The rise in hydrogen production powered by renewable energy is driving the field toward the adoption of systems comprising multiple alkaline water electrolyzers.These setups present various operational modes:independe...The rise in hydrogen production powered by renewable energy is driving the field toward the adoption of systems comprising multiple alkaline water electrolyzers.These setups present various operational modes:independent operation and multi-electrolyzer parallelization,each with distinct advantages and challenges.This study introduces an innovative configuration that incorporates a mutual lye mixer among electrolyzers,establishing a weakly coupled system that combines the advantages of two modes.This approach enables efficient heat utilization for faster hot-startup and maintains heat conservation post-lye interconnection,while preserving the option for independent operation after decoupling.A specialized thermal exchange model is developed for this topology,according to the dynamics of the lye mixer.The study further details startup procedures and proposes optimized control strategies tailored to this structural design.Waste heat from the caustic fully heats up the multiple electrolyzers connected to the lye mixing system,enabling a rapid hot start to enhance the system’s ability to track renewable energy.A control strategy is established to reduce heat loss and increase startup speed,and the optimal valve openings of the diverter valve and the manifold valve are determined.Simulation results indicate a considerable enhancement in operational efficiency,marked by an 18.28%improvement in startup speed and a 6.11%reduction in startup energy consumption inmulti-electrolyzer cluster systems,particularlywhen the systems are synchronized with photovoltaic energy sources.The findings represent a significant stride toward efficient and sustainable hydrogen production,offering a promising path for large-scale integration of renewable energy.展开更多
This paper addresses the micro wind-hydrogen coupled system,aiming to improve the power tracking capability of micro wind farms,the regulation capability of hydrogen storage systems,and to mitigate the volatility of w...This paper addresses the micro wind-hydrogen coupled system,aiming to improve the power tracking capability of micro wind farms,the regulation capability of hydrogen storage systems,and to mitigate the volatility of wind power generation.A predictive control strategy for the micro wind-hydrogen coupled system is proposed based on the ultra-short-term wind power prediction,the hydrogen storage state division interval,and the daily scheduled output of wind power generation.The control strategy maximizes the power tracking capability,the regulation capability of the hydrogen storage system,and the fluctuation of the joint output of the wind-hydrogen coupled system as the objective functions,and adaptively optimizes the control coefficients of the hydrogen storage interval and the output parameters of the system by the combined sigmoid function and particle swarm algorithm(sigmoid-PSO).Compared with the real-time control strategy,the proposed predictive control strategy can significantly improve the output tracking capability of the wind-hydrogen coupling system,minimize the gap between the actual output and the predicted output,significantly enhance the regulation capability of the hydrogen storage system,and mitigate the power output fluctuation of the wind-hydrogen integrated system,which has a broad practical application prospect.展开更多
This paper concerns ultimately bounded output-feedback control problems for networked systems with unknown nonlinear dynamics. Sensor-to-observer signal transmission is facilitated over networks that has communication...This paper concerns ultimately bounded output-feedback control problems for networked systems with unknown nonlinear dynamics. Sensor-to-observer signal transmission is facilitated over networks that has communication constraints.These transmissions are carried out over an unreliable communication channel. In order to enhance the utilization rate of measurement data, a buffer-aided strategy is novelly employed to store historical measurements when communication networks are inaccessible. Using the neural network technique, a novel observer-based controller is introduced to address effects of signal transmission behaviors and unknown nonlinear dynamics.Through the application of stochastic analysis and Lyapunov stability, a joint framework is constructed for analyzing resultant system performance under the introduced controller. Subsequently, existence conditions for the desired output-feedback controller are delineated. The required parameters for the observerbased controller are then determined by resolving some specific matrix inequalities. Finally, a simulation example is showcased to confirm method efficacy.展开更多
