Control rod is a primary control part of emergency control and power regulation in nuclear reactor. The main application of it is to control fast change of the reactivity. The theoretical analysis for the worth of con...Control rod is a primary control part of emergency control and power regulation in nuclear reactor. The main application of it is to control fast change of the reactivity. The theoretical analysis for the worth of control rod is necessary in the stage of design. Based on design requirements, some results are calculated. Firstly, control rod worth with different density of neutron absorber is calculated by MCNP here. Secondly, the study of integral and differential control rod worth is presented in this paper while the control rod is inserted into reactor core and total worth of three rods with different positions are also calculated. Finally, the effect of the axial and radial neutron flux in reactor core which is caused by the control rods is simulated. The simulation results of the control rods meet design requirements for TMSR.展开更多
Two tests initiated by unscrammed control rod withdrawal were performed on the High Temperature GasCooled Reactor-Test Module(HTR-10) in November 2003 after the reactor achieved its full power, and the test conditions...Two tests initiated by unscrammed control rod withdrawal were performed on the High Temperature GasCooled Reactor-Test Module(HTR-10) in November 2003 after the reactor achieved its full power, and the test conditions represented a typical transient scenario of modular high-temperature reactors(HTRs), called pressurized loss of forced cooling, and anticipated transient without scram.Based on the test parameters, the HTR-10 thermal behaviors under the test conditions were studied with the help of the system analysis code THERMIX. The combination of the test results and the investigation results makes the HTR-10 safety potential better understood. Key phenomena, such as the helium natural circulation and the temperature redistribution in the reactor, were revealed. As the safety feature of most significance, there is a large margin between the maximum fuel temperature and its safety limit in each test. Temperatures of thermocouples in different components were calculated by THERMIX and compared with the test values. The applicability of the code was verified by good agreement obtained from the comparison.展开更多
A permanent magnet BLDC(brushless direct current) motor is used to move the control rod of a miniature neutron source reactor(MNSR). The BLDC motor drive is modeled using MATLAB/SIMULINK. Two main parts of the modelin...A permanent magnet BLDC(brushless direct current) motor is used to move the control rod of a miniature neutron source reactor(MNSR). The BLDC motor drive is modeled using MATLAB/SIMULINK. Two main parts of the modeling are the inverter switching and the current control. Current control with chopping used to minimize the torque ripple of the MNSR control rod drive. Fuzzy logic current control together with soft chopping control shows the best response of all the three strategies. The prototype drive mechanism has an ATmega32 controller and power MOSFET switches. The simulation results are compared with experimental drive mechanism.展开更多
Control rod is used to change the power in nuclear reactor.?Certainly, the core at any moment can be made subcritical condition and shut downs when occurring?to emergency instance in the core. The rod is grouped based...Control rod is used to change the power in nuclear reactor.?Certainly, the core at any moment can be made subcritical condition and shut downs when occurring?to emergency instance in the core. The rod is grouped based?on their function and located at different places in the core where their feature is maximized.?Two methods of control rod calibration are the asymptotic period method and the rod-drop method, which were applied in this experiment. In the first method, the reactor is made supcritical by inserting the control rod to be calibrated a certain level. The rod drop method is to determine the subcritical;at the critical state, the rod to be calibrated is dropped into the core, and the resulting decay of neutron flux is observed and related to the reactivity. In this paper, the regulating rod will be calibrated according to the reactivity in OPR-1000 that corresponds to a certain control rod insert or withdraw, and the reactivity in power reactor depends?on the integral and differential control rod group too. The core simulator OPR1000 is used to test those methods.展开更多
