改进BIC的GNSS站坐标时序有色噪声特性分析

为了有效解决传统的极大似然估计方法存在的未知数多导致结果不准确的问题,提出一种改进BIC的GNSS站坐标时序有色噪声特性分析方法:选取全球范围内100个基准站2008—2022年坐标时序及仿真的100组坐标时序,采用赤池信息准则(AIC)、贝叶斯信息准则(BIC)、改进的贝叶斯信息准则(BIC_tp)对不同有色噪声模型进行噪声特性分析,获取基准站坐标序列的最优噪声模型及速度参数;探讨BIC_tp对噪声模型及速度估计的影响。结果表明,基准站坐标序列噪声模型呈现出多样性特征,在北(N)和东(E)方向主要表现为闪烁噪声+白噪声(FNWN)模型,天顶(U)方向主要表现为幂律噪声+白噪声(PLWN)模型;相比于AIC和BIC噪声模型估计准则,BIC_tp方法对有色噪声模型估计具有较高的准确性,尤其是闪烁噪声+随机游走噪声(RW)+白噪声(FNRWWN)模型对全球卫星导航系统(GNSS)站速度不确定度的影响在N与E方向远大于U方向;正确获取模型参数估计的实际不确定度及改正噪声分量对于合理应用GNSS坐标时间序列数据具有重要意义。

双层空竹超表面中基于BIC的局域太赫兹磁场增强的研究

设计了包含双层空竹的超表面,通过调节其晶格周期实现了不同阶晶格模式与超表面本征模式间的耦合,获得了3个强耦合区,并在两个晶格周期处实现了弗里德里希–温特根型连续域束缚态(Friedrich-Wintgen bound states in the continuum,FW-BIC)。基于耦合模理论对其进行分析,理论分析结果与模拟结果吻合,进一步证明了结构的有效性。讨论了在介质间隔层中基于强耦合和FW-BIC的局域磁场增强,发现最大磁场强度是入射太赫兹波磁场强度的41 209倍,且该值是单纯的由超表面电磁共振产生的磁场强度的4倍。这项研究将为强场太赫兹产生和太赫兹非线性研究提供参考。

BIC/FTC/TAF单片方案真实世界临床疗效和安全性研究

目的分析比克替拉韦/恩曲他滨/丙酚替诺福韦(bictegravir/emtricitabine/tenofovir alafenamide,BIC/FTC/TAF)三合一单片复方制剂在艾滋病抗病毒治疗患者中的疗效和安全性。方法纳入2022年2月1日至2022年6月1日期间接受单片复方制剂(BIC/FTC/TAF)的初治患者(初治组)和经历过治疗的患者(经治组),并使用前瞻性观察研究的方法对其治疗后的病毒学、免疫学和生化学指标进行了统计分析。结果基线共纳入了249名患者,其中经治组220例,初治组29例。48周时符合方案分析结果显示,初治组病毒完全抑制率为93.10%,经治组为98.55%。与基线相比,2组患者治疗48周后的CD4+T淋巴细胞计数和CD4^(+)/CD8^(+)T细胞比值均升高(P<0.001),血甘油三酯、总胆固醇、总胆红素和血肌酐较基线相比也有所升高,且差异具有统计学意义(P<0.05),门冬氨酸氨基转移酶和丙氨酸氨基转移酶较基线相比均有所降低,除了初治组丙氨酸氨基转移酶(P>0.05),其余3个差异均有统计学意义(P<0.05),而基于血肌酐估算的肾小球滤过率,初治组较基线有所改善(P<0.001),经治组无明显改变。结论BIC/FTC/TAF不论对初治患者还是经治患者均能有效抑制病毒的复制,提高患者的免疫能力,安全性也较好,是可以成为临床某些特定人群的首选治疗方案之一。

太赫兹全金属超构表面的极化无关准BICs研究

提出一种具有高Q值的太赫兹全金属超构表面。该超构表面由4个菱形孔组成,改变相邻菱形孔的尺寸,可以打破结构的对称性,产生准连续域束缚态(BICs);改变入射波的极化角度,激发的准BICs频率保持不变,超构表面具有极化不相关特性。优化结构参数,仿真结果表明,当尺寸偏差为3μm时,产生的准BICs实现了小于1 GHz的超窄带宽,对应Q值大于1300。实验测试结果显示,加工的样品(偏差30μm)测试Q值为40。相比于圆孔结构,菱形孔结构由于尖锐的转角可以实现较强的束缚场。本文提出的具有极化无关准BICs的超构表面在实时化学和生物分子传感中具有巨大的实际应用潜力。

Interface state-based bound states in continuum and below-continuum-resonance modes with high-Q factors in the rotational periodic system

We have introduced a new approach to calculate the orbital angular momentum(OAM)of bound states in continuum(BICs)and below-continuum-resonance(BCR)modes in the rotational periodic system nested inside and outside by transforming the Bloch wave number from the translational periodic system.We extensively classify and study these BICs and BCR modes,which exhibit high-quality(high-Q)factors,in different regions relative to the interface of the system.These BICs and BCR modes with a high-Q factor have been studied in detail based on distinctive structural parameters and scattering theory.The outcomes of this research break the periodic limitation of interface state-based BICs,and realize more and higher symmetry interface state-based BICs and BCR modes.Moreover,we can control the region where light is captured by adjusting the frequency,and show that the Q factor of BICs is more closely related to the ordinal number of rings and the rotational symmetry number of the system.

