Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and...Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.展开更多
Design and implementation of an effective control mechanism is the key to enable the controlledflight of flapping wing rotor micro aerial vehicles(FWR-MAVs).In order to address this open challenge,in this paper,a trip...Design and implementation of an effective control mechanism is the key to enable the controlledflight of flapping wing rotor micro aerial vehicles(FWR-MAVs).In order to address this open challenge,in this paper,a triple-wing FWR-MAV with its particular control system is proposed.The corresponding experimental study of the vehicle is conducted.As a result,the triple-wing propulsion system demonstrates advantages in both lift generation and flight stability based on the force measurement.The control torques of the proposed FWR-MAV are generated by a particular slipflow rudder mechanism.The effectiveness of such a design combination has been validated experimentally.A series of flight tests are conducted,including sustained hovering and forward-backward maneuvering.To the best of our knowledge,such a design yields the world's first FWR-MAV capable of sustained controlled flight.展开更多
基金sponsored by the National Key Research and Development Program of China(2021YFC2501800)the National Natural Science Foundation of China(No.U1909218)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004).
文摘Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.
基金supported by the National Natural Science Foundation of China(No.11572023).
文摘Design and implementation of an effective control mechanism is the key to enable the controlledflight of flapping wing rotor micro aerial vehicles(FWR-MAVs).In order to address this open challenge,in this paper,a triple-wing FWR-MAV with its particular control system is proposed.The corresponding experimental study of the vehicle is conducted.As a result,the triple-wing propulsion system demonstrates advantages in both lift generation and flight stability based on the force measurement.The control torques of the proposed FWR-MAV are generated by a particular slipflow rudder mechanism.The effectiveness of such a design combination has been validated experimentally.A series of flight tests are conducted,including sustained hovering and forward-backward maneuvering.To the best of our knowledge,such a design yields the world's first FWR-MAV capable of sustained controlled flight.
