar
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作者 Shangong Tong Wenlong Li +7 位作者 Yuandong Rao Yanqin Xiao Yingyin Yan Weiling Guo Xucong Lü Jinyuan Sun Lianzhong Ai Li Ni 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2765-2778,共14页
This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar,and explore the core functional microbes closely related to the formation of flavo... This study aimed to investigate microbial succession and metabolic dynamics during the traditional fermentation of Hongqu aged vinegar,and explore the core functional microbes closely related to the formation of flavor components.Microbiome analysis demonstrated that Lactobacillus,Acetobacter,Bacillus,Enterobacter,Lactococcus,Leuconostoc and Weissella were the predominant bacterial genera,while Aspergillus piperis,Aspergillus oryzae,Monascus purpureus,Candida athensensis,C.xylopsoci,Penicillium ochrosalmoneum and Simplicillium aogashimaense were the predominant fungal species.Correlation analysis revealed that Acetobacter was positively correlated with the production of tetramethylpyrazine,acetoin and acetic acid,Lactococcus showed positive correlation with the production of 2-nonanone,2-heptanone,ethyl caprylate,ethyl caprate,1-hexanol,1-octanol and 1-octen-3-ol,C.xylopsoci and C.rugosa were positively associated with the production of diethyl malonate,2,3-butanediyl diacetate,acetoin,benzaldehyde and tetramethylpyrazine.Correspondingly,non-volatile metabolites were also detected through ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.A variety of amino acids and functional dipeptides were identified during the traditional brewing of Hongqu aged vinegar.Correlation analysis revealed that Lactobacillus was significantly associated with DL-lactate,indolelactic acid,D-(+)-3-phenyllactic acid,pimelic acid,pregabalin and 3-aminobutanoic acid.This study is useful for understanding flavor formation mechanism and developing effective strategies for the suitable strains selection to improve the flavor quality of Hongqu aged vinegar. 展开更多
关键词 Hongqu aged vinegar Traditional fermentation Microbial dynamics Flavor components Bidirectional orthogonal partial least squares
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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation
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作者 Xu Liang Ni-Hui Zhang +4 位作者 Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao 《Traditional Medicine Research》 2025年第2期1-15,共15页
Background:Rosa chinensis Jacq.and Rosa rugosa Thunb.are not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional medicines.The two plants h... Background:Rosa chinensis Jacq.and Rosa rugosa Thunb.are not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional medicines.The two plants have some differences in efficacy,but the flower buds are easily confused for similar traits.In addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal roses.Therefore,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography fingerprints.Then,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large differences.Differential compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and Meigui.Results:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the samples.Through principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four groups.Partial least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavonoid glycosides,as well as phenolic acids.Eight differential components were screened out by orthogonal partial least-squares discriminant analysis and S-plot analysis.Quantitative analyses of the eight compounds,including gallic acid,ellagic acid,hyperoside,isoquercitrin,etc.,showed that Yueji was generally richer in phenolic acids and flavonoids than Meigui,and the quality of Yueji from Shandong and Hebei was better.It is worth noting that Xinjiang rose is rich in various components,which is worth focusing on more in-depth research.Conclusion:In this study,the fingerprints of Meigui and Yueji were established.The chemical components information of roses was further improved based on non-targeted metabolomics and mass spectrometry technology.At the same time,eight differential components of Meigui and Yueji were screened out and quantitatively analyzed.The research results provided a scientific basis for the quality control and rational development and utilization of Rosae Chinensis Flos and Rosae Rugosae Flos,and also laid a foundation for the study of their pharmacodynamic material basis. 展开更多
关键词 Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics CHEMOMETRICS multiple component quantification quality evaluation
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Leveraging React Components in Business Process Management (BPM) Applications
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作者 Ashok Reddy Annaram 《Journal of Computer and Communications》 2024年第4期86-94,共9页
As organizations increasingly embrace digital transformation, the integration of modern web technologies like React.js with Business Process Management (BPM) applications has become essential. React components offer f... As organizations increasingly embrace digital transformation, the integration of modern web technologies like React.js with Business Process Management (BPM) applications has become essential. React components offer flexibility, reusability, and scalability, making them ideal for enhancing user interfaces and driving user engagement within BPM environments. This article explores the benefits, challenges, and best practices of leveraging React components in BPM applications, along with real-world examples of successful implementations. 展开更多
关键词 React.js Digital Transformation User Interface (UI) Development component-Based Architecture Declarative UI Development User Experience (UX) REUSABILITY Modularity INTEGRATION CUSTOMIZATION Developer Productivity Legacy System Integration
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Recent research and development on forming for large magnesium alloy components with high mechanical properties 被引量:2
