Objective:To investigate the effect of compound laser acupuncture-moxibustion on blood glucose,fasting insulin and blood lipids levels in type 2 diabetes mellitus(T2DM)rats.Methods:Forty male Wistar rats were ran doml...Objective:To investigate the effect of compound laser acupuncture-moxibustion on blood glucose,fasting insulin and blood lipids levels in type 2 diabetes mellitus(T2DM)rats.Methods:Forty male Wistar rats were ran domly divided into 4 groups,in eluding the no rmal group,model control group,laser group and sham laser group(n=10 per group).The rats in the normal group were fed with a standard diet.Rats in other groups were fed with a high-sugar and high-fat diet for 4 weeks,then intraperitoneally injected with 1%streptozotocin to induce T2DM model.The laser group was irradiated by 10.6 μm and 650 nm compound laser on bilateral Pishu(BL 20),Shenshu(BL 23)and Sanyinjiao(SP 6)for 5 min,6 times a week for 5 weeks.The sham laser group received the same treatment as the laser group,but without laser output.The model control group and normal group were not treated.Blood glucose levels were measured before and after 1,2,3,4 and 5 weeks of treatment.The serum levels of fasting insulin,total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL),and high-density lipoprotein(HDL)were analyzed after the last treatment.Results:The blood glucose levels in the model control group in creased duri ng the 5 weeks of treatment compared with the no rmal group(P<0.05),while those in the laser group were significantly lower than the model control group after weekly treatment(P<0.01 or P<0.05).After 1,2 and 3 weeks of treatment,the blood glucose levels in the laser group decreased obviously compared with the sham laser group(P<0.01 or P<0.05).Compared with the normal group,the levels of fasti ng in suli n,TC and LDL in the model control group notably in creased(P<0.01 or P<0.05),while their levels in the laser group were significantly lower than the model control group after 5 weeks of treatment(P<0.05 or P<0.01).However,no statistically significant differences were observed in TG or HDL levels among the 4 groups(P>0.05).Conclusion:The compound laser acupuncture-moxibustion of 10.6μm and 650 nm had positive effects on the regulati on of hyperglycemia and insulin resista nee in T2DM rats,which may be a potential treatment for T2DM,and also provide an alternative to the traditional acupuncture and moxibustion therapy.展开更多
Compound eyes are unique optical imaging systems that consist of numerous separate light-sensitive units(ommatidia).Attempts have been made to produce artificial compound eyes via advanced 3 D nanotechnologies.Among t...Compound eyes are unique optical imaging systems that consist of numerous separate light-sensitive units(ommatidia).Attempts have been made to produce artificial compound eyes via advanced 3 D nanotechnologies.Among them,femtosecond laser direct writing(FsLDW)technology has emerged as an effective strategy due to its distinct advantages in 3 D designable and high precision fabrication capability.However,the point-by-point scanning process results in a very low fabrication efficiency,limiting the practical applications of the FsLDW technology.To solve this problem,we propose a high-efficiency method for the mass production of 3 D artificial compound eyes using a photopolymer template fabricated by FsLDW.The resultant 3 D SU-8 compound eye templates could be used to replicate polydimethylsiloxane(PDMS)compound eyes many times(over 50 times)with a highly improved efficiency(nearly 20 times higher than the efficiency of direct fabrication using the point-by-point FsLDW).The PDMS replicas showed good focusing and imaging performances.We anticipate that this method may serve as an enabler for the mass production of 3 D artificial compound eyes and promote their practical applications in the near future.展开更多
To investigate the effect of Au thickness on evolution of AuSnx IMCs, pads with 0. 1, 0. 5 and 4. 0 μm thickness of Au surface finish were utilized. Laser reflowed solder joints were aged in 125℃ isothermal ovens. R...To investigate the effect of Au thickness on evolution of AuSnx IMCs, pads with 0. 1, 0. 5 and 4. 0 μm thickness of Au surface finish were utilized. Laser reflowed solder joints were aged in 125℃ isothermal ovens. Results indicated that little IMC formed at the interface of solder and pad with 0. 1 μm thickness of Au. Even in condition of 744 hours aging, thickness of lMCs did not increase obviously. As for the joints with 0. 5 μm thickness of Au, most of AuSn4 IMCs stayed at the inteornce and were in needle-like or dendritic morphology. With the increase of aging time, AuSn4 IMCs beeame flat and changed to a continuous layer. In the joints with 4. 0 μm thickness of Au on pads, AuSn, AuSn2, AuSn4 IMCs and Au2Sn phase formed at the interface. As aging time was increased, more Sn rich IMCs formed at the interface, and evolved to AuSn4 IMCs in condition of long time aging. Thickness of AuSn4 IMCs reached about 30μm.展开更多
The formation of Fe-N compounds by laser nitriding in an atmospheric ambient was reported. By CW-CO2 laser irradiation on pure ferrite iron in the atmospheric ambient, Fe-N compounds (including Fe2N, .Fe3AT and Fe4N) ...The formation of Fe-N compounds by laser nitriding in an atmospheric ambient was reported. By CW-CO2 laser irradiation on pure ferrite iron in the atmospheric ambient, Fe-N compounds (including Fe2N, .Fe3AT and Fe4N) are formed as a result of a laser-enhanced and temperature-enhanced reactions. The samples were analyzed with X-ray diffraction. It is found that the laser power density, scanning speed and nitrogen temperature are the main factors influencing the formation of Fe-N compounds. Nitrogen can be activated by pre-heating at some temperature. Nitrogen activation and sample surface melting by CW-CO2 laser greatly enhance the reaction between the sample surface and nitrogen beam. After annealing at 500℃for 3h, some Fe2N and Fe3N converted into more stable Fe4N.展开更多
