With the progress of science and technology and the acceleration of industrialization,the modern industrial park is an important carrier of industrial development.The importance of its standard plant design has become...With the progress of science and technology and the acceleration of industrialization,the modern industrial park is an important carrier of industrial development.The importance of its standard plant design has become increasingly prominent.With the development of new quality productive forces as the background,this research deeply discusses the key points of standard plant design in modern industrial parks.This paper uses literature review and case analysis to systematically analyze the important role of standard plant design in developing new quality productive forces in modern industrial parks and puts forward suggestions for optimizing design.It is found that the rationality,intelligence,and environmental protection of plant design are the key factors affecting the development of new quality productive forces.The paper summarizes the core points of modern industrial park standard plant design to provide a reference for the future development of related industries.展开更多
The paper proposes the idea that in the primary stage of industrial product design, the aesthetic nature of the product should be grasped. In addition, the paper poses two questions about aesthetic nature industrial d...The paper proposes the idea that in the primary stage of industrial product design, the aesthetic nature of the product should be grasped. In addition, the paper poses two questions about aesthetic nature industrial design: first, what is the object of industrial design aesthetics? Second, what are the characteristics of design aesthetics of industrial products?展开更多
Electrochemical water splitting represents one of the most promising technologies to produce green hydrogen,which can help to realize the goal of achieving carbon neutrality.While substantial efforts on a laboratory s...Electrochemical water splitting represents one of the most promising technologies to produce green hydrogen,which can help to realize the goal of achieving carbon neutrality.While substantial efforts on a laboratory scale have been made for understanding fundamental catalysis and developing high-performance electrocatalysts for the two half-reactions involved in water electrocatalysis,much less attention has been paid to doing relevant research on a larger scale.For example,few such researches have been done on an industrial scale.Herein,we review the very recent endeavors to bridge the gaps between fundamental research and industrial applications for water electrolysis.We begin by introducing the fundamentals of electrochemical water splitting and then present comparisons of testing protocol,figure of merit,catalyst of interest,and manufacturing cost for laboratory and industry-based water-electrolysis research.Special attention is paid to tracking the surface reconstruction process and identifying real catalytic species under different testing conditions,which highlight the significant distinctions of corresponding electrochemical reconstruction mechanisms.Advances in catalyst designs for industry-relevant water electrolysis are also summarized,which reveal the progress of moving the practical applications forward and accelerating synergies between material science and engineering.Perspectives and challenges of electrocatalyst design strategies are proposed finally to further bridge the gaps between lab-scale research and large-scale electrocatalysis applications.展开更多
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine...The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo...Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nh) systems and Co-V-C system were modeled. Solution parameters and thermodynamic: properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.展开更多
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced...Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.展开更多
The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system (FMCAD) used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented (O-O) technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient ...In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient and reliable transmission with quality of service(QoS)guarantee for machinetype communication devices(MTCDs).Considering the IN in the industrial process,this paper establishes the multiuser multiple-input single-output(MU-MISO)orthogonal frequency division multiplexing(OFDM)system model,which combines transmitter and receiver design.Two precoding schemes are designed to improve communication effectiveness at the transmitter.More specifically,the precoder design scheme which combines semi-definite relaxation(SDR)with difference-of-two-convex-function(D.C.)iterative algorithm,is developed by utilizing the Dinkelbach method to improve the system effectiveness.To decrease the computational complexity,we devise the quadratic-based fractional programming(QFP)algorithm,which decouples the variables by using a quadratic transform method.On this basis,the IN mitigation scheme is studied to reduce the system error rate(SER)at the receiver.With the goal of improving the reliability of industrial wireless communications,we propose a hybrid nonlinear IN mitigation(HNINM)scheme and then derive its closed-form expression of SER.The simulation results show that the proposed QFP algorithm achieves superior performance while the HNINM scheme decreases the SER of industrial wireless communications.展开更多
Traditional Industrial Design has been an important aspect in the New Product Development process within the last dec- ades. User centered design is a growing research field for product innovation which needs support ...Traditional Industrial Design has been an important aspect in the New Product Development process within the last dec- ades. User centered design is a growing research field for product innovation which needs support from both design knowledge and research methodologies. Both TID and UCD focus on user's perspective when doing multi-disciplinary work. They take care of style, usability, and balancing the users need and reality. The skills from TID help design expression and realization to communicate effi- ciently with other participants by informative images and real prototypes. The methods from UCD help the idea generation and op- portunity discoveries by facilitating workshops and conducting interview with participants. TID and UCD represent different per- spectives of the subjective and the objective respectively.展开更多
There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating ...There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating design guided by this behavior. The design method carries out in four steps, first step is to focus on the analysis of individual action phase, pay attention to the explora- tion of the relationship between actions and tool ,and then list the importance order in the action phase, the third step is to take out the in-depth anatomical analysis of the stage, analyze the reason of the operational difficulty .and at last carries out the design concept to resolve the problem. All in all, this method revolves around the main stage of spontaneous behavior, and analyzes it in interim and solves the problem in stage.展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual sk...Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.展开更多
