Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9

RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant（Prx1Cre;Rbpjkf/f）, Rbpjk mutant/Sox9 haploinsufficient（Prx1Cre;Rbpjkf/f;Sox9f/1）,and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.

Adaptive signal control and coordination for urban traffic control in a connected vehicle environment: A review

Existing signal control systems for urban traffic are usually based on traffic flow data from fixed location detectors.Because of rapid advances in emerging vehicular communication,connected vehicle(CV)-based signal control demonstrates significant improvements over existing conventional signal control systems.Though various CV-based signal control systems have been investigated in the past decades,these approaches still have many issues and drawbacks to overcome.We summarize typical components and structures of these existing CV-based urban traffic signal control systems and digest several important issues from the summarized vital concepts.Last,future research directions are discussed with some suggestions.We hope this survey can facilitate the connected and automated vehicle and transportation research community to efficiently approach next-generation urban traffic signal control methods and systems.

An integrated and cooperative architecture for multi-intersection traffic signal control

Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms and traffic signal communication.In this paper,we propose(1)an integrated and cooperative Internet-of-Things architecture,namely General City Traffic Computing System(GCTCS),which simultaneously leverages an urban traffic simulation environment,TSC algorithms,and traffic signal communication;and(2)a general multi-agent reinforcement learning algorithm,namely General-MARL,considering cooperation and communication between traffic lights for multi-intersection TSC.In experiments,we demonstrate that the integrated and cooperative architecture of GCTCS is much closer to the real-life traffic environment.The General-MARL increases the average movement speed of vehicles in traffic by 23.2%while decreases the network latency by 11.7%.

FL-FN-MOGA Based Traffic Signal Control

In this paper, a traffic signal control method based on fuzzy logic (FL), fuzzy-neuro (FN) and multi-objective genetic algorithms (MOGA) for an isolated four-approach intersection with through and left-turning movements is presented. This method has an adaptive signal timing ability, and can make adjustments to signal timing in response to observed changes.The 'urgency degree' term, which can describe the different user's demand for green time is used in decision-making by which strategy of signal timing can be determined. Using a fuzzy logic controller, we can determine whether to extend or terminate the current signal phase and select the sequences of phases. In this paper, a method based on fuzzy-neuro can be used to predict traffic parameters used in fuzzy logic controller. The feasibility of using a multi-objective genetic algorithm ( MOGA) to find a group of optimizing sets of parameters for fuzzy logic controller depending on different objects is also demonstrated. Simulation results show that the proposed methed is effecfive to adjust the signal timing in response to changing traffic conditions on a real-time basis, and the controller can produce lower vehicle delays and percentage of stopped vehicles than a traffic-actuated controller.

Evolution of Road Traffic Congestion Control:A Survey from Perspective of Sensing,Communication,and Computation

Road traffic congestion can inevitably de-grade road infrastructure and decrease travel efficiency in urban traffic networks,which can be relieved by employing appropriate congestion control.Accord-ing to different developmental driving forces,in this paper,the evolution of road traffic congestion control is divided into two stages.The ever-growing num-ber of advanced sensing techniques can be seen as the key driving force of the first stage,called the sens-ing stage,in which congestion control strategies ex-perienced rapid growth owing to the accessibility of traffic data.At the second stage,i.e.,the communica-tion stage,communication and computation capabil-ity can be regarded as the identifying symbols for this stage,where the ability of collecting finer-grained in-sight into transportation and mobility reality improves dramatically with advances in vehicular networks,Big Data,and artificial intelligence.Specifically,as the pre-requisite for congestion control,in this paper,ex-isting congestion detection techniques are first elab-orated and classified.Then,a comprehensive survey of the recent advances for current congestion control strategies with a focus on traffic signal control,vehi-cle route guidance,and their combined techniques is provided.In this regard,the evolution of these strate-gies with continuous development of sensing,com-munication,and computation capability are also intro-duced.Finally,the paper concludes with several re-search challenges and trends to fully promote the in-tegration of advanced techniques for traffic congestion mitigation in transportation systems.

Bus Priority Control for Dynamic Exclusive Bus Lane

One problem with the existing dynamic exclusive bus lane strategies is that bus signal priority strategies with multi-phase priority request at intersections are not adequately considered.The principle of bus signal priority level was designed based on the isolated multi-phase structure principle consideration of the bus signal priority,and a new priority approach for the dynamic exclusive bus lane was proposed.Two types of priority strategies,green extension and red truncation,were proposed for current phase and next phase buses,respectively.The control parameters including minimum green time,green extension time,maximum green time and bus arrival time are calculated.The case studies for this paper were carried out using four consecutive intersections of Huaide Middle Road in Changzhou City.The signal control scheme was designed using the conventional,exclusive bus lane method,the dynamic exclusive bus lane without signal priority method,and the proposed approach,respectively.The authors used the VISSIM simulation platform to evaluate the efficiency of each approach.Results showed that the method of approach can significantly decrease delays caused by social and conventional buses and make up for the negative impact social buses have on the bus rapid transit(BRT)operation,which allows the method to complement the dynamic,exclusive bus lane design.

