Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and K...Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(BD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.展开更多
Based on Bloom’s“effective teaching theory,”this paper proposes pre-class activities to improve students’enthusiasm and autonomy in English learning.These include sentence construction,situational dubbing,famous q...Based on Bloom’s“effective teaching theory,”this paper proposes pre-class activities to improve students’enthusiasm and autonomy in English learning.These include sentence construction,situational dubbing,famous quotes,English songs,English games,Chinese stories,regional cultures,and theme debates,which combine life,interest,and inspiration as the main characteristics.The activities can enhance the sense of participation and achievement of all students to achieve the purpose of effective teaching.展开更多
Let G be a finite group with the property that for any conjugacy class order, G has exactly two conjugacy classes which have the same order. We prove that： （1） ff a Sylow 2-subgroup of G is Abelian, then G is isomo...Let G be a finite group with the property that for any conjugacy class order, G has exactly two conjugacy classes which have the same order. We prove that： （1） ff a Sylow 2-subgroup of G is Abelian, then G is isomorphic to the direct product of symmetric group with order 3 and cyclic group with order 2, or G is isomorphic to the semidirect product of a cyclic group with order 3 and a cyclic group with order 4; （2） if G＇ is nilpotent, then G is a group of {2,3,5 }.展开更多
From the National Agency for the Organization and Construction of Infrastructures (ANOCI) program to the Emerging Senegal Plan (PSE), construction in Senegal has improved considerably. However, deficiencies remain in ...From the National Agency for the Organization and Construction of Infrastructures (ANOCI) program to the Emerging Senegal Plan (PSE), construction in Senegal has improved considerably. However, deficiencies remain in the specification of materials used mainly in hydraulic concrete. They are generally related to the specification of aggregates for alkali reactivity and the choice of exposure classes specified in NF EN 206-1. The purpose of this article is to study the incidence of non-compliance with exposure classes in reinforced concrete structures. To carry out this study, surveys were carried out at several sites (districts) in Dakar (Cité Avion, Touba Ouakam, Cité Asecna, Cité Batrain, Cité Comico, Cité Assemblée and Terme Sud) in order to collect information on the formulation and implementation methods used. The comparison of the various readings carried out made it possible to deduce conclusions and to give recommendations when using standard NF EN 206-1.展开更多
The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria.Urgent measures need to be taken to curb this impending challenge.The highe...The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria.Urgent measures need to be taken to curb this impending challenge.The higher plant-derived sesquiterpene,quinoline alkaloids,and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were developed.Historical successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be developed.The aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against P.falciparum.To identify these novel scaffolds,we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological data.Natural products were assigned to different structural classes using NPClassifier.To identify the most promising chemical scaffolds,we then correlated natural compound class with bioactivity and other data,namely(i)potency,(ii)resistance index,(iii)selectivity index and(iv)physicochemical properties.We used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity data.From this analysis we identified the top-ranked natural product pathway as the alkaloids.The top three ranked super classes identified were(i)pseudoalkaloids,(ii)naphthalenes and(iii)tyrosine alkaloids and the top five ranked classes(i)quassinoids(of super class triterpenoids),(ii)steroidal alkaloids(of super class pseudoalkaloids)(iii)cycloeudesmane sesquiterpenoids(of super class triterpenoids)(iv)isoquinoline alkaloids(of super class tyrosine alkaloids)and(v)naphthoquinones(of super class naphthalenes).Launched chemical space of these identified classes of compounds was,by and large,distinct from that of‘legacy’antimalarial drugs.Our study was able to identify chemical scaffolds with acceptable biological properties that are structurally different from current and previously used antimalarial drugs.These molecules have the potential to be developed into new antimalarial drugs.展开更多
目的探讨成果导向型教育(outcome based education,OBE)教育理念联合案例教学法(case-based learning,CBL)的线上线下微课程教学模式在心外科临床实习教学中的效果。方法选取首都医科大学附属北京朝阳医院2021年9月—2022年5月的60名心...目的探讨成果导向型教育(outcome based education,OBE)教育理念联合案例教学法(case-based learning,CBL)的线上线下微课程教学模式在心外科临床实习教学中的效果。方法选取首都医科大学附属北京朝阳医院2021年9月—2022年5月的60名心外科临床实习生为研究对象,随机分为OBE+CBL线上线下微课程教学模式组和传统临床教师带教组,每组30名。传统临床教师带教组采用传统的实习教学模式,OBE+CBL线上线下微课程教学模式组给予OBE+CBL线上线下微课程教学模式。比较2组的随堂测试成绩和出科考试成绩、实习生满意度。结果OBE+CBL线上线下微课程教学模式组的随堂测试成绩为(96.2±5.8)分,高于传统临床教师带教组的(92.3±4.6)分,差异有统计学意义(P<0.05)。2组的出科考试成绩比较,差异无统计学意义(P>0.05)。30名实习生对心外科OBE+CBL线上线下微课程教学模式的满意度较高,认为该模式能提高自己的自学能力、学习兴趣,对掌握教学内容有帮助,能满足教学需求、提高自我能力,且没有实习生对该教学模式持不满意及一般态度。结论OBE+CBL线上线下微课程教学模式能增强实习生获取知识的能力和临床实习技能,临床实习生满意度较高。展开更多
基金supported by Undergraduate Training Program for Innovation and Entrepreneurship of China University of Mining and Technology (CUMT)(Grant No. 202110290059Z)Fundamental Research Funds for the Central Universities of CUMT (Grant No. 2020ZDPYMS33)。
文摘Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(BD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.
