Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to P...Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy activation.Pharmacological intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation model.As such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug pharmacology.These rats retain clinical features encompassing basal mitophagic flux changes with PD progression.We demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.展开更多
The elastic support/dry friction damper is a type of damper which is used for active vibration control in a rotor system.To establish the analytical model of this type of damper,a two-dimensional friction model-ball/p...The elastic support/dry friction damper is a type of damper which is used for active vibration control in a rotor system.To establish the analytical model of this type of damper,a two-dimensional friction model-ball/plate model was proposed.By using this ball/plate model,a dynamics model of rotor with elastic support/dry friction dampers was established and experimentally verified.Moreover,the damping performance of the elastic support/dry friction damper was studied numerically with respect to some variable parameters.The numerical study shows that the damping performance of the elastic support/dry friction damper is closely related to the stiffness distribution of the rotor-support system,the damper location,the pressing force between the moving and stationary disk,the friction coefficient,the tangential contact stiffness of the contact interface,and the stiffness of the stationary disk.In general,the damper should be located on an elastic support which has a large vibration amplitude in order to achieve a better damping performance,and the more vibration energy in this elastic support concentrates,the better performance of the damper will be.The larger the tangential contact stiffness of the contact interface,and the stiffness of the stationary disk are,the better performance of the damper will be.There will be an optimal value of the friction force at which the damper performs best.展开更多
We develop an interconnect crosstalk estimation model on the assumption of linearity for CMOS device. First, we analyze the terminal response of RC model on the worst condition from theS field to the time domain. The ...We develop an interconnect crosstalk estimation model on the assumption of linearity for CMOS device. First, we analyze the terminal response of RC model on the worst condition from theS field to the time domain. The exact 3 order coefficients inS field are obtained due to the interconnect tree model. Based on this, a crosstalk peak estimation formula is presented. Unlike other crosstalk equations in the literature, this formula is only used coupled capacitance and grand capacitance as parameter. Experimental results show that, compared with the SPICE results, the estimation formulae are simple and accurate. So the model is expected to be used in such fields as layout-driven logic and high level synthesis, performance-driven floorplanning and interconnect planning.展开更多
By establishing the VEC model, the relationship between Consumer Price Index (CPI) and Producer Price Index (PPI) is explored by using Johansen cointegration test and impulse response function. The results show that t...By establishing the VEC model, the relationship between Consumer Price Index (CPI) and Producer Price Index (PPI) is explored by using Johansen cointegration test and impulse response function. The results show that there is a long-term equilibrium cointegration relationship between CPI and PPI. CPI has a certain impact on PPI. PPI also has a certain impact on CPI. PPI has a great impact on itself both in the long-term and short-term. The current CPI will be adversely affected by the previous CPI and the positive impact of the previous PPI. The current PPI will be positively affected by the previous phase of CPI and the previous phase of PPI.展开更多
The emerging multi-energy system has brought new challenges and opportunities to energy business worldwide.To address the issues in multi-energy trading,this paper proposes an electricity,heating,and cooling trading m...The emerging multi-energy system has brought new challenges and opportunities to energy business worldwide.To address the issues in multi-energy trading,this paper proposes an electricity,heating,and cooling trading model for the interaction between the multi-energy service provider(MESP)and multi-energy consumer(MEC)by using bi-level programming.In the upper level,the model instructs the MESP to make decisions on the optimal energy purchasing scheme and energy economic dispatch.In the lower level,optimal consuming patterns of different energies with the given retail prices are modeled for the MEC.Specifically,a novel multi-energy demand response(DR)program that employs energy conversion devices is proposed.Numerical results show that MEC can reduce its consumption cost via the multi-energy DR.Meanwhile,MESP benefits greatly from the flexibilities of energy conversion.This research can provide theoretical support for the future development of multi-energy trading.展开更多
基金supported by the KIZ-CUHK Joint Lab of Bioresources and Molecular Research of Common Diseases(4750378)the VC Discretionary Fund provided to the Hong Kong Branch of Chinese Academy of Science Center for Excellence in Animal Evolution and Genetics(Acc 8601011)partially by the State Key Laboratory CUHKJinan MOE Key Laboratory for Regenerative medicine(2622009)。
文摘Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor network.Genetic studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy activation.Pharmacological intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation model.As such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug pharmacology.These rats retain clinical features encompassing basal mitophagic flux changes with PD progression.We demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.
基金supported by the National Natural Science Foundation of China(No.51405393)
文摘The elastic support/dry friction damper is a type of damper which is used for active vibration control in a rotor system.To establish the analytical model of this type of damper,a two-dimensional friction model-ball/plate model was proposed.By using this ball/plate model,a dynamics model of rotor with elastic support/dry friction dampers was established and experimentally verified.Moreover,the damping performance of the elastic support/dry friction damper was studied numerically with respect to some variable parameters.The numerical study shows that the damping performance of the elastic support/dry friction damper is closely related to the stiffness distribution of the rotor-support system,the damper location,the pressing force between the moving and stationary disk,the friction coefficient,the tangential contact stiffness of the contact interface,and the stiffness of the stationary disk.In general,the damper should be located on an elastic support which has a large vibration amplitude in order to achieve a better damping performance,and the more vibration energy in this elastic support concentrates,the better performance of the damper will be.The larger the tangential contact stiffness of the contact interface,and the stiffness of the stationary disk are,the better performance of the damper will be.There will be an optimal value of the friction force at which the damper performs best.
基金SupportedbytheNationalHighTechnologyResearchandDevelopmentProgramofChina (863Plan) (863 SOC Y 3 3 2 )
文摘We develop an interconnect crosstalk estimation model on the assumption of linearity for CMOS device. First, we analyze the terminal response of RC model on the worst condition from theS field to the time domain. The exact 3 order coefficients inS field are obtained due to the interconnect tree model. Based on this, a crosstalk peak estimation formula is presented. Unlike other crosstalk equations in the literature, this formula is only used coupled capacitance and grand capacitance as parameter. Experimental results show that, compared with the SPICE results, the estimation formulae are simple and accurate. So the model is expected to be used in such fields as layout-driven logic and high level synthesis, performance-driven floorplanning and interconnect planning.
文摘By establishing the VEC model, the relationship between Consumer Price Index (CPI) and Producer Price Index (PPI) is explored by using Johansen cointegration test and impulse response function. The results show that there is a long-term equilibrium cointegration relationship between CPI and PPI. CPI has a certain impact on PPI. PPI also has a certain impact on CPI. PPI has a great impact on itself both in the long-term and short-term. The current CPI will be adversely affected by the previous CPI and the positive impact of the previous PPI. The current PPI will be positively affected by the previous phase of CPI and the previous phase of PPI.
基金supported by National Key R&D Program of China(No.2016YFB0901900).
文摘The emerging multi-energy system has brought new challenges and opportunities to energy business worldwide.To address the issues in multi-energy trading,this paper proposes an electricity,heating,and cooling trading model for the interaction between the multi-energy service provider(MESP)and multi-energy consumer(MEC)by using bi-level programming.In the upper level,the model instructs the MESP to make decisions on the optimal energy purchasing scheme and energy economic dispatch.In the lower level,optimal consuming patterns of different energies with the given retail prices are modeled for the MEC.Specifically,a novel multi-energy demand response(DR)program that employs energy conversion devices is proposed.Numerical results show that MEC can reduce its consumption cost via the multi-energy DR.Meanwhile,MESP benefits greatly from the flexibilities of energy conversion.This research can provide theoretical support for the future development of multi-energy trading.
