AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity.METHODS: Totally 391 participants were recruited and taken the computerized diplopia test....AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity.METHODS: Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual acuity groups were analyzed respectively. Of 30 subjects were enrolled to testify the interobserver reliability. Another 46 subjects(including 26 normal subjects and 20 patients) were taken the test and theirs deviations were recorded to testify the validity of the reference value.RESULTS: The max horizontal and vertical deviations were 2.55° and 0.76° with normal corrected visual acuity while 3.88° and 1.46° for subjects with poor corrected vision. The differences between age groups was insignificant(Z =3.615, 4.758; P =0.461, 0.313 for horizontal and vertical respectively). The max horizontal deviation of female was smaller than male(Z =-2.177; P =0.029),but the difference in max vertical deviation was insignificant(Z =-1.296; P =0.195). The mean difference between observers were both-0.1°, with 95% confidence limits(CI) of-1.4° and 1.6° in max horizontal deviations while-2.1° and 1.8° in max vertical deviation. The mean deviation of 26 normal subjects was 1.02° ±0.84° for horizontal and 0.47° ±0.30° for vertical which both within the range of reference values. The mean deviation of 20 patients was 13.51°±11.69° for horizontal and 8.34°±8.58°for vertical which both beyond the reference range.CONCLUSION: The max amplitude of horizontal and vertical deviation is pointed as the numerical parameters of computerized diplopia test. The reference values are different between normal corrected visual acuity and poor corrected vision. These values may useful for evaluating patients with diplopia in veriety conditions during clinical practice.展开更多
Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we sho...Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we show that the decrease of working efficiency and sympathetic hyperactivity are associated with mental fatigue state caused by prolonged mental workload. Recently we made a new mental fatigue model of healthy volunteers caused by long-term computerized Kraepelin test (CKT) workload. CKT is our new software for automatically checking the calculation capability, with which it is easy to determine the reaction time (RT), coefficient of variance of reaction time (CV), and accuracy of the answers (AC) during tasks. We put 24 healthy volunteers into the fatigue state by subjecting them to 120 minutes’ CKT workload, and then studied the changes in fatigue sensation, RT, CV, and AC before and after the CKT workload. The fatigue sensation, RT, and CV were clearly increased by the fatigue-inducing task and recovered during the resting period. We also studied the changes in autonomic nerve activity by using heart rate variability analysis. The low/high frequency component ratio (LF/HF) was signifi-cantly increased by the fatigue-inducing task and decreased by resting, suggesting that mental stress causes a relatively sympathetic nerve activity-dominant state. Therefore, our new fatigue model involving a long-term CKT workload is a good mental fatigue model to provide much information about the fatigue state simultane-ously, and the increase of RT, CV, and proportion of sympathetic activity (LF/HF) are associated with mental fatigue state. These might be useful objective biomarkers or evaluating a mental fatigue state.展开更多
Objective. To study the difference of interstitial lung diseases (ILDs) in high-resolution computerized tomography and pulmonary function test among different connective tissue diseases (CTDs). Methods. 209 patients w...Objective. To study the difference of interstitial lung diseases (ILDs) in high-resolution computerized tomography and pulmonary function test among different connective tissue diseases (CTDs). Methods. 