To address the impact of wind-power fluctuations on the stability of power systems,we propose a comprehensive approach that integrates multiple strategies and methods to enhance the efficiency and reliability of a sys...To address the impact of wind-power fluctuations on the stability of power systems,we propose a comprehensive approach that integrates multiple strategies and methods to enhance the efficiency and reliability of a system.First,we employ a strategy that restricts long-and short-term power output deviations to smoothen wind power fluctuations in real time.Second,we adopt the sliding window instantaneous complete ensemble empirical mode decomposition with adaptive noise(SW-ICEEMDAN)strategy to achieve real-time decomposition of the energy storage power,facilitating internal power distribution within the hybrid energy storage system.Finally,we introduce a rule-based multi-fuzzy control strategy for the secondary adjustment of the initial power allocation commands for different energy storage components.Through simulation validation,we demonstrate that the proposed comprehensive control strategy can smoothen wind power fluctuations in real time and decompose energy storage power.Compared with traditional empirical mode decomposition(EMD),ensemble empirical mode decomposition(EEMD),and complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)decomposition strategies,the configuration of the energy storage system under the SW-ICEEMDAN control strategy is more optimal.Additionally,the state-of-charge of energy storage components fluctuates within a reasonable range,enhancing the stability of the power system and ensuring the secure operation of the energy storage system.展开更多
The traffic within data centers exhibits bursts and unpredictable patterns.This rapid growth in network traffic has two consequences:it surpasses the inherent capacity of the network’s link bandwidth and creates an i...The traffic within data centers exhibits bursts and unpredictable patterns.This rapid growth in network traffic has two consequences:it surpasses the inherent capacity of the network’s link bandwidth and creates an imbalanced network load.Consequently,persistent overload situations eventually result in network congestion.The Software Defined Network(SDN)technology is employed in data centers as a network architecture to enhance performance.This paper introduces an adaptive congestion control strategy,named DA-DCTCP,for SDN-based Data Centers.It incorporates Explicit Congestion Notification(ECN)and Round-Trip Time(RTT)to establish congestion awareness and an ECN marking model.To mitigate incorrect congestion caused by abrupt flows,an appropriate ECN marking is selected based on the queue length and its growth slope,and the congestion window(CWND)is adjusted by calculating RTT.Simultaneously,the marking threshold for queue length is continuously adapted using the current queue length of the switch as a parameter to accommodate changes in data centers.The evaluation conducted through Mininet simulations demonstrates that DA-DCTCP yields advantages in terms of throughput,flow completion time(FCT),latency,and resistance against packet loss.These benefits contribute to reducing data center congestion,enhancing the stability of data transmission,and improving throughput.展开更多
With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction ...With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction quality control are of great significance to enhance the competitiveness of construction enterprises and realize sustainable development.In this paper,the effective strategy of construction management and the effective strategy of construction quality control will be discussed in depth,aiming at providing useful management and quality control strategies for construction enterprises.展开更多
Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control ...Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical applications.In this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind farms.To reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake interaction.Meanwhile,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single agent.Optimized results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.展开更多
As government agencies continue to tighten emissions regulations due to the continued increase in greenhouse gas production, automotive industries are seeking to produce increasingly efficient vehicle technology. Hybr...As government agencies continue to tighten emissions regulations due to the continued increase in greenhouse gas production, automotive industries are seeking to produce increasingly efficient vehicle technology. Hybrid electric vehicles (HEVs) have been introduced to mitigate problems while improving fuel economy. HEVs have led to the demand of creating more advanced controls software to consider multiple components for propulsive power in a vehicle. A large section in the software development process is the implementation of an optimal energy management strategy meant to improve the overall fuel efficiency of the vehicle. Optimal strategies can be implemented when driving conditions are known a prior. The Equivalent Consumption Minimization Strategy (ECMS) is an optimal control strategy that uses an equivalence factor to equate electrical to mechanical power when performing torque split determination between the internal combustion engine and electric motor for propulsive and regenerative torque. This equivalence factor is determined from offline vehicle simulations using a sensitivity analysis to provide optimal fuel economy results while maintaining predetermined high voltage battery state of charge (SOC) constraints. When the control hierarchy is modified or different driving styles are applied, the analysis must be redone to update the equivalence factor. The goal of this work is to implement a fuzzy logic controller that dynamically updates the equivalence factor to improve fuel economy, maintain a strict charge sustaining window of operation for the high voltage battery, and reduce computational time required during algorithm development. The adaptive algorithm is validated against global optimum fuel economy and charge sustaining results from a sensitivity analysis performed for multiple drive cycles. Results show a maximum fuel economy improvement of 9.82% when using a mild driving style and a 95% success rate when maintaining an ending SOC within 5% of the desired SOC regardless of starting SOC.展开更多
