Comprehensive effects of traditional Chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis

BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.

Comprehensive Rehabilitation Therapy of Traditional Chinese Medicine Combined with Modern Rehabilitation Training Improves the Spasticity and Motor Function of Hemiplegia after Stroke

Objective:To analyze the impact of comprehensive rehabilitation therapy of traditional Chinese medicine(TCM)(based on modern rehabilitation training)on the spasticity and motor function in stroke patients with hemiplegia.Methods:Seventy-nine stroke and hemiplegia patients admitted to the hospital from June 2021 to June 2023 were selected and randomly divided into a control group(39 cases)using modern rehabilitation training,and an observation group combined with comprehensive TCM rehabilitation therapy(40 cases),over 1 month.The clinical index data of the two groups were compared.Results:There were differences in the clinical index data between the two groups.The total effective rate after 2 treatment in the observation group(92.50%)was higher than that of the control group(74.36%)(χ^(2)=4.727,P<0.05).All central sensitization inventory(CSI)and stroke quality of life(PRO)scores in both groups were lower after treatment,with the observation group having lower scores as compared to the control group(P<0.05).The scores of FMA(upper limbs,lower limbs),Barthel index scores,and Functional Ambulation Categories(FAC)scores of both groups increased after treatment,with the observation group having higher scores as compared to the control group(P<0.05).Conclusion:Comprehensive TCM rehabilitation therapy had a significant therapeutic effect on patients with hemiplegia after stroke.It improved the patient’s spasticity,limb movement,and walking function.Their daily living abilities and quality of life were also enhanced.

Quality of life and survival analyses of breast cancer cases treated with integrated traditional Chinese and Western medicine

BACKGROUND Breast cancer(BC)is the second leading cause of tumor-related mortality after lung cancer.Chemotherapy resistance remains a major challenge to progress in BC treatment,warranting further exploration of feasible and effective alternative therapies.AIM To analyzed the quality of life(QoL)and survival of patients with BC treated with integrated traditional Chinese and Western medicine(TCM-WM).METHODS This study included 226 patients with BC admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine between February 2018 and February 2023,including 100 who received conventional Western medicine treatment(control group)and 126 who received TCM-WM treatment(research group).The total effective rate,side effects(alopecia,nausea and vomiting,hepatorenal toxicity,and myelosuppression),QoL assessed using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30),1-year overall survival(OS),recurrence and metastasis rates,and serum inflammatory factors[interleukin(IL)-6,IL-10,and tumor necrosis factor alpha]were comparatively analyzed.RESULTS The research group showed statistically better overall efficacy,EORTC QoL-C30 scores,and 1-year OS than the control group,with markedly lower side effects and 1-year recurrence and metastasis rates.Moreover,the posttreatment levels of serum inflammatory in the research group were significantly lower than the baseline and those in the control group.CONCLUSION Overall,TCM-WM demonstrated significantly improved therapeutic efficacy while ensuring drug safety in BC,which not only improved patients’QoL and prolonged survival,but also significantly inhibited the inflammatory response.

Clinical Observation on the Prevention and Treatment of Juvenile Mild Myopia with Traditional Chinese Medicine Comprehensive Therapy

Objective:To observe the clinical effect of traditional Chinese medicine on the prevention and treatment ofjuvenile mild myopia.Methods:One hundred and twenty cases of juvenile mild myopia were randomly divided into six groups,with 20 cases in each group:western medicine group,ultrasonic group,acupuncture group,auricular point group,traditional Chinese oral decoction group,and traditional Chinese medicine comprehensive therapy group.The therapeutic effects of the treatment administered to the six groups were compared.Result:In the post-treatment and follow-up stages,the visual acuity of the traditional Chinese medicine comprehensive therapy group significantly improved along with reduced diopter compared to the other groups(p<0.05).However,the axial length of the six groups had no significant change compared with that before treatment(p>0.05).There were no adverse reactions in any of the patients.Conclusion:In the treatment of juvenile mild myopia,traditional Chinese medicine comprehensive therapy has good therapeutic effect without any adverse reactions;thus,it is worthy of clinical promotion.

Research progress in the treatment of diabetic foot with traditional Chinese medicine

Diabetic foot is one of the chronic complications of diabetes,which is serious and expensive to treat.As an effective method for treating diabetic foot,Chinese medicine plays an important role in improving the clinical symptoms and reducing the suffering of diabetic foot patients.The methods of traditional Chinese medicine to treat diabetic foot include internal treatment method,external treatment method and comprehensive therapy.This article reviews the research results of traditional Chinese medicine treatment of diabetic foot in order to provide reference for the treatment of diabetic foot.