209 patients with different CTDs were recruited and underwent lung HRCT and PFT. Eerythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin (SF), anti-SSA, and so on were tested. Based on HRCT, a patient was classified into ILD group (CTD+ILD) or non-ILD group (CTD-ILD). HRCT, PFT, and laboratory markers were compared according to CTDs and CTD-associated ILDs. Results. The incidences of ILD were 79.6%, 82.0%, 89.7%, and 97.1% respectively for Rheumatoid arthritis (RA), primary Sjogren’s symptom (pSS), dermatomyositis/polymyositis (DM/PM), and systemic sclerosis (SSc) groups. RA and pSS patients exhibited more nodules, patching, ground-glass opacity, and cord shadow foci in HRCT, DM/PM and SSc patients exhibited more reticular opacity and honeycombing foci. RA and pSS patients exhibited more obstructive ventilatory disorder, small airway dysfunction and emphysema in PFT, and DM/PM and SSc patients exhibited more restrictive ventilatory disorder, mixed ventilatory disorder. ESR, CRP and SF were significantly higher in total CTD+ILD group than in total CTD-ILD group (P = 0.047, 0.006, 0.004, respectively), and higher in different CTD+ ILD groups than in comparable CTD-ILD groups (P = 0.049, 0.048, and 0.023, pSS+ILD, SSc+ILD and RA+ILD compared to pSS-ILD, SSc-ILD and RA-ILD, respectively for ESR, CRP, SF). The positive rate of anti-SSA was significantly higher in DM/PM+ILD group than in DM/PM-ILD group (P = 0.025). Conclusions. The manifestations and incidences of ILDs differ among different CTDs in HRCT and PFT, and inflammation and anti-SSA are positively correlated with ILDs in different CTDs, which provide important evidences for judging disease condition and prognosis.展开更多
●AIM:To develop a novel approach called the Autoacuity Tester,and to evaluate its validity,especially the sensitivity and specificity for detecting amblyopia.●METHODS:Children aged from 3 to 12 y(n=552)were enrolled...●AIM:To develop a novel approach called the Autoacuity Tester,and to evaluate its validity,especially the sensitivity and specificity for detecting amblyopia.●METHODS:Children aged from 3 to 12 y(n=552)were enrolled in the study.The validity of the Autoacuity Tester was evaluated by comparing it to the Tumbling E Early Treatment Diabetic Retinopathy Study(ETDRS)acuity chart for school age children,and Lea Symbols and Teller acuity card(TAC)for preschool children.The repeatability was assessed by coefficient of repeatability(COR).The sensitivity and specificity for detecting amblyopia were calculated.●RESULTS:The mean difference(95%limits of agreement)between the Autoacuity Tester and the ETDRS tests were-0.03(-0.24,0.19)logMAR for the school age group.In preschool children,the mean difference was 0.04(-0.14,0.21)logMAR between the Autoacuity Tester and the TAC and 0.00(-0.17,0.18)logMAR between the Autoacuity Tester and the Lea Symbols.For the school age group,the COR was 0.20 logMAR for the Autoacuity Tester and 0.18 logMAR for the ETDRS.For the preschool group,the COR was 0.13 logMAR for the Autoacuity Tester and 0.21 logMAR for TAC.The Autoacuity Tester(88%)is more sensitive than TAC(72%)in detecting amblyopia(P=0.04),while had similar specificity(92%vs 90%,P=0.20).●CONCLUSION:The Autoacuity Tester provides a reliable alternative for assessing visual acuity,and offers advantage of higher testability and repeatability for preschool children.展开更多
Clinicians involved in HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) prevention of mother to child transmission (PMTCT) programme and research activities can benefit from the advantag...Clinicians involved in HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) prevention of mother to child transmission (PMTCT) programme and research activities can benefit from the advantages that computerized systems add to medical practice even in resource constrained sub-Saharan clinic settings. Their continued use of paper based systems presents clinical data management and patient care challenges. A portable point of care data capture electronic system and a computerized clinic patient management system (CCPMS) were implemented to remedy these challenges. PMTCT report compilation was easier with the portable data collection system whose data were found to be more complete and accurate with a 0.83% error rate compared to a 4.1% error rate in the paper registers. A resounding majority of clinicians preferred using the new CCPMS with many of the view that it improved drug inventory and general clinic management with a positive effect on patient care.展开更多
RompecPC is a computerized program designed to create and assemble jigsaw puzzles. The program automatically records the solver’s responses as the number of pieces positioned correctly, the number of correct and inco...RompecPC is a computerized program designed to create and assemble jigsaw puzzles. The program automatically records the solver’s responses as the number of pieces positioned correctly, the number of correct and incorrect movements, the number of times that she/he attempts to move a piece to the same place (perseverations), and the latency and place to which each piece is moved or attempted to be moved. These features facilitate the implementation and evaluation of puzzles while also reducing human error. Therefore, RompePC is a useful tool for the neuropsychological assessment of visuospatial skills in both clinical and experimental research.展开更多