The reactivity worth measurement system for control rods of the TRIGA MARK-II research reactor of Bangladesh has been design and developed. The theory of the kinetic technique of measuring reactivity has been used by ...The reactivity worth measurement system for control rods of the TRIGA MARK-II research reactor of Bangladesh has been design and developed. The theory of the kinetic technique of measuring reactivity has been used by this measurement system. The system comprises of indigenous hardware and software for online acquisition of neutron flux signals from reactor console and then computes the reactivity worth accordingly. Here for the TRIGA MARK-II research reactor, the reactivity measurement system was implemented with a dedicated circuit assembly and a conventional personal computer. A high-level Visual Basic real-time programming has been developed for data acquisition, reactivity calculation, online display (numerically as well as graphically), saving data, etc. To measure reactivity worth of TRIGA reactor control rods the rod drop experimental technique has been adopted. The results of tests experiments, carried out with the rod drop method for measuring various reactivity worth of control rods have been presented in the paper. A comparison between this results with the results using period method and that of computation method, demonstrated that the response of this reactivity measurement system is fast enough to monitor and measure the safety-related reactivity and power excursions in the reactor.展开更多
In this work,two approaches,based on the certified Reduced Basis method,have been developed for simulating the movement of nuclear reactor control rods,in time-dependent non-coercive settings featuring a 3D geometrica...In this work,two approaches,based on the certified Reduced Basis method,have been developed for simulating the movement of nuclear reactor control rods,in time-dependent non-coercive settings featuring a 3D geometrical framework.In particular,in a first approach,a piece-wise affine transformation based on subdomains division has been implemented for modelling the movement of one control rod.In the second approach,a“staircase”strategy has been adopted for simulating themovement of all the three rods featured by the nuclear reactor chosen as case study.The neutron kinetics has been modelled according to the so-called multi-group neutron diffusion,which,in the present case,is a set of ten coupled parametrized parabolic equations(two energy groups for the neutron flux,and eight for the precursors).Both the reduced order models,developed according to the two approaches,provided a very good accuracy comparedwith high-fidelity results,assumed as“truth”solutions.At the same time,the computational speed-up in the Online phase,with respect to the fine“truth”finite element discretization,achievable by both the proposed approaches is at least of three orders of magnitude,allowing a real-time simulation of the rod movement and control.展开更多
A code. OPTROD. based on dynamic programming method is developed and utilized to optimize control rod positions throughout the fuel cycle of the 200 MW nuclear heating reactor (NHR-200). A fuel cycle is divided into m...A code. OPTROD. based on dynamic programming method is developed and utilized to optimize control rod positions throughout the fuel cycle of the 200 MW nuclear heating reactor (NHR-200). A fuel cycle is divided into many steps or stages. Optimization of the multistage process is solved iteratively in the forward direction throughout a fuel cycle. The dynamic programming method is much more efficient than the normal nonlinear programming method. Convergence is obtained even if poor initial control rod positions are given.展开更多
Control rod is the most important approach to control reactivity in reactors,which is currently a cluster of pins filled with boron carbide(B4C).In this case,neutrons are captured in the outer region,and thus the inne...Control rod is the most important approach to control reactivity in reactors,which is currently a cluster of pins filled with boron carbide(B4C).In this case,neutrons are captured in the outer region,and thus the inner absorber is inefficient.Moreover,the lifetime of the control rod is challenged due to the high reactivity worth loss resulted from the excessive degradation of B4C in the high flux area.In this work,some control rod designs are proposed with optimized spatial structures including the spatially mixed rod,radially moderated rod,and composite control rod with small-sized pins.The control rod worth and effective absorption cross section of these designs are computed using the Monte Carlo code RMC.A long-time depletion calculation is conducted to evaluate their burnup stability.For the spatially mixed rod,rare-earth absorbers are combined with B4C in spatial structure.Compared with the homogenous B4C rod,mixed designs ensure more sufficient reactivity worth in the lifetime of the reactor.The minimum reactivity loss at the end of the cycle is only 1.8%from the dysprosium titanate rod,while the loss for pure B4C rod is nearly 12%.For the radially moderated design,a doubled neutronic efficiency is achieved when the volume ratio of moderator equals approximately 0.3,while excessive moderating may lead to the failure of control rods.The control rod with small-sized pins processes an enhanced safety performance and saves the investment in absorbers.The rod worth can be further enhanced by introducing small moderator pins,and the reactivity loss caused by the reduction of absorbers is sustainable.展开更多
