Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique fea...Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique features,stator active HEFSMs are preferred for EV/HEV applications.In this paper a new Segmented PM Consequent Pole HE-FSM(SPMCPHEFSM)with flux bridge is proposed for EV/HEV.The developed SPMCPHEFSM exhibits improved flux modulation and flux regulation capability at reduced PM usage(suppressed PM volume by 46.52%and PM cost by 46.48%)and eliminating stator leakage flux.First,SPMCPHEFSM is geometric optimized(GO)for investigating influence of leading design with key performance indicators such as flux linkage(Ф_(pp)),average torque(T_(avg)),cogging torque(T_(cog)),T_(den),average power(P_(avg))and power density(P_(den))and then proceeded optimized model to structure modification for optimal stator design and position of field excitation coils(FEC).Comprehensive performance analysis reveals that the developed SPMCPHEFSM show improvedФ_(pp)maximum up to 9.11%,improved T_(avg)maximum up to 23.63%,truncate T_(cog)up to 18.9%whereas T_(den)and P_(den)are boost up to 23.55%and 89.72%respectively.展开更多
Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power densi...Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power density(Pden)are the utmost requisite.However conventional PM-FSMs utilizes excessive rare earth PM volume VPM,higher cogging torque Tcog,high torque ripples(Trip)and comparatively lower(Tden)and Pden due to flux leakage.To overcome the aforesaid demerits,a new high(Tden)Segmented PM Consequent Pole(CP)FSM(SPMCPFSM)with flux bridge and barrier is proposed which successfully reduces VPM by 46.52%and PM cost by 46.48%.Moreover,Multi-Objective Optimization(MOO)examines electromagnetic performance due to variation in geometric parameters for global optimum parameters with key metric such as flux linkage(Φpp),flux harmonics(ΦTHD)average torque(Tavg),Tcog,Trip,Tden,average power(Pavg)and Pden.Analysis reveals that MOO improveΦpp by 22.68%,boost Tavg by 11.41%,enhanced Pavg by 4.55%and increased Tden and Pden by 11.41%.Detailed electromagnetic performance comparison with existing state of the art shows that proposed SPMCPFSM offer Tavg maximum up to 88.8%,truncate Trip up to 24.8%,suppress Tcog up to 22.74%,and results 2.45 times Tden and Pden.展开更多
Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless...Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation.展开更多
Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet ...Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet linear machine(CP-TFPMLM)is proposed and investigated.The origination of the proposed machine is from an existing transverse-flux flux-reversal linear machine(TF-FRLM),by partially replacing permanent magnet poles with soft magnetic iron for further reducing the cost of magnets.The fundamental structure and operating principle are introduced at first.The electromagnetic performance,including back EMF,detent force,and thrust force,are investigated with the finite element method.The proposed machine can achieve similar performance as compared to the TF-FRLM but with half of the magnets are used.展开更多
Silica-coated carbonyl iron particles (CIPs) are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and mic...Silica-coated carbonyl iron particles (CIPs) are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and microwave absorption of raw-CIPs and silica-coated CIPs are investigated using a scanning electron microscope, an energy dispersive spectrometer, a thermal-gravimetric analyzer, and a network analyzer. The results show that the heat-resistance of silica-coated CIPs is better than that of raw CIFs. The reflection losses exceeding -lOdB of silica-coated CIPs are obtained in the frequency range 9.5-12.4 GHz for the absorber thickness of 2.3 mm, and the same reflection losses of uncoated CIPs reach the data in the lower frequency range for the same thickness. The enhanced microwave absorption of silica-coated CIPs can be ascribed to the combination of proper electromagnetic impedance match and the decrease of dielectric permittivity.展开更多
The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depr...The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of"hard-linkage"faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of"hard-linkage",while the antithetic fault traps are formed at the beginning of the fault active period.展开更多
Let d and n are positive integers, n≥2,1≤d≤ 2.In this paper we obtain that the set of the 2 - common consequent of primitive digraphs of order n with exact d vertices having loop is{1,2,…, n-[]}.
Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor...Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural instability.It usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic dysfunction.The gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.2.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).展开更多
Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses...Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses excessive rare earth PM volumes which ultimately increases machine the machine weight and PM cost.Moreover,the PMs extended at the stator yoke results in stator leakage flux which degrades the performance.To suppress the leakage flux and diminish the PM volume,the consequent pole PMFSM(CPPMFSM)with flux bridges and barriers encompassing partitioned circumferential and radial magnetized PMs is proposed,thereby ensuring an alternate magnetic path for the working harmonics which improves the modulation effect and flux distribution.Moreover,the influence of the rotor pole number on seven different rotor structures namely,curved rotor,trapezoidal rotor,wide rotor tooth tip,wide rotor base width,rectangular segmented and eccentric rotors are investigated based on the electromagnetic performance and stress distribution.Finite element analysis(FEA)reveals that the 12S-13P CPPMFSM with a wider rotor base offers comparatively better electromagnetic performance.Compare to the conventional PMFSM,the proposed CPPMFSM reduces the PM volume which minimizes the overall machine cost and weight,suppresses the torque ripples by 16.49%,diminishes total harmonic distortion(THD)by 35.24%and decreases cogging torque by 32.88%.Furthermore,the torque and power density are enhanced by 7.028%and 7.025%respectively.展开更多
The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as obse...The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and death.Ischemic stroke is thus a vascular disorder with a dramatic neurological impact.There is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical success.Since accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be indispensable.Encouragingly,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.展开更多
With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the pr...With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of autonomy.Although the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.展开更多
The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and rev...The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and reviews written by faculty members,researchers and postgraduates in universities,colleges and research institutes all over China and overseas.It reports the latest and the most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across sub-disciplines.This journal is sponsored by Jilin University and mandated by the Ministry of Education of P.R.China.展开更多
When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream...When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction partners.In this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and apoptosis.That is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell types.Moreover,throughout vertebrate evolution,the protein sequence has remained completely unchanged.展开更多
Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize ...Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.展开更多
Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutan...Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant mixtures.Therefore,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.展开更多
Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare...Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).展开更多
The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are...The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are revolutionizing mining through robotic and data-driven innovations[4]-[7].While AI offers mining industry advantages,it is crucial to acknowledge the potential risks associated with its widespread use.Over-reliance on AI may lead to a loss of human control over mining operations in the future,resulting in unpredictable consequences.展开更多
Copper,as an essential trace nutrient,plays a crucial role in biological processes such as mitochondrial respiration,antioxidant stress response,and the synthesis of biomolecules.Typically,cellular copper concentratio...Copper,as an essential trace nutrient,plays a crucial role in biological processes such as mitochondrial respiration,antioxidant stress response,and the synthesis of biomolecules.Typically,cellular copper concentrations are maintained at very low levels,a pattern also observed in cancer cells to prevent adverse consequences of copper overload,such as cuproptosis.This involves copper dependency,accumulation of lipidated proteins,and a reduction in Fe-S cluster proteins[1].Various neurodegenerative diseases are associated with imbalances in copper homeostasis.展开更多
