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Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage 被引量:5
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作者 Jiatong Zhang Qi Zhu +4 位作者 Jie Wang Zheng Peng Zong Zhuang Chunhua Hang Wei Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期825-832,共8页
The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct facto... The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage. 展开更多
关键词 mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction mitochondrial fission and fusion mitochondrial quality control MITOPHAGY subarachnoid hemorrhage
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Application of Specialized Group Management in the Quality Control of Perioperative Nursing 被引量:2
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作者 Cong Fu Xuefei Li +4 位作者 Li Wang Yuanyuan Jiang Xinrong Qi Chen Ding Shanshan Tang 《Journal of Clinical and Nursing Research》 2024年第2期70-75,共6页
Objective:To explore the role of specialized group management in the quality control of perioperative nursing.Methods:45 surgical nurses from our hospital were selected as the research subjects.Traditional operating r... Objective:To explore the role of specialized group management in the quality control of perioperative nursing.Methods:45 surgical nurses from our hospital were selected as the research subjects.Traditional operating room management was adopted from July 2019 to June 2020,and specialized group management was adopted from July 2020 to June 2021.The surgeon’s satisfaction,surgical nurses’core professional competence,and surgical patients’satisfaction were obtained through surveys and the results were analyzed.Results:Surgeon satisfaction before the implementation of specialized group management was significantly lower than after its implementation(P<0.05).Besides,surgical nurses’core professional competency scores before the implementation of specialized group management were significantly lower than after its implementation(P<0.05).Lastly,surgical patients’satisfaction before the implementation of specialized group management was significantly lower than after its implementation(P<0.05).Conclusion:Specialized group management helps to improve the quality of perioperative care and should be applied in clinical practice. 展开更多
关键词 Specialized group management Operating room quality of care control
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Evaluation of the Impact of Refined Quality Control Management Model on the Qualified Rate of Disinfection and Sterilization of Surgical Instruments in the Sterilization Supply Center 被引量:1
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作者 Qin Liu 《Journal of Clinical and Nursing Research》 2024年第1期168-173,共6页
Objective:To evaluate the application value of a refined quality control management model for a sterilization supply center.Methods:A retrospective analysis was conducted on the work situation of the sterilization sup... Objective:To evaluate the application value of a refined quality control management model for a sterilization supply center.Methods:A retrospective analysis was conducted on the work situation of the sterilization supply center from January 2021 to January 2023.The work situation before January 31,2022,was classified as the control group;a routine quality control management model was implemented,and the work situation after January 31,2022,was classified as the observation group.The quality of medical device management and department satisfaction between the two groups were compared.Results:The timely recovery and supply rate,classification and cleaning pass rate,disinfection pass rate,packaging pass rate,sterilization pass rate,and department satisfaction score in the observation group were all higher than those of the control group(P<0.05).Conclusion:Implementing a refined quality control management model in the sterilization supply center can improve the quality management level of medical devices and department satisfaction and is worthy of promotion. 展开更多
关键词 Refined quality control management model Sterilization supply center Disinfection and sterilization pass rate
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Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control
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作者 Qi-Er Mu Yi-Sa A +1 位作者 Yan-Qiu Bai Chu-La Sa 《Traditional Medicine Research》 2024年第12期13-30,共18页
Gentiana macrophylla Pall.(G.macrophylla),whose genus and family belong to the Gentianaceae and Gentiana.The main distribution centers of G.macrophylla resources were the Loess Plateau and the eastern Qinghai-Tibet Pl... Gentiana macrophylla Pall.