Direct Digital Frequency Control Based on the Phase Step Change Characteristic between Signals

We present a new digital phase lock technology to achieve the frequency control and transformation through high precision multi-cycle group synchronization between signals without the frequency transformation circuit. In the case of digital sampling, the passing zero point of the phase of the controlled signal has the phase step characteristic, the phase step of the passing zero point is monotonic continuous with high resolution in the phase lock process, and using the border effect of digital fuzzy area, the gate can synchronize with the two signals, the quantization error is reduced. This technique is quite different from the existing methods of frequency transformation and frequency synthesis, the phase change characteristic between the periodic signals with different nominal is used. The phase change has the periodic phenomenon, and it has the high resolution step value. With the application of the physical law, the noise is reduced because of simplifying frequency transformation circuits, and the phase is locked with high precision. The regular phase change between frequency signals is only used for frequency measurement, and the change has evident randomness, but this randomness is greatly reduced in frequency control, and the certainty of the process result is clear. The experiment shows that the short term frequency stability can reach 10-12/s orders of magnitude.

DEVELOPMENT AND USAGE OF SIGNAL PR OCESSING AND SOUND SITIMULATING SYSTEM CONTROLLED BY COMPUTER

In hearing physiological experiments and clinic tests,we need not only a signal processing system,but also a synchronous sound stimulator’ Most of stimulators we are now using are function generators which are independent to processing units,and can be controlled only by hand. Although some of them have ports through which they can be controlled by computer,but as they are designed for industrial aims,not for hearing research,most of them can’t generate the special waveforms we need. We use the TDT signal processing system and develop a software package have both usage. On the interface of the program we can control the sampling parameters and generate stimulating waveforms’

Simulation of large-scale numerical substructure in real-time dynamic hybrid testing

A solution scheme is proposed in this paper for an existing RTDHT system to simulate large-scale finite element （FE） numerical substructures. The analysis of the FE numerical substructure is split into response analysis and signal generation tasks, and executed in two different target computers in real-time. One target computer implements the response analysis task, wherein a large time-step is used to solve the FE substructure, and another target computer implements the signal generation task, wherein an interpolation program is used to generate control signals in a small time-step to meet the input demand of the controller. By using this strategy, the scale of the FE numerical substructure simulation may be increased significantly. The proposed scheme is initially verified by two FE numerical substructure models with 98 and 1240 degrees of freedom （DOFs）. Thereafter, RTDHTs of a single frame-foundation structure are implemented where the foundation, considered as the numerical substructure, is simulated by the FE model with 1240 DOFs. Good agreements between the results of the RTDHT and those from the FE analysis in ABAQUS are obtained.

Robust backstepping global integral terminal sliding mode controller to enhance dynamic stability of hybrid AC/DC microgrids

In this paper,a Backstepping Global Integral Terminal Sliding Mode Controller(BGITSMC)with the view to enhancing the dynamic stability of a hybrid AC/DC microgrid has been presented.The proposed approach controls the switch-ing signals of the inverter,interlinking the DC-bus with the AC-bus in an AC/DC microgrid for a seamless interface and regulation of the output power of renewable energy sources(Solar Photovoltaic unit,PMSG-based wind farm),and Battery Energy Storage System.The proposed control approach guarantees the dynamic stability of a hybrid AC/DC microgrid by regulating the associated states of the microgrid system to their intended values.The dynamic stabil-ity of the microgrid system with the proposed control law has been proved using the Control Lyapunov Function.A simulation analysis was performed on a test hybrid AC/DC microgrid system to demonstrate the performance of the proposed control strategy in terms of maintaining power balance while the system’s operating point changed.Furthermore,the superiority of the proposed approach has been demonstrated by comparing its performance with the existing Sliding Mode Control(SMC)approach for a hybrid AC/DC microgrid.

Multifunctional Intelligent Security Integrated System of Highway Level Crossing

In consideration of the safety of drivers,we designed a multifunctional intelligent security guarantee integrated system for highway level crossing.Different from the existing intersection signs on the market,intelligent highway-level intersection indicators are based on the use of deep learning and computer vision technology to build a convolutional neural network model that can accurately recognize traffic accident images and traffic jams in a short period of time as well as obtain real-time road and highway meteorological environment information.

