Effect of forging on the microstructure and texture of a high Nb containing γ-TiAl alloy

The effect of forging on the microstructure and texture evolution of a high Nb containing Ti-45Al-7Nb-0.3W(at.%)alloy was investigated by X-ray diffractometer(XRD),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that the as-cast alloy is mainly composed of α_(2)/γ lamellar colonies with a mean size of 70μm,but the hot-forged pancake displays a near duplex microstructure(DP).Kinking and bending of lamellar colonies,deformation twinning and dynamic recrystallization(DRX)occur during hot forging.Meanwhile,dense dislocations in theβphase after forging suggest that the high-temperature β phase with a disordered structure is favorable for improving the hot-workability of the alloy.Unlike the common TiAl casting texture,the solidification process of the investigated as-cast alloy with high Nb content is completely via the β phase region,resulting in the formation of a<110>γ fiber texture where the<110>γ aligns parallel to the heat-flow direction.In comparison,the relatively strong<001>and weak<302>texture components in the as-forged alloy are attributed to the deformation twinning.After annealing,static recrystallization occurs at the twin boundary and intersections,which weakens the deformation texture.

High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer

BACKGROUND Patatin like phospholipase domain containing 8(PNPLA8)has been shown to play a significant role in various cancer entities.Previous studies have focused on its roles as an antioxidant and in lipid peroxidation.However,the role of PNPLA8 in colorectal cancer(CRC)progression is unclear.AIM To explore the prognostic effects of PNPLA8 expression in CRC.METHODS A retrospective cohort containing 751 consecutive CRC patients was enrolled.PNPLA8 expression in tumor samples was evaluated by immunohistochemistry staining and semi-quantitated with immunoreactive scores.CRC patients were divided into high and low PNPLA8 expression groups based on the cut-off va-lues,which were calculated by X-tile software.The prognostic value of PNPLA8 was identified using univariate and multivariate Cox regression analysis.The over-all survival(OS)rates of CRC patients in the study cohort were compared with Kaplan-Meier analysis and Log-rank test.RESULTS PNPLA8 expression was significantly associated with distant metastases in our cohort(P=0.048).CRC patients with high PNPLA8 expression indicated poor OS(median OS=35.3,P=0.005).CRC patients with a higher PNPLA8 expression at either stage I and II or stage III and IV had statistically significant shorter OS.For patients with left-sided colon and rectal cancer,the survival curves of two PN-PLA8-expression groups showed statistically significant differences.Multivariate analysis also confirmed that high PNPLA8 expression was an independent prog-nostic factor for overall survival(hazard ratio HR=1.328,95%CI:1.016-1.734,P=0.038).

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways,which are potentially involved in the regulation of thrombopoietin-dependent signaling and further impair proplatelet formation by megakaryocytes(MKs)[11].However,the positive regulators of ANKRD26,which might be associated with THC2 pathology,are still unknown.

Application of Thermodynamic Database to Corrosion of ZrO_(2) Containing Submerged Entry Nozzle in Steel Continuous Casting Process

The CALPHAD thermodynamic databases are very useful to analyze the complex chemical reactions happening in high temperature material process.The FactSage thermodynamic database can be used to calculate complex phase diagrams and equilibrium phases involving refractories in industrial process.In this study,the FactSage thermodynamic database relevant to ZrO_(2)-based refractories was reviewed and the application of the database to understanding the corrosion of continuous casting nozzle refractories in steelmaking was presented.

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.

A Novel Adsorbent Prepared by Aluminum-Containing Waste Residue and Its Application for Congo Red Wastewater Decolorization

Modified aluminum slag (MAS) was applied as an adsorbent for Congo red (CR) prepared by the hydrothermal treatment of Ca(OH)2. At 25°C, with a MAS dosage of 0.3 g, initial CR concentration of 100 mg/L and initial pH = 5, and the adsorption time was 40 min, the CR removal efficiency was 98.41%. The adsorption trend of CR conformed to the second-order kinetics, and the adsorption isotherm follows the Freundlich isotherm model. Compared with RAS, MAS has a larger pore volume and specific surface area. The mechanism of action of MAS on CR was the interaction between membrane diffusion and internal diffusion, and the adsorption rate during the membrane diffusion was the fastest.