We are placing more and more emphasis on the design of industrial floors when designing the structure of buildings. Currently there are only a few approved designing guidelines that practicing engineers can use to eas...We are placing more and more emphasis on the design of industrial floors when designing the structure of buildings. Currently there are only a few approved designing guidelines that practicing engineers can use to easily design industrial floors. Rather the best practice is that the manufacturers of certain products (concrete fibre reinforcement, dilatation joints) carry out the more or less professional designing. In addition, there are numerous incurring questions in connection with applying the internationally approved guidelines in terms of applicability and reliability. Our paper is based on years of experience in designing industrial floors. In the first part the main guidelines, their characteristics and opportunities of application are discussed. In the second part we take a closer look at the most common TR34 British guideline, presenting its most significant designing formulas, which support engineering practitioners in carrying out the design of industrial floors on their own. In the third part we demonstrate advanced finite element analyses, comparing results with real sized experiments and with results of the guidelines.展开更多
Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industria...Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industrial needs in pattern design and technology in China's Mainland. The data were collected from the employers and employees from the garment industry and students in the major of fashion and clothing studies. It indicated that there was a gap between the employer and employee, especially the requirements of the industrial needs and the course contents covered by the tertiary schools. The employers expected to recruit more experienced pattern designers, at the same time, they were not reluctant to hire fresh graduates and spent more resources on the training of employees. The students knew little about their employment situation of the garment industry, spent too little time on the course study and learned too little practical skills in pattern design. They could not make use of the knowledge which prevented them from being employed by the garment industry. Efforts should be taken by both the tertiary schools and the garment industry. The students should be aspirated towards the profession of pattern cutters and the syllabuses of pattern making should be more practical and industrial orientated. The solution might benefit the garment industry a lot in a long run.展开更多
The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on th...The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on the basis of shadow projections. This article provides basic information regarding CAD of X-ray microtomography and a scheme consisting of three levels. The article also shows basic relations of X-ray computed tomography, the generalized scheme of an X-ray microtomographic scanner. The methods of X-ray imaging of the spatial microstructure and morphometry of materials are described. The main characteristics of an X-ray microtomographic scanner, the X-ray source, X-ray optical elements and mechanical components of the positioning system are shown. The block scheme and software functional scheme for intelligent neural network system of analysis of the internal microstructure of objects are presented. The method of choice of design parameters of CAD of X-ray microtomography aims at improving the quality of design and reducing costs of it. It is supposed to reduce the design time and eliminate the growing number of engineers involved in development and construction of X-ray microtomographic scanners.展开更多
This paper describes economical strategies to design blast resistant electrical substations and control buildings that are commonly used at industrial plants.Limited literature addressed design aspects for this class ...This paper describes economical strategies to design blast resistant electrical substations and control buildings that are commonly used at industrial plants.Limited literature addressed design aspects for this class of buildings.Furthermore,little guidelines are available in practice to regulate this type of steel construction.The first part of the paper overviews the architectural and structural layouts of electrical buildings.Blast resistance requirements for occupied control buildings are also discussed.Simplified multiple degrees of freedom(MDOF)dynamic model is also illustrated that can be utilized for analysis of the blast resistant buildings.The economical aspects and cost savings resulting in using mobile blast resistant buildings are discussed.The article also highlights the engineering challenges that are encountered in design of mobile electrical facilities.The transportation procedure and design requirements are briefly described.Guidelines are proposed to calculate the center of mass of the building combined with interior equipment.The proposed design concept for electrical and control buildings is cost effective and can be implemented in industry to reduce projects cost.展开更多
With the continuous development and progress of China’s industry,it has become the only country in the world that has all the industrial categories in the United Nations Industrial Classification.China’s industrial ...With the continuous development and progress of China’s industry,it has become the only country in the world that has all the industrial categories in the United Nations Industrial Classification.China’s industrial products have gradually changed from“Made in China”to“Design in China”.The integration of Chinese national cultural elements into industrial product design has also become the future development trend in the field of design.This paper will analyze the application of national culture in industrial product design,and discuss how to better integrate the two with practical cases to promote the continuous development of the industry.展开更多
文摘With the progress of science and technology and the acceleration of industrialization,the modern industrial park is an important carrier of industrial development.The importance of its standard plant design has become increasingly prominent.With the development of new quality productive forces as the background,this research deeply discusses the key points of standard plant design in modern industrial parks.This paper uses literature review and case analysis to systematically analyze the important role of standard plant design in developing new quality productive forces in modern industrial parks and puts forward suggestions for optimizing design.It is found that the rationality,intelligence,and environmental protection of plant design are the key factors affecting the development of new quality productive forces.The paper summarizes the core points of modern industrial park standard plant design to provide a reference for the future development of related industries.