Using fracture-based continuum modeling of coupled geomechanical-hydrological processes for numerical simulation of hydraulic fracturing

This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture caging.The simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBCM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(i.e.no re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain grid.The simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injection to propagate the seeded fracture density hydraulically.FBCM combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing explicitly.Fractures are modeled as piecewise planar based on intersections with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured rock.Simulations are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical orientation.Simulations of a single-well model are used to determine the pattern and spacing for a multiple-well design.The results illustrate high-density fracturing and fracture caging through simultaneous fluid injection in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than horizontal.If preexisting fractures are steeply dipping or vertical,and considering the same in situ stress condition,well pressurization without fluid permeation appears to be the only practical way to induce new fractures and contain fracturing within the target domain.

Enhancing the Goos-Hänchen shift based on quasi-bound states in the continuum through material asymmetric dielectric compound gratings

Quasi-bound state in the continuum(QBIC)resonance is gradually attracting attention and being applied in Goos-Hänchen(GH)shift enhancement due to its high quality(Q)factor and superior optical confinement.Currently,symmetry-protected QBIC resonance is often achieved by breaking the geometric symmetry,but few cases are achieved by breaking the material symmetry.This paper proposes a dielectric compound grating to achieve a high Q factor and high-reflection symmetry-protectede QBIC resonance based on material asymmetry.Theoretical calculations show that the symmetry-protected QBIC resonance achieved by material asymmetry can significantly increase the GH shift up to-980 times the resonance wavelength,and the maximum GH shift is located at the reflection peak with unity reflectance.This paper provides a theoretical basis for designing and fabricating high-performance GH shift tunable metasurfaces/dielectric gratings in the future.

Static-to-kinematic modeling and experimental validation of tendon-driven quasi continuum manipulators with nonconstant subsegment stiffness

Continuum robots with high flexibility and compliance have the capability to operate in confined and cluttered environments. To enhance the load capacity while maintaining robot dexterity, we propose a novel non-constant subsegment stiffness structure for tendon-driven quasi continuum robots(TDQCRs) comprising rigid-flexible coupling subsegments.Aiming at real-time control applications, we present a novel static-to-kinematic modeling approach to gain a comprehensive understanding of the TDQCR model. The analytical subsegment-based kinematics for the multisection manipulator is derived based on screw theory and product of exponentials formula, and the static model considering gravity loading,actuation loading, and robot constitutive laws is established. Additionally, the effect of tension attenuation caused by routing channel friction is considered in the robot statics, resulting in improved model accuracy. The root-mean-square error between the outputs of the static model and the experimental system is less than 1.63% of the arm length(0.5 m). By employing the proposed static model, a mapping of bending angles between the configuration space and the subsegment space is established. Furthermore, motion control experiments are conducted on our TDQCR system, and the results demonstrate the effectiveness of the static-to-kinematic model.

Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed masses.The developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a matrix.The inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed masses.Additionally,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed masses.The discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization technique.The subsequent use of the second-order method of multiple scales(MMS)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed form.The novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPM for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed masses.Finally,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum models.These parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

Human immunodeficiency virus cascade–continuum of care stages and outcomes in a hospital in southern Brazil

BACKGROUND The human immunodeficiency virus(HIV)continuum of care cascade illustrates the 90-90-90 goals defined by the Joint United Nations Program on HIV/acquired immunodeficiency syndrome(UNAIDS).The care cascade includes the following five steps:Diagnosis,linkage to care,retention in care,adherence to antiretroviral therapy(ART),and viral suppression.AIM To elaborate the HIV cascade of patients diagnosed with HIV at the Nossa Senhora da Conceição Hospital(HNSC)and to determine possible local causes for the loss of patients between each step of the cascade.METHODS This retrospective cohort study included patients diagnosed with HIV infection from January 1,2015 to December 31,2016 and followed up until July 31,2019.The data were analyzed by IBM SPSS software version 25,and Poisson regression with simple robust variance was used to analyze variables in relation to each step of the cascade.Variables with P<0.20 were included in multivariable analysis,and P<0.05 was considered significant.Pearson’sχ^(2) test was used to compare the groups of patients followed up at the HNSC and those followed up at other sites.RESULTS The results were lower than those expected by the UNAIDS,with 94%of patients linked,91%retained,81%adhering to ART,and 84%in viral suppression.Age and site of follow-up were the variables with the highest statistical significance.A comparison showed that the cascade of patients from the HNSC had superior results than outpatients,with a significant difference in the last step of the cascade.CONCLUSION The specialized and continued care provided at the HNSC was associated with better results and was closer to the goals set by the UNAIDS.The development of the HIV cascade using local data allowed for the stratification and evaluation of risk factors associated with the losses occurring between each step of the cascade.

