Geo-engineering problems are known for their complexity and high uncertainty levels,requiring precise defini-tions,past experiences,logical reasoning,mathematical analysis,and practical insight to address them effecti...Geo-engineering problems are known for their complexity and high uncertainty levels,requiring precise defini-tions,past experiences,logical reasoning,mathematical analysis,and practical insight to address them effectively.Soft Computing(SC)methods have gained popularity in engineering disciplines such as mining and civil engineering due to computer hardware and machine learning advancements.Unlike traditional hard computing approaches,SC models use soft values and fuzzy sets to navigate uncertain environments.This study focuses on the application of SC methods to predict backbreak,a common issue in blasting operations within mining and civil projects.Backbreak,which refers to the unintended fracturing of rock beyond the desired blast perimeter,can significantly impact project timelines and costs.This study aims to explore how SC methods can be effectively employed to anticipate and mitigate the undesirable consequences of blasting operations,specifically focusing on backbreak prediction.The research explores the complexities of backbreak prediction and highlights the potential benefits of utilizing SC methods to address this challenging issue in geo-engineering projects.展开更多
Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal cord.It is a devastating disease and remains a significant public health challeng...Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal cord.It is a devastating disease and remains a significant public health challenge.This study investigates a bacterial meningitis model through deterministic and stochastic versions.Four-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and recovered.The model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric perturbations.Also,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known theorems.Standard and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic model.Unfortunately,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step size.In addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is zero.The simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.展开更多
The lower limb exoskeletons are used to assist wearers in various scenarios such as medical and industrial settings.Complex modeling errors of the exoskeleton in different application scenarios pose challenges to the ...The lower limb exoskeletons are used to assist wearers in various scenarios such as medical and industrial settings.Complex modeling errors of the exoskeleton in different application scenarios pose challenges to the robustness and stability of its control algorithm.The Radial Basis Function(RBF)neural network is used widely to compensate for modeling errors.In order to solve the problem that the current RBF neural network controllers cannot guarantee the asymptotic stability,a neural network robust control algorithm based on computed torque method is proposed in this paper,focusing on trajectory tracking.It innovatively incorporates the robust adaptive term while introducing the RBF neural network term,improving the compensation ability for modeling errors.The stability of the algorithm is proved by Lyapunov method,and the effectiveness of the robust adaptive term is verified by the simulation.Experiments wearing the exoskeleton under different walking speeds and scenarios were carried out,and the results show that the absolute value of tracking errors of the hip and knee joints of the exoskeleton are consistently less than 1.5°and 2.5°,respectively.The proposed control algorithm effectively compensates for modeling errors and exhibits high robustness.展开更多
A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic performance.In this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid ...A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic performance.In this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.展开更多
The collapse of granular material in fluids is a prevalent phenomenon in both natural and industrial processes,displaying a notable sensitivity to initial configuration of the system.This study is specifically oriente...The collapse of granular material in fluids is a prevalent phenomenon in both natural and industrial processes,displaying a notable sensitivity to initial configuration of the system.This study is specifically oriented towards falling process of collapsing material under various fluid conditions,employing the computational fluid dynamics-discrete element method(CFD-DEM)to primarily investigate the dynamics and scaling laws of deposit morphology of collapsed material.Through a comprehensive analysis of particle sedimentation in fluids,we introduce a refined inertial characteristic time for granular collapse within the inertial regime.Subsequently,we propose modifications to conventional fluid-particle density ratio and Reynolds number,aiming to enhance the accuracy of depicting collapse dynamics and identifying flow regimes across diverse column heights and fluid conditions.Finally,we construct a phase diagram of flow regimes using modified dimensionless numbers,emphasizing the role of column height in transition between viscous and inertial regimes.These parameters demonstrate enhanced relevance in governing the collapse of immersed granular columns,thereby contributing to a more nuanced understanding of fluid-particle interations in dense granular flows under different regimes.展开更多