(G.macrophylla),whose genus and family belong to the Gentianaceae and Gentiana.The main distribution centers of G.macrophylla resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in China.G.macrophylla,as a traditional medicine,has a long history and was used in different ethnic medicines.Its roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing swelling.From previous studies,it could be found that there were more than forty components isolated and identified from G.macrophylla.The main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and alkaloids.Iridoid terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of G.macrophylla,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract activities.The flower mainly contains isoorientin and isovitexin as the representative of flavonoids.They have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of melanin.It could be seen from previous studies that the research on G.macrophylla was mainly focused on the root,and the flower was rarely studied.It was reported that the experimental data of the anti-inflammatory and anti-tumor effects of G.macrophylla flowers show that its curative effect was very good.Therefore,the flowers of the flower of G.macrophylla can be used as potential medicinal parts for research.Given that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about G.macrophylla’s potential medical benefits.Based on botanical books,Chinese classic texts,medical monographs and academic search engines(Google,Google Scholar,Web of Science,SciFinder,Pubmed,CNKI,Sci-hub,Elsevier and Wanfang),the data and information on G.macrophylla in the past 20 years are inquired and summarized comprehensively.The basic source,traditional use,chemical composition,biological activity,pharmacodynamics and quality control of G.macrophylla was systematically reviewed,in order to provide reliable basis for the subsequent development and utilization of G.macrophylla. 展开更多
关键词 Gentiana macrophylla Pall basic source chemical component pharmacological activity quality control
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Identification of the Diffusion Coefficients of Pollutants ( N O 3 - and Mn2+) through the Walls of Concrete Tank and Vulnerability of the Stored Water Quality
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作者 Narcisse Malanda Bienvenu Ebata Ndion +2 位作者 Christian Tathy Thibault Mongo Paul Louzolokimbembe 《Engineering(科研)》 2024年第9期246-274,共29页
The populations of urban centers in Congo-Brazzaville have decided to develop various methods of water storage (concrete or masonry underground tanks) for domestic use, due to shortages in the distribution of water th... The populations of urban centers in Congo-Brazzaville have decided to develop various methods of water storage (concrete or masonry underground tanks) for domestic use, due to shortages in the distribution of water through the public network. However, questions remain as to the physico-chemical quality of the water stored in these tanks, when these structures are built in wet and relatively polluted areas. This paper presents a model of pollutant diffusion through the cementitious matrix (concrete) of tank walls simulated at a buried reservoir. The results of the experimental and numerical simulations show that certain concrete parameters, such as porosity, permeability and diffusivity, have a significant influence on the transfer of pollutants through the concrete walls, thus altering the physico-chemical quality of the stored water. The numerical models (1D) used to predict pollutant transfer and the quality of the stored water are consistent with those of the optimal control for identifying the diffusion coefficient. Major ion concentrations appear to be correlated with system porosity and diffusion coefficient. Nevertheless, the identification of the diffusion coefficient from the optimal control method, based on an explicit numerical resolution of a finite volume PDE for the approximation of the experiment, is not consistent with that of the optimal control method. 展开更多
关键词 Buried Tank Water concrete Modelling Optimal control Diffusion Coefficient
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Research on the Application of Evidence-Based Quality Control Circle to Improve the Implementation Rate of Airway Management Measures in Adult Critically Ill Patients
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作者 Yujiao Yan Jing Wu +4 位作者 Juan Liu Yanting Yuan Lixin Liu Huaxin Ye Juan Ding 《Yangtze Medicine》 2024年第1期8-19,共12页
Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs ... Objective: To explore the effect of evidence-based quality control circle (QCC) in improving the implementation rate of airway management measures in adult critically ill patients. Methods: Based on the Joanna Briggs Institute (JBI) evidence-based health care model, the best evidence of airway management in adult critically ill patients was obtained and applied to the clinic. Results: The total implementation rate of airway management measures in adult critically ill patients increased from 23.62% before the implementation of quality control circle to 88.82%, and the pulmonary infection rate in critically ill patients decreased from 42.31% to 21.74%, with statistical significance between the two groups (P 0.05). Conclusion: Evidence-based quality control circle activities can standardize the practice standards of airway management in critically ill patients, reduce the occurrence of patients’ airway related complications, and improve clinical outcomes. 展开更多
关键词 Critically Ill Patients Airway Management Be Evidence-Based quality control Circle Intensive Care Unit (ICU)
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Deep learning models semi-automatic training system for quality control of transthoracic echocardiography
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作者 QIAN Sunnan WENG Hexiang +7 位作者 CHENG Hanlin SHI Zhongqing WANG Xiaoxian GUO Guanjun FANG Aijuan LUO Shouhua YAO Jing QI Zhanru 《中国医学影像技术》 CSCD 北大核心 2024年第8期1140-1145,共6页