A multi process value-based reinforcement learning environment framework for adaptive traffic signal control

Realising adaptive traffic signal control(ATSC)through reinforcement learning(RL)is an important means to easetraffic congestion.This paper finds the computing power of the central processing unit(CPU)cannot fully usedwhen Simulation of Urban MObility(SUMO)is used as an environment simulator for RL.We propose a multi-process framework under value-basedRL.First,we propose a shared memory mechanism to improve exploration efficiency.Second,we use the weight sharing mechanism to solve the problem of asynchronous multi-process agents.We also explained the reason shared memory in ATSC does not lead to early local optima of the agent.Wehave verified in experiments the sampling efficiency of the 10-process method is 8.259 times that of the single process.The sampling efficiency of the 20-process method is 13.409 times that of the single process.Moreover,the agent can also converge to the optimal solution.

Adaptive feedback control of stability in an axial compressor with circumferential inlet distortion

The adaptive feedback control of stability with circumferential inlet distortion has been experimentally investigated in a low-speed,axial compressor.The flat-baffles with different span heights are used to simulate different distorted inflow cases.Compared with auto-correlation and root-mean-square analysis,cross-correlation analysis used to predict early stall warning does not depend on the distortion position.Hence,the cross-correlation coefficient was used to monitor the stable status of the compressor and provide the feedback signal in the active control strategy when suffering from different distortions.Based on the stall margin improvement of tip air injection obtained under different distorted inflow cases and the sensitivity analysis of cross-correlation coefficients to injected momentum ratios,tip air injection was adopted as the actuator for adaptive feedback control.The digital signal processing controller was designed and applied to achieve adaptive feedback control in distorted inflow conditions.The results show that the adaptive feedback control of air injection nearly achieves the same stall margin improvement as steady air injection under different distortion intensities with a reduced injection mass flow.Thus,the proposed adaptive feedback control method is ideal for the engine operation with circumferential distorted inflow,which frequently occurs in flight.

Intersection signal control multi-objective optimization based on genetic algorithm

A signal control intersection increases not only vehicle delay, but also vehicle emissions and fuel consumption in that area. Because more and more fuel and air pollution problems arise recently, an intersection signal control optimization method which aims at reducing vehicle emissions, fuel consumption and vehicle delay is required heavily. This paper proposed a signal control multi-object optimization method to reduce vehicle emissions, fuel consumption and vehicle delay simultaneously at an intersection. The optimization method combined the Paramics microscopic traffic simulation software, Comprehensive Modal Emissions Model （CMEM）, and genetic algorithm. An intersection in Haizhu District, Guangzhou, was taken for a case study. The result of the case study shows the optimal timing scheme obtained from this method is better than the Webster timing scheme.

State-Space Equations and the First-Phase Algorithm for Signal Control of Single Intersections

State-space equations were applied to formulate the queuing and delay of traffic at a single intersection in this paper. The signal control of a single intersection was then modeled as a discrete-time optimal control problem, with consideration of the constraints of stream conflicts, saturation flow rate, minimum green time, and maximum green time. The problem cannot be solved directly due to the nonlinear constraints. However, the results of qualitative analysis were used to develop a first-phase signal control algorithm. Simulation results show that the algorithm substantially reduces the total delay compared to fixed-time control.

Adaptive green traffic signal controlling using vehicular communication

The importance of using adaptive traffic signal control for figuring out the unpredictable traffic congestion in today's metropolitan life cannot be overemphasized. The vehicular ad hoc network(VANET), as an integral component of intelligent transportation systems(ITSs), is a new potent technology that has recently gained the attention of academics to replace traditional instruments for providing information for adaptive traffic signal controlling systems(TSCSs). Meanwhile, the suggestions of VANET-based TSCS approaches have some weaknesses:(1) imperfect compatibility of signal timing algorithms with the obtained VANET-based data types, and(2) inefficient process of gathering and transmitting vehicle density information from the perspective of network quality of service(Qo S). This paper proposes an approach that reduces the aforementioned problems and improves the performance of TSCS by decreasing the vehicle waiting time, and subsequently their pollutant emissions at intersections. To achieve these goals, a combination of vehicle-to-vehicle(V2V) and vehicle-to-infrastructure(V2I) communications is used. The V2 V communication scheme incorporates the procedure of density calculation of vehicles in clusters, and V2 I communication is employed to transfer the computed density information and prioritized movements information to the road side traffic controller. The main traffic input for applying traffic assessment in this approach is the queue length of vehicle clusters at the intersections. The proposed approach is compared with one of the popular VANET-based related approaches called MC-DRIVE in addition to the traditional simple adaptive TSCS that uses the Webster method. The evaluation results show the superiority of the proposed approach based on both traffic and network Qo S criteria.

