Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose detection.Microneedle technology is less invasive,yet microneedle adhesion with skin tissue is limited.In this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in vivo.The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle array.Due to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into skin.The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation state.Finally,the MASA was integrated into a monitoring system using custom circuitry.This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

Script-Based GPU-Ready ELM Development for Continuous Code Integration

Designing and optimizing complex scientific code for new computing architectures is a challenging task. To address this issue in the E3SM land model (ELM) development, we developed a software tool called SPEL, which facilitates code generation, verification, and performance tuning using compiler directives within a Function Unit Test framework. In this paper, we present a SPEL extension that leverages the version control system (e.g., Git) to autonomous code generation and demonstrate its application to continuous code integration and development of the ELM software system. The study can benefit the scientific software development community.

Scalable and fast fabrication of graphene integrated micro-supercapacitors with remarkable volumetric capacitance and flexibility through continuous centrifugal coating

Microscale electrochemical energy storage devices,e.g., micro-supercapacitors(MSCs),possessing tailored performance and diversified form factors of lightweight,miniaturization,flexibility and exceptional integration are highly necessary for the smart power sources-unitized electronics.Despite the great progress,the fabrication of MSCs combining high integration with high volumetric performance remains largely unsolved.Herein,we develop a simple,fast and scalable strategy to fabricate graphene based highly integrated MSCs by a new effective continuous centrifugal coating technique.Notably,the resulting highly conductive graphene films can act as not only patterned microelectrodes but also metal-free current collectors and interconnects,endowing modular MSCs with high integrity,remarkable flexibility,tailored voltage and capacitance output,and outstanding performance uniformity.More importantly,the strong centrifugal force and shear force generated in continuous centrifugal coating process lead to graphene films with high alignment,compactness and packing density,contributing to excellent volumetric capacitance of ~31.8 F cm^(-3) and volumetric energy density of ~2.8 mWh cm^(-3),exceeding most reported integrated MSCs.Therefore,our work paves a novel way for simple and scalable fabrication of integrated MSCs and offers promising opportunities as standalone microscale power sources for new-generation electronics.

Evaluation of vertical impact factor coefficients for continuous and integral railway bridges under high-speed moving loads

In the railway bridge analysis and design method,dynamic train loads are regarded as static loads enhanced by an impact factor(IF).The IF coefficients for various railway bridges have been reported as a function of span length or frequency of the bridges in Eurocode(2003).However,these IF coefficient values neglect the effects of very high speeds(>200 km/h)and soil-structure interaction(SSI).In this work,a comprehensive study to assess the impact factor coefficients of mid-span vertical displacements for continuous and integral railway bridges subjected to high-speed moving loads is reported.Three different configurations,each for the three-dimensional(3D)continuous and integral bridge,are considered.Also,single-track(1-T)and two-track(2-T)“real train”loading cases for both these bridge types are considered.Subsequently,finite element analysis of the full-scale 3D bridge models,to identify their IF values,considering the effects of SSI for three different soil conditions,is conducted.The IF values obtained from the study for both bridge types are comparable and are greater than the values recommended by Eurocode(2003).The results reveal that with a loss of soil stiffness,the IF value reduces;thus,it confirms the importance of SSI analysis.

Role of hepatitis B virus DNA integration in human hepatocarcinogenesis

Liver cancer ranks sixth in cancer incidence,and is the third leading cause of cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the most common type of liver cancer,which arises from hepatocytes and accounts for approximately 70%-85%of cases.Hepatitis B virus(HBV)frequently causes liver inflammation,hepatic damage and subsequent cirrhosis.Integrated viral DNA is found in 85%-90%of HBV-related HCCs.Its presence in tumors from non-cirrhotic livers of children or young adults further supports the role of viral DNA integration in hepatocarcinogenesis.Integration of subgenomic HBV DNA fragments into different locations within the host DNA is a significant feature of chronic HBV infection.Integration has two potential consequences:(1)the host genome becomes altered("cis"effect);and(2)the HBV genome becomes altered("trans"effect).The cis effect includes insertional mutagenesis,which can potentially disrupt host gene function or alter host gene regulation.Tumor progression is frequently associated with rearrangement and partial gain or loss of both viral and host sequences.However,the role of integrated HBV DNA in hepatocarcinogenesis remains controversial.Modern technology has provided a new paradigm to further our understanding ofdisease mechanisms.This review summarizes the role of HBV DNA integration in human carcinogenesis.