Two methods based on a slight modification of the regular traffic assignmentalgorithms are proposed to directly compute turn flows instead of estimating them from link flows orobtaining them by expanding the networks....Two methods based on a slight modification of the regular traffic assignmentalgorithms are proposed to directly compute turn flows instead of estimating them from link flows orobtaining them by expanding the networks. The first one is designed on the path-turn incidencerelationship, and it is similar to the computational procedure of link flows. It applies to thetraffic assignment algorithms that can provide detailed path structures. The second utilizes thelink-turn incidence relationship and the conservation of flow on links, a law deriving from thisrelationship. It is actually an improved version of Dial's logit assignment algorithm. The proposedapproaches can avoid the shortcomings both of the estimation methods, e. g. Furness's model andFrator's model, and of the network-expanding method in precision, stability and computation scale.Finally, they are validated by numerical examples.展开更多
Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed...Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.展开更多
Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using th...Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using the Mesri creep model to describe the soil characteristics and the Mindlin-Geddes method considering pile diameter to calculate the vertical additional stress of pile bottom.A program named CPPS was designed for this method to calculate the post-construction settlement of a high-speed railway bridge pile foundation.The result indicates that the post-construction settlement in 100 years meets the requirements of the engineering specifications,and in the first two decades,the post-construction settlement is about 80% of its total settlement,while the settlement in the rest eighty years tends to be stable.Compared with the measured settlement after laying railway tracks,the calculational result is closed to that of the measured,and the results are conservative with a high computational accuracy.It is noted that the method can be used to calculate the post-construction settlement for the preliminary design of high-speed railway bridge pile foundation.展开更多
Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer tra...Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer trajectories. In order to address the usually slow computational time for the determination of the landing footprint of a space-to-ground vehicle under finite thrust, this work proposes a method that uses polynomial equations to describe the boundaries of the landing footprint and uses back propagation(BP) neural networks to quickly determine the landing footprint of the space-to-ground vehicle. First, given orbital parameters and a manoeuvre moment, the solution model of the landing footprint of a space-to-ground vehicle under finite thrust is established. Second, given arbitrary orbital parameters and an arbitrary manoeuvre moment, a fast computational model for the landing footprint of a space-to-ground vehicle based on BP neural networks is provided.Finally, the simulation results demonstrate that under the premise of ensuring accuracy, the proposed method can quickly determine the landing footprint of a space-to-ground vehicle with arbitrary orbital parameters and arbitrary manoeuvre moments. The proposed fast computational method for determining a landing footprint lays a foundation for the parking-orbit configuration and supports the design of real-time transfer trajectories.展开更多
Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the et...Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the etiology of a malfunctioning prosthetic tricuspid valve is depicted on cardiac computed tomography to be as a result of thrombus lodged in the valve.展开更多
Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to el...Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods.This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning.The method obtains seed genes based on prior knowledge.Candidate genes are mined from biomedical literature.The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate genes.Furthermore,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of COVID-19.Experimental results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.展开更多
Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes...Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes.Even,a viral infection is often initiated through virus-host protein interactions.Protein-protein interactions(PPIs)are the physical contacts between two or more proteins and they represent complex biological functions.Nowadays,PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.Scientists have used PPIs to find the molecular basis of certain diseases and also some potential drug targets.In this review,we will discuss how PPI networks are essential to understand the molecular basis of virus-host relationships and several databases which are dedicated to virus-host interaction studies.Here,we present a short but comprehensive review on PPIs,including the experimental and computational methods of finding PPIs,the databases dedicated to virus-host PPIs,and the associated various applications in protein interaction networks of some lethal viruses with their hosts.展开更多
