Research on the Construction and Development of Aesthetic Education Bases in Higher Education Institutions

In order to implement the national aesthetic education policy,it is essential to organically integrate relevant aesthetic education resources,promote interdisciplinary education,and carry out extracurricular practical activities centered on aesthetic education.Strengthening the foundation of aesthetic education theory,addressing practical challenges in the teaching process,and closely linking research with teaching will create a feedback loop that benefits drama education.This article provides an in-depth analysis of the construction strategies,resource advantages and disadvantages,and development of aesthetic education bases,offering countermeasures and suggestions for their construction in universities.It aims to provide a solid research foundation for the growth and development of aesthetic education bases in higher education institutions.

Construction Method of Civil Aircraft Airborne⁃system Supplier Development Process System

Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process system"based on IPD(Integrated product development)in the organization.The development stage,process,activity and task are the logical framework elements of the system construction."Based on process decomposition,vertical stratification,horizontal segmentation,combination of special and common,process customized to tools,role and process integration,giving full consideration to the interface between supplier management and process modules"etc.are the concrete ideas.Moreover,formulate top⁃level system construction standards,implemented by process system management tool platform,so that the process system and development work can be effectively integrated to effectively guide the development work of airborne system suppliers,and meet the quality and airworthiness requirements of civil aircraft development.Through the development application of a certain type of flight control system,the process system and tool platform were verified and optimized in practice.

New aspects of a small GTPase RAB35 in brain development and function

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.

Construction of the Curriculum System of Software Engineering Based on the Agile Development Method

Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between development and demand design,team division of labor,difficult measurement of individual contribution,single assessment method,and other problems in traditional practice teaching,this paper proposes that under the guidance of agile development methods,software engineering courses should adopt Scrum framework to organize course project practice,use agile collaboration platform to implement individual work,follow up experiment progress,and ensure effective project advancement.The statistical data of curriculum“diversity”assessment show that there is an obvious improvement effect on students’software engineering ability and quality.

A Brief Discussion on the Construction of Practical Teaching System for the Traditional Chinese Medicine Resources and Development Major

China’s traditional medicine,science,and technology industry has great development potential.However,there is a problem of insufficient practitioners in the current industrial development.At the same time,the capabilities of existing practitioners do not match the demand standards.Therefore,it is necessary to actively promote the education of resources and development in Central Asia.As an institution for cultivating talents,colleges and universities must establish a practical teaching system for cultivating talents.Based on the requirements put forward by China in education,this article studies the development status of the traditional Chinese medicine resources and development major,determines the talent training goals,starts from the practical teaching aspect,and locates the industry’s requirements for the capabilities of personnel in the field of traditional Chinese medicine.It also puts forward the overall idea of the construction of the practical teaching system,summarizes the reform content of the practical teaching system,and lastly provides the specific path of the reform.

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

Influence of Urban Development and Construction on Ecological Water Conservancy Landscapes and Countermeasure Analysis——A Case Study of Ecological Water Conservancy Landscapes in Nanchang City,Jiangxi Province of China

Through analyzing influence of urban development and construction on ecological water conservancy landscapes,common ecological problems of existing water conservancy landscapes were explored.Causes responsible for these problems were summarized as poor knowledge about ecology,unclear objective of construction,water conservancy projects violating the principle of conserving and restoring ecological conditions,and degraded biodiversity of water environment.It was stressed that ecological construction of water conservancy landscapes should break traditional water conservancy concepts,adopt ecological treatment and build ecological landscapes;geomorphic,hydrological and hydraulic of original river systems should be maintained as much as possible;sewage not discharged to natural water directly;water circulation enhanced to promote self-purification capacity of water;necessary purification measures adopted for rivers and lakes.On the basis of above strategies,construction of ecological water conservancy landscapes in Nanchang City was taken for example to analyze problems in the previous construction and present achievements,then principles to be followed in the future construction and protection of ecological water conservancy landscapes in Nanchang City were proposed.

Construction of Artificial Wetlands and Ecotourism Resource Development in Jilin City

Definition of artificial wetlands or construction background and significance of artificial wetlands in Jilin City were introduced in this study,while characteristics of wetland tourist resources and advantages of ecotourism development in Jilin City were also analyzed,which put forward measures to develop artificial wetland ecotourism resources in Jilin City.