育苗容器对紫叶紫薇容器苗生长、开花及生理的影响

【目的】探讨育苗容器类型和规格对紫叶紫薇容器苗生长、开花及生理的影响,筛选出培育紫叶紫薇容器苗的适宜育苗容器,为高效培育紫薇容器苗提供理论依据。【方法】以紫叶紫薇优良新品种‘丹红紫叶’2年生苗木为研究材料,选用黑色塑料营养杯(C1)、白色无纺布美植袋(C2)、黑色控根容器(C3)3个类型以及16×16(D1)、21×21(D2)、25×25(D3)3种规格(直径×高,cm),组成9种容器组合处理,测定不同处理容器苗生长、开花及生理指标。【结果】(1)不同育苗容器处理对紫叶紫薇容器苗的生长、开花及生理指标均影响显著,同一容器类型苗木的生长、根系、生物量、花期、花径、花序、可溶性蛋白含量、可溶性糖含量、相对叶绿素含量、净光合速率、气孔导度、蒸腾速率等指标均随着育苗容器规格的增大而显著增加。(2)地径生长量、总根长、总根表面积、总根体积、根尖数、地上部干质量、地下部干质量、总干质量、花期均以C3D3处理最大,比最小的C1D1处理分别显著提高817.12%、108.12%、94.60%、75.66%、144.14%、135.67%、228.45%、164.65%、34.48%;苗高生长量、冠幅生长量、叶面积、花序长和宽均以C1D3处理最高,比最低的C1D1处理分别显著提高116.05%、81.39%、114.95%、70.44%和65.79%;相对叶绿素含量、水分利用效率均以C3D3处理最大,可溶性蛋白和可溶性糖含量、净光合速率、气孔导度均以C1D3处理最高;胞间CO_(2)浓度、水分利用效率在各处理之间无显著差异。(3)各处理隶属函数法综合评价得分排序为:C3D3>C1D3>C2D3>C3D2>C2D2>C1D2>C2D1>C3D1>C1D1。【结论】黑色控根容器在地径生长量、根系生长指标、生物量、花期和花径、叶绿素相对含量及净光合速率方面表现最佳;紫叶紫薇2年生苗的最适宜育苗容器是直径25 cm、高25 cm的黑色控根容器。

油水分离技术的研究进展

综述了含油废水的定义､油的存在形态､油水分离技术以及吸油材料的研究进展。油水分离技术包括物理分离法､化学分离法､物理化学分离法以及组合工艺等。阐述了各种油水分离技术的基本原理､流程和特点,综合比较分析发现,应依据含油废水中油品的性质及存在形式选择合适的油水分离技术,并且兼顾经济效益。组合工艺是油水分离的发展趋势;高性能低成本油水分离材料以及油水分离设备的研发是未来油水分离技术发展的重点。

水利部数字孪生流域模型管理云平台设计及应用研究

【目的】智慧水利是推动新阶段水利高质量发展的实施路径之一,建设数字孪生流域是实现智慧水利的核心与关键。为提升水利部数字孪生平台建设中水利模型的易用性、可扩展性、复用率和可维护性【方法】按照数字孪生流域水利模型建设“标准化、模块化、云服务”的要求,采用“分治+集成”的思想,基于组件技术、工作流技术、SOA架构和容器技术等构建水利部数字孪生流域模型管理云平台。平台通过提供水利专业模型、智能识别模型的组件化封装和流程化搭建功能,以微服务的方式对外提供模型共享和模型计算服务。【结果】依托重点研发项目分别在示范区域——屯溪流域和白鹤滩水库开展“洪水预报-预警-调度”业务应用和工程管理范围形变监测业务应用,验证了平台设计的合理性和应用的可行性。【结论】研究成果可为数字孪生流域模型平台的建设与应用提供一定技术支持和经验借鉴。