小儿推拿联合中医护理在婴幼儿运动发育迟缓康复中的应用

目的 探究小儿推拿联合中医护理在婴幼儿运动发育迟缓康复治疗中的临床效果。方法 选取聊城市人民医院2021年12月—2022年2月收治的68例运动发育迟缓患儿作为研究对象,随机分成对照组和试验组,各34例。对照组予常规治疗和护理,试验组在对照组基础上予小儿推拿联合中医护理干预,比较2组患儿干预前后的粗大运动发育商(GMQ)、精细运动发育商(FMQ)和总体发育商(TMQ)变化情况。结果 干预前,2组患者的GMQ、FMQ、TMQ评分比较,差异无统计学意义(P>0.05);干预后,试验组患者的GMQ、FMQ、TMQ评分均显著高于对照组,差异有统计学意义(P<0.05)。结论 小儿推拿联合中医护理应用于婴幼儿运动发育迟缓康复的临床效果显著,可有效提高患儿的运动发育水平,改善生活质量,值得在临床推广。

龙胆汤联合足浴治疗脑卒中后失眠临床观察

目的研究龙胆汤内服联合足浴在脑卒中后失眠老年患者中的临床疗效。方法选取66例脑卒中后失眠患者,随机分为对照组和观察组,每组33例。对照组采用艾司唑仑片口服治疗,观察组采用龙胆汤内服联合足浴治疗。疗程均为4周,比较2组患者的临床疗效。结果治疗后观察组总有效率为93.94%(31/33),明显高于对照组的66.67%(22/33),差异有统计学意义(P<0.01)。结论采用龙胆汤内服联合足浴治疗脑卒中后失眠,可有效改善患者睡眠质量,且无明显不良反应,值得临床推广。

养阴清肺汤联合中药熏蒸治疗干眼症临床观察

目的 探讨养阴清肺汤联合中药熏蒸治疗干眼症的临床效果。方法 选取中国医科大学附属盛京医院122例干眼症患者随机分为对照组和试验组,各61例。对照组予以玻璃酸钠滴眼液治疗,试验组在对照组基础上予以养阴清肺汤联合中药熏蒸治疗,均连续治疗4周。比较2组临床疗效、泪膜破裂时间(BUT)和泪液分泌量、中医症状积分及视觉相关生命质量。结果 治疗后,试验组总有效率为90.16%(55/61),高于对照组的72.13%(44/61)(P<0.05);试验组泪液分泌量、BUT高于对照组(P<0.05);试验组眼疲劳感、干涩感、异物感及烧灼感等中医症状积分低于对照组(P<0.05);试验组一般健康状况、活动障碍及视力障碍评分高于对照组(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 养阴清肺汤联合中药熏蒸治疗干眼症的临床效果显著,能明显促进泪液分泌,提高泪膜稳定性。

深圳市公立中医医院医疗服务价格改革历程与思考

通过梳理深圳市公立中医医院医疗服务价格改革历程,分析优势与难点,提出动态调整中医药服务价格,定价应体现中医劳务价值和技术价值,完善医疗服务价格目录,建立中医医疗技术评定指标体系等建议,以助推中医药综合改革,优化深圳中医医疗服务价格改革模式。

基于多方位综合素质培养的研究生教育模式探索与实践—以湖南中医药大学中医诊断研究所为例

医学研究生是医学研究的重要力量,同时也是培养高层次创新医学人才的重要储备。医学教育的根本任务是加强医学相关学科的建设布局和支持力度,培养高层次的、具有国际视野的复合型医学人才。在此背景下,探索如何提升中医学术型研究生的综合素质是高层次医学创新型人才培养的关键课题。文章以湖南中医药大学中医诊断研究所为例,在培养中医诊断学学术型研究生过程中,通过实验室结合可共享数字化学术资源为主的开放式共享平台,联合产学研合作、学科竞赛及人文素质教育的培养模式,探讨了提升中医诊断学学术型研究生综合素质的可行性,旨在为该教育模式的推广提供依据和参考。

综合性医科大学中药学专业建设的实践与思考——以首都医科大学为例

首都医科大学中药学专业在长期办学实践中分析身处综合性医科大学的教育教学资源特点,结合生源及其就业趋向,逐步树立了院校教育与师承教育相结合培养中药专业人才的精品教育理念,实施一系列深化中药学专业教育教学综合改革的措施,使人才培养质量显著提升。通过专业认证更加明确自身存在的问题,并制定了持续推进国家级一流专业建设、进一步提升人才培养质量的具体措施。

