Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to el...Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods.This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning.The method obtains seed genes based on prior knowledge.Candidate genes are mined from biomedical literature.The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate genes.Furthermore,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of COVID-19.Experimental results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.展开更多
In 2021,most of the developing countries are fighting polio,and parents are concerned with the disabling of their children.Poliovirus transmits from person to person,which can infect the spinal cord,and paralyzes the ...In 2021,most of the developing countries are fighting polio,and parents are concerned with the disabling of their children.Poliovirus transmits from person to person,which can infect the spinal cord,and paralyzes the parts of the body within a matter of hours.According to the World Health Organization(WHO),18 million currently healthy people could have been paralyzed by the virus during 1988–2020.Almost all countries but Pakistan,Afghanistan,and a fewmore have been declared polio-free.The mathematical modeling of poliovirus is studied in the population by categorizing it as susceptible individuals(S),exposed individuals(E),infected individuals(I),and recovered individuals(R).In this study,we study the fundamental properties such as positivity and boundedness of the model.We also rigorously study the model’s stability and equilibria with or without poliovirus.For numerical study,we design the Euler,Runge–Kutta,and nonstandard finite difference method.However,the standard techniques are time-dependent and fail to present the results for an extended period.The nonstandard finite difference method works well to study disease dynamics for a long time without any constraints.Finally,the results of different methods are compared to prove their effectiveness.展开更多
Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed...Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.展开更多
Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer tra...Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer trajectories. In order to address the usually slow computational time for the determination of the landing footprint of a space-to-ground vehicle under finite thrust, this work proposes a method that uses polynomial equations to describe the boundaries of the landing footprint and uses back propagation(BP) neural networks to quickly determine the landing footprint of the space-to-ground vehicle. First, given orbital parameters and a manoeuvre moment, the solution model of the landing footprint of a space-to-ground vehicle under finite thrust is established. Second, given arbitrary orbital parameters and an arbitrary manoeuvre moment, a fast computational model for the landing footprint of a space-to-ground vehicle based on BP neural networks is provided.Finally, the simulation results demonstrate that under the premise of ensuring accuracy, the proposed method can quickly determine the landing footprint of a space-to-ground vehicle with arbitrary orbital parameters and arbitrary manoeuvre moments. The proposed fast computational method for determining a landing footprint lays a foundation for the parking-orbit configuration and supports the design of real-time transfer trajectories.展开更多
Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes...Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes.Even,a viral infection is often initiated through virus-host protein interactions.Protein-protein interactions(PPIs)are the physical contacts between two or more proteins and they represent complex biological functions.Nowadays,PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.Scientists have used PPIs to find the molecular basis of certain diseases and also some potential drug targets.In this review,we will discuss how PPI networks are essential to understand the molecular basis of virus-host relationships and several databases which are dedicated to virus-host interaction studies.Here,we present a short but comprehensive review on PPIs,including the experimental and computational methods of finding PPIs,the databases dedicated to virus-host PPIs,and the associated various applications in protein interaction networks of some lethal viruses with their hosts.展开更多
The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wa...The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wave⁃structure interaction require efficiency and accuracy,as well as the ability in calculating in open sea states,the HOS method has its strength in both generating extreme waves in open seas and fast convergence in simulations,while computational fluid dynamics(CFD)method has its advantages in simulating violent wave⁃structure interactions.This paper provides the new thoughts for fast and accurate simulations,as well as the future work on innovations in fine fluid field of numerical simulations.展开更多
Three-dimensional(3 D) reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction, with many cryo-electron microscopy techniques firs...Three-dimensional(3 D) reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction, with many cryo-electron microscopy techniques first established for structural studies of icosahedral viruses, owing to their high symmetry and large mass. This review summarizes the computational methods for icosahedral and symmetry-mismatch reconstruction of viruses, as well as the likely challenges and bottlenecks in virus reconstruction, such as symmetry mismatch reconstruction, contrast transformation function(CTF)correction, and particle distortion.展开更多