不同配方基质对枳容器苗生长的影响

为了筛选适宜枳砧木繁育的基质,采用红壤土、椰糠、泥炭、有机肥以不同比例配比组成23种基质用于枳容器苗培养,比较了不同基质上植株的株高、茎粗、根总长、根表面积、根直径、根体积、根尖数、地上部分鲜质量、地下部分鲜质量、地上部分干质量、地下部分干质量差异。结果表明,S15(红壤土∶椰糠∶泥炭:有机肥=7∶2∶0∶1,体积比,下同)基质能提高枳苗木的茎粗、株高和地下部分干质量,分别比CK(红壤土)高出67.40%、86.79%和82.05%;S7(椰糠∶有机肥=7∶3)基质提高了植株根总长,比CK高出51.30%;S11(椰糠∶泥炭=7∶3)基质提高了地下部分鲜质量和地上部分干质量,分别比CK高出105.48%和207.14%;S14(椰糠∶泥炭=5∶5)基质提高了枳苗木地下部分干质量,比CK高出了74.35%。结合考虑成本,筛选S15(红壤土∶椰糠∶泥炭∶有机肥=7∶2∶0∶1)基质为枳容器苗繁育的最适基质。

钢铁工业含锌尘泥回转窑处置技术的应用进展

钢铁冶炼过程(炼铁、炼钢)会产生大量的含锌尘泥,该尘泥不宜直接返回炼铁工序,一般以厂内长期堆存或外委等方式进行处理。随着我国钢铁企业“固废不出厂”“循环经济”“绿色制造”等新理念的深入推进,在钢铁厂内部采用新型回转窑技术直接处置含锌尘泥成为大势所趋。本文介绍了传统回转窑处置含锌尘泥技术的工艺流程,从原料、生产过程和产品特点等方面分析其不足,提出采用原料造球、多喷孔分级进风等创新技术的新型回转窑处置技术,该技术明显提高了回转窑处置能力,缓解了回转窑结圈,已相继在永锋钢铁、八一钢铁、诚钰环保等钢铁企业和环保公司稳定运行,产生了良好的经济与社会效益。该技术在多固废协同处置、热渣干式冷却等方面具备应用前景。

温胆汤含药血清对10 mmol/L谷氨酸环境下星型胶质细胞PI3K、Akt、mTOR表达的影响

目的 探讨温胆汤含药血清对10 mmol/L谷氨酸诱导的大鼠星型胶质细胞凋亡、周期及磷脂酰肌醇3-激酶(phosphoinositide 3-kinase, PI3K)、蛋白激酶B(protein kinase B,Akt)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin, mTOR)表达的影响。方法 将60只SPF级SD雄性大鼠随机分为5组,其中正常组20只,氯氮平组和温胆汤高、中、低剂量组各10只。正常组予20 g/kg 0.9%氯化钠溶液灌胃,氯氮平组予氯氮平原药20 mg/kg灌胃,温胆汤高、中、低剂量组分别予40、20、10 g/kg温胆汤灌胃,1次/d,共8 d。处死大鼠后取血,离心取血清,灭活除菌,EP管分装备用。将大鼠星型胶质细胞分为正常血清组、模型血清组,氯氮平含药血清组和温胆汤高、中、低剂量含药血清组,除正常血清组外,其余各组予10μmol/mL谷氨酸处理48 h后,流式细胞仪检测细胞凋亡和细胞周期;Western bloting、Real-time PCR分别测定细胞PI3K、Akt、mTOR蛋白和mRNA表达。结果 温胆汤含药血清可明显降低谷氨酸环境下大鼠星型胶质细胞凋亡率(P<0.01)和G0/G1期细胞占比(P<0.05),升高S期及G2/M期细胞占比;降低细胞P-P13K/P13K、P-ATK/AKT、P-mTOR/mTOR蛋白表达比值(温胆汤低剂量血清组除外,P<0.05)和细胞PI3K、Akt、mTOR mRNA表达(温胆汤低剂量血清组除外,P<0.01)。结论 温胆汤含药血清可有效调节大鼠星形胶质细胞PI3K、Akt、mTOR表达,达到保护神经细胞的目的,这可能是温胆汤治疗精神分裂症的作用机制之一。

