As the exertion development (PUAP) develop in Rejang Lebong Regency in Bengkulu province which had been started since 2008 by giving a kind of fund aid called Bantuan Langsung Masyarakat (BLM PUAP), to Gapoktan (Gabun...As the exertion development (PUAP) develop in Rejang Lebong Regency in Bengkulu province which had been started since 2008 by giving a kind of fund aid called Bantuan Langsung Masyarakat (BLM PUAP), to Gapoktan (Gabungan Kelompok Tani) or an organization of farmers such by giving some money as the capital used for 1) food plant cultiva-tion, horticulture, animal husbandry, plantation, and2) non-cultivation exertion such as;home industry of agriculture, small marketing scale and another agriculture exertion. By the approach which had been done is hoped to get the important result, on the other way the role of analysis factor (Social Network Analysis) from all undertaking stakeholders programs PUAP to be relevance steps aimed to understand the relation or connectivity from all factors in the network and also the role of factor inside the network itself be the relevance steps in arranging the strategy and work intention from the realization stage of PUAP program for the continuity of the realization program in the future (finding the good strategy) which aimed to develop the program of PUAP in Rejang Lebong Regency in Bengkulu Province, and to be a reference from doing the program as a national program in Indonesia.展开更多
Single-cell RNA-sequencing datasets of Arabidopsis roots have been generated,but related comprehensive gene co-expression network analyses are lacking.We conducted a single-cell gene co-expression network analysis wit...Single-cell RNA-sequencing datasets of Arabidopsis roots have been generated,but related comprehensive gene co-expression network analyses are lacking.We conducted a single-cell gene co-expression network analysis with publicly available scRNA-seq datasets of Arabidopsis roots using a SingleCellGGM algorithm.The analysis identified 149 gene co-expression modules,which we considered to be gene expression programs(GEPs).By examining their spatiotemporal expression,we identified GEPs specifically expressed in major root cell types along their developmental trajectories.These GEPs define gene programs regulating root cell development at different stages and are enriched with relevant developmental regulators.As examples,a GEP specific for the quiescent center(QC)contains 20 genes regulating QC and stem cell niche homeostasis,and four GEPs are expressed in sieve elements(SEs)from early to late developmental stages,with the early-stage GEP containing 17 known SE developmental regulators.We also identified GEPs for metabolic pathways with cell-type-specific expression,suggesting the existence of cell-type-specific metabolism in roots.Using the GEPs,we discovered and verified a columellaspecific gene,NRL27,as a regulator of the auxin-related root gravitropism response.Our analysis thus systematically reveals GEPs that regulate Arabidopsis root development and metabolism and provides ample resources for root biology studies.展开更多
Purpose:We analyzed the structure of a community of authors working in the field of social network analysis(SNA)based on citation indicators:direct citation and bibliographic coupling metrics.We observed patterns at t...Purpose:We analyzed the structure of a community of authors working in the field of social network analysis(SNA)based on citation indicators:direct citation and bibliographic coupling metrics.We observed patterns at the micro,meso,and macro levels of analysis.Design/methodology/approach:We used bibliometric network analysis,including the“temporal quantities”approach proposed to study temporal networks.Using a two-mode network linking publications with authors and a one-mode network of citations between the works,we constructed and analyzed the networks of citation and bibliographic coupling among authors.We used an iterated saturation data collection approach.Findings:At the macro-level,we observed the global structural features of citations between authors,showing that 80%of authors have not more than 15 citations from other works.At the meso-level,we extracted the groups of authors citing each other and similar to each other according to their citation patterns.We have seen a division of authors in SNA into groups of social scientists and physicists,as well as into other groups of authors from different disciplines.We found some examples of brokerage between different groups that maintained the common identity of the field.At the micro-level,we extracted authors with extremely high values of received citations,who can be considered as the most prominent authors in the field.We examined the temporal properties of the most popular authors.Research limitations:The main challenge in this approach is the resolution of the author’s name(synonyms and homonyms).We faced the author disambiguation,or“multiple personalities”(Harzing,2015)problem.To remain consistent and comparable with our previously published articles,we used the same SNA data collected up to 2018.The analysis and conclusions on the activity,productivity,and visibility of the authors are relative only to the field of SNA.Practical implications:The proposed approach can be utilized for similar objectives and identifying key structures and characteristics in other disciplines.This may potentially inspire the application of network approaches in other research areas,creating more authors collaborating in the field of SNA.Originality/value:We identified and applied an innovative approach and methods to study the structure of scientific communities,which allowed us to get the findings going beyond those obtained with other methods.We used a new approach to temporal network analysis,which is an important addition to the analysis as it provides detailed information on different measures for the authors and pairs of authors over time.展开更多