Objective To explore the value of deep learning(DL)models semi-automatic training system for automatic optimization of clinical image quality control of transthoracic echocardiography(TTE).Methods Totally 1250 TTE vid... Objective To explore the value of deep learning(DL)models semi-automatic training system for automatic optimization of clinical image quality control of transthoracic echocardiography(TTE).Methods Totally 1250 TTE videos from 402 patients were retrospectively collected,including 490 apical four chamber(A4C),310 parasternal long axis view of left ventricle(PLAX)and 450 parasternal short axis view of great vessel(PSAX GV).The videos were divided into development set(245 A4C,155 PLAX,225 PSAX GV),semi-automated training set(98 A4C,62 PLAX,90 PSAX GV)and test set(147 A4C,93 PLAX,135 PSAX GV)at the ratio of 5∶2∶3.Based on development set and semi-automatic training set,DL model of quality control was semi-automatically iteratively optimized,and a semi-automatic training system was constructed,then the efficacy of DL models for recognizing TTE views and assessing imaging quality of TTE were verified in test set.Results After optimization,the overall accuracy,precision,recall,and F1 score of DL models for recognizing TTE views in test set improved from 97.33%,97.26%,97.26%and 97.26%to 99.73%,99.65%,99.77%and 99.71%,respectively,while the overall accuracy for assessing A4C,PLAX and PSAX GV TTE as standard views in test set improved from 89.12%,83.87%and 90.37%to 93.20%,90.32%and 93.33%,respectively.Conclusion The developed DL models semi-automatic training system could improve the efficiency of clinical imaging quality control of TTE and increase iteration speed. 展开更多
关键词 ECHOCARDIOGRAPHY quality control artificial intelligence
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Data Quality Control Method of a New Drifting Observation Technology Named Drifting Air-Sea Interface Buoy
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作者 LI Shuo WANG Bin +3 位作者 DENG Zeng’an WU Baoqin ZHU Xiande CHEN Zhaohui 《Journal of Ocean University of China》 CAS CSCD 2024年第1期11-22,共12页
An integral quality control(QC)procedure that integrates various QC methods and considers the design indexes and operational status of the instruments for the observations of drifting air-sea interface buoy was develo... An integral quality control(QC)procedure that integrates various QC methods and considers the design indexes and operational status of the instruments for the observations of drifting air-sea interface buoy was developed in the order of basic in-spection followed by targeted QC.The innovative method of combining a moving Hampel filter and local anomaly detection com-plies with statistical laws and physical processes,which guarantees the QC performance of meteorological variables.Two sets of observation data were used to verify the applicability and effectiveness of the QC procedure,and the effect was evaluated using the observations of the Kuroshio Extension Observatory buoy as the reference.The results showed that the outliers in the time series can be correctly identified and processed,and the quality of data improved significantly.The linear correlation between the quality-controlled observations and the reference increased,and the difference decreased.The correlation coefficient of wind speed before and after QC increased from 0.77 to 0.82,and the maximum absolute error decreased by approximately 2.8ms^(-1).In addition,air pressure and relative humidity were optimized by 10^(-3)–10^(-2) orders of magnitude.For the sea surface temperature,the weight of coefficients of the continuity test algorithm was optimized based on the sea area of data acquisition,which effectively expanded the applicability of the algorithm. 展开更多
关键词 drifting air-sea interface buoy quality control oceanic variables meteorological variables continuity test
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Spatiotemporal variations in ecosystem services and their trade-offs and synergies against the background of the gully control and land consolidation project on the Loess Plateau,China
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作者 WANG Jing WEI Yulu +2 位作者 PENG Biao LIU Siqi LI Jianfeng 《Journal of Arid Land》 SCIE CSCD 2024年第1期131-145,共15页
Studying the spatiotemporal variations in ecosystem services and their interrelationships on the Loess Plateau against the background of the gully control and land consolidation(GCLC)project has significant implicatio... Studying the spatiotemporal variations in ecosystem services and their interrelationships on the Loess Plateau against the background of the gully control and land consolidation(GCLC)project has significant implications for ecological protection and quality development of the Yellow River Basin.Therefore,in this study,we took Yan'an City,Shaanxi Province of China,as the study area,selected four typical ecosystem services,including soil conservation service,water yield service,carbon storage service,and habitat quality service,and quantitatively evaluated the spatiotemporal variation characteristics and trade-offs and synergies of ecosystem services from 2010 to 2018 using the Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model.We also analysed the relationship between the GCLC project and regional ecosystem service changes in various regions(including 1 city,2 districts,and 10 counties)of