In this editorial,we discuss the status of a therapeutic approach to emotional reactions accompanying thermal skin injuries.Burns are considered a major health problem,as well as an economic and social problem,with po...In this editorial,we discuss the status of a therapeutic approach to emotional reactions accompanying thermal skin injuries.Burns are considered a major health problem,as well as an economic and social problem,with potentially devastating and life-changing consequences.They affect a wide range of patients with different damage mechanisms,varied depths,and localizations of the burns.The most common are thermal burns,with more than 11 million occurrences annually according to the World Health Organization data.Thermal skin injuries are among the most tragic and catastrophic injuries,almost unsurpassed in terms of severity,morbidity,and mortality,as well as functional,aesthetic,social,economic,and psychological consequences.Burn survivors face stress,anxiety,depression,low self-esteem,body deformity,social isolation,unemployment,financial burden,and family problems.The advances in acute burn care have allowed researchers and physicians to pay more attention to other effects of burns,focusing on psychological consequences in particular.Apart from the significant improvements in routine protocols,it seems useful to take care of psychological disturbances that occur simultaneously but may emerge as the most lasting outcome of those injuries.In that sense,various standards and additional approaches may be involved to achieve overall recovery.展开更多
Introduction: Uterine fibroids are the most common gynecological tumors in women of childbearing age and have multiple clinical manifestations. Objective: To determine factors associated with uterine fibroids in the B...Introduction: Uterine fibroids are the most common gynecological tumors in women of childbearing age and have multiple clinical manifestations. Objective: To determine factors associated with uterine fibroids in the Borgou department of Benin in 2022. Method: Descriptive, analytical cross-sectional study from August 22 to September 22, 2022. The sample consisted of women consulting for gynecological problems in 6 hospitals in the Borgou department in the North of Benin. Results: Of the 744 women surveyed, 10.1% were diagnosed with uterine fibroids. Women with uterine fibroids were often married, paucigesture, and nulliparous. Their main reasons for consultation were the desire for motherhood (50.7%), pelvic pain (46.7%), and genital hemorrhage (14.7%). Age, history of miscarriage, high blood pressure, and diabetes were significantly associated with the presence of uterine fibroids (Conclusion: Uterine fibroids are common in hospitals in northern Benin. There were factors associated with them that should be taken into account in management strategies.展开更多
文摘Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique features,stator active HEFSMs are preferred for EV/HEV applications.In this paper a new Segmented PM Consequent Pole HE-FSM(SPMCPHEFSM)with flux bridge is proposed for EV/HEV.The developed SPMCPHEFSM exhibits improved flux modulation and flux regulation capability at reduced PM usage(suppressed PM volume by 46.52%and PM cost by 46.48%)and eliminating stator leakage flux.First,SPMCPHEFSM is geometric optimized(GO)for investigating influence of leading design with key performance indicators such as flux linkage(Ф_(pp)),average torque(T_(avg)),cogging torque(T_(cog)),T_(den),average power(P_(avg))and power density(P_(den))and then proceeded optimized model to structure modification for optimal stator design and position of field excitation coils(FEC).Comprehensive performance analysis reveals that the developed SPMCPHEFSM show improvedФ_(pp)maximum up to 9.11%,improved T_(avg)maximum up to 23.63%,truncate T_(cog)up to 18.9%whereas T_(den)and P_(den)are boost up to 23.55%and 89.72%respectively.
文摘Due to double salient structure,Flux Switching Machines(FSMs)are preferred for brushless AC high speed applications.Permanent Magnet(PM)FSMs(PM-FSMs)are suited applicants where high torque density(Tden)and power density(Pden)are the utmost requisite.However conventional PM-FSMs utilizes excessive rare earth PM volume VPM,higher cogging torque Tcog,high torque ripples(Trip)and comparatively lower(Tden)and Pden due to flux leakage.To overcome the aforesaid demerits,a new high(Tden)Segmented PM Consequent Pole(CP)FSM(SPMCPFSM)with flux bridge and barrier is proposed which successfully reduces VPM by 46.52%and PM cost by 46.48%.Moreover,Multi-Objective Optimization(MOO)examines electromagnetic performance due to variation in geometric parameters for global optimum parameters with key metric such as flux linkage(Φpp),flux harmonics(ΦTHD)average torque(Tavg),Tcog,Trip,Tden,average power(Pavg)and Pden.Analysis reveals that MOO improveΦpp by 22.68%,boost Tavg by 11.41%,enhanced Pavg by 4.55%and increased Tden and Pden by 11.41%.Detailed electromagnetic performance comparison with existing state of the art shows that proposed SPMCPFSM offer Tavg maximum up to 88.8%,truncate Trip up to 24.8%,suppress Tcog up to 22.74%,and results 2.45 times Tden and Pden.
文摘Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation.
基金This work was supported by the National Natural Science Foundation of China under Grant 51520105010。
文摘Transverse-flux machines have the advantage of high force density owing to the peculiarity of decoupling of electric loading and magnetic loading.In this paper,a novel consequent-pole transverse-flux permanent magnet linear machine(CP-TFPMLM)is proposed and investigated.The origination of the proposed machine is from an existing transverse-flux flux-reversal linear machine(TF-FRLM),by partially replacing permanent magnet poles with soft magnetic iron for further reducing the cost of magnets.The fundamental structure and operating principle are introduced at first.The electromagnetic performance,including back EMF,detent force,and thrust force,are investigated with the finite element method.The proposed machine can achieve similar performance as compared to the TF-FRLM but with half of the magnets are used.