Urban Intersection Traffic Signal Control Based on Fuzzy Logic

This paper presents a fuzzy logic adaptive traffic signal control method for an isolated four-approach intersection with through and left-turning movements. In the proposed method, the fuzzy logic controller can make adjustments to signal timing in response to observed changes. The 'urgency degree' term that can describe different user's demands for a green light is used in the fuzzy logic decision-making. In addition, a three-level fuzzy controller model decides whether to extend or terminate the current signal phase and the sequence of phases. Simulation results show that the fuzzy controller can adjust its signal timing in response to changing traffic conditions on a real-time basis and that the proposed fuzzy logic controller leads to less vehicle delays and a lower percentage of stopped vehicles.

Image-based traffic signal control via world models

Traffic signal control is shifting from passive control to proactive control, which enables the controller to direct current traffic flow to reach its expected destinations. To this end, an effective prediction model is needed for signal controllers. What to predict, how to predict, and how to leverage the prediction for control policy optimization are critical problems for proactive traffic signal control. In this paper, we use an image that contains vehicle positions to describe intersection traffic states. Then, inspired by a model-based reinforcement learning method, DreamerV2,we introduce a novel learning-based traffic world model. The traffic world model that describes traffic dynamics in image form is used as an abstract alternative to the traffic environment to generate multi-step planning data for control policy optimization. In the execution phase, the optimized traffic controller directly outputs actions in real time based on abstract representations of traffic states, and the world model can also predict the impact of different control behaviors on future traffic conditions. Experimental results indicate that the traffic world model enables the optimized real-time control policy to outperform common baselines, and the model achieves accurate image-based prediction, showing promising applications in futuristic traffic signal control.

Traffic signal control in mixed traffic environment based on advance decision and reinforcement learning

Reinforcement learning-based traffic signal control systems (RLTSC) can enhance dynamic adaptability, save vehicle travelling timeand promote intersection capacity. However, the existing RLTSC methods do not consider the driver’s response time requirement, sothe systems often face efficiency limitations and implementation difficulties.We propose the advance decision-making reinforcementlearning traffic signal control (AD-RLTSC) algorithm to improve traffic efficiency while ensuring safety in mixed traffic environment.First, the relationship between the intersection perception range and the signal control period is established and the trust region state(TRS) is proposed. Then, the scalable state matrix is dynamically adjusted to decide the future signal light status. The decision will bedisplayed to the human-driven vehicles (HDVs) through the bi-countdown timer mechanism and sent to the nearby connected automatedvehicles (CAVs) using the wireless network rather than be executed immediately. HDVs and CAVs optimize the driving speedbased on the remaining green (or red) time. Besides, the Double Dueling Deep Q-learning Network algorithm is used for reinforcementlearning training;a standardized reward is proposed to enhance the performance of intersection control and prioritized experiencereplay is adopted to improve sample utilization. The experimental results on vehicle micro-behaviour and traffic macro-efficiencyshowed that the proposed AD-RLTSC algorithm can simultaneously improve both traffic efficiency and traffic flow stability.

Improving schedule adherence based on dynamic signal control and speed guidance in connected bus system

Purpose–The purpose of this paper is to develop a dynamic control method to improve bus schedule adherence under connected bus system.Design/methodology/approach–The authors developed a dynamic programming model that optimally schedules the bus operating speed at road sections and multiple signal timing plans at intersections to improve bus schedule adherence.First,the bus route was partitioned into three types of sections:stop,road and intersection.Then,transit agencies can control buses in real time based on all collected information;i.e.control bus operating speed on road sections and adjust the signal timing plans through signal controllers to improve the schedule adherence in connected bus environment.Finally,bus punctuality at the downstream stop and the saturation degree deviations of intersections were selected as the evaluation criteria in optimizing signal control plans and bus speeds jointly.Findings–An illustrative case study by using a bus rapid transit line in Jinan city was performed to verify the proposed model.It revealed that based on the proposed strategy,the objective value could be reduced by 73.7%,which indicated that the punctuality was highly improved but not to incur excessive congestion for other vehicular traffic.Originality/value–In this paper,the authors applied speed guidance and the adjustment of the signal control plans for multiple cycles in advance to improve the scheduled stability;furthermore,the proposed control strategy can reduce the effect on private traffics to the utmost extend.