Yan'an City and proposed a coordinated development strategy between the GCLC project and the ecological environment.The results showed that,from 2010 to 2018,soil conservation service decreased by 7.76%,while the other three ecosystem services changed relatively little,with water yield service increasing by 0.56% and carbon storage service and habitat quality service decreasing by 0.16% and 0.14%,respectively.The ecological environment of Yan'an City developed in a balanced way between 2010 and 2018,and the four ecosystem services showed synergistic relationships,among which the synergistic relationships between soil conservation service and water yield service and between carbon storage service and habitat quality service were significant.The GCLC project had a negative impact on the ecosystem services of Yan'an City,and the impact on carbon storage service was more significant.This study provides a theoretical basis for the scientific evaluation of the ecological benefits of the GCLC project and the realization of a win-win situation between food security and ecological security. 展开更多
关键词 ecosystem services trade-offs and synergies gully control and land consolidation habitat quality Integrated Valuation of Ecosystem Services and Trade-offs(InVEST)model Loess Plateau
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Identification of Sudanese Sesame Oil Quality Using a 680 nm Semiconductor Laser Spectrometer and Other Techniques
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作者 Mohammed Uthman Orsod Mubarak Dirar Abdalla +2 位作者 Ganesan Krishnan Babikir Osman Elbashir Faiz Mohamed Budr Elshafia 《Optics and Photonics Journal》 2024年第3期29-45,共17页
This study investigates the optical properties of sesame oil from traditional and industrial sources using a custom-designed semiconductor laser spectrometer, UV-Vis spectroscopy, and FTIR spectroscopy. Six samples we... This study investigates the optical properties of sesame oil from traditional and industrial sources using a custom-designed semiconductor laser spectrometer, UV-Vis spectroscopy, and FTIR spectroscopy. Six samples were collected from traditional presses and factories in Khartoum State and White Nile State. The spectrometer, constructed with a 680 nm semiconductor laser and various resistor values, measured the absorbance of sesame oil samples. UV-Vis spectroscopy identified absorbance peaks at 670 nm and 417 nm, corresponding to chlorophyll a and b. FTIR analysis showed nearly identical spectra among the samples, indicating similar chemical compositions. Laser spectrometer analysis revealed specific absorbance values for each sample. The results highlight the feasibility of using a 680 nm semiconductor laser for analyzing sesame oil, providing a cost-effective alternative to other wavelengths. This study demonstrates the potential of integrating traditional methods with modern spectroscopic techniques for the quality assessment of sesame oil. 展开更多
关键词 Industrial Oil Production Laser Spectroscopy quality control Sudanese Sesame Oil Traditional Sesame Oil Traditional Oil Presses
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Construction of a New Model of Contactless Medical Services for Outpatients Based on the Project-Achieving Quality Control Circle 被引量:2
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作者 Shuang Chen Zhihong Gao +1 位作者 Xiaoxia Huang Zhiqin Yin 《Journal of Clinical and Nursing Research》 2023年第4期29-37,共9页
Objective: To carry out empirical research on the role of project-achieving quality control circle (QCC) in constructing a new model of contactless medical service for outpatients. Methods: A QCC, consisting of inform... Objective: To carry out empirical research on the role of project-achieving quality control circle (QCC) in constructing a new model of contactless medical service for outpatients. Methods: A QCC, consisting of information office members from a grade A tertiary hospital in Wenzhou, was established to conduct a research project with the theme “Constructing a new model of contactless medical service based on outpatients’ experience.” According to the ten steps and PDCA cycle, an analysis was carried out before and after the QCC activities, focusing on improving pre-consultation services, providing steward-like services, and facilitating post-consultation management. Results: After the QCC activities, the mobile appointment rate, missed appointment rate, the proportion of smart check-ins, and the average check-in time were 55.68%, 4.02%, 39.75%, and 8.24 ± 3.66 min, respectively;in contrast, before the activities, they were 32.00%, 7.88%, 0.00%, and 14.96 ± 4.98 min, respectively;the difference between the two groups was statistically significant (χ2 = 3480.112, 4994.496;Fisher’s exact probability = 963788.570;t = 5.323, P < 0.001). Many experts have also visited the hospital to learn about this system, thus rendering social and economic benefits. Conclusion: Project-achieving QCC activities are suitable for complex situations, such as constructing a new model of contactless medical service, and can significantly improve outpatient service quality, enhance patients’ experience, and improve the abilities of circle members. 展开更多
关键词 quality control circle Project-achieving Outpatient Contactless medical service Patient experience