文摘Silica-coated carbonyl iron particles (CIPs) are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and microwave absorption of raw-CIPs and silica-coated CIPs are investigated using a scanning electron microscope, an energy dispersive spectrometer, a thermal-gravimetric analyzer, and a network analyzer. The results show that the heat-resistance of silica-coated CIPs is better than that of raw CIFs. The reflection losses exceeding -lOdB of silica-coated CIPs are obtained in the frequency range 9.5-12.4 GHz for the absorber thickness of 2.3 mm, and the same reflection losses of uncoated CIPs reach the data in the lower frequency range for the same thickness. The enhanced microwave absorption of silica-coated CIPs can be ascribed to the combination of proper electromagnetic impedance match and the decrease of dielectric permittivity.
基金Supported by the National Natural Science Foundation of China(41602129,41602164)China National Science and Technology Major Project(2016ZX05007003,2016ZX05006-005)
文摘The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of"hard-linkage"faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of"hard-linkage",while the antithetic fault traps are formed at the beginning of the fault active period.
文摘Let d and n are positive integers, n≥2,1≤d≤ 2.In this paper we obtain that the set of the 2 - common consequent of primitive digraphs of order n with exact d vertices having loop is{1,2,…, n-[]}.
基金supported by Department of Clinical and Movement Neurosciences,UCL Queen Square Institute of Neurology,London,United Kingdom,WC1N 3BGAligning Science Across Parkinson’s(ASAP)Collaborative Research Network,Chevy Chase,MD,United States(to AHVS)。
文摘Parkinson’s disease(PD,OMIM#168600)is a common neurodegenerative disorder with a global prevalence of approximately 8.5 million.PD is characterized by four cardinal motor symptoms:bradykinesia,rigidity,resting tremor,and subsequently by postural instability.It usually involves non-motor symptoms such as rapid eye movement sleep disorder,dementia,anosmia,and autonomic dysfunction.The gene glucocerebrosidase 1(GBA1),which encodes the lysosomal enzyme glucocerebrosidase(GCase)(IUBMB:EC 3.2.1.45),shows strong linkage with PD;variants of GBA1 are the commonest genetic association with PD(Sidransky et al.,2009).Several mechanisms may underlie the relationship between GBA1 mutations/variants and the molecular pathology of PD(Figure 1A and B).
文摘Permanent magnet flux switching machines(PMFSM)have attracted significant research interest and are considered as competent candidates when higher torque density is primary requirement.However,conventional PMFSMs uses excessive rare earth PM volumes which ultimately increases machine the machine weight and PM cost.Moreover,the PMs extended at the stator yoke results in stator leakage flux which degrades the performance.To suppress the leakage flux and diminish the PM volume,the consequent pole PMFSM(CPPMFSM)with flux bridges and barriers encompassing partitioned circumferential and radial magnetized PMs is proposed,thereby ensuring an alternate magnetic path for the working harmonics which improves the modulation effect and flux distribution.Moreover,the influence of the rotor pole number on seven different rotor structures namely,curved rotor,trapezoidal rotor,wide rotor tooth tip,wide rotor base width,rectangular segmented and eccentric rotors are investigated based on the electromagnetic performance and stress distribution.Finite element analysis(FEA)reveals that the 12S-13P CPPMFSM with a wider rotor base offers comparatively better electromagnetic performance.Compare to the conventional PMFSM,the proposed CPPMFSM reduces the PM volume which minimizes the overall machine cost and weight,suppresses the torque ripples by 16.49%,diminishes total harmonic distortion(THD)by 35.24%and decreases cogging torque by 32.88%.Furthermore,the torque and power density are enhanced by 7.028%and 7.025%respectively.
基金supported by Swiss National Science Foundation grant 31003A_150062(to OOO).
文摘The human brain has exceedingly high metabolic demands.The cerebral vasculature has the critical task of providing sufficient blood supply to meet this demand.The sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and death.Ischemic stroke is thus a vascular disorder with a dramatic neurological impact.There is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical success.Since accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be indispensable.Encouragingly,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.