An algorithm for the computation of the unstructured real stability radius of high dimensional linearsystem is presented. Using the accurate formula of the real stability radius of 2-dimensional system linear systemch...An algorithm for the computation of the unstructured real stability radius of high dimensional linearsystem is presented. Using the accurate formula of the real stability radius of 2-dimensional system linear systemchecks the algorithm. The result shows that the algorithm is reliable and efficient. As applications, the unstructuredreal stability radii of 2-dimensional Chua's circuit and 3-dimensional piecewise-linear system are calculated, thedynamical orbits of the corresponding perturbed systems are simulated.展开更多
In this paper a simplified computation method of natural frequency of jacket platforms is given. Shear, bending and rotary inertia effects are considered in the equation, while the jacket shape, rotary inertia and cen...In this paper a simplified computation method of natural frequency of jacket platforms is given. Shear, bending and rotary inertia effects are considered in the equation, while the jacket shape, rotary inertia and centralized mass of the platform top are all determined by using a coefficient-revising method.展开更多
A numerical investigation of the structure of the vortical flowfield over delta wings at high angles of attack in longitudinal and with small sideslip angle is presented. Three-dimensional Navier-Stokes numerical simu...A numerical investigation of the structure of the vortical flowfield over delta wings at high angles of attack in longitudinal and with small sideslip angle is presented. Three-dimensional Navier-Stokes numerical simulations were carried out to predict the complex leeward-side flowfield characteristics that are dominated by the effect of the breakdown of the leading-edge vortices. The methods that analyze the flowfield structure quantitatively were given by using flowfield data from the computational results. In the region before the vortex breakdown, the vortex axes are approximated as being straight line. As the angle of attack increases, the vortex axes are closer to the root chord, and farther away from the wing surface. Along the vortex axes, as the adverse pressure gradients occur, the axial velocity decreases, that is, A is negativee, so the vortex is unstable, and it is possible to breakdown. The occurrence of the breakdown results in the instability of lateral motion for a delta wing, and the lateral moment diverges after a small perturbation occurs at high angles of attack. However, after a critical angle of attack is reached the vortices breakdown completely at the wing apex, and the instability resulting from the vortex breakdown disappears.展开更多
Ultimate bearing capacity(UBC)is a key subject in geotechnical/foundation engineering as it determines the limit of loads imposed on the foundation.The most reliable means of determining UBC is through experiment,but ...Ultimate bearing capacity(UBC)is a key subject in geotechnical/foundation engineering as it determines the limit of loads imposed on the foundation.The most reliable means of determining UBC is through experiment,but it is costly and time-consuming which has led to the development of various models based on the simplified assumptions.The outcomes of the models are usually validated with the experimental results,but a large gap usually exists between them.Therefore,a model that can give a close prediction of the experimental results is imperative.This study proposes a grasshopper optimization algorithm(GOA)and salp swarm algorithm(SSA)to optimize artificial neural networks(ANNs)using the existing UBC experimental database.The performances of the proposed models are evaluated using various statistical indices.The obtained results are compared with the existing models.The proposed models outperformed the existing models.The proposed hybrid GOA-ANN and SSA-ANN models are then transformed into mathematical forms that can be incorporated into geotechnical/foundation engineering design codes for accurate UBC measurements.展开更多
The twenty-first century is one of the most complex in the history of humanity,mainly due to the ecological crisis it is going through.The construction sector generates about 40%of CO2 emissions into the environment;t...The twenty-first century is one of the most complex in the history of humanity,mainly due to the ecological crisis it is going through.The construction sector generates about 40%of CO2 emissions into the environment;the foregoing should motivate this sector to seek new alternatives to develop new building practices.Taking these current needs into account,this document classifies and presents a multidisciplinary solution that integrates biology,engineering and architecture to develop a new and innovative lightweight timber structure;it divides with a main structure made of timber and an innovative joint system made of bio-polymers connecting all the panels.Through the study of diatoms,it was able to analyze the bio-morphology of the structure,joints and in particular the geometry since they were the inspiration for the design of this structure that presents an innovative and novel design of structural optimization.Through parametric design and digital fabrication,it was able to create a complex geometry that obtains excellent structural behavior.This research discusses and explores how materials,geometry led to the optimization of a structure and how new structures can arise,thanks to biology new solutions can be obtained that are completely sustainable,being a clear example of how to combat the effects of the climate change and in a precise way it highlights the advantages of the bio-design in the architectural design.展开更多