Objective:To determine the clinical value of compound Xueshuantong capsule in the treatment of diabetic retinopathy on the basis of laser treatment.Methods:Data were collected from 98 patients with diabetic retinopath...Objective:To determine the clinical value of compound Xueshuantong capsule in the treatment of diabetic retinopathy on the basis of laser treatment.Methods:Data were collected from 98 patients with diabetic retinopathy from February 2021 to February 2022.They were divided into two groups by drawing lots.The experimental group was treated with compound Xueshuantong capsule and laser treatment,whereas the control group was treated with laser treatment alone.Results:The absorption of exudation,resolution of retinal edema,and absorption of bleeding took longer in the control group;the incidence of visual acuity recovery to more than 0.5 and the patients’blood glucose levels were better in the experimental group,p<0.05.Conclusion:For patients with diabetic retinopathy,laser treatment combined with compound Xueshuantong capsule can effectively improve the visual function and rehabilitation efficiency of patients with diabetic retinopathy as well as stabilize their blood sugar levels.It has high clinical application value.展开更多
Laser cladding,together with laser nitriding was used to synthesize a titanium nickel intermetallic compound layer on the nickel substrate and a TiN coating on the cladding layer. During the laser cladding, Ti and Ni ...Laser cladding,together with laser nitriding was used to synthesize a titanium nickel intermetallic compound layer on the nickel substrate and a TiN coating on the cladding layer. During the laser cladding, Ti and Ni powders were blown into the melting pool by a six-hole coaxial nozzle powder injection system. Exothermic reactions between Ti and Ni took place in the melting pool, and a cladding layer of titanium nickel intermetallic compounds was produced. Laser nitriding in a nitrogen-rich atmosphere followed the production of the cladding layer, and formed a golden yellow TiN layer over it. An optical and a scanning electron microscope were used to investigate the microstructures and measure the thicknesses of the cladding layer and the TiN layer. Phase identification was carried out by XRD. For the nitriding sample, the microhardness profile of the clad layer was tested. The optimal process parameters of the in situ synthesis of titanium nickel intermetallic compounds were obtained.展开更多
基金Supported by the Science Foundation of Shanghai Municipal Commission of Science and Technology(No.19441901200)the Three-Year Development Plan Project for Traditional Chinese Medicine of Shanghai Municipal Health Commission[No.ZY(2018-2020)-CCCX-2001-05]
文摘Objective:To investigate the effect of compound laser acupuncture-moxibustion on blood glucose,fasting insulin and blood lipids levels in type 2 diabetes mellitus(T2DM)rats.Methods:Forty male Wistar rats were ran domly divided into 4 groups,in eluding the no rmal group,model control group,laser group and sham laser group(n=10 per group).The rats in the normal group were fed with a standard diet.Rats in other groups were fed with a high-sugar and high-fat diet for 4 weeks,then intraperitoneally injected with 1%streptozotocin to induce T2DM model.The laser group was irradiated by 10.6 μm and 650 nm compound laser on bilateral Pishu(BL 20),Shenshu(BL 23)and Sanyinjiao(SP 6)for 5 min,6 times a week for 5 weeks.The sham laser group received the same treatment as the laser group,but without laser output.The model control group and normal group were not treated.Blood glucose levels were measured before and after 1,2,3,4 and 5 weeks of treatment.The serum levels of fasting insulin,total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL),and high-density lipoprotein(HDL)were analyzed after the last treatment.Results:The blood glucose levels in the model control group in creased duri ng the 5 weeks of treatment compared with the no rmal group(P<0.05),while those in the laser group were significantly lower than the model control group after weekly treatment(P<0.01 or P<0.05).After 1,2 and 3 weeks of treatment,the blood glucose levels in the laser group decreased obviously compared with the sham laser group(P<0.01 or P<0.05).Compared with the normal group,the levels of fasti ng in suli n,TC and LDL in the model control group notably in creased(P<0.01 or P<0.05),while their levels in the laser group were significantly lower than the model control group after 5 weeks of treatment(P<0.05 or P<0.01).However,no statistically significant differences were observed in TG or HDL levels among the 4 groups(P>0.05).Conclusion:The compound laser acupuncture-moxibustion of 10.6μm and 650 nm had positive effects on the regulati on of hyperglycemia and insulin resista nee in T2DM rats,which may be a potential treatment for T2DM,and also provide an alternative to the traditional acupuncture and moxibustion therapy.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant Nos.#61935008,#61590930,#61775078,and#61605055
文摘Compound eyes are unique optical imaging systems that consist of numerous separate light-sensitive units(ommatidia).Attempts have been made to produce artificial compound eyes via advanced 3 D nanotechnologies.Among them,femtosecond laser direct writing(FsLDW)technology has emerged as an effective strategy due to its distinct advantages in 3 D designable and high precision fabrication capability.However,the point-by-point scanning process results in a very low fabrication efficiency,limiting the practical applications of the FsLDW technology.To solve this problem,we propose a high-efficiency method for the mass production of 3 D artificial compound eyes using a photopolymer template fabricated by FsLDW.The resultant 3 D SU-8 compound eye templates could be used to replicate polydimethylsiloxane(PDMS)compound eyes many times(over 50 times)with a highly improved efficiency(nearly 20 times higher than the efficiency of direct fabrication using the point-by-point FsLDW).The PDMS replicas showed good focusing and imaging performances.We anticipate that this method may serve as an enabler for the mass production of 3 D artificial compound eyes and promote their practical applications in the near future.