基金supported by The David and Inez Myers Foundation,Beachwood,OH,USA(to DT)。
文摘With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of autonomy.Although the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.
文摘The journal Chemical Research in Chinese Universities is a comprehensive academic journal in the field of chemistry,published bimonthly since 1984.The journal publishes research articles,letters/communications and reviews written by faculty members,researchers and postgraduates in universities,colleges and research institutes all over China and overseas.It reports the latest and the most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across sub-disciplines.This journal is sponsored by Jilin University and mandated by the Ministry of Education of P.R.China.
基金supported by Lundbeckfonden(R250-2017-134,to HHJ).
文摘When calcium ions enter the cytosol,it is a stimulatory signal for cellular events.The calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction partners.In this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and apoptosis.That is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell types.Moreover,throughout vertebrate evolution,the protein sequence has remained completely unchanged.
文摘Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.
基金supported by the National Nature Science Foundation of China(42005136)Innovation Team Fund of Southwest Regional Meteorological Center+3 种基金China Meteorological Administration(XNQYCXTD-202203)China Postdoctoral Science(2020M670419)Key Research and Development program for Social Development in Yunnan Provincial(in China)(202203AC100006,202203AC100005)National Key Research and Development Program of China(2016YFA0602004)。
文摘Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant mixtures.Therefore,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.
文摘Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).
文摘The mining sector historically drove the global economy but at the expense of severe environmental and health repercussions,posing sustainability challenges[1]-[3].Recent advancements on artificial intelligence(AI)are revolutionizing mining through robotic and data-driven innovations[4]-[7].While AI offers mining industry advantages,it is crucial to acknowledge the potential risks associated with its widespread use.Over-reliance on AI may lead to a loss of human control over mining operations in the future,resulting in unpredictable consequences.
文摘Copper,as an essential trace nutrient,plays a crucial role in biological processes such as mitochondrial respiration,antioxidant stress response,and the synthesis of biomolecules.Typically,cellular copper concentrations are maintained at very low levels,a pattern also observed in cancer cells to prevent adverse consequences of copper overload,such as cuproptosis.This involves copper dependency,accumulation of lipidated proteins,and a reduction in Fe-S cluster proteins[1].Various neurodegenerative diseases are associated with imbalances in copper homeostasis.
文摘In this editorial,we discuss the status of a therapeutic approach to emotional reactions accompanying thermal skin injuries.Burns are considered a major health problem,as well as an economic and social problem,with potentially devastating and life-changing consequences.They affect a wide range of patients with different damage mechanisms,varied depths,and localizations of the burns.The most common are thermal burns,with more than 11 million occurrences annually according to the World Health Organization data.Thermal skin injuries are among the most tragic and catastrophic injuries,almost unsurpassed in terms of severity,morbidity,and mortality,as well as functional,aesthetic,social,economic,and psychological consequences.Burn survivors face stress,anxiety,depression,low self-esteem,body deformity,social isolation,unemployment,financial burden,and family problems.The advances in acute burn care have allowed researchers and physicians to pay more attention to other effects of burns,focusing on psychological consequences in particular.Apart from the significant improvements in routine protocols,it seems useful to take care of psychological disturbances that occur simultaneously but may emerge as the most lasting outcome of those injuries.In that sense,various standards and additional approaches may be involved to achieve overall recovery.
文摘Introduction: Uterine fibroids are the most common gynecological tumors in women of childbearing age and have multiple clinical manifestations. Objective: To determine factors associated with uterine fibroids in the Borgou department of Benin in 2022. Method: Descriptive, analytical cross-sectional study from August 22 to September 22, 2022. The sample consisted of women consulting for gynecological problems in 6 hospitals in the Borgou department in the North of Benin. Results: Of the 744 women surveyed, 10.1% were diagnosed with uterine fibroids. Women with uterine fibroids were often married, paucigesture, and nulliparous. Their main reasons for consultation were the desire for motherhood (50.7%), pelvic pain (46.7%), and genital hemorrhage (14.7%). Age, history of miscarriage, high blood pressure, and diabetes were significantly associated with the presence of uterine fibroids (Conclusion: Uterine fibroids are common in hospitals in northern Benin. There were factors associated with them that should be taken into account in management strategies.