This paper introduces the simulation, and controls using Simulink of MATLAB for PCTRAN (Personal Computer Transient Analysis) of the power control system (PWR) type pressurized water reactor of PWR WESTINGHOUSE AP1000...This paper introduces the simulation, and controls using Simulink of MATLAB for PCTRAN (Personal Computer Transient Analysis) of the power control system (PWR) type pressurized water reactor of PWR WESTINGHOUSE AP1000. The power controller model produces mathematical model description in nonlinear relation form in Simulink of MATLAB which is an important and popular program used at most universities for education. The power controller is described by a block diagram in this paper and some details introduce to clearly understand the work function. The results of action control compared with the PCTRAN programme in modes of automatic and manual control.展开更多
小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型...小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型棒控压水堆控制棒布置与动作策略设计分析。首先,基于OpenMC程序开发带棒燃耗程序;其次,比较堆芯带控制棒与无控制棒运行时的堆芯寿期等指标;最后,分析不同动作策略对轴向功率偏移等指标的影响。结果表明:控制棒将堆芯寿期从590 EFPDs(等效满功率天,Effective full power days)延长至650~698 EFPDs;低价值棒组优先动作策略使轴向功率偏移程度由−0.69与+0.80分别下降至−0.29与+0.52。因此,要准确计算长寿期压水堆寿期必须采用带控制棒燃耗计算策略,并且通过合理的动作策略能够有效减小控制棒带来的轴向功率偏移。展开更多
An integral terminal sliding mode controller is proposed in order to control chaos in a rod-type plasma torch system.In this method, a new sliding surface is defined based on a combination of the conventional sliding ...An integral terminal sliding mode controller is proposed in order to control chaos in a rod-type plasma torch system.In this method, a new sliding surface is defined based on a combination of the conventional sliding surface in terminal sliding mode control and a nonlinear function of the integral of the system states. It is assumed that the dynamics of a chaotic system are unknown and also the system is exposed to disturbance and unstructured uncertainty. To achieve a chattering-free and high-speed response for such an unknown system, an adaptive neuro-fuzzy inference system is utilized in the next step to approximate the unknown part of the nonlinear dynamics. Then, the proposed integral terminal sliding mode controller stabilizes the approximated system based on Lyapunov's stability theory. In addition, a Bee algorithm is used to select the coefficients of integral terminal sliding mode controller to improve the performance of the proposed method. Simulation results demonstrate the improvement in the response speed, chattering rejection, transient response,and robustness against uncertainties.展开更多
背景:随着磁控制生长棒技术在治疗脊柱畸形领域的不断完善进步,已有大量的研究投入到该项领域当中,但主要研究现状、热点与发展趋势尚不够明确。目的:基于文献计量学探讨来自不同国家运用磁控制生长棒治疗脊柱畸形研究领域中文章的质量...背景:随着磁控制生长棒技术在治疗脊柱畸形领域的不断完善进步,已有大量的研究投入到该项领域当中,但主要研究现状、热点与发展趋势尚不够明确。目的:基于文献计量学探讨来自不同国家运用磁控制生长棒治疗脊柱畸形研究领域中文章的质量和数量,旨在阐明磁控制生长棒在全球发展趋势以及评估在世界范围内研究生产力、研究趋势与研究热点。方法:主要基于Web of Science核心集数据库对1998-2023年发表的文章进行检索。使用CiteSpace 5.8和VOSviewer 1.6.19软件对数据进行分析,并生成可视化知识图谱。对所有研究进行以下参数的评估:发表论文总数、中心性、h指数、国家、作者、期刊的贡献,通过文献共被引、高被引文献和文献关键词爆发等分析来进行趋势与热点的探究。结果与结论:①最终纳入138篇文献。在2009-2020年,该领域发表的文章数量逐渐增加。美国发文量最多(53篇,37.32%),同时美国的文章研究h指数及中心性最高。②关键词分析结果显示,排名前10位的关键词例如早发性脊柱侧弯、外科手术及并发症等,客观真实地反映了磁控制生长棒在治疗脊柱畸形领域的现状和热点;因磁控制生长棒例如锚钉拔出、植入失败和杆断裂等风险因素而导致的治疗失效、相应医学分级的精准运用、生活质量和大脑性瘫痪等并发症的监测治疗是该领域近年来的研究热点。③文献共被引结果显示,结合磁控制生长棒技术的创新性和有效性研究,对应脊柱畸形的分型应用以及相关并发症的监测治疗可能是该领域的研究趋势。④诸多高被引文献进一步强调了磁控制生长棒技术的治疗运用效果,为矫正脊柱畸形领域提供一种有效的治疗新思路与技术支持。⑤文献关键词爆发分析结果显示,磁控制生长棒应用的风险因素、医学分级、生活质量和大脑性瘫痪可能成为该领域的研究前沿。⑥文章结果证实,磁控制生长棒技术对脊柱畸形的分型运用以及相关并发症的深度研究是该领域的发展趋势,但要深入了解磁控制生长棒技术治疗脊柱畸形的有效性与安全性,还需要一个长期的随访证据;该领域整体研究水平近年来稳步提升,但也存在高质量文献数量较少及各地区研究发展不平衡等问题。展开更多
基金Supported by "Strategic Priority Research Program" of the Chinese Academy of Science (XDA02001003)
