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Osteoarthritis:toward a comprehensive understanding of pathological mechanism 被引量:142
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作者 Di Chen Jie Shen +4 位作者 Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im 《Bone Research》 SCIE CAS CSCD 2017年第1期1-13,共13页
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the d... Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. 展开更多
关键词 OA Osteoarthritis:toward a comprehensive understanding of pathological mechanism ADAMTS NGF
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