Construction of Tourism Development Mode for Guizhou Province Based on Sustainable Development

External environment for rural tourism development in Guizhou Province was analyzed from the perspectives of social economy,culture and ecology,and a sustainable mode was constructed.

Forecasting of development of the Jiangsu construction industry and its case analysis

In order to grasp the development path of the Jiangsu construction industry, a multivariable linear regression model for forecasting is proposed. Five factors affecting development of the Jiangsu construction industry are chosen as explanatory variables. They are the construction industry＇s fixed assets K, the gross domestic product （GDP）, real estate added value （REAV）, construction industry export （WS）and investment in construction and installation projects（JA）. The principal component analysis is used to resolve multicollinearity between them. The construction added value （CAV） is chosen as a dependant variable, and the growth model of the Jiangsu construction industry is established. Statistical data from 1990 to 2008 are used to test the prediction accuracy of the model. The predictive results show that from 2009 to 2012, the average annual growth rate of the Jiangsu construction industry added value will be 17. 65% while the GDP growth rate will be 14. 16% . the Jiangsu construction industry will grow faster than the GDP in the near future. The construction output of the GDP continues to rise, and its pillar position will be further strengthened.

Analysis of Rural Tourism Development in Zhejiang Province under New Rural Construction

Based on analyzing the current situation of rural tourism in Zhejiang Province,the exiting problems were analyzed,then the development methods and strategies were put forward.

Development and Utilization of Catering Culture and New Countryside Construction in Guizhou of China

The paper pointed out that catering cultural resources played an important role in vitalizing Guizhou,promoting rural tourism development,innovating characteristic mountainous economy,increasing villagers' income and constructing ecological civilization.It emphasized that development and utilization of catering resources could contribute to promotion of economic development and preservation of good ecology on condition that natural environment was not destroyed.Advantages and potentials for development and utilization of catering culture in Guizhou had been analyzed,which lied in diversified food production methods,abundant food materials,obvious regionality,colorful national catering cultures,green foods and so on.It proposed that Guizhou catering culture had gained attention of relevant departments currently and had been developed to a certain degree.Its development status was introduced in brief.On this basis,it put forward relevant strategies,emphasized depending on government's guidance,stimulating villagers' activity,rooting in the soil of Guizhou historical culture,paying attention to establishment and protection of native catering cultural brand,and doing well in sales promotion.

On Construction and Development of Ecological Garden City in Handan

Through introducing the connotation of ecological garden city, the paper analyzed the current construction situations and problems in Handan City and proposed the countermeasures of building national garden city in Handan.

Research on Sightseeing Leisure Agricultural Development Based on New Rural Construction——A Case Study of North Jiangsu Province in China

The paper has introduced the connotation of new rural construction,agricultural industrialization,leisure agriculture and North Jiangsu Region,and proposed that leisure agriculture has made following effects on the development of North Jiangsu:promoting rural production of North Jiangsu and improving villagers' life standard;developing agricultural ecological resources in North Jiangsu and facilitating agricultural sustainable development;and transferring surplus labors in North Jiangsu and increasing the value of human resources.It has concluded natural condition,resources condition,human condition and market condition for leisure agricultural development in North Jiangsu.On this basis,it has proposed countermeasures to accelerate leisure agricultural development in North Jiangsu.The government should give political and financial support and provide vocational training;it should create the development concept and business organization mode of leisure agriculture;build service consciousness and make brand publicity with the market as the guidance;perfect government's function,complete organization management and expand public service;and reform rural financial credit system and formulate leisure agriculture insurance measures.

The situation and development trend of health industrial park construction in China

[目的] 描述我国健康产业园区基本现状,总结园区发展模式,为园区未来发展提供理论基础. [方法]利用百度搜索、CNKI和万方数据库全面搜索国内健康产业园区的相关信息和文献资料,基于文献内容 分析法和案例分析法对园区信息进行归纳与分析.[结果]共检索到健康产业园区3 5 个,涉及 1 8个省市,最 早的园区于1994年创办,园区平均面积为16.82 km2,平均投资金额为140.9亿元.从管理运营、投融资、产 业类型、研发方面归纳了园区的不同发展模式,发现园区建设中的问题并提出未来发展趋势.[结 论 ]我国健 康产业园区正在蓬勃发展,但是仍然存在重复建设缺乏特色,监管机制尚不完善等问题,还需政府进-步完善 审批、优惠等政策,引导园区健康发展.