G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)...G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)在线标定新方法SCADOCM,以期促进CD-CAT在实践中的推广与应用。本研究分别基于模拟题库以及真实题库进行研究,结果表明:相比传统的SIE方法,SCADOCM在各实验条件下均具有较为理想的标定精度与标定效率,应用前景较好;SIE方法不适用于饱和的G-DINA等模型,其各实验条件下的Q矩阵标定精度均较低。展开更多
The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory e...The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory experiments and numerical simulations.In this study,the computerized tomography (CT) scanning and photogrammetry were employed to obtain the internal and surface joint structures of a limestone sample,respectively.To describe the joint geometry,the edge detection algorithms and a three-dimensional (3D) matrix mapping method were applied to reconstruct CT-based and photogrammetry-based jointed rock models.For comparison tests,the numerical uniaxial compression tests were conducted on an intact rock sample and a sample with a joint simplified to a plane using the parallel computing method.The results indicate that the mechanical characteristics and failure process of jointed rocks are significantly affected by the geometry of joints.The presence of joints reduces the uniaxial compressive strength (UCS),elastic modulus,and released acoustic emission (AE) energy of rocks by 37%–67%,21%–24%,and 52%–90%,respectively.Compared to the simplified joint sample,the proposed photogrammetry-based numerical model makes the most of the limited geometry information of joints.The UCS,accumulative released AE energy,and elastic modulus of the photogrammetry-based sample were found to be very close to those of the CT-based sample.The UCS value of the simplified joint sample (i.e.38.5 MPa) is much lower than that of the CT-based sample (i.e.72.3 MPa).Additionally,the accumulative released AE energy observed in the simplified joint sample is 3.899 times lower than that observed in the CT-based sample.CT scanning provides a reliable means to visualize the joints in rocks,which can be used to verify the reliability of photogrammetry techniques.The application of the photogrammetry-based sample enables detailed analysis for estimating the mechanical properties of jointed rocks.展开更多
基金Supported by Natural Science Foundation of China(No.81674052)Key Project of Natural Science Foundation of Heilongjiang Province(No.ZD201211)Project of innovational scientific research of Harbin Medical University(N0.2016LCZX49)
文摘AIM: To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the validity.METHODS: Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual acuity groups were analyzed respectively. Of 30 subjects were enrolled to testify the interobserver reliability. Another 46 subjects(including 26 normal subjects and 20 patients) were taken the test and theirs deviations were recorded to testify the validity of the reference value.RESULTS: The max horizontal and vertical deviations were 2.55° and 0.76° with normal corrected visual acuity while 3.88° and 1.46° for subjects with poor corrected vision. The differences between age groups was insignificant(Z =3.615, 4.758; P =0.461, 0.313 for horizontal and vertical respectively). The max horizontal deviation of female was smaller than male(Z =-2.177; P =0.029),but the difference in max vertical deviation was insignificant(Z =-1.296; P =0.195). The mean difference between observers were both-0.1°, with 95% confidence limits(CI) of-1.4° and 1.6° in max horizontal deviations while-2.1° and 1.8° in max vertical deviation. The mean deviation of 26 normal subjects was 1.02° ±0.84° for horizontal and 0.47° ±0.30° for vertical which both within the range of reference values. The mean deviation of 20 patients was 13.51°±11.69° for horizontal and 8.34°±8.58°for vertical which both beyond the reference range.CONCLUSION: The max amplitude of horizontal and vertical deviation is pointed as the numerical parameters of computerized diplopia test. The reference values are different between normal corrected visual acuity and poor corrected vision. These values may useful for evaluating patients with diplopia in veriety conditions during clinical practice.