互联网背景下探究中医药院校综合素质人才培养模式

近年来,互联网一直是受到人们热议的话题之一。互联网是一把双刃剑,如何科学地将互联网利用到课堂教学中,并且减少其负面作用越来越引起重视。基于此,在充分研究互联网的利与弊之后,中医综合诊断与杂病论这门课程在沿用传统教学方法的基础上,结合了互联网优势,尽可能避开了互联网劣势,大胆创新,勇于改变,做出了符合课程特点的改革,并已经取得了初步成效。

综合性医科大学中医创新人才培养模式探索与实践

综合性医科大学既拥有西医优势学科和教育教学资源,同时具有厚重的中医药文化基础和学科人才优势。深刻剖析目前综合性医科大学中医药人才培养中普遍存在中医经典学习不够系统、实践能力不足及创新能力有待提高等一些共性问题,结合习近平总书记对中医药工作作出的“传承精华,守正创新”重要指示,本文以我校开办“名老中医传承班”为例,在着重阐述中医人才培养的核心理念与路径创新的基础上,创新性地提出综合性医科大学构建新型中医创新人才培养的“三重四结合”模式,以期为中医创新人才培养提供借鉴与新的范式。

小针刀联合补肾活血祛痛方治疗腰椎间盘突出症临床观察

目的 探讨小针刀联合补肾活血祛痛方治疗腰椎间盘突出症(LDH)的临床效果。方法 选取2016年7月—2018年4月沈阳市中医院收治的135例患者作为研究对象,将所有患者随机分为甲组(小针刀联合补肾活血祛痛方)、乙组(补肾活血祛痛方)和丙组(小针刀),观察与对比3组患者的腰痛分级、治疗前后视觉模拟量表(VAS)评分和总体效果。结果 甲组总有效率为97.78%(44/45),高于乙组的88.89%(40/45)、丙组的82.22%(37/45),差异具有统计学意义(P<0.05);甲组治疗后VAS评分下降程度明显大于乙组和丙组;甲组治疗后Denis腰痛分级明显优于乙组和丙组,差异具有统计学意义(P<0.05)。结论对LDH患者进行小针刀联合补肾活血祛痛方治疗可以有效缓解患者的疼痛程度、缩短患者的住院时间、提升患者的生活质量,同时患者腰椎功能可以得到快速恢复,值得临床应用与推广。

辨证施护联合热敏灸治疗肝硬化腹水临床观察

目的探究中医辨证施护联合热敏灸治疗肝硬化腹水的临床效果。方法选择肝硬化腹水患者60例,分为对照组(予常规治疗)和试验组(予热敏灸联合中药治疗),对比两组临床疗效及不良反应发生率。结果试验组治疗总有效率为96.67%(29/30),高于对照组的83.33%(25/30),差异有统计学意义(P<0.05)。对照组不良反应发生率为6.67%(2/30),而试验组患者未出现不良反应,差异有统计学意义(P<0.05)。结论中医辨证施护联合热敏灸治疗肝硬化腹水效果显著、安全高,值得临床推广应用。

针刺结合引火归元穴位贴敷治疗上实下虚型颈性眩晕临床观察

目的观察针刺结合引火归元穴位贴敷治疗上实下虚型颈性眩晕的临床效果。方法选取120例上实下虚型颈性眩晕患者,按随机数字表法分为针刺组、引火归元组、针刺+引火归元组与西药组并行相应治疗,每组30例。比较四组治疗前后颈性眩晕症状与功能评估量表评分、血清内皮型一氧化氮合酶(eNOS)及人降钙素基因相关肽(CGRP)水平变化,治疗结束后3个月进行回访比较复发率。结果治疗后,四组颈性眩晕症状与功能评估量表评分均较治疗前显著升高,且针刺+引火归元组升高幅度大于其余三组(P<0.05);四组血清eNOS、CGRP水平均较治疗前显著升高,且针刺+引火归元组升高幅度大于其余三组。治疗结束3个月后,针刺+引火归元组复发率为26.67%(8/30),低于其余三组。结论常规针刺、引火归元穴位贴敷、针刺结合引火归元穴位贴敷与口服甲磺酸倍他司汀片等方法对上实下虚型颈性眩晕患者均疗效确切,且针刺结合引火归元穴位贴敷效果最优、复发率最低,值得推广。