Strategy for Construction of World Modern Garden City in Chengdu of China under the Background of Integration of Urban-rural Development

In the perspective of natural geological climate and social economic situation of Chengdu City,the paper had analyzed the tendency of integration of urban-rural development in Chengdu,and proposed strategy to construct world modern garden city.It had illustrated basic conditions to construct world modern garden city in Chengdu at current period,and it was considered that good timing,geographical convenience and good human relations were involved in this strategy.In order to satisfy the six traits of word modern garden city,it had proposed short-term,mid-term and long-term targets;and focused on industrial development,enriching and benefiting the people,opening up to the outside world and institutional innovation.It also suggested weakening original economic geological pattern of Chengdu,so as to form complete urban system of sharing homogeneity of market construction,policy allocation,basic facilities,and social security system,seek for general welfare and diverse cooperation,and finally construct world modern garden city with good living environment,excellent investment environment,fine cultural atmosphere,high functional level,and strong comprehensive competitiveness.

Study on the Influence of Over Development and Construction of Traditional Villages on the Development of B&B and Its Planning Strategy:A Case Study of Jinlin Village in Zhaoqing,Guangdong Province

The development types of traditional village B&B can be divided into spontaneous style,scenic area driven style and new rural construction led style.The development of B&B in Jinlin Village has certain livable environment and resource conditions,good location,profound cultural heritage and government support.It has experienced three stages of construction,namely scenic spot development,civilized village and new countryside.The development type of B&B in Jinlin Village belongs to the dual type of scenic spot driving and new countryside construction.However,over construction has negative impact on the development of B&B.Four planning strategies are put forward,including protecting and activating the traditional houses,increasing the green space to isolate and buffer the impact of new houses on traditional dwellings,opening up new lakeside residential area,and fully protecting and utilizing peripheral farmlands.

Preliminary Discussion on the Construction and Development of Modern Refinery in China

Sustainable development of refinery is an important problem that refining industry faces in the21st Century. The situation and challenges in front of refining industry are analyzed and illustrated byexamples in this paper. It is also recognized that large-scale, clean, light-oriented and integrated refinery isthe mode of development in future, and also an important measure for the sustainable development ofpetroleum resource.

Spatio-temporal Evolution Characteristics and Driving Mechanism of the New Infrastructure Construction Development Potential in China

With the advent of the era of big data and artificial intelligence, new infrastructure construction(NIC) has attracted the attention of many countries. The development of NIC provides an opportunity to bridge the digital divide and narrow the regional gap,providing continuous impetus to further promote economic development. Here, we considered 31 provincial-level administrative units in China(not including Hong Kong, Macao, and Taiwan of China due to data unavailable) and established comprehensive evaluation indicators for the development potential of NIC. Afterward, we used the entropy-weight TOPSIS model to determine the development potential of NIC and analyze its spatio-temporal evolution characteristics. Furthermore, the GeoDetector model was applied to explore the driving mechanism of the NIC development potential. The conclusions were as follows: (1) The Chinese NIC development potential is generally low. The eastern China was the region with the highest development potential year by year, while the development potential in the central China was found to be in an accelerating phase. (2) The evolution of the Chinese NIC development potential’s spatial pattern has been characterized by an inland extension and coastal agglomeration. Moreover, we identified a superior development zone, a rising development zone, an inferior development zone, and a declining development zone. (3) The scope of Chinese NIC development potential agglomeration areas has gradually expanded and its degree has gradually deepened. The range of high-value agglomeration in eastern area gradually expanded and its degree gradually deepened. (4) Investment in innovative talents appears as the core factor affecting the Chinese NIC development potential. Whether acting alone or synergistically with other factors, its promoting effect on Chinese NIC development potential is the strongest.