On the basis of measuring the regional high-quality development in China from 2011 to 2020,this study uses gravity model to build spatial correlation network,and uses social network analysis method to analyze the stru...On the basis of measuring the regional high-quality development in China from 2011 to 2020,this study uses gravity model to build spatial correlation network,and uses social network analysis method to analyze the structural characteristics and influencing factors of correlation network.The results are shown as follows.First,from 2011 to 2020,the level of regional high-quality development in China is rising gradually,and the discrete characteristics between regions are gradually obvious,showing a step-like distribution structure decreasing from east to west.Second,the network density of regional high-quality development is generally low and tends to decline,but it has strong stability and correlation strength.Third,the spatial correlation network has an obvious core-edge structure.Shanghai is always at the center of the network and plays a significant intermediary role,while Qinghai and Xinjiang are always at the edge of the network.Fourth,the regional high-quality development association network can be divided into four major sectors:main benefit,net benefit,net spillover,and broker,showing the spatial correlation characteristics of inter-plate contact and intra-plate agglomeration.Fifth,the level of economic development,the level of urbanization and geographical proximity have a significant impact on the formation of regional high-quality development correlation network.展开更多
Low-impact development (LID) technologies have a great potential to reduce water usage and stormwa- ter runoff and are therefore seen as sustainable improvements that can be made to traditional water infrastructure,...Low-impact development (LID) technologies have a great potential to reduce water usage and stormwa- ter runoff and are therefore seen as sustainable improvements that can be made to traditional water infrastructure, These technologies include bioretention areas, rainwater capturing, and xeriscaping, all of which can be used in residential zones, Within the City of Atlanta, residential water usage accounts for 53% of the total water consumption; therefore, residential zones offer significant impact potential for the implementation of LID, This study analyzes the use of LID strategies within the different residen- tial zones of the City of Atlanta from an ecological perspective by drawing analogies to natural ecosys- tems, The analysis shows that these technologies, especially with the addition of a graywater system, work to improve the conventional residential water network based upon these ecological metrics, The higher metric values suggest greater parity with healthy, natural ecosystems.展开更多
The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecos...The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecosystem services(ES)-based solutions can offer possible co-benefits for SDGs implementation that are often overlooked or underexploited.In this study,we cover this gap and investigate how experts from different countries value the SDGs and relate them with ES.A total of 66 countries participated to the survey,and answers were grouped into three macro-regions:Asia;Europe,North America,and Oceania(ENO);Latin America,Caribbean and Africa(LA).Results show that the most prioritized SDGs in the three macro-regions are usually those related to essential material needs and environmental conditions,such as SDG2(Zero Hunger),SDG1(No Poverty),and SDG6(Clean Water).At a global scale,the number of prioritized synergies between SDGs and ES largely exceeded trade-offs.The highest amount of synergies was observed for SDG1(No Poverty),mainly with SDG2,SDG3(Good Health),SDG5(Gender Equality),and SDG8(Economic Growth).Other major synergies among SDGs include SDG14-15(Life below water-Life on land),SDG5-10(Gender Equity-Reduced Inequality),and SDG1-2(No poverty-Zero Hunger).At a global scale,SDG15,SDG13,SDG14,and SDG6 were closely related to ES like climate regulation,freshwater,food,water purification,biodiversity,and education.SDG11(Sustainable Cities)and SDG3 were also relevant in Asia and in LA,respectively.Overall,this study shows the potential to couple future policies that can implement SDGs’strategies while adopting ES-based solutions in different regions of the world.展开更多
In this research,we aim to identify and investigate the impacts of key influencers on community formations and developments.We assess the impacts of key influencers by analyzing the activities and structure of the soc...In this research,we aim to identify and investigate the impacts of key influencers on community formations and developments.We assess the impacts of key influencers by analyzing the activities and structure of the social media presence of a local community.Results of our analysis show that key influencers play important roles in connecting the community,transferring information,and improving overall sentiment of the community members.Our findings suggest that community practitioners can apply social network analysis to identify value-added influencers and discover strategies for improving the community and keeping leadership roles.展开更多
Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and res...Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and resources,varied national priorities,and the intricate nature of the goals.As we approach 2030 and beyond,an urgent need for an effective,data-driven prioritisation system exists to optimise what can be accomplished.A considerable knowledge gap persists in identifying the priority areas that demand concentrated attention and how their improvement would propel overall sustainability goals.To bridge this gap,our study presents a priori-tisation approach that identifies significant SDG indicators based on urgency and impact,utilising Benchmarking,Bivariate,and Network analysis.Furthermore,we introduce an innovative Impact Index(IMIN)to assess an indi-cator’s extensive effect on the SDG network.This system carries significant international relevance by establishing a robust framework to identify key,potent,and interconnected indicators.It supports decision-makers worldwide in comprehending their nation’s SDG performance and promotes efficient resource allocation.In the specific con-text of Australia,our analysis spotlights several impactful,yet underperforming SDG indicators.These include the protection of Freshwater,Terrestrial,and Mountain Key Biodiversity Areas(KBAs),the share of renewable energy and energy intensity level of primary energy,targeted research and development,gender equality in national parliaments,and carbon-efficient manufacturing,amongst others.展开更多
In this paper, on the basis of the implementation of the national chemical industry standard analytical test methods and analysis of test items, a food additive quality analysis and inspection of network management ap...In this paper, on the basis of the implementation of the national chemical industry standard analytical test methods and analysis of test items, a food additive quality analysis and inspection of network management applications are developed using the development technology of Visual Basic language and computer system operating environment, to achieve a network management software for users on food additives of quality analytical testing. The software sets up an information sharing network platform for enterprise and quality management departments, which is a major innovation in the food additive quality analysis on test management methods and tools.展开更多
With the improvements in computer computing ability,data accumulation and rapid algorithm development,the integration of artificial intelligence(AI)and drug synthesis has been accelerated,significantly improving the d...With the improvements in computer computing ability,data accumulation and rapid algorithm development,the integration of artificial intelligence(AI)and drug synthesis has been accelerated,significantly improving the design and synthesis of drug molecules.Recently,data-driven computer-aided synthesis tools have been quickly and widely applied in retrosynthetic analysis,reaction prediction and automated synthesis,which can effectively accelerate the process of drug discovery and development and improve the quality of designed and synthesized drug molecules.Here,we review the development and applications of computer-aided synthesis technology and introduce recent advances in computer-aided drug development from three aspects:computer-aided drug design,computer-aided drug synthesis route design and computer-aided intelligent drug synthesis machines.Furthermore,the challenges and opportunities of computer-aided drug synthesis technology are discussed.展开更多
Integration of internal and external cues into developmental programs is indispensable for growth and development of plants, which involve complex interplays among signaling pathways activated by the internal and exte...Integration of internal and external cues into developmental programs is indispensable for growth and development of plants, which involve complex interplays among signaling pathways activated by the internal and external factors (IEFs). However, decoding these complex interplays is still challenging. Here, we present a web-based platform that identifies key regulators and Network models delineating Interplays among Developmental signaling (iNID) in Arabidopsis. iNID provides a comprehensive resource of (1) transcriptomes previously collected under the conditions treated with a broad spectrum of IEFs and (2) protein and genetic interactome data in Arabidopsis. In addition, iNID provides an array of tools for identifying key regulators and network models related to interplays among IEFs using transcriptome and interactome data. To demonstrate the utility of iNID, we investigated the interplays of (1) phytohormones and light and (2) phytohormones and biotic stresses. The results revealed 34 potential regulators of the interplays, some of which have not been reported in association with the interplays, and also network models that delineate the involvement of the 34 regulators in the interplays, providing novel insights into the interplays collectively defined by phytohormones, light, and biotic stresses. We then experimentally verified that BME3 and TEM1, among the selected regulators, are involved in the auxin-brassinosteroid (BR)-blue light interplay. Therefore, iNID serves as a useful tool to provide a basis for understanding interplays among IEFs.展开更多