综合评估指导的中医护理干预在老年COPD患者中的应用效果

目的分析老年慢性阻塞性肺疾病(COPD)患者实施综合评估为指导的中医护理干预,对其衰弱状态、生活质量、肺功能及营养状态的影响,旨在改善老年COPD患者的衰弱状态,提高其生活质量和功能独立性,对于优化老年COPD患者的管理和护理提供依据。方法研究对象为启东市中医院呼吸内科在2021年4月—2023年3月收治且符合研究要求的COPD患者180例,基于组间基线资料具有可比性条件下将纳入患者分为对照组和观察组各90例。对照组行常规护理干预,观察组患者给予老年综合评估指导下的中医护理干预。比较观察两组患者衰弱状态、肺功能水平[第一秒用力呼气容积占用力肺活量百分比(FEV_(1)/FVC)、第一秒用力呼气容积占预计值百分比(FEV_(1)%)]、营养状况[血清总蛋白(TP)、白蛋白(ALB)水平和NRS-2002评分]以及生活质量[慢性阻塞性肺疾病评分(CAT)]变化情况。结果干预前两组患者衰弱状态分级、TP、ALB水平、NRS-2002评分、FEV_(1)/FVC、FEV_(1)%水平、CAT评分比较差异无统计学意义(P>0.05)。干预后,观察组患者衰弱状态轻于对照组,观察组TP、ALB水平高于对照组,NRS-2002评分低于对照组,观察组FEV_(1)/FVC、FEV_(1)%水平高于对照组,观察组CAT评分低于对照组,两组以上指标比较差异均有统计学意义(P<0.05)。结论老年综合评估指导下的中医护理干预策略可进一步提高患者营养水平和肺功能,最终改善患者衰弱状态,减轻COPD对生活质量的影响。

针灸联合六味地黄丸序贯治疗肾精亏虚型早发性卵巢功能不全临床观察

目的探究针灸联合六味地黄丸序贯治疗对肾精亏虚型早发性卵巢功能不全(POI)的临床效果。方法将63例POI患者纳入试验,于月经期、经后期口服六味地黄丸,排卵期、经前期行灸法序贯治疗,针刺治疗贯穿后三期,隔日1次,每周治疗3次;连续治疗3个月经周期。观察序贯治疗对患者促卵泡生成激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平及中医证候积分的影响。结果治疗3个月后,患者E2增高,FSH、LH均降低,中医证候得到有效改善(P<0.05)。结论采用针灸联合六味地黄丸序贯治疗肾精亏虚型POI,能较好地改善性激素水平及临床症状,且具有良好安全性。

金黄膏联合田七祛瘀胶囊治疗胫腓骨骨折术后肿胀临床观察

目的探讨金黄膏联合田七祛瘀胶囊治疗胫腓骨骨折术后肿胀的临床效果。方法以抽样法选取南昌市洪都中医院创伤骨科2022年7月—2022年12月收治的胫腓骨骨折患者60例作为研究对象,根据入组标准,按随机数字表法分为对照组和观察组,每组30例。对照组采用自制中药金黄膏治疗,观察组在对照组的基础上口服田七祛瘀胶囊治疗。治疗后,对两组临床效果进行评估。结果治疗后,观察组患者膝关节疼痛评分低于对照组(P<0.05),两组术后1、3 d肿胀值差异无统计学意义(P>0.05),观察组术后5、7 d肿胀值低于对照组(P<0.05),观察组总有效率96.67%(29/30)高于对照组的73.33%(22/30)(P<0.05)。结论在治疗胫腓骨骨折术后肿胀过程中将内服外敷有效结合,能够取长补短,起到消肿止痛的效果,还能降低疼痛程度,促进患者恢复。

俞募配穴温针灸法联合健脾止泻汤治疗慢性小儿腹泻临床观察

目的研究俞募配穴温针灸法联合健脾止泻汤治疗慢性小儿腹泻的临床效果。方法选择2020年6月—2022年3月江西省兴国县人民医院儿科收治的50例慢性腹泻患儿,以随机抽签法分为观察组与参照组,各25例。观察组施予俞募配穴温针灸法联合健脾止泻汤治疗,参照组给予常规西药治疗。观察两组各项症状缓解时间;检验免疫蛋白及肠道微生物数量。结果观察组各项症状缓解时间均较参照组短(P<0.05)。治疗2周后,两组免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平均升高,且观察组高于参照组(P<0.05);两组双歧杆菌属、乳杆菌属肠道微生物数量均升高,且观察组高于参照组(P<0.05);两组大肠杆菌属、肠球菌属肠道微生物数量均降低,且观察组低于参照组(P<0.05)。结论慢性腹泻患儿接受俞募配穴温针灸法联合健脾止泻汤治疗,症状改善明显,有利于患儿优势菌群数量恢复,提高免疫功能。