基于P-BiCS架构的hynix 3D Nand Flash产品结构分析

阐述随着电子产品及大数据信息存储应用需求增加,3D Nand Flash产品市场持续增长。介绍一种主流的3D Nand Flash技术架构,并分析应用P-BiCS架构的hynix 3D Nand Flash产品的结构及成分。

基于BIC-KMeans和SWMM的城市雨洪快速模拟方法

针对城市雨洪模型率定过程过于烦琐复杂的问题,耦合贝叶斯信息准则(BIC)和K均值聚类机器学习算法(KMeans)构建了BIC-KMeans算法。根据样本参数在不同城市功能区的分布规律,结合暴雨洪水管理模型(SWMM)提出了城市雨洪快速模拟方法。分别在郑州大学主校区、郑州市金水区南部、郑州市中心城区3个集水区选取了6、3、4场历史观测洪水事件进行了验证。结果表明:提出的城市雨洪快速模拟方法适用性较好;洼蓄量、地表曼宁系数、入渗率和衰减系数等不确定性参数在不同城市功能区的取值由小到大依次为工商业区、居民区、公共用地区;3个集水区雨洪模拟洪水流量相对误差均小于12%、纳什效率系数均大于0.75、决定系数均大于0.80,各项指标均优于传统调参法;SWMM模拟精度会随着集水区空间尺度增大而变小,峰现时间误差在较小尺度集水区雨洪模拟中是分钟级,在较大尺度为小时级。

General Kinetostatic Modeling and Deformation Analysis of a Two-Module Rod-Driven Continuum Robot with Friction Considered

Continuum robots actuated by flexible rods have large potential applications,such as detection and operation tasks in confined environments,since the push and pull actuation of flexible rods withstand tension and compressive force,and increase the structure's rigidity.In this paper,a generalized kinetostatics model for multi-module and multi-segment continuum robots considering the effect of friction based on the Cosserat rod theory is established.Then,the model is applied to a two-module rod-driven continuum robot with winding ropes to analyze its deformation and load characteristics.Four different in-plane configurations under the external load term as S1,S2,C1,and C2 are defined.Taking a bending plane as an example,the tip deformation along thex-axis of these shapes is simulated and compared,which shows that the load capacity of C1 and C2 is generally larger than that of S1 and S2.Furthermore,the deformation experiments and simulations show that the maximum error ratio without external loads relative to the total length is no more than 3%,and it is no more than 4.7%under the external load.The established kinetostatics model is proven sufficient to accurately analyze the rod-driven continuum robot with the consideration of internal friction.

Variation of soil-plant-atmosphere continuum stable isotope and water source in Qinghai spruce forest of the eastern Qilian Mountains

Understanding the hydrogen and oxygen stable isotope composition and characteristics of different water bodies in soil-plant-atmosphere continuum is of significance for revealing regional hydrological processes and water cycle mechanisms.In this study,we analyzed the stable isotopic composition,relationship and indicative significance of precipitation,soil water(0~100 cm depth)and xylem water of Qinghai spruce(Picea crassifolia)forest in the eastern Qilian Mountains,and explored the circulation process among different water bodies.The results show that the stable isotopes of precipitation vary greatly during the entire observation period.The values ofδ2H andδ^(18)O in the precipitation in the warm season are richer than those in the cold season,and the slope and intercept of local meteoric water line(LMWL,δ2H=6.79δ18O+7.13)are both smaller than global meteoric water line(GMWL,δ2H=8.17δ18O+10.56).The stable isotopes of soil water at different depths underwent different degrees of evaporative fractionation,and theδ18O andδ2H of shallow soil water varied greatly,while the deep soil water tended to be similar.The topsoil(0~10 cm)can respond quickly to precipitation,and the response of the deep soil has a time lag.In the whole growing season,0~30 cm and 60~100 cm soil water are the main water sources of Qinghai spruce.The water source of Qinghai spruce was from all soil layers in May and September,mainly from the shallow soil layer(0~30 cm)in August and October,and mainly from the deep soil layer(60~100 cm)in June and July.