Based on the tectonic genesis and seismic data of fault-controlled fractured-vuggy reservoirs,the typical fractured-vuggy structure features were analyzed.A 3D large-scale visual physical model of“tree-like”fracture...Based on the tectonic genesis and seismic data of fault-controlled fractured-vuggy reservoirs,the typical fractured-vuggy structure features were analyzed.A 3D large-scale visual physical model of“tree-like”fractured-vuggy structure was designed and made.The experiments of bottom-water flooding and multi-media synergistic oil displacement after bottom-water flooding were conducted with different production rates and different well-reservoir configuration relationships.The formation mechanisms and distribution rules of residual oil during bottom-water flooding under such fractured-vuggy structure were revealed.The producing characteristics of residual oil under different production methods after bottom-water flooding were discovered.The results show that the remaining oil in"tree-like"fractured-vuggy structure after bottom-water flooding mainly include the remaining oil of non-well controlled fault zones and the attic remaining oil at the top of well controlled fault zones.There exists obvious water channeling of bottom-water along the fault at high production rate,but intermittent drainage can effectively weaken the interference effect between fault zones to inhibit water channeling.Compared with the vertical well,horizontal well can reduce the difference in flow conductivity between fault zones and show better resistance to water channeling.The closer the horizontal well locates to the upper part of the“canopy”,the higher the oil recovery is at the bottom-water flooding stage.However,comprehensive consideration of the bottom-water flooding and subsequent gas injection development,the total recovery is higher when the horizontal well locates in the middle part of the“canopy”and drills through a large number of fault zones.After bottom water flooding,the effect of gas huff and puff is better than that of gas flooding,and the effect of gas huff and puff with large slug is better than that of small slug.Because such development method can effectively develop the remaining oil of non-well controlled fault zones and the attic remaining oil at the top of well controlled fault zones transversely connected with oil wells,thus greatly improving the oil recovery.展开更多
Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve...Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve the expected economy.This paper constructs an operating simulation model of the park power grid operation considering demand response and proposes a multi-time scale operating simulation method that combines day-ahead optimization and model predictive control(MPC).In the day-ahead stage,an operating simulation plan that comprehensively considers the user’s side comfort and operating costs is proposed with a long-term time scale of 15 min.In order to cope with power fluctuations of photovoltaic,wind turbine and conventional load,MPC is used to track and roll correct the day-ahead operating simulation plan in the intra-day stage to meet the actual operating operation status of the park.Finally,the validity and economy of the operating simulation strategy are verified through the analysis of arithmetic examples.展开更多
The merits of compressed air energy storage(CAES)include large power generation capacity,long service life,and environmental safety.When a CAES plant is switched to the grid-connected mode and participates in grid reg...The merits of compressed air energy storage(CAES)include large power generation capacity,long service life,and environmental safety.When a CAES plant is switched to the grid-connected mode and participates in grid regulation,using the traditional control mode with low accuracy can result in excess grid-connected impulse current and junction voltage.This occurs because the CAES output voltage does not match the frequency,amplitude,and phase of the power grid voltage.Therefore,an adaptive linear active disturbance-rejection control(A-LADRC)strategy was proposed.Based on the LADRC strategy,which is more accurate than the traditional proportional integral controller,the proposed controller is enhanced to allow adaptive adjustment of bandwidth parameters,resulting in improved accuracy and response speed.The problem of large impulse current when CAES is switched to the grid-connected mode is addressed,and the frequency fluctuation is reduced.Finally,the effectiveness of the proposed strategy in reducing the impact of CAES on the grid connection was verified using a hardware-in-the-loop simulation platform.The influence of the k value in the adaptive-adjustment formula on the A-LADRC was analyzed through simulation.The anti-interference performance of the control was verified by increasing and decreasing the load during the presynchronization process.展开更多