The evolution of networks in rural industrial clusters,in particular in the context of China has been paid more attention to in the world.Applying the theory and techniques of social network analysis (SNA),this study ...The evolution of networks in rural industrial clusters,in particular in the context of China has been paid more attention to in the world.Applying the theory and techniques of social network analysis (SNA),this study is with particular regard to the business network relationships and their evolutionary dynamics of steel measuring tape manufacturing clustered in Nanzhuang Village,Yucheng County of Henan Province,China,which is important for better understanding the industrial and regional development in less developed rural areas.From data collected by comprehensive questionnaire survey in 2002 and mass interviews with 60 enterprises and assembling families and several government authorities in 2002,2003,2004,2005 and 2008,four types of networks are identified: spin-off,consulting,communication and cooperative.The characteristic of these networks is outlined in detail.Compared with the high-tech clusters of typical developed areas,the networks that have evolved in traditional manufacturing clusters are more affected by emotive linkages.The cluster networks are shown to exhibit a polycentric hierarchical structure.The family relationships are the dominate spin-off channels of enterprises,while the supply and demand relationships and the mobility of the skilled workers are also important paths of network learning,and the cooperation relationships are comparatively stable.Besides the root enterprises,the middle-sized enterprises are comparatively more active than small-sized enterprises,and the intermediary agencies and the service institutions act as bridges of the inter-enterprises cooperation.By analysis of the structure of networks and the interactions between the networks,the four stages of network evolution are also identified.The four stages are dominated by the family networks,the internal division production networks,the local innovation networks and the global supply networks respectively,and they play different roles in cluster development.展开更多
文摘As the exertion development (PUAP) develop in Rejang Lebong Regency in Bengkulu province which had been started since 2008 by giving a kind of fund aid called Bantuan Langsung Masyarakat (BLM PUAP), to Gapoktan (Gabungan Kelompok Tani) or an organization of farmers such by giving some money as the capital used for 1) food plant cultiva-tion, horticulture, animal husbandry, plantation, and2) non-cultivation exertion such as;home industry of agriculture, small marketing scale and another agriculture exertion. By the approach which had been done is hoped to get the important result, on the other way the role of analysis factor (Social Network Analysis) from all undertaking stakeholders programs PUAP to be relevance steps aimed to understand the relation or connectivity from all factors in the network and also the role of factor inside the network itself be the relevance steps in arranging the strategy and work intention from the realization stage of PUAP program for the continuity of the realization program in the future (finding the good strategy) which aimed to develop the program of PUAP in Rejang Lebong Regency in Bengkulu Province, and to be a reference from doing the program as a national program in Indonesia.
基金supported by grants from the Strategic Priority Research Program of the Chinese Academy of Science(XDA24010303)the National Natural Science Foundation of China(31770268)+1 种基金the Fundamental Research Funds for the Central Universities(WK2070000091)the University of Science and Technology of China(start-up fund to S.M.)。
文摘Single-cell RNA-sequencing datasets of Arabidopsis roots have been generated,but related comprehensive gene co-expression network analyses are lacking.We conducted a single-cell gene co-expression network analysis with publicly available scRNA-seq datasets of Arabidopsis roots using a SingleCellGGM algorithm.The analysis identified 149 gene co-expression modules,which we considered to be gene expression programs(GEPs).By examining their spatiotemporal expression,we identified GEPs specifically expressed in major root cell types along their developmental trajectories.These GEPs define gene programs regulating root cell development at different stages and are enriched with relevant developmental regulators.As examples,a GEP specific for the quiescent center(QC)contains 20 genes regulating QC and stem cell niche homeostasis,and four GEPs are expressed in sieve elements(SEs)from early to late developmental stages,with the early-stage GEP containing 17 known SE developmental regulators.We also identified GEPs for metabolic pathways with cell-type-specific expression,suggesting the existence of cell-type-specific metabolism in roots.Using the GEPs,we discovered and verified a columellaspecific gene,NRL27,as a regulator of the auxin-related root gravitropism response.Our analysis thus systematically reveals GEPs that regulate Arabidopsis root development and metabolism and provides ample resources for root biology studies.