文摘Control rod is a primary control part of emergency control and power regulation in nuclear reactor. The main application of it is to control fast change of the reactivity. The theoretical analysis for the worth of control rod is necessary in the stage of design. Based on design requirements, some results are calculated. Firstly, control rod worth with different density of neutron absorber is calculated by MCNP here. Secondly, the study of integral and differential control rod worth is presented in this paper while the control rod is inserted into reactor core and total worth of three rods with different positions are also calculated. Finally, the effect of the axial and radial neutron flux in reactor core which is caused by the control rods is simulated. The simulation results of the control rods meet design requirements for TMSR.
基金supported by the Chinese National S&T Major Project(No.ZX069)
文摘Two tests initiated by unscrammed control rod withdrawal were performed on the High Temperature GasCooled Reactor-Test Module(HTR-10) in November 2003 after the reactor achieved its full power, and the test conditions represented a typical transient scenario of modular high-temperature reactors(HTRs), called pressurized loss of forced cooling, and anticipated transient without scram.Based on the test parameters, the HTR-10 thermal behaviors under the test conditions were studied with the help of the system analysis code THERMIX. The combination of the test results and the investigation results makes the HTR-10 safety potential better understood. Key phenomena, such as the helium natural circulation and the temperature redistribution in the reactor, were revealed. As the safety feature of most significance, there is a large margin between the maximum fuel temperature and its safety limit in each test. Temperatures of thermocouples in different components were calculated by THERMIX and compared with the test values. The applicability of the code was verified by good agreement obtained from the comparison.
基金Supported by Research Contract of the Islamic Azad University’s Aliabad Katoul branch
文摘A permanent magnet BLDC(brushless direct current) motor is used to move the control rod of a miniature neutron source reactor(MNSR). The BLDC motor drive is modeled using MATLAB/SIMULINK. Two main parts of the modeling are the inverter switching and the current control. Current control with chopping used to minimize the torque ripple of the MNSR control rod drive. Fuzzy logic current control together with soft chopping control shows the best response of all the three strategies. The prototype drive mechanism has an ATmega32 controller and power MOSFET switches. The simulation results are compared with experimental drive mechanism.
文摘Control rod is used to change the power in nuclear reactor.?Certainly, the core at any moment can be made subcritical condition and shut downs when occurring?to emergency instance in the core. The rod is grouped based?on their function and located at different places in the core where their feature is maximized.?Two methods of control rod calibration are the asymptotic period method and the rod-drop method, which were applied in this experiment. In the first method, the reactor is made supcritical by inserting the control rod to be calibrated a certain level. The rod drop method is to determine the subcritical;at the critical state, the rod to be calibrated is dropped into the core, and the resulting decay of neutron flux is observed and related to the reactivity. In this paper, the regulating rod will be calibrated according to the reactivity in OPR-1000 that corresponds to a certain control rod insert or withdraw, and the reactivity in power reactor depends?on the integral and differential control rod group too. The core simulator OPR1000 is used to test those methods.
文摘The reactivity worth measurement system for control rods of the TRIGA MARK-II research reactor of Bangladesh has been design and developed. The theory of the kinetic technique of measuring reactivity has been used by this measurement system. The system comprises of indigenous hardware and software for online acquisition of neutron flux signals from reactor console and then computes the reactivity worth accordingly. Here for the TRIGA MARK-II research reactor, the reactivity measurement system was implemented with a dedicated circuit assembly and a conventional personal computer. A high-level Visual Basic real-time programming has been developed for data acquisition, reactivity calculation, online display (numerically as well as graphically), saving data, etc. To measure reactivity worth of TRIGA reactor control rods the rod drop experimental technique has been adopted. The results of tests experiments, carried out with the rod drop method for measuring various reactivity worth of control rods have been presented in the paper. A comparison between this results with the results using period method and that of computation method, demonstrated that the response of this reactivity measurement system is fast enough to monitor and measure the safety-related reactivity and power excursions in the reactor.