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Analysis of the Effect of Quality Control Circle on the Central Sterile Supply Department 被引量:1
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作者 Xiaoxiao Kong 《Journal of Clinical and Nursing Research》 2023年第6期89-94,共6页
Objective:To analyze the effect of quality control circle on the central sterile supply department(CSSD).Methods:The control group and the observation group each consisted of 180 instruments received by the sterilizat... Objective:To analyze the effect of quality control circle on the central sterile supply department(CSSD).Methods:The control group and the observation group each consisted of 180 instruments received by the sterilization supply center from January to March 2023 and 11 CSSD staff.The control group underwent routine management while quality control circle was implemented in the observation group.The quality of work,disinfection and sterilization qualification rates,disinfection and sterilization of various instruments,cleaning indicators,and management satisfaction of both groups were compared.Results:The observation group scored higher in terms of work quality,the qualification rate of disinfection and sterilization in each link,the disinfection and sterilization of instruments,and cleaning indicators compared to the control group.Besides,the management satisfaction of the observation group was higher than that of the control group(P<0.05).Conclusion:A quality control circle ensures the quality of work,improves the cleaning,disinfection,and sterilization of instruments of the CSSD,and improves the management satisfaction of the CSSD staff. 展开更多
关键词 quality control circle Central sterile supply department Nursing quality Disinfection and sterilization
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Establishment of Characteristic Chromatogram of Honeysuckle Stem Formula Granules Based on the Concept of Whole Process Quality Control
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作者 Minling WEI Haixi LI +2 位作者 Xiongmei HUANG Bingli LIANG Hongyan WEI 《Medicinal Plant》 CAS 2023年第3期29-32,37,共5页
[Objectives]To establish a HPLC characteristic spectrum of honeysuckle stem formula granules,and to evaluate the quality consistency based on the standard decoction.[Methods]Using Agilent ZORBAX SB-C_(18)(5μm,250 mm&... [Objectives]To establish a HPLC characteristic spectrum of honeysuckle stem formula granules,and to evaluate the quality consistency based on the standard decoction.[Methods]Using Agilent ZORBAX SB-C_(18)(5μm,250 mm×4.6 mm)chromatographic column;gradient elution with acetonitrile-0.4%phosphoric acid solution(0.2:99.8,V/V),column temperature at 25℃;detection wavelength at 236 nm;flow rate 1.0 mL/min;using"Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine",to evaluate the similarity of the characteristic chromatogram of crude drug,standard decoction and formula granules of honeysuckle stem.[Results]The similarity of characteristic chromatogram was higher than 0.94,and 6 components were identified from 10 characteristic peaks.[Conclusions]The established method can more comprehensively reflect the overall appearance of the chemical substances in the honeysuckle stem and the transmission law,and can provide an experimental basis for the consistency of the quality of the honeysuckle stem formula granules. 展开更多
关键词 Honeysuckle stem formula granules Standard decoction Characteristic chromatogram HPLC Correlation quality control
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The Construction and Implementation Path of the Audit System for Quality Control in the Big Data Era
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作者 Wenjun Zou 《Proceedings of Business and Economic Studies》 2023年第6期111-115,共5页
In the era of big data,the construction and implementation of a quality control audit system are particularly crucial.This article delves into the impact of big data technology on quality control auditing,establishes ... In the era of big data,the construction and implementation of a quality control audit system are particularly crucial.This article delves into the impact of big data technology on quality control auditing,establishes a quality control auditing system in the big data era,and elucidates the pathway to realizing this system.Through the application of big data technology to quality control audits,there is an enhancement in audit efficiency,the attainment of more accurate risk assessment,and the provision of robust support for the sustainable development of enterprises. 展开更多
关键词 Big data quality control Audit system
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The pathogenic mechanism of TAR DNA-binding protein 43(TDP-43)in amyotrophic lateral sclerosis 被引量:2
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作者 Xinxin Wang Yushu Hu Renshi Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期800-806,共7页