Internal friction characteristic is one of the basic properties of geotechnical materials and it exists in mechanical elements all the time. However,until now internal friction is only considered in limit analysis and...Internal friction characteristic is one of the basic properties of geotechnical materials and it exists in mechanical elements all the time. However,until now internal friction is only considered in limit analysis and plastic mechanics but not included in elastic theory for rocks and soils. We consider that internal friction exists in both elastic state and plastic state of geotechnical materials,so the mechanical unit of friction material is constituted. Based on study results of soil tests,the paper also proposes that cohesion takes effect first and internal friction works gradually with the increment of deformation. By assuming that the friction coefficient is proportional to the strain,the internal friction is computed. At last,by imitating the linear elastic mechanics,the nonlinear elastic mechanics model of friction material is established,where the shear modulus G is not a constant. The new model and the traditional elastic model are used simultaneously to analyze an elastic foundation. The results indicate that the displacements computed by the new model are less than those from the traditional method,which agrees with the fact and shows that the mechanical units of friction material are suitable for geotechnical material.展开更多
We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids...We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data.展开更多
The paper presents a very simple method, which in two stages enables to calculate the plane statically indeterminate truss by the application of one of methods used for the force calculation in members of the statical...The paper presents a very simple method, which in two stages enables to calculate the plane statically indeterminate truss by the application of one of methods used for the force calculation in members of the statically determinate trusses. The results are obtained in a very simple and quick way. Although the force values are approximated but they are relatively very close to those, which are determined by the exact methods. The point of the two-stage calculation process of the statically indeterminate trusses is to determine schemes of two independent and simple statically determined trusses, which after superposition of their patterns will give in the result a pattern of the initial, more complex form of the statically indeterminate truss. Each of the simple truss has to be of the same clear span and the load forces have to be of the half values and they have to be applied to the same nodes like in truss of the initial structural configuration.展开更多
The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wa...The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wave⁃structure interaction require efficiency and accuracy,as well as the ability in calculating in open sea states,the HOS method has its strength in both generating extreme waves in open seas and fast convergence in simulations,while computational fluid dynamics(CFD)method has its advantages in simulating violent wave⁃structure interactions.This paper provides the new thoughts for fast and accurate simulations,as well as the future work on innovations in fine fluid field of numerical simulations.展开更多
Conventionally, multiple reference frame(MRF) method and sliding mesh(SM) method are used in the simulation of stirred tanks, however, both methods have limitations. In this study, a hybrid immersed-boundary(IB)techni...Conventionally, multiple reference frame(MRF) method and sliding mesh(SM) method are used in the simulation of stirred tanks, however, both methods have limitations. In this study, a hybrid immersed-boundary(IB)technique is developed in a finite difference context for the numerical simulation of stirred tanks. IBs based on Lagrangian markers and solid volume fractions are used for moving and stationary boundaries, respectively, to achieve optimal efficiency and accuracy. To cope with the high computational cost in the simulation of stirred tanks, the technique is implemented on computers with hybrid architecture where central processing units(CPUs) and graphics processing units(GPUs) are used together. The accuracy and efficiency of the present technique are first demonstrated in a relatively simple case, and then the technique is applied to the simulation of turbulent flow in a Rushton stirred tank with large eddy simulation(LES). Finally the proposed methodology is coupled with discrete element method(DEM) to accomplish particle-resolved simulation of solid suspensions in small stirred tanks. It demonstrates that the proposed methodology is a promising tool in simulating turbulent flow in stirred tanks with complex geometries.展开更多
Battery models are of great importance to develop portable computing systems,for whether the design of low power hardware architecture or the design of battery-aware scheduling policies.In this paper,we present a phys...Battery models are of great importance to develop portable computing systems,for whether the design of low power hardware architecture or the design of battery-aware scheduling policies.In this paper,we present a physically justified iterative computing method to illustrate the discharge,recovery and charge process of Li/Li-ion batteries.The discharge and recovery processes correspond well to an existing accurate analytical battery model:R-V-W's analytical model,and thus interpret this model algorithmically.Our method can also extend R-V-W's model easily to accommodate the charge process.The work will help the system designers to grasp the characteristics of R-V-W's battery model and also,enable to predict the battery behavior in the charge process in a uniform way as the discharge process and the recovery process.Experiments are performed to show the ac-curacy of the extended model by comparing the predicted charge times with those derived from the DUALFOIL simulations.Various profiles with different combinations of battery modes were tested.The experimental results show that the extended battery model preserves high accuracy in predicting the charge behavior.展开更多