基金We acknowledge CINECA and Regione Lombardia LISA computational initiative,for the availability of high performance computing resources and support.G.Rozza acknowledges INDAM-GNCS national activity group and NOFYSAS program of SISSA.
文摘In this work,two approaches,based on the certified Reduced Basis method,have been developed for simulating the movement of nuclear reactor control rods,in time-dependent non-coercive settings featuring a 3D geometrical framework.In particular,in a first approach,a piece-wise affine transformation based on subdomains division has been implemented for modelling the movement of one control rod.In the second approach,a“staircase”strategy has been adopted for simulating themovement of all the three rods featured by the nuclear reactor chosen as case study.The neutron kinetics has been modelled according to the so-called multi-group neutron diffusion,which,in the present case,is a set of ten coupled parametrized parabolic equations(two energy groups for the neutron flux,and eight for the precursors).Both the reduced order models,developed according to the two approaches,provided a very good accuracy comparedwith high-fidelity results,assumed as“truth”solutions.At the same time,the computational speed-up in the Online phase,with respect to the fine“truth”finite element discretization,achievable by both the proposed approaches is at least of three orders of magnitude,allowing a real-time simulation of the rod movement and control.
文摘A code. OPTROD. based on dynamic programming method is developed and utilized to optimize control rod positions throughout the fuel cycle of the 200 MW nuclear heating reactor (NHR-200). A fuel cycle is divided into many steps or stages. Optimization of the multistage process is solved iteratively in the forward direction throughout a fuel cycle. The dynamic programming method is much more efficient than the normal nonlinear programming method. Convergence is obtained even if poor initial control rod positions are given.
基金the National Key R&D Project(Grant No.2020YFB1901700)the National Natural Science Foundation of China(Grant No.11775127).
文摘Control rod is the most important approach to control reactivity in reactors,which is currently a cluster of pins filled with boron carbide(B4C).In this case,neutrons are captured in the outer region,and thus the inner absorber is inefficient.Moreover,the lifetime of the control rod is challenged due to the high reactivity worth loss resulted from the excessive degradation of B4C in the high flux area.In this work,some control rod designs are proposed with optimized spatial structures including the spatially mixed rod,radially moderated rod,and composite control rod with small-sized pins.The control rod worth and effective absorption cross section of these designs are computed using the Monte Carlo code RMC.A long-time depletion calculation is conducted to evaluate their burnup stability.For the spatially mixed rod,rare-earth absorbers are combined with B4C in spatial structure.Compared with the homogenous B4C rod,mixed designs ensure more sufficient reactivity worth in the lifetime of the reactor.The minimum reactivity loss at the end of the cycle is only 1.8%from the dysprosium titanate rod,while the loss for pure B4C rod is nearly 12%.For the radially moderated design,a doubled neutronic efficiency is achieved when the volume ratio of moderator equals approximately 0.3,while excessive moderating may lead to the failure of control rods.The control rod with small-sized pins processes an enhanced safety performance and saves the investment in absorbers.The rod worth can be further enhanced by introducing small moderator pins,and the reactivity loss caused by the reduction of absorbers is sustainable.
文摘This paper introduces the simulation, and controls using Simulink of MATLAB for PCTRAN (Personal Computer Transient Analysis) of the power control system (PWR) type pressurized water reactor of PWR WESTINGHOUSE AP1000. The power controller model produces mathematical model description in nonlinear relation form in Simulink of MATLAB which is an important and popular program used at most universities for education. The power controller is described by a block diagram in this paper and some details introduce to clearly understand the work function. The results of action control compared with the PCTRAN programme in modes of automatic and manual control.