基金supported in part by the Slovenian Research Agency(VB,research program P1-0294)(VB,research project J5-2557)+2 种基金(VB,research project J5-4596)COST EU(VB,COST action CA21163(HiTEc)is prepared within the framework of the HSE University Basic Research Program.
文摘Purpose:We analyzed the structure of a community of authors working in the field of social network analysis(SNA)based on citation indicators:direct citation and bibliographic coupling metrics.We observed patterns at the micro,meso,and macro levels of analysis.Design/methodology/approach:We used bibliometric network analysis,including the“temporal quantities”approach proposed to study temporal networks.Using a two-mode network linking publications with authors and a one-mode network of citations between the works,we constructed and analyzed the networks of citation and bibliographic coupling among authors.We used an iterated saturation data collection approach.Findings:At the macro-level,we observed the global structural features of citations between authors,showing that 80%of authors have not more than 15 citations from other works.At the meso-level,we extracted the groups of authors citing each other and similar to each other according to their citation patterns.We have seen a division of authors in SNA into groups of social scientists and physicists,as well as into other groups of authors from different disciplines.We found some examples of brokerage between different groups that maintained the common identity of the field.At the micro-level,we extracted authors with extremely high values of received citations,who can be considered as the most prominent authors in the field.We examined the temporal properties of the most popular authors.Research limitations:The main challenge in this approach is the resolution of the author’s name(synonyms and homonyms).We faced the author disambiguation,or“multiple personalities”(Harzing,2015)problem.To remain consistent and comparable with our previously published articles,we used the same SNA data collected up to 2018.The analysis and conclusions on the activity,productivity,and visibility of the authors are relative only to the field of SNA.Practical implications:The proposed approach can be utilized for similar objectives and identifying key structures and characteristics in other disciplines.This may potentially inspire the application of network approaches in other research areas,creating more authors collaborating in the field of SNA.Originality/value:We identified and applied an innovative approach and methods to study the structure of scientific communities,which allowed us to get the findings going beyond those obtained with other methods.We used a new approach to temporal network analysis,which is an important addition to the analysis as it provides detailed information on different measures for the authors and pairs of authors over time.
文摘On the basis of measuring the regional high-quality development in China from 2011 to 2020,this study uses gravity model to build spatial correlation network,and uses social network analysis method to analyze the structural characteristics and influencing factors of correlation network.The results are shown as follows.First,from 2011 to 2020,the level of regional high-quality development in China is rising gradually,and the discrete characteristics between regions are gradually obvious,showing a step-like distribution structure decreasing from east to west.Second,the network density of regional high-quality development is generally low and tends to decline,but it has strong stability and correlation strength.Third,the spatial correlation network has an obvious core-edge structure.Shanghai is always at the center of the network and plays a significant intermediary role,while Qinghai and Xinjiang are always at the edge of the network.Fourth,the regional high-quality development association network can be divided into four major sectors:main benefit,net benefit,net spillover,and broker,showing the spatial correlation characteristics of inter-plate contact and intra-plate agglomeration.Fifth,the level of economic development,the level of urbanization and geographical proximity have a significant impact on the formation of regional high-quality development correlation network.
基金This work was supported by a grant for "Resilient Interdependent Infrastructure Processes and Systems (RIPS) Type 2: Participatory Modeling of Complex Urban Infrastructure Systems (Model Urban SysTems)" (#0836046) from the National Science Foundation, Division of Emerging Frontiers in Research and Innovations (EFRI). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. The authors acknowledge the work of Jeong et al. for the use of data and support in this analysis.