The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves t... The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves the muscles of the upper and/or lower extremities,and the muscles of the bulbar and/or respiratory regions.However,as the disease progresses,it affects the adjacent body regions,leading to generalized muscle weakness,occasionally along with memory,cognitive,behavioral,and language impairments;respiratory dysfunction occurs at the final stage of the disease.The disease has a complicated pathophysiology and currently,only riluzole,edaravone,and phenylbutyrate/taurursodiol are licensed to treat amyotrophic lateral sclerosis in many industrialized countries.The TAR DNA-binding protein 43 inclusions are observed in 97%of those diagnosed with amyotrophic lateral sclerosis.This review provides a preliminary overview of the potential effects of TAR DNAbinding protein 43 in the pathogenesis of amyotrophic lateral sclerosis,including the abnormalities in nucleoplasmic transport,RNA function,post-translational modification,liquid-liquid phase separation,stress granules,mitochondrial dysfunction,oxidative stress,axonal transport,protein quality control system,and non-cellular autonomous functions(e.g.,glial cell functions and prion-like propagation). 展开更多
关键词 amyotrophic lateral sclerosis axonal transport liquid-liquid phase separation noncellular autonomous functions oxidative stress PATHOGENESIS post-translational modification protein quality control system stress granules TAR DNA-binding protein 43(TDP-43)
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Basic regulatory science behind drug substance and drug product specifications of monoclonal antibodies and other protein therapeutics
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作者 Patanachai K.Limpikirati Sorrayut Mongkoltipparat +7 位作者 Thinnaphat Denchaipradit Nathathai Siwasophonpong Wudthipong Pornnopparat Parawan Ramanandana Phumrapee Pianpaktr Songsak Tongchusak Maoxin Tim Tian Trairak Pisitkun 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第6期785-804,共20页
In this review,we focus on providing basics and examples for each component of the protein therapeutic specifications to interested pharmacists and biopharmaceutical scientists with a goal to strengthen understanding ... In this review,we focus on providing basics and examples for each component of the protein therapeutic specifications to interested pharmacists and biopharmaceutical scientists with a goal to strengthen understanding in regulatory science and compliance.Pharmaceutical specifications comprise a list of important quality attributes for testing,references to use for test procedures,and appropriate acceptance criteria for the tests,and they are set up to ensure that when a drug product is administered to a patient,its intended therapeutic benefits and safety can be rendered appropriately.Conformance of drug substance or drug product to the specifications is achieved by testing an article according to the listed tests and analytical methods and obtaining test results that meet the acceptance criteria.Quality attributes are chosen to be tested based on their quality risk,and consideration should be given to the merit of the analytical methods which are associated with the acceptance criteria of the specifications.Acceptance criteria are set forth primarily based on efficacy and safety profiles,with an increasing attention noted for patient-centric specifications.Discussed in this work are related guidelines that support the biopharmaceutical specification setting,how to set the acceptance criteria,and examples of the quality attributes and the analytical methods from 60 articles and 23 pharmacopeial monographs.Outlooks are also explored on process analytical technologies and other orthogonal tools which are on-trend in biopharmaceutical characterization and quality control. 展开更多
关键词 Biopharmaceutical analysis Biopharmaceutical quality control Biopharmaceutical specifications Monoclonal antibodies Protein therapeutics Regulatory science
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An improved wind quality control for the China-France Oceanography Satellite (CFOSAT) scatterometer
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作者 Xiaoheng Mou Wenming Lin 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第5期100-109,共10页
Quality control(QC)is an essential procedure in scatterometer wind retrieval,which is used to distinguish good-quality data from poor-quality wind vector cells(WVCs)for the sake of wind applications.The current wind p... Quality control(QC)is an essential procedure in scatterometer wind retrieval,which is used to distinguish good-quality data from poor-quality wind vector cells(WVCs)for the sake of wind applications.The current wind processor of the China-France Oceanography Satellite(CFOSAT)scatterometer(CSCAT)adopts a maximum likelihood estimator(MLE)-based QC method to filter WVCs affected by geophysical noise,such as rainfall and wind variability.As the first Ku-band rotating fan-beam scatterometer,CSCAT can acquire up to 16 observations over a single WVC,giving abundant information with diverse incidence/azimuth angles,as such its MLE statistical characteristics may be different from the previous scatterometers.In this study,several QC indicators,including MLE,its spatially averaged value(MLE_(m)),and the singularity exponents(SE),are analyzed using the collocated Global Precipitation Mission rainfall data as well as buoy data,to compare their sensitivity to rainfall and wind quality.The results show that wind error characteristics of CSCAT under different QC methods are similar to those of other Ku-band scatterometers,i.e.,SE is more suitable than other parameters for the wind QC at outer-swath and nadir regions,while MLE_(m) is the best QC indicator for the sweet region WVCs.Specifically,SE is much more favorable than others at high wind speeds.By combining different indicators,an improved QC method is developed for CSCAT.The validation with the collocated buoy data shows that it accepts more WVCs,and in turn,improves the quality control of CSCAT wind data. 展开更多