文摘The paper proposes the idea that in the primary stage of industrial product design, the aesthetic nature of the product should be grasped. In addition, the paper poses two questions about aesthetic nature industrial design: first, what is the object of industrial design aesthetics? Second, what are the characteristics of design aesthetics of industrial products?
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)supported by National R&D Program through the National Research Foundation of Korea(NRF),grant number 2021M3H4A1A01079300the Korea Research Institute of Chemical Technology Core Research Program funded by the Korea Research Council for Industrial Science and Technology,grant number KS2222-10.
文摘Electrochemical water splitting represents one of the most promising technologies to produce green hydrogen,which can help to realize the goal of achieving carbon neutrality.While substantial efforts on a laboratory scale have been made for understanding fundamental catalysis and developing high-performance electrocatalysts for the two half-reactions involved in water electrocatalysis,much less attention has been paid to doing relevant research on a larger scale.For example,few such researches have been done on an industrial scale.Herein,we review the very recent endeavors to bridge the gaps between fundamental research and industrial applications for water electrolysis.We begin by introducing the fundamentals of electrochemical water splitting and then present comparisons of testing protocol,figure of merit,catalyst of interest,and manufacturing cost for laboratory and industry-based water-electrolysis research.Special attention is paid to tracking the surface reconstruction process and identifying real catalytic species under different testing conditions,which highlight the significant distinctions of corresponding electrochemical reconstruction mechanisms.Advances in catalyst designs for industry-relevant water electrolysis are also summarized,which reveal the progress of moving the practical applications forward and accelerating synergies between material science and engineering.Perspectives and challenges of electrocatalyst design strategies are proposed finally to further bridge the gaps between lab-scale research and large-scale electrocatalysis applications.
文摘The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nh) systems and Co-V-C system were modeled. Solution parameters and thermodynamic: properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.
基金The study was financially supported by the key project of Science and Technology Commission of Shanghai Local Gov-ernment (No. 015211010), the National Natural Science Foundation of China (No. 50171038) and the China-Belgium bi-lateral project (No. 2001-242).
文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.
文摘The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system (FMCAD) used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented (O-O) technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
基金supported in part by the National Natural Science Foundation of China under Grant 62071472in part the Program for“Industrial Io T and Emergency Collaboration”Innovative Research Team in CUMT(No.2020ZY002)。
文摘In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient and reliable transmission with quality of service(QoS)guarantee for machinetype communication devices(MTCDs).Considering the IN in the industrial process,this paper establishes the multiuser multiple-input single-output(MU-MISO)orthogonal frequency division multiplexing(OFDM)system model,which combines transmitter and receiver design.Two precoding schemes are designed to improve communication effectiveness at the transmitter.More specifically,the precoder design scheme which combines semi-definite relaxation(SDR)with difference-of-two-convex-function(D.C.)iterative algorithm,is developed by utilizing the Dinkelbach method to improve the system effectiveness.To decrease the computational complexity,we devise the quadratic-based fractional programming(QFP)algorithm,which decouples the variables by using a quadratic transform method.On this basis,the IN mitigation scheme is studied to reduce the system error rate(SER)at the receiver.With the goal of improving the reliability of industrial wireless communications,we propose a hybrid nonlinear IN mitigation(HNINM)scheme and then derive its closed-form expression of SER.The simulation results show that the proposed QFP algorithm achieves superior performance while the HNINM scheme decreases the SER of industrial wireless communications.
文摘Traditional Industrial Design has been an important aspect in the New Product Development process within the last dec- ades. User centered design is a growing research field for product innovation which needs support from both design knowledge and research methodologies. Both TID and UCD focus on user's perspective when doing multi-disciplinary work. They take care of style, usability, and balancing the users need and reality. The skills from TID help design expression and realization to communicate effi- ciently with other participants by informative images and real prototypes. The methods from UCD help the idea generation and op- portunity discoveries by facilitating workshops and conducting interview with participants. TID and UCD represent different per- spectives of the subjective and the objective respectively.