This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven artifa...This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven artifact.Kagome is a trihexagonal pattern employed in traditional bamboo basketry as a triaxial weaving system,resulting in an object with a self-bracing capacity without the use of fasteners owing to its interlacing lattices.Although existing studies and tools have addressed triaxial weaving design and representation,the current consideration of the advantages of weaving with bamboo is insufficient.To address this research gap,this study develops a computational design method based on studies on bamboo basketry.This allows for the representation and exploration of design geometries using combinations of regular triangular meshes for the fabrication of Kagome woven bamboo artifacts.A full-scale mock-up was fabricated to evaluate the effectiveness of the method.The mock-up demonstrated the self-bracing properties of Kagome,but there were discrepancies between the mock-up and the design.Factors affecting bamboo weaving on an architectural scale have been identified within this study to inform future research on woven bamboo structures.展开更多
Identifying thermal bridges on building façades has been a great challenge for architects,especially during the conceptual design stage.This is not only due to the complexity of parameters when calculating therma...Identifying thermal bridges on building façades has been a great challenge for architects,especially during the conceptual design stage.This is not only due to the complexity of parameters when calculating thermal bridges,but also lack of feature integration between building energy simulation(BES)tools and the actual building conditions.For example,existing BES tools predominantly calculate thermal bridges only in steady state without considering the temperature dynamic behaviour of building outdoors.Consequently,relevant features such as thermal delay,decrement factor,and operative temperature are often neglected,and this can lead to miscalculation of energy consumption.This study then proposes an integrated method to calculate dynamic thermal bridges under transient conditions by incorporating field observations and computational simulations of thermal bridges.More specifically,the proposed method employs several measurement tools such as HOBO data logger to record the actual conditions of indoor and outdoor room temperature and thermal cameras to identify the surface temperature of selected building junctions.The actual datasets are then integrated with the simulation workflow developed in BES tools.This study ultimately enables architects not only to identify potential thermal bridges on existing building façades but also to support material and geometric exploration in early design phase.展开更多
Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,comp...Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,compared to the traditional methods.This paper presents an overview of some soft computing techniques as well as their applications in underground excavations.A case study is adopted to compare the predictive performances of soft computing techniques including eXtreme Gradient Boosting(XGBoost),Multivariate Adaptive Regression Splines(MARS),Artificial Neural Networks(ANN),and Support Vector Machine(SVM) in estimating the maximum lateral wall deflection induced by braced excavation.This study also discusses the merits and the limitations of some soft computing techniques,compared with the conventional approaches available.展开更多
Excited by ocean currents, random wave and vessel motion, deepwater drilling risers exhibit significant dynamic response. In time domain, a method is proposed to calculate the nonlinear dynmnic response of deepwater d...Excited by ocean currents, random wave and vessel motion, deepwater drilling risers exhibit significant dynamic response. In time domain, a method is proposed to calculate the nonlinear dynmnic response of deepwater drilling risers subjected to random wave and dynamic large displacement vessel motion boundary condition. Structural and functional loads, external and intemal pressure, free surfaee effect of irregular wave, hydrodynamic forees induced by current and wave, as well as wave and low frequency (drift) motion of the drilling vessel are all accounted for. An example is presented which illustrates the application of the proposed method. The study shows that long term drift motion of the vessel has profound effect on the envelopes of bending stress and lateral displacement, as well as the range of lower flex joint angle of the deepwater riser. It can also be concluded that vessel motion is the principal dynamic loading of nonlinear dynamic response for the deepwater risers rather than wave force.展开更多
This paper presents a further study of the Manning and Darcy-Weisbach resistance coefficients, as they play a significant role in assessing the cross-sectional mean velocity, conveyance capacity and determining the la...This paper presents a further study of the Manning and Darcy-Weisbach resistance coefficients, as they play a significant role in assessing the cross-sectional mean velocity, conveyance capacity and determining the lateral distribution of depth mean velocity and local boundary shear stress in compound channels. The relationships between the local, zonal and overall resistance coefficients, and a wide range of geometries and different roughness between the main channel and the flood plain are established by analyzing a vast amount of experimental data from a British Science and Engineering Research Council Flood Channel Facility (SERC-FCF). And the experimental results also show that the overall Darcy-Weisbach resistance coefficient for a compound channel is the function of Reynolds number, but the function relationship is different from that for a single channel. By comparing and analyzing the conventional methods with the experimental data to predict composite roughness in compound channels, it is found that these methods are not suitable for compound channels. Moreover, the reason why the conventional methods cannot assess correctly the conveyance capacity of compound channels is also analyzed in this paper.展开更多