The computational methods of a typical dynamic mathematical model that can describe the differential element and the inertial element for the system simulation are researched. The stability of numerical solutions of t...The computational methods of a typical dynamic mathematical model that can describe the differential element and the inertial element for the system simulation are researched. The stability of numerical solutions of the dynamic mathematical model is researched. By means of theoretical analysis, the error formulas, the error sign criteria and the error relationship criterion of the implicit Euler method and the trapezoidal method are given, the dynamic factor affecting the computational accuracy has been found, the formula and the methods of computing the dynamic factor are given. The computational accuracy of the dynamic mathematical model like this can be improved by use of the dynamic factor.展开更多
Three-dimensional(3 D)reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction,with many cryo-electron microscopy techniques first es...Three-dimensional(3 D)reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction,with many cryo-electron microscopy techniques first established for structural studies of icosahedral viruses,owing to their high symmetry and large mass.This review summarizes the computational methods for icosahedral and symmetry-mismatch reconstruction of viruses,as well as the likely challenges and bottlenecks in virus reconstruction,such as symmetry mismatch reconstruction,contrast transformation function(CTF)correction,and particle distortion.展开更多
文摘Geo-engineering problems are known for their complexity and high uncertainty levels,requiring precise defini-tions,past experiences,logical reasoning,mathematical analysis,and practical insight to address them effectively.Soft Computing(SC)methods have gained popularity in engineering disciplines such as mining and civil engineering due to computer hardware and machine learning advancements.Unlike traditional hard computing approaches,SC models use soft values and fuzzy sets to navigate uncertain environments.This study focuses on the application of SC methods to predict backbreak,a common issue in blasting operations within mining and civil projects.Backbreak,which refers to the unintended fracturing of rock beyond the desired blast perimeter,can significantly impact project timelines and costs.This study aims to explore how SC methods can be effectively employed to anticipate and mitigate the undesirable consequences of blasting operations,specifically focusing on backbreak prediction.The research explores the complexities of backbreak prediction and highlights the potential benefits of utilizing SC methods to address this challenging issue in geo-engineering projects.
基金Deanship of Research and Graduate Studies at King Khalid University for funding this work through large Research Project under Grant Number RGP2/302/45supported by the Deanship of Scientific Research,Vice Presidency forGraduate Studies and Scientific Research,King Faisal University,Saudi Arabia(Grant Number A426).
文摘Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal cord.It is a devastating disease and remains a significant public health challenge.This study investigates a bacterial meningitis model through deterministic and stochastic versions.Four-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and recovered.The model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric perturbations.Also,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known theorems.Standard and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic model.Unfortunately,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step size.In addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is zero.The simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.
基金Supported by National Key R&D Program of China(Grant No.2022YFB4701200)National Natural Science Foundation of China(NSFC)(Grant Nos.T2121003,52205004).
文摘The lower limb exoskeletons are used to assist wearers in various scenarios such as medical and industrial settings.Complex modeling errors of the exoskeleton in different application scenarios pose challenges to the robustness and stability of its control algorithm.The Radial Basis Function(RBF)neural network is used widely to compensate for modeling errors.In order to solve the problem that the current RBF neural network controllers cannot guarantee the asymptotic stability,a neural network robust control algorithm based on computed torque method is proposed in this paper,focusing on trajectory tracking.It innovatively incorporates the robust adaptive term while introducing the RBF neural network term,improving the compensation ability for modeling errors.The stability of the algorithm is proved by Lyapunov method,and the effectiveness of the robust adaptive term is verified by the simulation.Experiments wearing the exoskeleton under different walking speeds and scenarios were carried out,and the results show that the absolute value of tracking errors of the hip and knee joints of the exoskeleton are consistently less than 1.5°and 2.5°,respectively.The proposed control algorithm effectively compensates for modeling errors and exhibits high robustness.
基金supported by the National Natural Science Foundation of China(Grant No.52078010)Beijing Natural Science Foundation(Grant No.JQ19029).
文摘A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic performance.In this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.
基金the National Natural Science Foundation of China(grant Nos.12272158 and 11872028).