文摘Fatigue is a common sense caused by crushing labor, stressful social events and various illnesses. It is usually judged by their subjective symptoms, but it should be evaluated in an objective perspective. Here we show that the decrease of working efficiency and sympathetic hyperactivity are associated with mental fatigue state caused by prolonged mental workload. Recently we made a new mental fatigue model of healthy volunteers caused by long-term computerized Kraepelin test (CKT) workload. CKT is our new software for automatically checking the calculation capability, with which it is easy to determine the reaction time (RT), coefficient of variance of reaction time (CV), and accuracy of the answers (AC) during tasks. We put 24 healthy volunteers into the fatigue state by subjecting them to 120 minutes’ CKT workload, and then studied the changes in fatigue sensation, RT, CV, and AC before and after the CKT workload. The fatigue sensation, RT, and CV were clearly increased by the fatigue-inducing task and recovered during the resting period. We also studied the changes in autonomic nerve activity by using heart rate variability analysis. The low/high frequency component ratio (LF/HF) was signifi-cantly increased by the fatigue-inducing task and decreased by resting, suggesting that mental stress causes a relatively sympathetic nerve activity-dominant state. Therefore, our new fatigue model involving a long-term CKT workload is a good mental fatigue model to provide much information about the fatigue state simultane-ously, and the increase of RT, CV, and proportion of sympathetic activity (LF/HF) are associated with mental fatigue state. These might be useful objective biomarkers or evaluating a mental fatigue state.
文摘Objective. To study the difference of interstitial lung diseases (ILDs) in high-resolution computerized tomography and pulmonary function test among different connective tissue diseases (CTDs). Methods. 209 patients with different CTDs were recruited and underwent lung HRCT and PFT. Eerythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin (SF), anti-SSA, and so on were tested. Based on HRCT, a patient was classified into ILD group (CTD+ILD) or non-ILD group (CTD-ILD). HRCT, PFT, and laboratory markers were compared according to CTDs and CTD-associated ILDs. Results. The incidences of ILD were 79.6%, 82.0%, 89.7%, and 97.1% respectively for Rheumatoid arthritis (RA), primary Sjogren’s symptom (pSS), dermatomyositis/polymyositis (DM/PM), and systemic sclerosis (SSc) groups. RA and pSS patients exhibited more nodules, patching, ground-glass opacity, and cord shadow foci in HRCT, DM/PM and SSc patients exhibited more reticular opacity and honeycombing foci. RA and pSS patients exhibited more obstructive ventilatory disorder, small airway dysfunction and emphysema in PFT, and DM/PM and SSc patients exhibited more restrictive ventilatory disorder, mixed ventilatory disorder. ESR, CRP and SF were significantly higher in total CTD+ILD group than in total CTD-ILD group (P = 0.047, 0.006, 0.004, respectively), and higher in different CTD+ ILD groups than in comparable CTD-ILD groups (P = 0.049, 0.048, and 0.023, pSS+ILD, SSc+ILD and RA+ILD compared to pSS-ILD, SSc-ILD and RA-ILD, respectively for ESR, CRP, SF). The positive rate of anti-SSA was significantly higher in DM/PM+ILD group than in DM/PM-ILD group (P = 0.025). Conclusions. The manifestations and incidences of ILDs differ among different CTDs in HRCT and PFT, and inflammation and anti-SSA are positively correlated with ILDs in different CTDs, which provide important evidences for judging disease condition and prognosis.
基金Supported by National Key Research and Development Program of China(No.2017YFC1104600)National Natural Science Foundation of China(No.81770909)the Production&Education and Research Key Project of Guangdong Provincial Program(No.2011B090400499).
文摘●AIM:To develop a novel approach called the Autoacuity Tester,and to evaluate its validity,especially the sensitivity and specificity for detecting amblyopia.●METHODS:Children aged from 3 to 12 y(n=552)were enrolled in the study.The validity of the Autoacuity Tester was evaluated by comparing it to the Tumbling E Early Treatment Diabetic Retinopathy Study(ETDRS)acuity chart for school age children,and Lea Symbols and Teller acuity card(TAC)for preschool children.The repeatability was assessed by coefficient of repeatability(COR).The sensitivity and specificity for detecting amblyopia were calculated.●RESULTS:The mean difference(95%limits of agreement)between the Autoacuity Tester and the ETDRS tests were-0.03(-0.24,0.19)logMAR for the school age group.In preschool children,the mean difference was 0.04(-0.14,0.21)logMAR between the Autoacuity Tester and the TAC and 0.00(-0.17,0.18)logMAR between the Autoacuity Tester and the Lea Symbols.For the school age group,the COR was 0.20 logMAR for the Autoacuity Tester and 0.18 logMAR for the ETDRS.For the preschool group,the COR was 0.13 logMAR for the Autoacuity Tester and 0.21 logMAR for TAC.The Autoacuity Tester(88%)is more sensitive than TAC(72%)in detecting amblyopia(P=0.04),while had similar specificity(92%vs 90%,P=0.20).●CONCLUSION:The Autoacuity Tester provides a reliable alternative for assessing visual acuity,and offers advantage of higher testability and repeatability for preschool children.
