AIM: To assess the value of plasma melatonin in pre-dicting acute pancreatitis when combined with the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and bedside index for severity in acute pancreatitis ...AIM: To assess the value of plasma melatonin in pre-dicting acute pancreatitis when combined with the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and bedside index for severity in acute pancreatitis (BISAP) scoring systems. METHODS: APACHEⅡ and BISAP scores were calculated for 55 patients with acute physiology (AP) in the first 24 h of admission to the hospital. Additionally, morning (6:00 AM) serum melatonin concentrations were measured on the first day after admission. According to the diagnosis and treatment guidelines for acute pancreatitis in China, 42 patients suffered mild AP (MAP). The other 13 patients developed severe AP (SAP). A total of 45 healthy volunteers were used in this study as controls. The ability of melatonin and the APACHEⅡ and BISAP scoring systems to predict SAP was evaluated using a receiver operating characteristic (ROC) curve. The optimal melatonin cutoff concentration for SAP patients, based on the ROC curve, was used to classify the patients into either a high concen-tration group (34 cases) or a low concentration group (21 cases). Differences in the incidence of high scores, according to the APACHEⅡ and BISAP scoring sys- tems, were compared between the two groups. RESULTS: The MAP patients had increased melatonin levels compared to the SAP (38.34 ng/L vs 26.77 ng/L) (P = 0.021) and control patients (38.34 ng/L vs 30.73 ng/L) (P = 0.003). There was no significant difference inmelatoninconcentrations between the SAP group and the control group. The accuracy of determining SAP based on the melatonin level, the APACHEⅡ score and the BISAP score was 0.758, 0.872, and 0.906, respectively, according to the ROC curve. A melatonin concentration ≤ 28.74 ng/L was associated with an increased risk of developing SAP. The incidence of high scores (≥ 3) using the BISAP system was significantly higher in patients with low melatonin concentration (≤ 28.74 ng/L) compared to patients with high melatonin concentration (> 28.74 ng/L) (42.9% vs 14.7%, P = 0.02). The incidence of high APACHEⅡ scores (≥ 10) between the two groups was not significantly different. CONCLUSION: The melatonin concentration is closely related to the severity of AP and the BISAP score. Therefore, we can evaluate the severity of disease by measuring the levels of serum melatonin.展开更多
Objective By hybridization in situ and biomech anical approach of platelet-derive d growth fator mRNA(PDGFmRNA)and in-sulin-like growth factor mRNA(IGFmRNA),we discussed the influence of the platelet concentrated liqu...Objective By hybridization in situ and biomech anical approach of platelet-derive d growth fator mRNA(PDGFmRNA)and in-sulin-like growth factor mRNA(IGFmRNA),we discussed the influence of the platelet concentrated liquid on the healing of rabbit ulna frac-ture.Method We selected 24New Zealand rabbits,divided them into 4groups randomly(blank group,serum-control group,g roup with platelet concentrated liquid and group with b one graft and platelet concentrated liquid),and then made the fracture model on t he middle of ulna which was fixed by finger armor plate.Before t he operation,we drew out 6ml blood fr om femoral artery,performed anti-c oagulation with the Sodium Citrate and centrifugated by low and the followed high speed.We purified the white blood plate and injected it into the fracture position.The rabbits were killed at 1st,2nd,4th and 6th week.Q ualitative analysis by hybridizati on in situ of PDGFmRNAand IGFmRNAand biomechanical measurement on the 6th week sample were made.Result Bone callus could be seen on the radiu s specimen in various degrees when th e rabbits were killed at 1st,2nd,4th and 6th week,particularly i n the last week.The average maximum d estructive load on the fracture tip i s higher to the control,and there is significant difference(P <0.01).Conclusion The local application of platelet co ncentration on the fracture tip can a ccelerate its healing.展开更多
