Background: The fatality of adverse drug reactions (ADR) has become one of the major causes of the non-natural disease deaths globally, with the issue of drug safety emerging as a common topic of concern. Objective: T...Background: The fatality of adverse drug reactions (ADR) has become one of the major causes of the non-natural disease deaths globally, with the issue of drug safety emerging as a common topic of concern. Objective: The personalized ADR early warning method, based on contextual ontology and rule learning, proposed in this study aims to provide a reference method for personalized health and medical information services. Methods: First, the patient data is formalized, and the user contextual ontology is constructed, reflecting the characteristics of the patient population. The concept of ontology rule learning is then proposed, which is to mine the rules contained in the data set through machine learning to improve the efficiency and scientificity of ontology rule generation. Based on the contextual ontology of ADR, the high-level context information is identified and predicted by means of reasoning, so the occurrence of the specific adverse reaction in patients from different populations is extracted. Results: Finally, using diabetes drugs as an example, contextual information is identified and predicted through reasoning, to mine the occurrence of specific adverse reactions in different patient populations, and realize personalized medication decision-making and early warning of ADR.展开更多
Contextual question answering （CQA）, in which user information needs are satisfied through an interactive question answering （QA） dialog, has recently attracted more research attention. One challenge is to fuse co...Contextual question answering （CQA）, in which user information needs are satisfied through an interactive question answering （QA） dialog, has recently attracted more research attention. One challenge is to fuse contextual information into the understanding process of relevant questions. In this paper, a discourse structure is proposed to maintain semantic information, and approaches for recognition of relevancy type and fusion of contextual information according to relevancy type are proposed. The system is evaluated on real contextual QA data. The results show that better performance is achieved than a baseline system and almost the same performance as when these contextual phenomena are resolved manually. A detailed evaluation analysis is presented.展开更多
文摘Background: The fatality of adverse drug reactions (ADR) has become one of the major causes of the non-natural disease deaths globally, with the issue of drug safety emerging as a common topic of concern. Objective: The personalized ADR early warning method, based on contextual ontology and rule learning, proposed in this study aims to provide a reference method for personalized health and medical information services. Methods: First, the patient data is formalized, and the user contextual ontology is constructed, reflecting the characteristics of the patient population. The concept of ontology rule learning is then proposed, which is to mine the rules contained in the data set through machine learning to improve the efficiency and scientificity of ontology rule generation. Based on the contextual ontology of ADR, the high-level context information is identified and predicted by means of reasoning, so the occurrence of the specific adverse reaction in patients from different populations is extracted. Results: Finally, using diabetes drugs as an example, contextual information is identified and predicted through reasoning, to mine the occurrence of specific adverse reactions in different patient populations, and realize personalized medication decision-making and early warning of ADR.
文摘Contextual question answering （CQA）, in which user information needs are satisfied through an interactive question answering （QA） dialog, has recently attracted more research attention. One challenge is to fuse contextual information into the understanding process of relevant questions. In this paper, a discourse structure is proposed to maintain semantic information, and approaches for recognition of relevancy type and fusion of contextual information according to relevancy type are proposed. The system is evaluated on real contextual QA data. The results show that better performance is achieved than a baseline system and almost the same performance as when these contextual phenomena are resolved manually. A detailed evaluation analysis is presented.