文摘The collapse of granular material in fluids is a prevalent phenomenon in both natural and industrial processes,displaying a notable sensitivity to initial configuration of the system.This study is specifically oriented towards falling process of collapsing material under various fluid conditions,employing the computational fluid dynamics-discrete element method(CFD-DEM)to primarily investigate the dynamics and scaling laws of deposit morphology of collapsed material.Through a comprehensive analysis of particle sedimentation in fluids,we introduce a refined inertial characteristic time for granular collapse within the inertial regime.Subsequently,we propose modifications to conventional fluid-particle density ratio and Reynolds number,aiming to enhance the accuracy of depicting collapse dynamics and identifying flow regimes across diverse column heights and fluid conditions.Finally,we construct a phase diagram of flow regimes using modified dimensionless numbers,emphasizing the role of column height in transition between viscous and inertial regimes.These parameters demonstrate enhanced relevance in governing the collapse of immersed granular columns,thereby contributing to a more nuanced understanding of fluid-particle interations in dense granular flows under different regimes.
文摘Two methods based on a slight modification of the regular traffic assignmentalgorithms are proposed to directly compute turn flows instead of estimating them from link flows orobtaining them by expanding the networks. The first one is designed on the path-turn incidencerelationship, and it is similar to the computational procedure of link flows. It applies to thetraffic assignment algorithms that can provide detailed path structures. The second utilizes thelink-turn incidence relationship and the conservation of flow on links, a law deriving from thisrelationship. It is actually an improved version of Dial's logit assignment algorithm. The proposedapproaches can avoid the shortcomings both of the estimation methods, e. g. Furness's model andFrator's model, and of the network-expanding method in precision, stability and computation scale.Finally, they are validated by numerical examples.
文摘Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.
基金Projects(2009G008-B,2010G018-E-3) supported by Key Projects of China Railway Ministry Science and Technology Research and Development ProgramProject(CX2013B076) supported by Hunan Provincial Innovation Foundation For Postgraduate,China
文摘Based on reasonable assumptions that simplified the calculational model,a simple and practical method was proposed to calculate the post-construction settlement of high-speed railway bridge pile foundation by using the Mesri creep model to describe the soil characteristics and the Mindlin-Geddes method considering pile diameter to calculate the vertical additional stress of pile bottom.A program named CPPS was designed for this method to calculate the post-construction settlement of a high-speed railway bridge pile foundation.The result indicates that the post-construction settlement in 100 years meets the requirements of the engineering specifications,and in the first two decades,the post-construction settlement is about 80% of its total settlement,while the settlement in the rest eighty years tends to be stable.Compared with the measured settlement after laying railway tracks,the calculational result is closed to that of the measured,and the results are conservative with a high computational accuracy.It is noted that the method can be used to calculate the post-construction settlement for the preliminary design of high-speed railway bridge pile foundation.
基金supported by the National Natural Science Foundation of China (61603398)。
文摘Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer trajectories. In order to address the usually slow computational time for the determination of the landing footprint of a space-to-ground vehicle under finite thrust, this work proposes a method that uses polynomial equations to describe the boundaries of the landing footprint and uses back propagation(BP) neural networks to quickly determine the landing footprint of the space-to-ground vehicle. First, given orbital parameters and a manoeuvre moment, the solution model of the landing footprint of a space-to-ground vehicle under finite thrust is established. Second, given arbitrary orbital parameters and an arbitrary manoeuvre moment, a fast computational model for the landing footprint of a space-to-ground vehicle based on BP neural networks is provided.Finally, the simulation results demonstrate that under the premise of ensuring accuracy, the proposed method can quickly determine the landing footprint of a space-to-ground vehicle with arbitrary orbital parameters and arbitrary manoeuvre moments. The proposed fast computational method for determining a landing footprint lays a foundation for the parking-orbit configuration and supports the design of real-time transfer trajectories.
文摘Ebstein's anomaly(EA) is a rare cardiac congenital malformation with displacement of septal and posterior tricuspid leaflets,resulting in atrialization of the right ventricle.We report a case of EA in which the etiology of a malfunctioning prosthetic tricuspid valve is depicted on cardiac computed tomography to be as a result of thrombus lodged in the valve.