文摘There is a close relationship between individual spontaneous behavior and Industrial design. As individual spontaneous behavior can sent especial meaning for industrial design, there is a great necessity for creating design guided by this behavior. The design method carries out in four steps, first step is to focus on the analysis of individual action phase, pay attention to the explora- tion of the relationship between actions and tool ,and then list the importance order in the action phase, the third step is to take out the in-depth anatomical analysis of the stage, analyze the reason of the operational difficulty .and at last carries out the design concept to resolve the problem. All in all, this method revolves around the main stage of spontaneous behavior, and analyzes it in interim and solves the problem in stage.
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
文摘Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.
文摘We are placing more and more emphasis on the design of industrial floors when designing the structure of buildings. Currently there are only a few approved designing guidelines that practicing engineers can use to easily design industrial floors. Rather the best practice is that the manufacturers of certain products (concrete fibre reinforcement, dilatation joints) carry out the more or less professional designing. In addition, there are numerous incurring questions in connection with applying the internationally approved guidelines in terms of applicability and reliability. Our paper is based on years of experience in designing industrial floors. In the first part the main guidelines, their characteristics and opportunities of application are discussed. In the second part we take a closer look at the most common TR34 British guideline, presenting its most significant designing formulas, which support engineering practitioners in carrying out the design of industrial floors on their own. In the third part we demonstrate advanced finite element analyses, comparing results with real sized experiments and with results of the guidelines.
文摘Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industrial needs in pattern design and technology in China's Mainland. The data were collected from the employers and employees from the garment industry and students in the major of fashion and clothing studies. It indicated that there was a gap between the employer and employee, especially the requirements of the industrial needs and the course contents covered by the tertiary schools. The employers expected to recruit more experienced pattern designers, at the same time, they were not reluctant to hire fresh graduates and spent more resources on the training of employees. The students knew little about their employment situation of the garment industry, spent too little time on the course study and learned too little practical skills in pattern design. They could not make use of the knowledge which prevented them from being employed by the garment industry. Efforts should be taken by both the tertiary schools and the garment industry. The students should be aspirated towards the profession of pattern cutters and the syllabuses of pattern making should be more practical and industrial orientated. The solution might benefit the garment industry a lot in a long run.
文摘The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on the basis of shadow projections. This article provides basic information regarding CAD of X-ray microtomography and a scheme consisting of three levels. The article also shows basic relations of X-ray computed tomography, the generalized scheme of an X-ray microtomographic scanner. The methods of X-ray imaging of the spatial microstructure and morphometry of materials are described. The main characteristics of an X-ray microtomographic scanner, the X-ray source, X-ray optical elements and mechanical components of the positioning system are shown. The block scheme and software functional scheme for intelligent neural network system of analysis of the internal microstructure of objects are presented. The method of choice of design parameters of CAD of X-ray microtomography aims at improving the quality of design and reducing costs of it. It is supposed to reduce the design time and eliminate the growing number of engineers involved in development and construction of X-ray microtomographic scanners.
文摘This paper describes economical strategies to design blast resistant electrical substations and control buildings that are commonly used at industrial plants.Limited literature addressed design aspects for this class of buildings.Furthermore,little guidelines are available in practice to regulate this type of steel construction.The first part of the paper overviews the architectural and structural layouts of electrical buildings.Blast resistance requirements for occupied control buildings are also discussed.Simplified multiple degrees of freedom(MDOF)dynamic model is also illustrated that can be utilized for analysis of the blast resistant buildings.The economical aspects and cost savings resulting in using mobile blast resistant buildings are discussed.The article also highlights the engineering challenges that are encountered in design of mobile electrical facilities.The transportation procedure and design requirements are briefly described.Guidelines are proposed to calculate the center of mass of the building combined with interior equipment.The proposed design concept for electrical and control buildings is cost effective and can be implemented in industry to reduce projects cost.
基金Tutor system research project of Huashang School of Guangdong University of Finance and Economics(Number:2019HSDS21).
文摘With the continuous development and progress of China’s industry,it has become the only country in the world that has all the industrial categories in the United Nations Industrial Classification.China’s industrial products have gradually changed from“Made in China”to“Design in China”.The integration of Chinese national cultural elements into industrial product design has also become the future development trend in the field of design.This paper will analyze the application of national culture in industrial product design,and discuss how to better integrate the two with practical cases to promote the continuous development of the industry.