文摘小型棒控压水堆舍弃了可溶硼,并高度依赖控制棒与可燃毒物棒控制堆芯的反应性。为研究控制棒对堆芯关键性能的影响,本文以核动力破冰船用KLT-40模型为对象,以轴向功率偏移、堆芯寿期、燃料利用率与径向功率峰因子为指标,开展长寿期小型棒控压水堆控制棒布置与动作策略设计分析。首先,基于OpenMC程序开发带棒燃耗程序;其次,比较堆芯带控制棒与无控制棒运行时的堆芯寿期等指标;最后,分析不同动作策略对轴向功率偏移等指标的影响。结果表明:控制棒将堆芯寿期从590 EFPDs(等效满功率天,Effective full power days)延长至650~698 EFPDs;低价值棒组优先动作策略使轴向功率偏移程度由−0.69与+0.80分别下降至−0.29与+0.52。因此,要准确计算长寿期压水堆寿期必须采用带控制棒燃耗计算策略,并且通过合理的动作策略能够有效减小控制棒带来的轴向功率偏移。
文摘An integral terminal sliding mode controller is proposed in order to control chaos in a rod-type plasma torch system.In this method, a new sliding surface is defined based on a combination of the conventional sliding surface in terminal sliding mode control and a nonlinear function of the integral of the system states. It is assumed that the dynamics of a chaotic system are unknown and also the system is exposed to disturbance and unstructured uncertainty. To achieve a chattering-free and high-speed response for such an unknown system, an adaptive neuro-fuzzy inference system is utilized in the next step to approximate the unknown part of the nonlinear dynamics. Then, the proposed integral terminal sliding mode controller stabilizes the approximated system based on Lyapunov's stability theory. In addition, a Bee algorithm is used to select the coefficients of integral terminal sliding mode controller to improve the performance of the proposed method. Simulation results demonstrate the improvement in the response speed, chattering rejection, transient response,and robustness against uncertainties.
文摘背景:随着磁控制生长棒技术在治疗脊柱畸形领域的不断完善进步,已有大量的研究投入到该项领域当中,但主要研究现状、热点与发展趋势尚不够明确。目的:基于文献计量学探讨来自不同国家运用磁控制生长棒治疗脊柱畸形研究领域中文章的质量和数量,旨在阐明磁控制生长棒在全球发展趋势以及评估在世界范围内研究生产力、研究趋势与研究热点。方法:主要基于Web of Science核心集数据库对1998-2023年发表的文章进行检索。使用CiteSpace 5.8和VOSviewer 1.6.19软件对数据进行分析,并生成可视化知识图谱。对所有研究进行以下参数的评估:发表论文总数、中心性、h指数、国家、作者、期刊的贡献,通过文献共被引、高被引文献和文献关键词爆发等分析来进行趋势与热点的探究。结果与结论:①最终纳入138篇文献。在2009-2020年,该领域发表的文章数量逐渐增加。美国发文量最多(53篇,37.32%),同时美国的文章研究h指数及中心性最高。②关键词分析结果显示,排名前10位的关键词例如早发性脊柱侧弯、外科手术及并发症等,客观真实地反映了磁控制生长棒在治疗脊柱畸形领域的现状和热点;因磁控制生长棒例如锚钉拔出、植入失败和杆断裂等风险因素而导致的治疗失效、相应医学分级的精准运用、生活质量和大脑性瘫痪等并发症的监测治疗是该领域近年来的研究热点。③文献共被引结果显示,结合磁控制生长棒技术的创新性和有效性研究,对应脊柱畸形的分型应用以及相关并发症的监测治疗可能是该领域的研究趋势。④诸多高被引文献进一步强调了磁控制生长棒技术的治疗运用效果,为矫正脊柱畸形领域提供一种有效的治疗新思路与技术支持。⑤文献关键词爆发分析结果显示,磁控制生长棒应用的风险因素、医学分级、生活质量和大脑性瘫痪可能成为该领域的研究前沿。⑥文章结果证实,磁控制生长棒技术对脊柱畸形的分型运用以及相关并发症的深度研究是该领域的发展趋势,但要深入了解磁控制生长棒技术治疗脊柱畸形的有效性与安全性,还需要一个长期的随访证据;该领域整体研究水平近年来稳步提升,但也存在高质量文献数量较少及各地区研究发展不平衡等问题。