关键词 China-France Oceanography Satellite(CFOSAT) SCATTEROMETER winds quality control(QC) singularity exponent(SE)
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Application of Sigma Metric Analysis to Evaluate the Performance of the Biochemistry Analytical System in a Medical Biology Laboratory in Côte d’Ivoire
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作者 Koffi Akissi Joelle Kouakou Francisk +3 位作者 Kouadio Charlotte Yeo Karna Ahiboh Hugues Hauhouot-Attoungbré Marie-Laure 《Journal of Analytical Sciences, Methods and Instrumentation》 2024年第1期14-21,共8页
Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology... Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology laboratory. Using the sigma metric, this study assessed the performance of the Biochemistry analytical system of a medical biology laboratory in Côte d'Ivoire. Methods: Six Sigma methodology was applied to 3 analytes (alanine aminotransferase, glucose and creatinine). Performance indicators such as measurement imprecision and bias were determined based on the results of internal and external quality controls. The sigma number was calculated using the total allowable error values proposed by Ricos et al. Results: For both control levels, ALT had a sigma number greater than 6 (7.6 for normal control and 7.9 for pathological control). However, low sigma numbers, less than or equal to 2 for creatinine (1.4 for normal control and 2 for pathological control) and less than 1 for glucose were found. Conclusion: This study revealed good analytical performance of ALT from the point of view of 6 sigma analysis. However, modifications to the overall quality control procedure for glucose and creatinine are needed to improve their analytical performance. The study should be extended to the entire laboratory’s analytes in order to modify the strategies of quality control procedures based on metric analysis for an overall improvement in analytical performance. 展开更多
关键词 Six Sigma Qualities controls BIAS IMPRECISION Total Allowable Error
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Application of PDCA in improving hand hygiene compliance and nosocomial infection quality in orthopedics
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作者 Ya-Ping Su Rui-Ling Li +2 位作者 Yuan-Yuan Wang Yu-Rui Zhang Ya-Jie Ji 《Frontiers of Nursing》 2024年第3期327-336,共10页
Objective:To explore the effect of the Plan-Do-Check-Action(PDCA)cycle on hand hygiene and nosocomial infection quality of or thopedic medical staff.Methods:The whole year of 2021 was selected to monitor the quality o... Objective:To explore the effect of the Plan-Do-Check-Action(PDCA)cycle on hand hygiene and nosocomial infection quality of or thopedic medical staff.Methods:The whole year of 2021 was selected to monitor the quality of hand hygiene and hospitalization.Follow-up monitoring and real-time recording during the period of morning shift and medical operation concentration time,and compare the compliance of hand hygiene before and after implementation,and evaluate the quality of nosocomial infection.Results:The hand hygiene compliance of doctors and nurses in stage P was 82%.The compliance of medical staff in stage D was 93%.The compliance of stage C was 94%and that of stage A was 95%.The quality score of hospital self-examination nosocomial infection was also significantly increased.Conclusions:The PDCA management cycle can effectively improve the compliance of hand hygiene and the nosocomial infection quality,which is wor thy of circulatory application in or thopedic nosocomial infection quality control,especially improving the quality of hand hygiene. 展开更多
关键词 hand hygiene quality improvement PDCA nosocomial infection infection control nursing management
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Research on Quality Management Measures of Green Building Construction
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作者 Jie Hong Xiang Xu 《Journal of Architectural Research and Development》 2024年第3期8-13,共6页
Urbanization has led to the rapid development of the construction industry.However,this has also led to higher requirements for the construction engineering management.Other than the quality monitoring of engineering ... Urbanization has led to the rapid development of the construction industry.However,this has also led to higher requirements for the construction engineering management.Other than the quality monitoring of engineering construction,the energy-saving properties of the building should also be considered.Therefore,a scientific management approach should be adopted to improve green building management.This paper primarily examines the importance of quality management in green building construction,along with the factors influencing it.It also identifies the quality issues present in current green building construction.Finally,it proposes measures for quality management in the green building construction process to facilitate the industry’s healthy development. 展开更多
关键词 Green building engineering Construction process control quality management Construction publicity
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