Despite advances in diagnosis and treatment,gastric cancer remains one of the most common malignant tumors worldwide,and early diagnosis remains a challenge.The lack of effective methods to detect these tumors early i...Despite advances in diagnosis and treatment,gastric cancer remains one of the most common malignant tumors worldwide,and early diagnosis remains a challenge.The lack of effective methods to detect these tumors early is a major factor contributing to the high mortality in patients with gastric cancer,who are typically diagnosed at an advanced stage.Additionally,the early detection of metastases and the curative treatment of gastric cancer are difficult to achieve,and the detailed mechanisms remain to be fully elucidated.Thus,the identification of valuable predictive biomarkers and therapeutic targets to improve the prognosis of patients with gastric cancer is becoming increasingly important.Contactin 1(CNTN1),a cell adhesion molecule,is a glycosylphosphatidylinositolanchored neuronal membrane protein that plays an important role in cancer progression.The expression of CNTN1 is upregulated in primary lesions,and its expression level correlates with tumor metastasis in cancer patients.The current evidence reveals that the functions of CNTN1 in the development and progression of cancer likely promote the invasion and metastasis of cancer cells via the VEGFC/FLT4 axis,the RHOAdependent pathway,the Notch signaling pathway and the epithelial-mesenchymal transition progression.Therefore,CNTN1 may be a novel biomarker and a possible therapeutic target in cancer treatment in the near future.展开更多
基金Supported by National Natural Science Foundation of China,No.81101850the Shanghai Municipal Health Bureau Foundation of China,No.20134393the Science Research Foundation of Shanghai Jiao Tong University School of Medicine,No.13XJ10028
文摘Despite advances in diagnosis and treatment,gastric cancer remains one of the most common malignant tumors worldwide,and early diagnosis remains a challenge.The lack of effective methods to detect these tumors early is a major factor contributing to the high mortality in patients with gastric cancer,who are typically diagnosed at an advanced stage.Additionally,the early detection of metastases and the curative treatment of gastric cancer are difficult to achieve,and the detailed mechanisms remain to be fully elucidated.Thus,the identification of valuable predictive biomarkers and therapeutic targets to improve the prognosis of patients with gastric cancer is becoming increasingly important.Contactin 1(CNTN1),a cell adhesion molecule,is a glycosylphosphatidylinositolanchored neuronal membrane protein that plays an important role in cancer progression.The expression of CNTN1 is upregulated in primary lesions,and its expression level correlates with tumor metastasis in cancer patients.The current evidence reveals that the functions of CNTN1 in the development and progression of cancer likely promote the invasion and metastasis of cancer cells via the VEGFC/FLT4 axis,the RHOAdependent pathway,the Notch signaling pathway and the epithelial-mesenchymal transition progression.Therefore,CNTN1 may be a novel biomarker and a possible therapeutic target in cancer treatment in the near future.