Although three-dimensional protein structure determination using nuclear magnetic res- onance (NMR) spectroscopy is a computationally costly and tedious process that would benefit from advanced computational techniq...Although three-dimensional protein structure determination using nuclear magnetic res- onance (NMR) spectroscopy is a computationally costly and tedious process that would benefit from advanced computational techniques, it has not garnered much research attention from special- ists in bioinformatics and computational biology. In this paper, we review recent advances in com- putational methods for NMR protein structure determination. We summarize the advantages of and bottlenecks in the existing methods and outline some open problems in the field. We also dis- cuss current trends in NMR technology development and suggest directions for research on future computational methods for NMR.展开更多
The paper presents the conceptual and operational basis of the creation of IDSS based on our recent research experience. In this paper, an intelligent decision support system, IDSS is defined as: any interactive syste...The paper presents the conceptual and operational basis of the creation of IDSS based on our recent research experience. In this paper, an intelligent decision support system, IDSS is defined as: any interactive system that is specially designed to improve the decision making of its user by extending the user's cognitive decision making abilities. As a result, this view of man-machine joint cognitive system stresses the need to use computational technology to aid the user in the decision making process. And the human's role is to achieve total systems's objectives. The paper outlines the designing procedure in successive steps. First, the decision maker's cognitive needs for decision support are identified. Second, the computationally realizable support functions are defined that could be provided by IDSS. Then, the specific techniques that would best fill the decision needs are discussed. And finally, for system implementation the modern computational technology infrastructure is emphasized.展开更多
Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the et...Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the etiology of a malfunctioning prosthetic tricuspid valve is depicted on cardiac computed tomography to be as a result of thrombus lodged in the valve.展开更多
基金This research is supported by the National Natural Science Foundation of China(Grant Nos.61502243,61802193)Natural Science Foundation of Jiangsu Province(BK20170934)+4 种基金Zhejiang Engineering Research Center of Intelligent Medicine under 2016E10011China Postdoctoral Science Foundation(2018M632349)NUPTSF(NY217136)Foundation of Smart Health Big Data Analysis and Location Services Engineering Laboratory of Jiangsu Province(SHEL221-001)Natural Science Foundation of the Higher Education Institutions of Jiangsu Province in China(16KJD520003).
文摘Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods.This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning.The method obtains seed genes based on prior knowledge.Candidate genes are mined from biomedical literature.The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate genes.Furthermore,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of COVID-19.Experimental results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.
基金The authors express their gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project(Grant No.PNURSP2022R61),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘In 2021,most of the developing countries are fighting polio,and parents are concerned with the disabling of their children.Poliovirus transmits from person to person,which can infect the spinal cord,and paralyzes the parts of the body within a matter of hours.According to the World Health Organization(WHO),18 million currently healthy people could have been paralyzed by the virus during 1988–2020.Almost all countries but Pakistan,Afghanistan,and a fewmore have been declared polio-free.The mathematical modeling of poliovirus is studied in the population by categorizing it as susceptible individuals(S),exposed individuals(E),infected individuals(I),and recovered individuals(R).In this study,we study the fundamental properties such as positivity and boundedness of the model.We also rigorously study the model’s stability and equilibria with or without poliovirus.For numerical study,we design the Euler,Runge–Kutta,and nonstandard finite difference method.However,the standard techniques are time-dependent and fail to present the results for an extended period.The nonstandard finite difference method works well to study disease dynamics for a long time without any constraints.Finally,the results of different methods are compared to prove their effectiveness.
文摘Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.
基金supported by the National Natural Science Foundation of China (61603398)。
文摘Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer trajectories. In order to address the usually slow computational time for the determination of the landing footprint of a space-to-ground vehicle under finite thrust, this work proposes a method that uses polynomial equations to describe the boundaries of the landing footprint and uses back propagation(BP) neural networks to quickly determine the landing footprint of the space-to-ground vehicle. First, given orbital parameters and a manoeuvre moment, the solution model of the landing footprint of a space-to-ground vehicle under finite thrust is established. Second, given arbitrary orbital parameters and an arbitrary manoeuvre moment, a fast computational model for the landing footprint of a space-to-ground vehicle based on BP neural networks is provided.Finally, the simulation results demonstrate that under the premise of ensuring accuracy, the proposed method can quickly determine the landing footprint of a space-to-ground vehicle with arbitrary orbital parameters and arbitrary manoeuvre moments. The proposed fast computational method for determining a landing footprint lays a foundation for the parking-orbit configuration and supports the design of real-time transfer trajectories.