文摘Low-impact development (LID) technologies have a great potential to reduce water usage and stormwa- ter runoff and are therefore seen as sustainable improvements that can be made to traditional water infrastructure, These technologies include bioretention areas, rainwater capturing, and xeriscaping, all of which can be used in residential zones, Within the City of Atlanta, residential water usage accounts for 53% of the total water consumption; therefore, residential zones offer significant impact potential for the implementation of LID, This study analyzes the use of LID strategies within the different residen- tial zones of the City of Atlanta from an ecological perspective by drawing analogies to natural ecosys- tems, The analysis shows that these technologies, especially with the addition of a graywater system, work to improve the conventional residential water network based upon these ecological metrics, The higher metric values suggest greater parity with healthy, natural ecosystems.
基金This work was supported by National Key R&D Program of China(Grant No.2017YFA0604700)National Natural Science Foundation of China(Grant No.4181101243)+2 种基金the Fundamental Research Funds for the Central UniversitiesFrancesco Cherubini was supported by Nor-wegian Research Council(Grant No.286773)Paulo Pereira was sup-ported by the European Social Fund project LINESAM(Grant No.09.3.3-LMT-K-712-01-0104).
文摘The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecosystem services(ES)-based solutions can offer possible co-benefits for SDGs implementation that are often overlooked or underexploited.In this study,we cover this gap and investigate how experts from different countries value the SDGs and relate them with ES.A total of 66 countries participated to the survey,and answers were grouped into three macro-regions:Asia;Europe,North America,and Oceania(ENO);Latin America,Caribbean and Africa(LA).Results show that the most prioritized SDGs in the three macro-regions are usually those related to essential material needs and environmental conditions,such as SDG2(Zero Hunger),SDG1(No Poverty),and SDG6(Clean Water).At a global scale,the number of prioritized synergies between SDGs and ES largely exceeded trade-offs.The highest amount of synergies was observed for SDG1(No Poverty),mainly with SDG2,SDG3(Good Health),SDG5(Gender Equality),and SDG8(Economic Growth).Other major synergies among SDGs include SDG14-15(Life below water-Life on land),SDG5-10(Gender Equity-Reduced Inequality),and SDG1-2(No poverty-Zero Hunger).At a global scale,SDG15,SDG13,SDG14,and SDG6 were closely related to ES like climate regulation,freshwater,food,water purification,biodiversity,and education.SDG11(Sustainable Cities)and SDG3 were also relevant in Asia and in LA,respectively.Overall,this study shows the potential to couple future policies that can implement SDGs’strategies while adopting ES-based solutions in different regions of the world.
文摘In this research,we aim to identify and investigate the impacts of key influencers on community formations and developments.We assess the impacts of key influencers by analyzing the activities and structure of the social media presence of a local community.Results of our analysis show that key influencers play important roles in connecting the community,transferring information,and improving overall sentiment of the community members.Our findings suggest that community practitioners can apply social network analysis to identify value-added influencers and discover strategies for improving the community and keeping leadership roles.
基金funded by the Australian Government Research Train-ing Program Scholarship provided by the Australian Commonwealth Government and the University of Melbourne。
文摘Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and resources,varied national priorities,and the intricate nature of the goals.As we approach 2030 and beyond,an urgent need for an effective,data-driven prioritisation system exists to optimise what can be accomplished.A considerable knowledge gap persists in identifying the priority areas that demand concentrated attention and how their improvement would propel overall sustainability goals.To bridge this gap,our study presents a priori-tisation approach that identifies significant SDG indicators based on urgency and impact,utilising Benchmarking,Bivariate,and Network analysis.Furthermore,we introduce an innovative Impact Index(IMIN)to assess an indi-cator’s extensive effect on the SDG network.This system carries significant international relevance by establishing a robust framework to identify key,potent,and interconnected indicators.It supports decision-makers worldwide in comprehending their nation’s SDG performance and promotes efficient resource allocation.In the specific con-text of Australia,our analysis spotlights several impactful,yet underperforming SDG indicators.These include the protection of Freshwater,Terrestrial,and Mountain Key Biodiversity Areas(KBAs),the share of renewable energy and energy intensity level of primary energy,targeted research and development,gender equality in national parliaments,and carbon-efficient manufacturing,amongst others.
文摘In this paper, on the basis of the implementation of the national chemical industry standard analytical test methods and analysis of test items, a food additive quality analysis and inspection of network management applications are developed using the development technology of Visual Basic language and computer system operating environment, to achieve a network management software for users on food additives of quality analytical testing. The software sets up an information sharing network platform for enterprise and quality management departments, which is a major innovation in the food additive quality analysis on test management methods and tools.
