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A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting 被引量:1
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作者 Yuanrong Li Mingjun Xie +4 位作者 Shang Lv Yuan Sun Zhuang Li Zeming Gu Yong He 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第4期486-499,共14页
Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and... Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism. 展开更多
关键词 biomimetic air-blood barrier composite material design controllable mechanical stimulus structure
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Composition dependence of phase structure and electrical properties of(1-y)Bi_(1-x)Nd_xFeO_(3-y)BiScO_3 ceramics
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作者 TAO Hong WU JiaGang 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第7期1029-1035,共7页
In this work, we have studied a new lead-free ceramic of(1-y)Bi1-xNdxFeO3-yBiScO3(0.05≤x≤0.15 and 0.05≤y≤0.15) prepared by a conventional solid-state method, and the influences of Nd and Sc content on their ph... In this work, we have studied a new lead-free ceramic of(1-y)Bi1-xNdxFeO3-yBiScO3(0.05≤x≤0.15 and 0.05≤y≤0.15) prepared by a conventional solid-state method, and the influences of Nd and Sc content on their phase structure and electrical properties were investigated in detail. The ceramics with 0.05≤x≤0.10 and 0.05≤y≤0.15 belong to an R3 c phase, and the rhombohedral-like and orthorhombic multiphase coexistence is established in the composition range of 0.125≤x≤0.15 and y=0. The electrical properties of the ceramics can be enhanced by modifying x and y values. The highest piezoelectric coefficient(d33~51 p C/N) is obtained in the ceramics with x=0.075 and y=0.125, which is superior to that of a pure BiFeO3 ceramic. In addition, a lowest dielectric loss(tan δ~0.095%, f=100 k Hz) is shown in the ceramics with x=0.15 and y=0 due to the involvement of low defect concentrations, and the improved thermal stability of piezoelectricity at 20–600℃ is possessed in the ceramics. We believe that the ceramics can play a meaningful role in the high-temperature lead-free piezoelectric applications. 展开更多
关键词 BiFeO_3 ceramics composition design phase structure piezoelectric properties
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