文摘Clinicians involved in HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) prevention of mother to child transmission (PMTCT) programme and research activities can benefit from the advantages that computerized systems add to medical practice even in resource constrained sub-Saharan clinic settings. Their continued use of paper based systems presents clinical data management and patient care challenges. A portable point of care data capture electronic system and a computerized clinic patient management system (CCPMS) were implemented to remedy these challenges. PMTCT report compilation was easier with the portable data collection system whose data were found to be more complete and accurate with a 0.83% error rate compared to a 4.1% error rate in the paper registers. A resounding majority of clinicians preferred using the new CCPMS with many of the view that it improved drug inventory and general clinic management with a positive effect on patient care.
文摘RompecPC is a computerized program designed to create and assemble jigsaw puzzles. The program automatically records the solver’s responses as the number of pieces positioned correctly, the number of correct and incorrect movements, the number of times that she/he attempts to move a piece to the same place (perseverations), and the latency and place to which each piece is moved or attempted to be moved. These features facilitate the implementation and evaluation of puzzles while also reducing human error. Therefore, RompePC is a useful tool for the neuropsychological assessment of visuospatial skills in both clinical and experimental research.
文摘G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)在线标定新方法SCADOCM,以期促进CD-CAT在实践中的推广与应用。本研究分别基于模拟题库以及真实题库进行研究,结果表明:相比传统的SIE方法,SCADOCM在各实验条件下均具有较为理想的标定精度与标定效率,应用前景较好;SIE方法不适用于饱和的G-DINA等模型,其各实验条件下的Q矩阵标定精度均较低。
基金supported by the National Natural Science Foundation of China(Grant Nos.42277150,41977219)Henan Provincial Science and Technology Research Project(Grant No.222102320271).
文摘The geometry of joints has a significant influence on the mechanical properties of rocks.To simplify the curved joint shapes in rocks,the joint shape is usually treated as straight lines or planes in most laboratory experiments and numerical simulations.In this study,the computerized tomography (CT) scanning and photogrammetry were employed to obtain the internal and surface joint structures of a limestone sample,respectively.To describe the joint geometry,the edge detection algorithms and a three-dimensional (3D) matrix mapping method were applied to reconstruct CT-based and photogrammetry-based jointed rock models.For comparison tests,the numerical uniaxial compression tests were conducted on an intact rock sample and a sample with a joint simplified to a plane using the parallel computing method.The results indicate that the mechanical characteristics and failure process of jointed rocks are significantly affected by the geometry of joints.The presence of joints reduces the uniaxial compressive strength (UCS),elastic modulus,and released acoustic emission (AE) energy of rocks by 37%–67%,21%–24%,and 52%–90%,respectively.Compared to the simplified joint sample,the proposed photogrammetry-based numerical model makes the most of the limited geometry information of joints.The UCS,accumulative released AE energy,and elastic modulus of the photogrammetry-based sample were found to be very close to those of the CT-based sample.The UCS value of the simplified joint sample (i.e.38.5 MPa) is much lower than that of the CT-based sample (i.e.72.3 MPa).Additionally,the accumulative released AE energy observed in the simplified joint sample is 3.899 times lower than that observed in the CT-based sample.CT scanning provides a reliable means to visualize the joints in rocks,which can be used to verify the reliability of photogrammetry techniques.The application of the photogrammetry-based sample enables detailed analysis for estimating the mechanical properties of jointed rocks.