基金National Natural Science Foundation of China,No.31971180 and No.11474013.
文摘Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes.Even,a viral infection is often initiated through virus-host protein interactions.Protein-protein interactions(PPIs)are the physical contacts between two or more proteins and they represent complex biological functions.Nowadays,PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.Scientists have used PPIs to find the molecular basis of certain diseases and also some potential drug targets.In this review,we will discuss how PPI networks are essential to understand the molecular basis of virus-host relationships and several databases which are dedicated to virus-host interaction studies.Here,we present a short but comprehensive review on PPIs,including the experimental and computational methods of finding PPIs,the databases dedicated to virus-host PPIs,and the associated various applications in protein interaction networks of some lethal viruses with their hosts.
基金National Natural Science Foundation of China(Grant No.51879159)the National Key Research and Development Program of China(Grant Nos.2019YFB1704200 and 2019YFC0312400)+2 种基金the Chang Jiang Scholars Program(Grant No.T2014099)the Shanghai Excellent Academic Leaders Program(Grant No.17XD1402300)the Innovative Special Project of Numerical Tank of Ministry of Industry and Information Technology of China(Grant No.2016-23/09).
文摘The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wave⁃structure interaction require efficiency and accuracy,as well as the ability in calculating in open sea states,the HOS method has its strength in both generating extreme waves in open seas and fast convergence in simulations,while computational fluid dynamics(CFD)method has its advantages in simulating violent wave⁃structure interactions.This paper provides the new thoughts for fast and accurate simulations,as well as the future work on innovations in fine fluid field of numerical simulations.
基金Project supported by the National Key R&D Program of China(Grant No.2016YFA0501100)the National Natural Science Foundation of China(Grant Nos.91530321,31570742,and 31570727)Science and Technology Planning Project of Hunan Province,China(Grant No.2017RS3033)
文摘Three-dimensional(3 D) reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction, with many cryo-electron microscopy techniques first established for structural studies of icosahedral viruses, owing to their high symmetry and large mass. This review summarizes the computational methods for icosahedral and symmetry-mismatch reconstruction of viruses, as well as the likely challenges and bottlenecks in virus reconstruction, such as symmetry mismatch reconstruction, contrast transformation function(CTF)correction, and particle distortion.
文摘An algorithm for the computation of the unstructured real stability radius of high dimensional linearsystem is presented. Using the accurate formula of the real stability radius of 2-dimensional system linear systemchecks the algorithm. The result shows that the algorithm is reliable and efficient. As applications, the unstructuredreal stability radii of 2-dimensional Chua's circuit and 3-dimensional piecewise-linear system are calculated, thedynamical orbits of the corresponding perturbed systems are simulated.
基金The project is supported by the National Natural Science Foundation of China
文摘In this paper a simplified computation method of natural frequency of jacket platforms is given. Shear, bending and rotary inertia effects are considered in the equation, while the jacket shape, rotary inertia and centralized mass of the platform top are all determined by using a coefficient-revising method.
基金Project supported by the Foundation of Aeronautical Science (No.99A53001)
文摘A numerical investigation of the structure of the vortical flowfield over delta wings at high angles of attack in longitudinal and with small sideslip angle is presented. Three-dimensional Navier-Stokes numerical simulations were carried out to predict the complex leeward-side flowfield characteristics that are dominated by the effect of the breakdown of the leading-edge vortices. The methods that analyze the flowfield structure quantitatively were given by using flowfield data from the computational results. In the region before the vortex breakdown, the vortex axes are approximated as being straight line. As the angle of attack increases, the vortex axes are closer to the root chord, and farther away from the wing surface. Along the vortex axes, as the adverse pressure gradients occur, the axial velocity decreases, that is, A is negativee, so the vortex is unstable, and it is possible to breakdown. The occurrence of the breakdown results in the instability of lateral motion for a delta wing, and the lateral moment diverges after a small perturbation occurs at high angles of attack. However, after a critical angle of attack is reached the vortices breakdown completely at the wing apex, and the instability resulting from the vortex breakdown disappears.
基金supported by Korea Research Fellowship Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(Grant No.2019H1D3A1A01102993)the Inha University Research Grant(2022).