臭氧浓度的预测对于大气环境治理、空气质量改善等起到了重要的作用。本文提出了一种交互差分时空LSTM网络预测模型(ST-IDN)来挖掘臭氧浓度历史数据的时间相关性和空间相关性,并成功将其应用到网格化臭氧浓度数据预测上。在该模型中,首...臭氧浓度的预测对于大气环境治理、空气质量改善等起到了重要的作用。本文提出了一种交互差分时空LSTM网络预测模型(ST-IDN)来挖掘臭氧浓度历史数据的时间相关性和空间相关性,并成功将其应用到网格化臭氧浓度数据预测上。在该模型中,首先交互模块(IC)可以通过一系列的卷积操作来捕捉短期上下文信息,其次层融合模块(LF)可以融合不同层的空间信息来获得上一时刻丰富的空间信息,最后差分时空LSTM模块(DSTM)将捕捉到的时间信息和空间信息进行统一建模实现臭氧浓度预测。所构建模型分别与卷积LSTM网络(ConvLSTM)、预测循环神经网络(PredRNN)以及Memory in Memory网络(MIM)模型在河北省气象局提供的臭氧浓度数据上进行了对比分析,ST-IDN模型的平均绝对误差分别降低了19.836%、12.924%、7.506%。实验结果表明,所提出的模型能够提高臭氧浓度的预测精度。展开更多
目的：研究丙戊酸钠血药浓度与抗癫痫疗效及影响因素的关系，为临床个体化用药指导提供依据。方法对重庆医科大学附属永川医院133例服用丙戊酸钠的患者进行血药浓度测定，对血药浓度监测结果进行统计分析，并对133例患者抗癫痫疗效进行...目的：研究丙戊酸钠血药浓度与抗癫痫疗效及影响因素的关系，为临床个体化用药指导提供依据。方法对重庆医科大学附属永川医院133例服用丙戊酸钠的患者进行血药浓度测定，对血药浓度监测结果进行统计分析，并对133例患者抗癫痫疗效进行观察及分析。结果80例患者癫痫得到了控制，占60．15％，有效血药浓度（50～100 m g／L ）范围内有51例患者癫痫得到控制，占38．35％。血药浓度小于50 m g／L的44例患者中，26例未得到控制；男性与女性的血药浓度分布相似；丙戊酸钠血药浓度在各年龄组之间存在差异，成年组有52．87％患者血药浓度低于或高于治疗范围，未成年组则有39．13％；随着血药浓度增加，不良反应增加。结论丙戊酸钠的血药浓度与患者抗癫痫疗效之间存在个体差异，临床应用时，应根据患者的丙戊酸钠血药浓度、癫痫控制情况及年龄进行合理的个体化给药。展开更多
基金Supported by The Wenzhou Municipal Science and Technology Commission Major Projects Funds,No.20090006
文摘AIM: To assess the value of plasma melatonin in pre-dicting acute pancreatitis when combined with the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and bedside index for severity in acute pancreatitis (BISAP) scoring systems. METHODS: APACHEⅡ and BISAP scores were calculated for 55 patients with acute physiology (AP) in the first 24 h of admission to the hospital. Additionally, morning (6:00 AM) serum melatonin concentrations were measured on the first day after admission. According to the diagnosis and treatment guidelines for acute pancreatitis in China, 42 patients suffered mild AP (MAP). The other 13 patients developed severe AP (SAP). A total of 45 healthy volunteers were used in this study as controls. The ability of melatonin and the APACHEⅡ and BISAP scoring systems to predict SAP was evaluated using a receiver operating characteristic (ROC) curve. The optimal melatonin cutoff concentration for SAP patients, based on the ROC curve, was used to classify the patients into either a high concen-tration group (34 cases) or a low concentration group (21 cases). Differences in the incidence of high scores, according to the APACHEⅡ and BISAP scoring sys- tems, were compared between the two groups. RESULTS: The MAP patients had increased melatonin levels compared to the SAP (38.34 ng/L vs 26.77 ng/L) (P = 0.021) and control patients (38.34 ng/L vs 30.73 ng/L) (P = 0.003). There was no significant difference inmelatoninconcentrations between the SAP group and the control group. The accuracy of determining SAP based on the melatonin level, the APACHEⅡ score and the BISAP score was 0.758, 0.872, and 0.906, respectively, according to the ROC curve. A melatonin concentration ≤ 28.74 ng/L was associated with an increased risk of developing SAP. The incidence of high scores (≥ 3) using the BISAP system was significantly higher in patients with low melatonin concentration (≤ 28.74 ng/L) compared to patients with high melatonin concentration (> 28.74 ng/L) (42.9% vs 14.7%, P = 0.02). The incidence of high APACHEⅡ scores (≥ 10) between the two groups was not significantly different. CONCLUSION: The melatonin concentration is closely related to the severity of AP and the BISAP score. Therefore, we can evaluate the severity of disease by measuring the levels of serum melatonin.