文摘Based on Bloom’s“effective teaching theory,”this paper proposes pre-class activities to improve students’enthusiasm and autonomy in English learning.These include sentence construction,situational dubbing,famous quotes,English songs,English games,Chinese stories,regional cultures,and theme debates,which combine life,interest,and inspiration as the main characteristics.The activities can enhance the sense of participation and achievement of all students to achieve the purpose of effective teaching.
基金The Natural Science Foundation ofChongqing Education Committee (No.KG051107)
文摘Let G be a finite group with the property that for any conjugacy class order, G has exactly two conjugacy classes which have the same order. We prove that： （1） ff a Sylow 2-subgroup of G is Abelian, then G is isomorphic to the direct product of symmetric group with order 3 and cyclic group with order 2, or G is isomorphic to the semidirect product of a cyclic group with order 3 and a cyclic group with order 4; （2） if G＇ is nilpotent, then G is a group of {2,3,5 }.
文摘From the National Agency for the Organization and Construction of Infrastructures (ANOCI) program to the Emerging Senegal Plan (PSE), construction in Senegal has improved considerably. However, deficiencies remain in the specification of materials used mainly in hydraulic concrete. They are generally related to the specification of aggregates for alkali reactivity and the choice of exposure classes specified in NF EN 206-1. The purpose of this article is to study the incidence of non-compliance with exposure classes in reinforced concrete structures. To carry out this study, surveys were carried out at several sites (districts) in Dakar (Cité Avion, Touba Ouakam, Cité Asecna, Cité Batrain, Cité Comico, Cité Assemblée and Terme Sud) in order to collect information on the formulation and implementation methods used. The comparison of the various readings carried out made it possible to deduce conclusions and to give recommendations when using standard NF EN 206-1.
文摘The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against malaria.Urgent measures need to be taken to curb this impending challenge.The higher plant-derived sesquiterpene,quinoline alkaloids,and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were developed.Historical successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be developed.The aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against P.falciparum.To identify these novel scaffolds,we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological data.Natural products were assigned to different structural classes using NPClassifier.To identify the most promising chemical scaffolds,we then correlated natural compound class with bioactivity and other data,namely(i)potency,(ii)resistance index,(iii)selectivity index and(iv)physicochemical properties.We used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity data.From this analysis we identified the top-ranked natural product pathway as the alkaloids.The top three ranked super classes identified were(i)pseudoalkaloids,(ii)naphthalenes and(iii)tyrosine alkaloids and the top five ranked classes(i)quassinoids(of super class triterpenoids),(ii)steroidal alkaloids(of super class pseudoalkaloids)(iii)cycloeudesmane sesquiterpenoids(of super class triterpenoids)(iv)isoquinoline alkaloids(of super class tyrosine alkaloids)and(v)naphthoquinones(of super class naphthalenes).Launched chemical space of these identified classes of compounds was,by and large,distinct from that of‘legacy’antimalarial drugs.Our study was able to identify chemical scaffolds with acceptable biological properties that are structurally different from current and previously used antimalarial drugs.These molecules have the potential to be developed into new antimalarial drugs.
文摘目的探讨成果导向型教育(outcome based education,OBE)教育理念联合案例教学法(case-based learning,CBL)的线上线下微课程教学模式在心外科临床实习教学中的效果。方法选取首都医科大学附属北京朝阳医院2021年9月—2022年5月的60名心外科临床实习生为研究对象,随机分为OBE+CBL线上线下微课程教学模式组和传统临床教师带教组,每组30名。传统临床教师带教组采用传统的实习教学模式,OBE+CBL线上线下微课程教学模式组给予OBE+CBL线上线下微课程教学模式。比较2组的随堂测试成绩和出科考试成绩、实习生满意度。结果OBE+CBL线上线下微课程教学模式组的随堂测试成绩为(96.2±5.8)分,高于传统临床教师带教组的(92.3±4.6)分,差异有统计学意义(P<0.05)。2组的出科考试成绩比较,差异无统计学意义(P>0.05)。30名实习生对心外科OBE+CBL线上线下微课程教学模式的满意度较高,认为该模式能提高自己的自学能力、学习兴趣,对掌握教学内容有帮助,能满足教学需求、提高自我能力,且没有实习生对该教学模式持不满意及一般态度。结论OBE+CBL线上线下微课程教学模式能增强实习生获取知识的能力和临床实习技能,临床实习生满意度较高。