基金This research is supported by the National Natural Science Foundation of China(Grant Nos.61502243,61802193)Natural Science Foundation of Jiangsu Province(BK20170934)+4 种基金Zhejiang Engineering Research Center of Intelligent Medicine under 2016E10011China Postdoctoral Science Foundation(2018M632349)NUPTSF(NY217136)Foundation of Smart Health Big Data Analysis and Location Services Engineering Laboratory of Jiangsu Province(SHEL221-001)Natural Science Foundation of the Higher Education Institutions of Jiangsu Province in China(16KJD520003).
文摘Novel coronavirus disease 2019(COVID-19)is an ongoing health emergency.Several studies are related to COVID-19.However,its molecular mechanism remains unclear.The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods.This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning.The method obtains seed genes based on prior knowledge.Candidate genes are mined from biomedical literature.The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate genes.Furthermore,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of COVID-19.Experimental results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.
基金National Natural Science Foundation of China,No.31971180 and No.11474013.
文摘Almost all the cellular processes in a living system are controlled by proteins:They regulate gene expression,catalyze chemical reactions,transport small molecules across membranes,and transmit signal across membranes.Even,a viral infection is often initiated through virus-host protein interactions.Protein-protein interactions(PPIs)are the physical contacts between two or more proteins and they represent complex biological functions.Nowadays,PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.Scientists have used PPIs to find the molecular basis of certain diseases and also some potential drug targets.In this review,we will discuss how PPI networks are essential to understand the molecular basis of virus-host relationships and several databases which are dedicated to virus-host interaction studies.Here,we present a short but comprehensive review on PPIs,including the experimental and computational methods of finding PPIs,the databases dedicated to virus-host PPIs,and the associated various applications in protein interaction networks of some lethal viruses with their hosts.
文摘Internal friction characteristic is one of the basic properties of geotechnical materials and it exists in mechanical elements all the time. However,until now internal friction is only considered in limit analysis and plastic mechanics but not included in elastic theory for rocks and soils. We consider that internal friction exists in both elastic state and plastic state of geotechnical materials,so the mechanical unit of friction material is constituted. Based on study results of soil tests,the paper also proposes that cohesion takes effect first and internal friction works gradually with the increment of deformation. By assuming that the friction coefficient is proportional to the strain,the internal friction is computed. At last,by imitating the linear elastic mechanics,the nonlinear elastic mechanics model of friction material is established,where the shear modulus G is not a constant. The new model and the traditional elastic model are used simultaneously to analyze an elastic foundation. The results indicate that the displacements computed by the new model are less than those from the traditional method,which agrees with the fact and shows that the mechanical units of friction material are suitable for geotechnical material.
基金supported by the National Natural Science Foundation of China(Grants 41374046 and41174034)
文摘We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data.
文摘The paper presents a very simple method, which in two stages enables to calculate the plane statically indeterminate truss by the application of one of methods used for the force calculation in members of the statically determinate trusses. The results are obtained in a very simple and quick way. Although the force values are approximated but they are relatively very close to those, which are determined by the exact methods. The point of the two-stage calculation process of the statically indeterminate trusses is to determine schemes of two independent and simple statically determined trusses, which after superposition of their patterns will give in the result a pattern of the initial, more complex form of the statically indeterminate truss. Each of the simple truss has to be of the same clear span and the load forces have to be of the half values and they have to be applied to the same nodes like in truss of the initial structural configuration.
基金National Natural Science Foundation of China(Grant No.51879159)the National Key Research and Development Program of China(Grant Nos.2019YFB1704200 and 2019YFC0312400)+2 种基金the Chang Jiang Scholars Program(Grant No.T2014099)the Shanghai Excellent Academic Leaders Program(Grant No.17XD1402300)the Innovative Special Project of Numerical Tank of Ministry of Industry and Information Technology of China(Grant No.2016-23/09).