文摘Objective By hybridization in situ and biomech anical approach of platelet-derive d growth fator mRNA(PDGFmRNA)and in-sulin-like growth factor mRNA(IGFmRNA),we discussed the influence of the platelet concentrated liquid on the healing of rabbit ulna frac-ture.Method We selected 24New Zealand rabbits,divided them into 4groups randomly(blank group,serum-control group,g roup with platelet concentrated liquid and group with b one graft and platelet concentrated liquid),and then made the fracture model on t he middle of ulna which was fixed by finger armor plate.Before t he operation,we drew out 6ml blood fr om femoral artery,performed anti-c oagulation with the Sodium Citrate and centrifugated by low and the followed high speed.We purified the white blood plate and injected it into the fracture position.The rabbits were killed at 1st,2nd,4th and 6th week.Q ualitative analysis by hybridizati on in situ of PDGFmRNAand IGFmRNAand biomechanical measurement on the 6th week sample were made.Result Bone callus could be seen on the radiu s specimen in various degrees when th e rabbits were killed at 1st,2nd,4th and 6th week,particularly i n the last week.The average maximum d estructive load on the fracture tip i s higher to the control,and there is significant difference(P <0.01).Conclusion The local application of platelet co ncentration on the fracture tip can a ccelerate its healing.
文摘臭氧浓度的预测对于大气环境治理、空气质量改善等起到了重要的作用。本文提出了一种交互差分时空LSTM网络预测模型(ST-IDN)来挖掘臭氧浓度历史数据的时间相关性和空间相关性,并成功将其应用到网格化臭氧浓度数据预测上。在该模型中,首先交互模块(IC)可以通过一系列的卷积操作来捕捉短期上下文信息,其次层融合模块(LF)可以融合不同层的空间信息来获得上一时刻丰富的空间信息,最后差分时空LSTM模块(DSTM)将捕捉到的时间信息和空间信息进行统一建模实现臭氧浓度预测。所构建模型分别与卷积LSTM网络(ConvLSTM)、预测循环神经网络(PredRNN)以及Memory in Memory网络(MIM)模型在河北省气象局提供的臭氧浓度数据上进行了对比分析,ST-IDN模型的平均绝对误差分别降低了19.836%、12.924%、7.506%。实验结果表明,所提出的模型能够提高臭氧浓度的预测精度。
文摘目的：研究丙戊酸钠血药浓度与抗癫痫疗效及影响因素的关系，为临床个体化用药指导提供依据。方法对重庆医科大学附属永川医院133例服用丙戊酸钠的患者进行血药浓度测定，对血药浓度监测结果进行统计分析，并对133例患者抗癫痫疗效进行观察及分析。结果80例患者癫痫得到了控制，占60．15％，有效血药浓度（50～100 m g／L ）范围内有51例患者癫痫得到控制，占38．35％。血药浓度小于50 m g／L的44例患者中，26例未得到控制；男性与女性的血药浓度分布相似；丙戊酸钠血药浓度在各年龄组之间存在差异，成年组有52．87％患者血药浓度低于或高于治疗范围，未成年组则有39．13％；随着血药浓度增加，不良反应增加。结论丙戊酸钠的血药浓度与患者抗癫痫疗效之间存在个体差异，临床应用时，应根据患者的丙戊酸钠血药浓度、癫痫控制情况及年龄进行合理的个体化给药。