基于主动探测的Web容器探测识别方法

随着工业互联网的飞速发展,各类Web容器的广泛使用呈现不断增长的趋势,然而,这也使得Web容器资产管理的问题变得更加复杂.随之而来的是诸多网络安全风险和潜在隐患,对于这些挑战,提升网络安全防御水平显得尤为迫切.为了解决这一问题,本文引入了一种新的基于主动探测的Web容器探测识别方法.在探测阶段,采用了一种先进的Web容器探针构建方法,通过此方法构建了Web容器探针.这个探针在识别阶段发挥关键作用,借助一种基于负载内容的Web容器识别方法,通过协议解码技术,实现了对Web容器的高度准确的识别.通过结合这两种先进的识别方法,成功识别了4种不同类型的Web容器,并且提升了精度,能够精确地区分这些Web容器的各个版本,总计实现了10个版本的准确识别.通过这种先进的主动探测方法,企业可以更好地了解和管理其Web容器资产,降低网络安全风险,并确保网络系统的稳定性和安全性.

新一代含氟环保气体绿色制造标准体系的构建

新一代含氟环保气体是解决臭氧层消耗和全球变暖问题的新兴产品。本文针对当前新一代含氟环保气体绿色制造标准少、不全面、不系统等问题,分析了当前国内新一代含氟环保气体绿色制造标准发展存在的问题及标准化需求,提出了新一代含氟环保气体绿色制造标准体系框架,从新一代含氟环保气体绿色制造标准体系的发展现状、建立意义及构建等三个方面进行探讨。为新一代含氟环保气体绿色制造工作指明了方向,为新一代含氟环保气体绿色制造的管理和高质量发展提供了支持。

全球价值链的脱钩与反脱钩:来自中国制造业企业微观数据的经验证据

本文基于中国制造业上市公司的微观数据和WIOD及亚行的世界投入产出表数据,考察美国的价值链脱钩策略对中国企业创新内在动力的激发效应和对中国全球价值链地位攀升的影响。研究发现:首先,美国的价值链脱钩策略对中国企业创新内在动力存在显著的正向激发作用,且激发效应能够抵消遏制效应。其次,脱钩策略对中国全球价值链地位攀升的叠加效应显著为正,与产业上游度负相关,表明美国的脱钩策略并不会阻断中国全球价值链地位的攀升和产业技术水平的提高。最后,中国企业自主创新对FDI技术外溢的吸收和转化等“学习效应”过于依赖,存在“低质低效”的双低现象,降低了价值链地位攀升的效率。FDI对产业价值链地位有显著的提升作用,但对国内企业“高质高效”的自主创新具有抑制作用。本文结论为提高企业自主创新质量和效率以及价值链地位提供了政策启示。

基于DQN的自动化集装箱码头自动引导车多目标调度优化

以自动引导车利用率最大和能源消耗量最小为目标,建立AGV调度优化数学模型,设计7种不同调度策略作为可变调度策略空间,提炼自动引导车调度问题的状态特征和奖励函数,提出一种基于深度Q学习网络算法(deep Q-network,DQN)的可变调度策略的调度算法。算例分析结果表明:与GA算法和Q-learning算法相比,采用基于DQN的调度优化方法求得的调度方案可使自动引导车的利用率分别提高14.76%和19.92%;能源消耗方面,采用DQN算法求得的调度方案平均能耗与GA算法和Q-learning算法相比分别降低16.88%和10.77%。通过与固定调度策略相比,平均利用率提升12.39%,平均能耗降低7.58%。可见本文方法的求解质量更高,同时与固定策略相比验证了所提出可变策略的有效性。