文摘The present paper reviews the recent developments of a high⁃order⁃spectral method(HOS)and the combination with computational fluid dynamics(CFD)method for wave⁃structure interactions.As the numerical simulations of wave⁃structure interaction require efficiency and accuracy,as well as the ability in calculating in open sea states,the HOS method has its strength in both generating extreme waves in open seas and fast convergence in simulations,while computational fluid dynamics(CFD)method has its advantages in simulating violent wave⁃structure interactions.This paper provides the new thoughts for fast and accurate simulations,as well as the future work on innovations in fine fluid field of numerical simulations.
基金Supported by the National Natural Science Foundation of China(21225628,51106168,11272312)the“Strategic Priority Research Program”of the Chinese Academy of Sciences(XDA07080000)
文摘Conventionally, multiple reference frame(MRF) method and sliding mesh(SM) method are used in the simulation of stirred tanks, however, both methods have limitations. In this study, a hybrid immersed-boundary(IB)technique is developed in a finite difference context for the numerical simulation of stirred tanks. IBs based on Lagrangian markers and solid volume fractions are used for moving and stationary boundaries, respectively, to achieve optimal efficiency and accuracy. To cope with the high computational cost in the simulation of stirred tanks, the technique is implemented on computers with hybrid architecture where central processing units(CPUs) and graphics processing units(GPUs) are used together. The accuracy and efficiency of the present technique are first demonstrated in a relatively simple case, and then the technique is applied to the simulation of turbulent flow in a Rushton stirred tank with large eddy simulation(LES). Finally the proposed methodology is coupled with discrete element method(DEM) to accomplish particle-resolved simulation of solid suspensions in small stirred tanks. It demonstrates that the proposed methodology is a promising tool in simulating turbulent flow in stirred tanks with complex geometries.
基金Project partly supported by the Key Program of the National NaturalScience Foundation of China (No. 60533040)the National Natural Science Funds for Distinguished Young Scholar (No. 60525202)+1 种基金the Program for New Century Excellent Talents in University (No. NCET-04-0545)the Key Scientific and Technological Project of Hangzhou Technology Bureau (No. 20062412B01),China
文摘Battery models are of great importance to develop portable computing systems,for whether the design of low power hardware architecture or the design of battery-aware scheduling policies.In this paper,we present a physically justified iterative computing method to illustrate the discharge,recovery and charge process of Li/Li-ion batteries.The discharge and recovery processes correspond well to an existing accurate analytical battery model:R-V-W's analytical model,and thus interpret this model algorithmically.Our method can also extend R-V-W's model easily to accommodate the charge process.The work will help the system designers to grasp the characteristics of R-V-W's battery model and also,enable to predict the battery behavior in the charge process in a uniform way as the discharge process and the recovery process.Experiments are performed to show the ac-curacy of the extended model by comparing the predicted charge times with those derived from the DUALFOIL simulations.Various profiles with different combinations of battery modes were tested.The experimental results show that the extended battery model preserves high accuracy in predicting the charge behavior.
文摘The computational methods of a typical dynamic mathematical model that can describe the differential element and the inertial element for the system simulation are researched. The stability of numerical solutions of the dynamic mathematical model is researched. By means of theoretical analysis, the error formulas, the error sign criteria and the error relationship criterion of the implicit Euler method and the trapezoidal method are given, the dynamic factor affecting the computational accuracy has been found, the formula and the methods of computing the dynamic factor are given. The computational accuracy of the dynamic mathematical model like this can be improved by use of the dynamic factor.
基金Project supported by the National Key R&D Program of China(Grant No.2016YFA0501100)the National Natural Science Foundation of China(Grant Nos.91530321,31570742,and 31570727)Science and Technology Planning Project of Hunan Province,China(Grant No.2017RS3033)
文摘Three-dimensional(3 D)reconstruction of icosahedral viruses has played a crucial role in the development of cryoelectron microscopy single-particle reconstruction,with many cryo-electron microscopy techniques first established for structural studies of icosahedral viruses,owing to their high symmetry and large mass.This review summarizes the computational methods for icosahedral and symmetry-mismatch reconstruction of viruses,as well as the likely challenges and bottlenecks in virus reconstruction,such as symmetry mismatch reconstruction,contrast transformation function(CTF)correction,and particle distortion.