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作者 Zhimin Zhang Jianmin Yu +3 位作者 Yong Xue Beibei Dong Xi Zhao Qiang Wang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第11期4054-4081,共28页
The lightweight of high-end equipment relies on high mechanical properties magnesium(Mg) alloy structural components, because it is the best way to improve equipment service performance and reduce energy consumption. ... The lightweight of high-end equipment relies on high mechanical properties magnesium(Mg) alloy structural components, because it is the best way to improve equipment service performance and reduce energy consumption. This article summarizes the current progress and characteristics of large-scale high-performance Mg alloy components by analyzing the strengthening-toughening mechanisms, characteristics of plastic forming, and the preparation of large high mechanical properties forging blanks. Due to the lack of breakthroughs in the key technologies for forming large-scale Mg alloy components, their uniformity of mechanical properties and consistency are poor, the forming accuracy of components is low, and the production cost is high, which limit their engineering application and restrict the lightweight level of high-end equipment. In view of the above problems, the forming trends and research directions of large-scale and high mechanical properties Mg alloy components are proposed in this paper. It can provide help for the breakthrough of the key technology of large-scale Mg alloy components with high mechanical properties and expand the application of Mg alloy in high-end products. 展开更多
关键词 Mg alloys Wrought Mg alloys components Plastic forming Large-scale Mg alloys components High mechanical properties
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Effect of dissolved components of malachite and calcite on surface properties and flotation behavior 被引量:2
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作者 Zhihao Shen Shuming Wen +4 位作者 Han Wang Yongchao Miao Xiao Wang Shengbing Meng Qicheng Feng 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2023年第7期1297-1309,共13页
In general,malachite is recovered via sulfidization–xanthate flotation,although many unsatisfactory flotation indexes are frequently obtained as a result of the presence of associated calcite.This phenomenon occurs b... In general,malachite is recovered via sulfidization–xanthate flotation,although many unsatisfactory flotation indexes are frequently obtained as a result of the presence of associated calcite.This phenomenon occurs because the dissolved components of malachite and calcite affect the flotation behavior of both minerals.In this study,the effect of the dissolved components derived from malachite and calcite on the flotation behavior and surface characteristics of both minerals was investigated.Flotation tests indicated that malachite recovery decreased when the calcite supernatant was introduced,while the presence of the malachite supernatant increased the recovery of calcite.Dissolution and adsorption tests,along with zeta potential measurements,X-ray photoelectron spectroscopy,Fourier transform infrared spectrometry,and timeof-flight secondary ion mass spectrometry demonstrated that the Ca species in the calcite supernatant were adsorbed on the malachite surface,which hindered the interaction of Na2S with malachite,thereby resulting in the insufficient adsorption of sodium isoamyl xanthate(NaIX)on the surface of malachite.By contrast,the Cu species in the malachite supernatant were adsorbed on the calcite surface,and they provided active sites for the subsequent adsorption of Na_(2)S and NaIX. 展开更多
关键词 MALACHITE CALCITE dissolved components sulfidization-xanthate flotation surface properties
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Vision-based multi-level synthetical evaluation of seismic damage for RC structural components: a multi-task learning approach 被引量:1
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作者 Xu Yang Qiao Weidong +2 位作者 Zhao Jin Zhang Qiangqiang Li Hui 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2023年第1期69-85,共17页
Recent studies for computer vision and deep learning-based,post-earthquake inspections on RC structures mainly perform well for specific tasks,while the trained models must be fine-tuned and re-trained when facing new... Recent studies for computer vision and deep learning-based,post-earthquake inspections on RC structures mainly perform well for specific tasks,while the trained models must be fine-tuned and re-trained when facing new tasks and datasets,which is inevitably time-consuming.This study proposes a multi-task learning approach that simultaneously accomplishes the semantic segmentation of seven-type structural components,three-type seismic damage,and four-type deterioration states.The proposed method contains a CNN-based encoder-decoder backbone subnetwork with skip-connection modules and a multi-head,task-specific recognition subnetwork.The backbone subnetwork is designed to extract multi-level features of post-earthquake RC structures.The multi-head,task-specific recognition subnetwork consists of three individual self-attention pipelines,each of which utilizes extracted multi-level features from the backbone network as a mutual guidance for the individual segmentation task.A synthetical loss function is designed with real-time adaptive coefficients to balance multi-task losses and focus on the most unstably fluctuating one.Ablation experiments and comparative studies are further conducted to demonstrate their effectiveness and necessity.The results show that the proposed method can simultaneously recognize different structural components,seismic damage,and deterioration states,and that the overall performance of the three-task learning models gains general improvement when compared to all single-task and dual-task models. 展开更多
关键词 post-earthquake evaluation multi-task learning computer vision structural component segmentation seismic damage recognition deterioration state assessment
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