CONTINUOUS IMPROVEMENT THROUGH INTEGRATION OF QUALITY TOOLS

The relationship between major quality tools such as quality function development （QFD）, failure mode and effects analysis （FMEA）, design of experiments （DOE） and statistical process control （SPC） is analyzed through an extensive review of the literature and the concurrent quality engineering philosophy, and a basic structure for the integration of quality tools is presented. An integrated quality management system （IQMS） is developed using C＋＋ Builder, running in the Windows 2000 Server environment with the basic internet connections, and SQL Server 2000 as the platform for developing the database, An illustrative example applying IQMS to the continuous quality improvement for a crane equipment manufacturing is reported. The result shows that the application of IQMS can optimize the process of design and manufacturing, shorten the cycle time of product, reduce the cost, and realize quality improvement continuously, The proposed integrated framework with IOMS is believed to be applicable to continuous quality improvement in many manufacturing companies.

Expert consensus on diagnosis and treatment of ulcerative colitis with integrated traditional Chinese and Western medicine:A nursing perspective

Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western medicine.Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low cost.Therefore,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in UC.On the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine.In this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts.This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.

流程生产风险防控的功能安全完整性

为提升流程生产安全管理水平,降低事故发生概率,提出了生产过程中风险防控的功能安全完整性分析方法,并结合钢铁连铸场景进行验证。首先评估流程生产中主要事故类型的危险程度和确定其可接受频率标准;运用保护层分析法计算作业现场高危险性事故发生的真实概率,通过与可接受频率比较,判断是否需要新增防护措施;运用蒙特卡洛-马尔可夫模型验证新增防护措施的功能安全完整性等级。以大冶特钢炼钢转炉厂连铸作业区为例,结果表明:研究区内存在熔融物爆炸、火灾和中毒窒息3类高危险性事故隐患,且熔融物爆炸事故的人员伤亡后果为不可接受,需新增功能安全完整性等级为2级的防护措施;设计了防爆炸保护系统,其失效概率为4.37×10-3,满足功能安全完整性等级要求。

高质量公共政策的设计逻辑

高质量公共政策一直是行政人员和社会公众的追求与期待。政策作为人工物,是设计的产物。西方政策设计理论反思了政策过程理论和政策工具理论,认为它们过于偏重行为过程而忽略了政策内容,而政策内容才是政策的核心。然而,西方政策设计理论遗漏了以政策目标为导向的政策工具设计,也没有注意到在中国一项公共政策有多文本设计以及设计过程与政策过程相互交织的现象。基于此,论文提出,高质量公共政策的出台存在政策工具设计、过程整合设计和政策持续设计的三重设计逻辑。其中,政策工具设计是为了给不断细化的政策目标匹配高质量的具体措施,过程整合设计是将设计过程与政治过程融合以改善政策质量,而持续设计是根据多变的政策环境和多层次的政策体系不断调适政策内容。由此可见,高质量公共政策设计逻辑既是政策制定者、政策设计者与政策参与者的互动逻辑,又是科学决策、民主决策和技术决策的优化逻辑。

地铁连续刚构桥上无砟轨道无缝线路纵向力分析

【目的】为研究地铁连续刚构桥上无砟轨道无缝线路纵向受力与变形规律,对地铁连续刚构桥上无砟轨道无缝线路设计改进、运营养护维修提供理论指导。【方法】根据梁-板-轨相互作用原理,建立地铁连续刚构桥上整体道床式无砟轨道无缝线路空间耦合模型,计算伸缩、挠曲、制动、断轨工况下轨道结构和桥梁纵向力及位移,并对轨道结构静力特性进行对比分析,为地铁连续刚构桥上无缝线路轨道结构设计提供参考。【结果】结果表明:双线列车荷载中点与中部梁端处重合时为列车垂向荷载最不利工况,此时钢轨纵向力与钢轨、桥梁纵向位移均为最大,均出现在中部梁端附近,数值分别为70.3 kN与0.6,0.8 mm;双线制动荷载列车尾部位于两侧梁端时为列车制动荷载最不利工况,此时钢轨纵向力与钢轨、桥梁纵向位移均为最大,数值分别为107.8 kN与1.6,1.7 mm。【结论】伸缩力作用下各个端部桥缝处为薄弱部位,在平时养护中应特别注意梁端部桥缝处轨道结构,防止因伸缩力过大而产生断轨;钢轨发生断轨时,在断缝处纵向力、纵向位移均发生突变,严重影响线路行车安全。

基于路径故障概率分析的软件可靠性评估仿真

为了保证软件运行安全,减少故障发生概率,提出了一种持续集成环境中软件可靠性评估方法。计算软件故障率,根据计算结果划分故障等级,充分考虑组件的重要程度,量化可靠性指标,选用偏导数描述软件组件的重要程度。引入路径概念,根据软件可靠性特征,建立路径原则,对持续集成环境软件可靠性进行分析,明确路径故障概率后,当路径上的某一项运算发生错误时,整个路径即为故障路径,由此得到路径故障率,实现整体软件可靠性评估。由实验结果可知,所提方法能够得到更为精准的软件可靠性评估结果,有利于保证网络运行稳定安全。

