After completion of the human genome project, health professionals and the public become more aware aboutthe role of genetic information in medical practice. We are in a transition period to enter a new“genomic medi-...After completion of the human genome project, health professionals and the public become more aware aboutthe role of genetic information in medical practice. We are in a transition period to enter a new“genomic medi-cine”era[1,2]. In the past two decades, many mutations at disease causing genes have been identified and correla-ted to clinical phenotypes. Molecular diagnostic tests for such mutations have been developed and shown their pro-found impacts on clinical medicine and public health. With the development of new genomic technologies, large-scale analysis of human genome and transcriptome are become possible. For example,microarray analysis allows as-sessment of entire expression profile of cancer. By integrating of information from genome and expression profileswith clinical data, cancer molecular classification will become a powerful clinical tool to correlation cancers withtheir prognostics, sensitivity to chemotherapy, and the potential of metastasis[3]. Thus, molecular diagnosis will be-come important soon for clinical physicians and cancer patients on selection of the optimal healthcare approaches.展开更多
文摘After completion of the human genome project, health professionals and the public become more aware aboutthe role of genetic information in medical practice. We are in a transition period to enter a new“genomic medi-cine”era[1,2]. In the past two decades, many mutations at disease causing genes have been identified and correla-ted to clinical phenotypes. Molecular diagnostic tests for such mutations have been developed and shown their pro-found impacts on clinical medicine and public health. With the development of new genomic technologies, large-scale analysis of human genome and transcriptome are become possible. For example,microarray analysis allows as-sessment of entire expression profile of cancer. By integrating of information from genome and expression profileswith clinical data, cancer molecular classification will become a powerful clinical tool to correlation cancers withtheir prognostics, sensitivity to chemotherapy, and the potential of metastasis[3]. Thus, molecular diagnosis will be-come important soon for clinical physicians and cancer patients on selection of the optimal healthcare approaches.