基金This work was supported by grants from the National Natural Science Foundation of China(Nos.81922064,22177083,81874290,81803755)Sichuan University Postdoctoral Interdisciplinary Innovation Fund,and West China Nursing Discipline Development Special Fund Project,Sichuan University(No.HXHL21011).
文摘With the improvements in computer computing ability,data accumulation and rapid algorithm development,the integration of artificial intelligence(AI)and drug synthesis has been accelerated,significantly improving the design and synthesis of drug molecules.Recently,data-driven computer-aided synthesis tools have been quickly and widely applied in retrosynthetic analysis,reaction prediction and automated synthesis,which can effectively accelerate the process of drug discovery and development and improve the quality of designed and synthesized drug molecules.Here,we review the development and applications of computer-aided synthesis technology and introduce recent advances in computer-aided drug development from three aspects:computer-aided drug design,computer-aided drug synthesis route design and computer-aided intelligent drug synthesis machines.Furthermore,the challenges and opportunities of computer-aided drug synthesis technology are discussed.
文摘Integration of internal and external cues into developmental programs is indispensable for growth and development of plants, which involve complex interplays among signaling pathways activated by the internal and external factors (IEFs). However, decoding these complex interplays is still challenging. Here, we present a web-based platform that identifies key regulators and Network models delineating Interplays among Developmental signaling (iNID) in Arabidopsis. iNID provides a comprehensive resource of (1) transcriptomes previously collected under the conditions treated with a broad spectrum of IEFs and (2) protein and genetic interactome data in Arabidopsis. In addition, iNID provides an array of tools for identifying key regulators and network models related to interplays among IEFs using transcriptome and interactome data. To demonstrate the utility of iNID, we investigated the interplays of (1) phytohormones and light and (2) phytohormones and biotic stresses. The results revealed 34 potential regulators of the interplays, some of which have not been reported in association with the interplays, and also network models that delineate the involvement of the 34 regulators in the interplays, providing novel insights into the interplays collectively defined by phytohormones, light, and biotic stresses. We then experimentally verified that BME3 and TEM1, among the selected regulators, are involved in the auxin-brassinosteroid (BR)-blue light interplay. Therefore, iNID serves as a useful tool to provide a basis for understanding interplays among IEFs.
基金Under the auspices of National Natural Science Foundation of China (No.41071080,41071082)Key Bidding Project for Soft Science in Henan Province in 2010 (No.102400410002)Key Project of the Humanities and Social Sciences Research Base in Ministry of Education (No.YRCSD08A10)
文摘The evolution of networks in rural industrial clusters,in particular in the context of China has been paid more attention to in the world.Applying the theory and techniques of social network analysis (SNA),this study is with particular regard to the business network relationships and their evolutionary dynamics of steel measuring tape manufacturing clustered in Nanzhuang Village,Yucheng County of Henan Province,China,which is important for better understanding the industrial and regional development in less developed rural areas.From data collected by comprehensive questionnaire survey in 2002 and mass interviews with 60 enterprises and assembling families and several government authorities in 2002,2003,2004,2005 and 2008,four types of networks are identified: spin-off,consulting,communication and cooperative.The characteristic of these networks is outlined in detail.Compared with the high-tech clusters of typical developed areas,the networks that have evolved in traditional manufacturing clusters are more affected by emotive linkages.The cluster networks are shown to exhibit a polycentric hierarchical structure.The family relationships are the dominate spin-off channels of enterprises,while the supply and demand relationships and the mobility of the skilled workers are also important paths of network learning,and the cooperation relationships are comparatively stable.Besides the root enterprises,the middle-sized enterprises are comparatively more active than small-sized enterprises,and the intermediary agencies and the service institutions act as bridges of the inter-enterprises cooperation.By analysis of the structure of networks and the interactions between the networks,the four stages of network evolution are also identified.The four stages are dominated by the family networks,the internal division production networks,the local innovation networks and the global supply networks respectively,and they play different roles in cluster development.