文摘Ultimate bearing capacity(UBC)is a key subject in geotechnical/foundation engineering as it determines the limit of loads imposed on the foundation.The most reliable means of determining UBC is through experiment,but it is costly and time-consuming which has led to the development of various models based on the simplified assumptions.The outcomes of the models are usually validated with the experimental results,but a large gap usually exists between them.Therefore,a model that can give a close prediction of the experimental results is imperative.This study proposes a grasshopper optimization algorithm(GOA)and salp swarm algorithm(SSA)to optimize artificial neural networks(ANNs)using the existing UBC experimental database.The performances of the proposed models are evaluated using various statistical indices.The obtained results are compared with the existing models.The proposed models outperformed the existing models.The proposed hybrid GOA-ANN and SSA-ANN models are then transformed into mathematical forms that can be incorporated into geotechnical/foundation engineering design codes for accurate UBC measurements.
文摘The twenty-first century is one of the most complex in the history of humanity,mainly due to the ecological crisis it is going through.The construction sector generates about 40%of CO2 emissions into the environment;the foregoing should motivate this sector to seek new alternatives to develop new building practices.Taking these current needs into account,this document classifies and presents a multidisciplinary solution that integrates biology,engineering and architecture to develop a new and innovative lightweight timber structure;it divides with a main structure made of timber and an innovative joint system made of bio-polymers connecting all the panels.Through the study of diatoms,it was able to analyze the bio-morphology of the structure,joints and in particular the geometry since they were the inspiration for the design of this structure that presents an innovative and novel design of structural optimization.Through parametric design and digital fabrication,it was able to create a complex geometry that obtains excellent structural behavior.This research discusses and explores how materials,geometry led to the optimization of a structure and how new structures can arise,thanks to biology new solutions can be obtained that are completely sustainable,being a clear example of how to combat the effects of the climate change and in a precise way it highlights the advantages of the bio-design in the architectural design.
基金the Start-up Grant from the School of Architecture at The Chinese University of Hong Kong[ARC]partially by the General Research Fund[RGC Ref.No.CUHK 14617122]from the Hong Kong Research Grants Council.
文摘This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven artifact.Kagome is a trihexagonal pattern employed in traditional bamboo basketry as a triaxial weaving system,resulting in an object with a self-bracing capacity without the use of fasteners owing to its interlacing lattices.Although existing studies and tools have addressed triaxial weaving design and representation,the current consideration of the advantages of weaving with bamboo is insufficient.To address this research gap,this study develops a computational design method based on studies on bamboo basketry.This allows for the representation and exploration of design geometries using combinations of regular triangular meshes for the fabrication of Kagome woven bamboo artifacts.A full-scale mock-up was fabricated to evaluate the effectiveness of the method.The mock-up demonstrated the self-bracing properties of Kagome,but there were discrepancies between the mock-up and the design.Factors affecting bamboo weaving on an architectural scale have been identified within this study to inform future research on woven bamboo structures.
基金This research is funded by Directorate of Research and Development,Universitas Indonesia under Hibah PUTI Q1 Batch 22022(NKB-1149/UN2.RST/HKP.05.00/2022)awarded to Dr.Miktha Farid Alkadri S.Ars.,M.Ars.We also thank to Dr.Eng.Arnas,ST.,M.T.,from the Department of Mechanical Engineering,Universitas Indonesia,who has provided valuable input during the research process and HTflux team who has supplied a license for thermal bridge simulation.
文摘Identifying thermal bridges on building façades has been a great challenge for architects,especially during the conceptual design stage.This is not only due to the complexity of parameters when calculating thermal bridges,but also lack of feature integration between building energy simulation(BES)tools and the actual building conditions.For example,existing BES tools predominantly calculate thermal bridges only in steady state without considering the temperature dynamic behaviour of building outdoors.Consequently,relevant features such as thermal delay,decrement factor,and operative temperature are often neglected,and this can lead to miscalculation of energy consumption.This study then proposes an integrated method to calculate dynamic thermal bridges under transient conditions by incorporating field observations and computational simulations of thermal bridges.More specifically,the proposed method employs several measurement tools such as HOBO data logger to record the actual conditions of indoor and outdoor room temperature and thermal cameras to identify the surface temperature of selected building junctions.The actual datasets are then integrated with the simulation workflow developed in BES tools.This study ultimately enables architects not only to identify potential thermal bridges on existing building façades but also to support material and geometric exploration in early design phase.