基于改进络合铁法的含硫化氢尾气处理工艺模拟与优化

目的有效处理含硫尾气,确保装置“安、稳、长、满、优”运行。方法采用Aspen Plus V11软件基于Peng-Robinson热力学模型对改进络合铁装置的H_(2)S处理过程进行了全流程模拟,并根据Box-Behnken Design对其进行了响应面设计,得到了最佳H_(2)S脱除率及其对应的优化操作参数。结果此模拟流程能够较好地反映改进络合铁装置的实际运行情况,可以作为后续优化研究的基础模型。当循环溶液温度为47.2℃、循环溶液中Fe^(3+)质量分数为8.4100%、循环溶液体积流量为3.12 m^(3)/h、电解槽电压为0.64 V时,改进络合铁装置的H_(2)S脱除率高达99.999988%。此时,外排气中H_(2)S质量浓度为9.5 mg/m^(3),完全可以满足外排气中H_(2)S质量浓度不大于10 mg/m^(3)的约束条件;t检验结果表明,采用响应面法优化得到的预测值和验证值之间不存在显著差异,其准确度一致。结论该研究结果可为进一步提升含H_(2)S尾气处理水平提供准确、可靠的理论支撑和数据来源。

双高箱办理站装卸设备协同调度研究

为提高双高箱列车装卸作业效率,针对双高箱办理站不设主作业区、“完全间接装卸”、装卸作业多流向及出站箱同步转运的特点,考虑设备能力、作业序列、轨道吊安全距离约束等现实约束,详细拆分设备间的衔接、共用及等待时间构成,以最小化完成装卸作业用时、装卸线轨道吊等待时间最小化和作业均衡率最大化为优化目标,构建轨道吊、AGV、空箱堆垛机和智能举升机间的协同调度模型,并基于遗传算法和模拟退火算法设计混合算法求解模型。通过实例验证模型及算法的有效性、混合算法和多目标协同优化的优越性,分析表明双高箱办理站布局及装卸作业模式可行,优化指标间两两无单向相关性。最后通过灵敏度分析验证模型可用于装卸设备配置优化,以实现双高箱办理站低成本高效运作。

改进动态规划算法求解同尺寸物品的装箱问题

装箱问题是在一个容量有限的箱内尽可能多的装入各类物品。文中研究同尺寸的物品装箱问题,在一个集装箱中装入大小规格一致的小箱,使集装箱的空间利用率最大,即装入的小箱数量最多。采用分层装载思想和同质条带的布局方式设计装箱方案,利用改进的动态规划算法求解层装的布局问题,使用背包算法求解同质条带内的小箱布局问题。与已有文献算法相比,文中算法的运行速度更快,得到的装箱方案更便捷,利于装箱操作,而且在一定程序上提高了装箱率。使用国际标准尺寸的集装箱和随机尺寸的物品小箱进行实验,结果表明文中算法比传统的动态规划算法有更好的求解效果,可适用于实际的集装箱物品装载。

基于改进Canny边缘检测的堆叠货箱分割定位方法

为了提高集装箱卸货的自动化水平,针对集装箱内堆叠货箱难分割定位的问题,提出了一种基于改进Canny边缘检测的堆叠货箱分割定位方法。通过阈值分割和形态学处理进行图像预处理,去除背景干扰,提取堆叠货箱区域图像,基于改进Canny算法对堆叠货箱进行边缘检测,根据堆叠货箱边缘特征进行筛选并基于最小二乘法进行直线拟合,解决边缘线条不连续和虚假边缘问题,对边缘进行区域化处理,以此将堆叠货箱分割成独立的货箱区域,提取每个独立货箱的最小外接矩形,得到货箱中心点的位置信息。实验结果表明,该方法对堆叠货箱有很好的分割效果,定位精度小于5 mm,满足定位精度要求。