Hybrid bound states in the continuum in terahertz metasurfaces

Bound states in the continuum(BICs)have exhibited extraordinary properties in photonics for enhanced light-matter interactions that enable appealing applications in nonlinear optics,biosensors,and ultrafast optical switches.The most common strategy to apply BICs in a metasurface is by breaking symmetry of resonators in the uniform array that leaks the otherwise uncoupled mode to free space and exhibits an inverse quadratic relationship between quality factor(Q)and asymmetry.Here,we propose a scheme to further reduce scattering losses and improve the robustness of symmetry-protected BICs by decreasing the radiation density with a hybrid BIC lattice.We observe a significant increase of radiative Q in the hybrid lattice compared to the uniform lattice with a factor larger than 14.6.In the hybrid BIC lattice,modes are transferred toГpoint inherited from high symmetric X,Y,and M points in the Brillouin zone that reveal as multiple Fano resonances in the far field and would find applications in hyperspectral sensing.This work initiates a novel and generalized path toward reducing scattering losses and improving the robustness of BICs in terms of lattice engineering that would release the rigid requirements of fabrication accuracy and benefit applications of photonics and optoelectronic devices.

A New Extended BIC and Sequential Lasso Regression Analysis and Their Application in Classification

In this paper, firstly, we propose a new method for choosing regularization parameter λ for lasso regression, which differs from traditional method such as multifold cross-validation, our new method gives the maximum value of parameter λ directly. Secondly, by considering another prior form over model space in the Bayes approach, we propose a new extended Bayes information criterion family, and under some mild condition, our new EBIC (NEBIC) is shown to be consistent. Then we apply our new method to choose parameter for sequential lasso regression which selects features by sequentially solving partially penalized least squares problems where the features selected in earlier steps are not penalized in the subsequent steps. Then sequential lasso uses NEBIC as the stopping rule. Finally, we apply our algorithm to identify the nonzero entries of precision matrix for high-dimensional linear discrimination analysis. Simulation results demonstrate that our algorithm has a lower misclassification rate and less computation time than its competing methods under considerations.

Variable Curvature Modeling Method of Soft Continuum Robots with Constraints

The inherent compliance of continuum robots holds great promise in the fields of soft manipulation and safe human–robot interaction.This compliance reduces the risk of damage to the manipulated object and its surroundings.However,continuum robots possess theoretically infinite degrees of freedom,and this high flexibility usually leads to complex deformations when subjected to external forces and positional constraints.Describing these complex deformations is the main challenge in modeling continuum robots.In this study,we investigated a novel variable curvature modeling method for continuum robots,considering external forces and positional constraints.The robot configuration curve is described using the developed mechanical model,and then the robot is fitted to the curve.A ten-section continuum robot prototype with a length of 1 m was developed in order to validate the model.The feasibility and accuracy of the model were verified by the ability of the robot to reach target points and track complex trajectories with a load.This work was able to serve as a new perspective for the design analysis and motion control of continuum robots.

Alfvén continuum in the presence of a magnetic island in a cylinder configuration

In this work,the effect of a magnetic island on Alfvén waves is studied.A physical model is established wherein Alfvén waves propagate in the presence of a magnetic island in a cylindrical geometry.The structure of the Alfvén wave continuum is calculated by considering only the coupling caused by the periodicity in the helical angle of the magnetic island.The results show that the magnetic island can induce an upshift in the Alfvén continuum.Moreover,the coupling between different branches of the continuous spectrum becomes more significant with increasing continuum mode numbers near the boundary of the magnetic island.

Fundamentals and applications of photonic waveguides with bound states in the continuum

Photonic waveguides are the most fundamental element for photonic integrated circuits(PICs).Waveguide properties,such as propagation loss,modal areas,nonlinear coefficients,etc.,directly determine the functionalities and performance of PICs.Recently,the emerging waveguides with bound states in the continuum(BICs)have opened new opportunities for PICs because of their special properties in resonance and radiation.Here,we review the recent progress of PICs composed of waveguides with BICs.First,fundamentals including background physics and design rules of a BIC-based waveguide will be introduced.Next,two types of BIC-based waveguide structures,including shallowly etched dielectric and hybrid waveguides,will be presented.Lastly,the challenges and opportunities of PICs with BICs will be discussed.

The Primes and Their Subsets as Continuum like the Integers

The present paper gives the proof of the set of primes as a continuum. It starts with the density of the primes, and shortly recapitulates the prime-number-formula and the complete-prime-number-formula. Reflecting the series of the primes over any prime gives the double density of occupation of integer positions by the union of the series of multiples of the primes. The remaining free positions render it possible to prove Goldbach’s conjecture and the set of primes as a continuum. The theoretical evaluation is followed in annexes by numerical evaluation, demonstrating the theoretical results. The numerical evaluation results in different constants and relations, which represent inherent properties of the set of primes.