基金supported by High-end Foreign Expert Introduction program (No.G20190022002)Chongqing Construction Science and Technology Plan Project (2019-0045)
文摘Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,compared to the traditional methods.This paper presents an overview of some soft computing techniques as well as their applications in underground excavations.A case study is adopted to compare the predictive performances of soft computing techniques including eXtreme Gradient Boosting(XGBoost),Multivariate Adaptive Regression Splines(MARS),Artificial Neural Networks(ANN),and Support Vector Machine(SVM) in estimating the maximum lateral wall deflection induced by braced excavation.This study also discusses the merits and the limitations of some soft computing techniques,compared with the conventional approaches available.
基金supported by the National High Technology Research and Development Program of China(863 Program,Grant No.2006AA09A106-4)
文摘Excited by ocean currents, random wave and vessel motion, deepwater drilling risers exhibit significant dynamic response. In time domain, a method is proposed to calculate the nonlinear dynmnic response of deepwater drilling risers subjected to random wave and dynamic large displacement vessel motion boundary condition. Structural and functional loads, external and intemal pressure, free surfaee effect of irregular wave, hydrodynamic forees induced by current and wave, as well as wave and low frequency (drift) motion of the drilling vessel are all accounted for. An example is presented which illustrates the application of the proposed method. The study shows that long term drift motion of the vessel has profound effect on the envelopes of bending stress and lateral displacement, as well as the range of lower flex joint angle of the deepwater riser. It can also be concluded that vessel motion is the principal dynamic loading of nonlinear dynamic response for the deepwater risers rather than wave force.
基金The project supported by the National Natural Science Foundation of China(50279024)the National Key Basic Research and Development Program of China(973 Program)(2003CB415202)the Specialized Research Fund for the Doctoral Program of Higher Education(2
文摘This paper presents a further study of the Manning and Darcy-Weisbach resistance coefficients, as they play a significant role in assessing the cross-sectional mean velocity, conveyance capacity and determining the lateral distribution of depth mean velocity and local boundary shear stress in compound channels. The relationships between the local, zonal and overall resistance coefficients, and a wide range of geometries and different roughness between the main channel and the flood plain are established by analyzing a vast amount of experimental data from a British Science and Engineering Research Council Flood Channel Facility (SERC-FCF). And the experimental results also show that the overall Darcy-Weisbach resistance coefficient for a compound channel is the function of Reynolds number, but the function relationship is different from that for a single channel. By comparing and analyzing the conventional methods with the experimental data to predict composite roughness in compound channels, it is found that these methods are not suitable for compound channels. Moreover, the reason why the conventional methods cannot assess correctly the conveyance capacity of compound channels is also analyzed in this paper.
基金supportedby the GRP-CF award (Grant No. GRP-CF-2011-19-P-Gao-Huang)a GMSV-OCRF award from King Abdullah University of Science and Technology (KAUST)
文摘Although three-dimensional protein structure determination using nuclear magnetic res- onance (NMR) spectroscopy is a computationally costly and tedious process that would benefit from advanced computational techniques, it has not garnered much research attention from special- ists in bioinformatics and computational biology. In this paper, we review recent advances in com- putational methods for NMR protein structure determination. We summarize the advantages of and bottlenecks in the existing methods and outline some open problems in the field. We also dis- cuss current trends in NMR technology development and suggest directions for research on future computational methods for NMR.
文摘The paper presents the conceptual and operational basis of the creation of IDSS based on our recent research experience. In this paper, an intelligent decision support system, IDSS is defined as: any interactive system that is specially designed to improve the decision making of its user by extending the user's cognitive decision making abilities. As a result, this view of man-machine joint cognitive system stresses the need to use computational technology to aid the user in the decision making process. And the human's role is to achieve total systems's objectives. The paper outlines the designing procedure in successive steps. First, the decision maker's cognitive needs for decision support are identified. Second, the computationally realizable support functions are defined that could be provided by IDSS. Then, the specific techniques that would best fill the decision needs are discussed. And finally, for system implementation the modern computational technology infrastructure is emphasized.
文摘Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the etiology of a malfunctioning prosthetic tricuspid valve is depicted on cardiac computed tomography to be as a result of thrombus lodged in the valve.