指数有界双连续n阶α次积分C半群的扰动

利用经典算子半群理论中的研究方法,在指数有界双连续α次积分C半群的基础上,讨论了指数有界双连续n阶α次积分C半群的扰动定理。设A为次生成元的指数有界双连续n阶α次积分C半群{T(t)}_(t≥0),B为界线性算子,A、B、C可交换,则在一定条件下,C^(-1)(A+B)C_(B)生成双连续n阶α次积分C半群{T_(B)(t)}_(t≥0),并给出T_(B)(t)的表达式,从而推广了n阶α次积分C半群相关的扰动定理。

指数有界n阶α次积分C群的紧性

利用指数有界n阶α次积分C群及其次生成元的定义,并借助经典算子理论的研究方法,给出了指数有界n阶α次积分C群紧的定义,从而推导出指数有界n阶α次积分C群的紧性的一些性质。

思政教育“四个融入”高等学历继续教育人才培养全过程的实践和探索——以XX学院为例

加强学生思想政治教育是新时代赋予高校学历继续教育的使命。近年来,XX学院高等学历继续教育落实“立德树人”根本任务,积极探索思想政治教育“四个融入”,即融入思政课程、课程思政、思政队伍建设和第二课堂,推动思政教育贯穿高等学历继续教育人才培养全过程,探索线上线下相结合的思政育人新模式,构建全员、全过程、全方位的“大思政”育人格局。

NC-OFDM雷达通信一体化设计

雷达通信一体化有利于提高设备硬件资源利用率和频谱利用率,已成为近年来的研究热点。针对目前频谱资源稀缺的情况,结合认知无线电的概念,提出了基于非连续正交频分复用(NC-OFDM)的雷达通信一体化设计,对NC-OFDM雷达通信一体化信号测量目标特征进行了距离及速度的估计,并对基于NC-OFDM雷达通信一体化信号模糊函数、雷达成像的距离分辨率和方位分辨率、自相关性及误码率进行了分析,同时,选取互信息作为指标,利用优化算法进行波形设计。仿真结果表明,NC-OFDM雷达通信一体化信号具有较好的雷达探测性能和更为优良的无线通信性能。

电子耳蜗CIS语音信号处理方案的计算机仿真及声音合成

电子耳蜗是用有限个电极刺激听神经以恢复全聋人听觉的装置。本文利用耳蜗的电刺激简化模型， 在计算机上对连续交替取样 （ｃｏｎｔｉｎｕｅｄ ｉｎｔｅｒｌｅａｖｅｄ ｓａｍ ｐｌｉｎｇ， 简称ＣＩＳ） 方案进行了仿真及声音合成， 以模拟耳蜗植入者感受到的声音。仿真方法和结果对研究语音信号处理的新方案及临床参数选择具有一定的意义。

连续化工生产过程CIPS的理论与实践

针对连续化工生产过程的具体特点，对它们的ＣＩＰＳ进行了一些研究，给出了相应的功能结构模型，阐明了严格在线模拟技术及在此基础上的信息综合集成问题，最后对ＣＩＰＳ的开发方法和建设策略作了一些探讨．

连续时间域内具有积分作用的广义预测控制(CIGPC)

文献[1]推导了连续时间域内的广义预测控制规律,但由该方法所获得的控制作用不具有积分作用。因此,对于大量具有自平衡能力的过程,当设计模型的比例增益同实际过程存在误差时,将导致系统输出的稳态偏差,本文在文[1]的基础上提出了一种具有积分作用的广义预测控制方法,仿真结果表明,本文的方法不仅能够消除系统的稳态偏差,而且可使系统具有较好的控制品质。

定点DSP实现电子耳蜗CIS策略研究

连续交错采样(CIS)语音处理策略,是目前商用电子耳蜗较多采用的语音处理策略,具有较高的刺激速率和植入者对语音识别的准确率。详细阐述算法原理,并介绍在通用16位定点DSP TMS320VC5502实现CIS算法中,如何抑制溢出、保持算法稳定、滤波器系数最小字长确定及系数定标。实验数据运行结果表明,定点DSP实现CIS策略是有效可行的方法,为开发低成本商用电子耳蜗提供可靠依据。

数字化转型下的职继融通智慧化管理路径研究

加快建设高质量教育体系,统筹职业教育、高等教育、继续教育协同创新是建设教育强国、办好人民满意教育的关键任务。新时代新形势下“互联网+教育”以数字化为载体,拓展教育教学体系,是提高教育质量和效益的必然要求,是推动教育改革和创新的必由之路,是实现教育公平和普及的必然选择。