基金Acknowledgement This work is finaneially supported by the National Natural Science Foundation of China （Grant No. 51005058）, National Hight- eeh R＆D Program （863 Program ） of China （Grant No. 2007AA04Z314） and Natural Scientific Research Innovation Foundation in Harbin Institute of Technology （ HIT. NSRIF. 2009037 ）.
文摘To investigate the effect of Au thickness on evolution of AuSnx IMCs, pads with 0. 1, 0. 5 and 4. 0 μm thickness of Au surface finish were utilized. Laser reflowed solder joints were aged in 125℃ isothermal ovens. Results indicated that little IMC formed at the interface of solder and pad with 0. 1 μm thickness of Au. Even in condition of 744 hours aging, thickness of lMCs did not increase obviously. As for the joints with 0. 5 μm thickness of Au, most of AuSn4 IMCs stayed at the inteornce and were in needle-like or dendritic morphology. With the increase of aging time, AuSn4 IMCs beeame flat and changed to a continuous layer. In the joints with 4. 0 μm thickness of Au on pads, AuSn, AuSn2, AuSn4 IMCs and Au2Sn phase formed at the interface. As aging time was increased, more Sn rich IMCs formed at the interface, and evolved to AuSn4 IMCs in condition of long time aging. Thickness of AuSn4 IMCs reached about 30μm.
文摘The formation of Fe-N compounds by laser nitriding in an atmospheric ambient was reported. By CW-CO2 laser irradiation on pure ferrite iron in the atmospheric ambient, Fe-N compounds (including Fe2N, .Fe3AT and Fe4N) are formed as a result of a laser-enhanced and temperature-enhanced reactions. The samples were analyzed with X-ray diffraction. It is found that the laser power density, scanning speed and nitrogen temperature are the main factors influencing the formation of Fe-N compounds. Nitrogen can be activated by pre-heating at some temperature. Nitrogen activation and sample surface melting by CW-CO2 laser greatly enhance the reaction between the sample surface and nitrogen beam. After annealing at 500℃for 3h, some Fe2N and Fe3N converted into more stable Fe4N.
文摘Objective:To determine the clinical value of compound Xueshuantong capsule in the treatment of diabetic retinopathy on the basis of laser treatment.Methods:Data were collected from 98 patients with diabetic retinopathy from February 2021 to February 2022.They were divided into two groups by drawing lots.The experimental group was treated with compound Xueshuantong capsule and laser treatment,whereas the control group was treated with laser treatment alone.Results:The absorption of exudation,resolution of retinal edema,and absorption of bleeding took longer in the control group;the incidence of visual acuity recovery to more than 0.5 and the patients’blood glucose levels were better in the experimental group,p<0.05.Conclusion:For patients with diabetic retinopathy,laser treatment combined with compound Xueshuantong capsule can effectively improve the visual function and rehabilitation efficiency of patients with diabetic retinopathy as well as stabilize their blood sugar levels.It has high clinical application value.
文摘Laser cladding,together with laser nitriding was used to synthesize a titanium nickel intermetallic compound layer on the nickel substrate and a TiN coating on the cladding layer. During the laser cladding, Ti and Ni powders were blown into the melting pool by a six-hole coaxial nozzle powder injection system. Exothermic reactions between Ti and Ni took place in the melting pool, and a cladding layer of titanium nickel intermetallic compounds was produced. Laser nitriding in a nitrogen-rich atmosphere followed the production of the cladding layer, and formed a golden yellow TiN layer over it. An optical and a scanning electron microscope were used to investigate the microstructures and measure the thicknesses of the cladding layer and the TiN layer. Phase identification was carried out by XRD. For the nitriding sample, the microhardness profile of the clad layer was tested. The optimal process parameters of the in situ synthesis of titanium nickel intermetallic compounds were obtained.