To ensure frequency stability in power systems with high wind penetration,the doubly-fed induction generator(DFIG)is often used with the frequency fast response control(FFRC)to participate in frequency response.Howeve...To ensure frequency stability in power systems with high wind penetration,the doubly-fed induction generator(DFIG)is often used with the frequency fast response control(FFRC)to participate in frequency response.However,a certain output power suppression amount(OPSA)is generated during frequency support,resulting in the frequency modulation(FM)capability of DFIG not being fully utilised,and the system’s unbalanced power will be increased during speed recovery,resulting in a second frequency drop(SFD)in the system.Firstly,the frequency response characteristics of the power system with DFIG containing FFRC are analysed.Then,based on the analysis of the generation mechanism of OPSA and SFD,a combined wind-storage FM control strategy is proposed to improve the system’s frequency response characteristics.This strategy reduces the effect of OPSA and improves the FM capability of DFIG by designing the fuzzy logic of the coefficients of FFRC according to the system frequency index in the frequency support stage.During the speed recovery stage,the energy storage(ES)active power reference value is calculated according to the change of DFIG rotor speed,and the ES output power is dynamically adjusted to reduce the SFD.Finally,taking the IEEE 39-bus test system as an example,real-time digital simulation verification was conducted based on the RTLAB OP5707 simulation platform.The simulation results showthat theproposedmethodcan improve theFMcapabilityofDFIG,reduce the SFDunder thepremise of guaranteeing the rapid rotor speed recovery,and avoid the overshooting phenomenon so that the systemfrequency can be quickly restored to a stable state.展开更多
Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and...Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.展开更多
In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To ...In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To address this issue,the application of a virtual synchronous generator(VSG)in grid-connected inverters control is referenced and proposes a control strategy called the analogous virtual synchronous generator(AVSG)control strategy for the interface DC/DC converter of the battery in the microgrid.Besides,a flexible parameter adaptive control method is introduced to further enhance the inertial behavior of the AVSG control.Firstly,a theoretical analysis is conducted on the various components of the DC microgrid,the structure of analogous virtual synchronous generator,and the control structure’s main parameters related to the DC microgrid’s inertial behavior.Secondly,the voltage change rate tracking coefficient is introduced to adjust the change of the virtual capacitance and damping coefficient flexibility,which further strengthens the inertia trend of the DC microgrid.Additionally,a small-signal modeling approach is used to analyze the approximate range of the AVSG’s main parameters ensuring system stability.Finally,conduct a simulation analysis by building the model of the DC microgrid system with photovoltaic(PV)and battery energy storage(BES)in MATLAB/Simulink.Simulation results from different scenarios have verified that the AVSG control introduces fixed inertia and damping into the droop control of the battery,resulting in a certain level of inertia enhancement.Furthermore,the additional adaptive control strategy built upon the AVSG control provides better and flexible inertial support for the DC microgrid,further enhances the stability of the DC bus voltage,and has a more positive impact on the battery performance.展开更多
Building Information Modeling(BIM)technology can not only achieve project refinement management of the construction process based on a 3D model but also form a BIM-5D model based on the fusion of progress data and cos...Building Information Modeling(BIM)technology can not only achieve project refinement management of the construction process based on a 3D model but also form a BIM-5D model based on the fusion of progress data and cost data to achieve the dynamic control of the whole process of project cost.This paper discusses the application of BIM-5D in the cost control of finished house construction,aiming to provide technical reference for China’s finished house project units,so that they can master how to realize the construction of cost control system based on BIM,the monitoring of the key coefficients of the cost,corrective action,to ensure that the project cost deviation is within the controllable range,and to make an effective guarantee for the economic benefits of the project construction.展开更多
Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard cli...Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard clinical precautions and tracing the source of infection were the focus of IPC in medical institutions during the pandemic.Therefore,the core competences of IPC professionals during the pandemic,and how these contributed to successful prevention and control of the epidemic,should be studied.To investigate,using a systematic review and cluster analysis,fundamental improvements in the competences of infection control and prevention professionals that may be emphasized in light of the COVID-19 pandemic.We searched the PubMed,Embase,Cochrane Library,Web of Science,CNKI,WanFang Data,and CBM databases for original articles exploring core competencies of IPC professionals during the COVID-19 pandemic(from January 1,2020 to February 7,2023).Weiciyun software was used for data extraction and the Donohue formula was followed to distinguish high-frequency technical terms.Cluster analysis was performed using the within-group linkage method and squared Euclidean distance as the metric to determine the priority competencies for development.We identified 46 studies with 29 high-frequency technical terms.The most common term was“infection prevention and control training”(184 times,17.3%),followed by“hand hygiene”(172 times,16.2%).“Infection prevention and control in clinical practice”was the most-reported core competency(367 times,34.5%),followed by“microbiology and surveillance”(292 times,27.5%).Cluster analysis showed two key areas of competence:Category 1(program management and leadership,patient safety and occupational health,education and microbiology and surveillance)and Category 2(IPC in clinical practice).During the COVID-19 pandemic,IPC program management and leadership,microbiology and surveillance,education,patient safety,and occupational health were the most important focus of development and should be given due consideration by IPC professionals.展开更多
BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of ...BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes.展开更多
The virtual synchronous generator(VSG)technology has been proposed to address the problem of system frequency and active power oscillation caused by grid-connected new energy power sources.However,the traditional volt...The virtual synchronous generator(VSG)technology has been proposed to address the problem of system frequency and active power oscillation caused by grid-connected new energy power sources.However,the traditional voltage-current double-closed-loop control used in VSG has the disadvantages of poor disturbance immunity and insufficient dynamic response.In light of the issues above,a virtual synchronous generator voltage outer-loop control strategy based on improved linear autonomous disturbance rejection control(ILADRC)is put forth for consideration.Firstly,an improved first-order linear self-immunity control structure is established for the characteristics of the voltage outer loop;then,the effects of two key control parameters-observer bandwidthω_(0)and controller bandwidthω_(c)on the control system are analyzed,and the key parameters of ILADRC are optimally tuned online using improved gray wolf optimizer-radial basis function(IGWO-RBF)neural network.A simulationmodel is developed using MATLAB to simulate,analyze,and compare the method introduced in this paper.Simulations are performed with the traditional control strategy for comparison,and the results demonstrate that the proposed control method offers superior anti-interference performance.It effectively addresses power and frequency oscillation issues and enhances the stability of the VSG during grid-connected operation.展开更多
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
基金supported by the Key Technology Research and Application Demonstration Project for Large-Scale Multi-Scenario Water Electrolysis Hydrogen Production(CTGTC/2023-LQ-06).
文摘The rise in hydrogen production powered by renewable energy is driving the field toward the adoption of systems comprising multiple alkaline water electrolyzers.These setups present various operational modes:independent operation and multi-electrolyzer parallelization,each with distinct advantages and challenges.This study introduces an innovative configuration that incorporates a mutual lye mixer among electrolyzers,establishing a weakly coupled system that combines the advantages of two modes.This approach enables efficient heat utilization for faster hot-startup and maintains heat conservation post-lye interconnection,while preserving the option for independent operation after decoupling.A specialized thermal exchange model is developed for this topology,according to the dynamics of the lye mixer.The study further details startup procedures and proposes optimized control strategies tailored to this structural design.Waste heat from the caustic fully heats up the multiple electrolyzers connected to the lye mixing system,enabling a rapid hot start to enhance the system’s ability to track renewable energy.A control strategy is established to reduce heat loss and increase startup speed,and the optimal valve openings of the diverter valve and the manifold valve are determined.Simulation results indicate a considerable enhancement in operational efficiency,marked by an 18.28%improvement in startup speed and a 6.11%reduction in startup energy consumption inmulti-electrolyzer cluster systems,particularlywhen the systems are synchronized with photovoltaic energy sources.The findings represent a significant stride toward efficient and sustainable hydrogen production,offering a promising path for large-scale integration of renewable energy.
基金the Key Research&Development Program of Xinjiang(Grant Number 2022B01003).
文摘This paper addresses the micro wind-hydrogen coupled system,aiming to improve the power tracking capability of micro wind farms,the regulation capability of hydrogen storage systems,and to mitigate the volatility of wind power generation.A predictive control strategy for the micro wind-hydrogen coupled system is proposed based on the ultra-short-term wind power prediction,the hydrogen storage state division interval,and the daily scheduled output of wind power generation.The control strategy maximizes the power tracking capability,the regulation capability of the hydrogen storage system,and the fluctuation of the joint output of the wind-hydrogen coupled system as the objective functions,and adaptively optimizes the control coefficients of the hydrogen storage interval and the output parameters of the system by the combined sigmoid function and particle swarm algorithm(sigmoid-PSO).Compared with the real-time control strategy,the proposed predictive control strategy can significantly improve the output tracking capability of the wind-hydrogen coupling system,minimize the gap between the actual output and the predicted output,significantly enhance the regulation capability of the hydrogen storage system,and mitigate the power output fluctuation of the wind-hydrogen integrated system,which has a broad practical application prospect.
基金supported in part by the National Natural Science Foundation of China (61933007,62273087,U22A2044,61973102,62073180)the Shanghai Pujiang Program of China (22PJ1400400)+1 种基金the Royal Society of the UKthe Alexander von Humboldt Foundation of Germany。
文摘This paper concerns ultimately bounded output-feedback control problems for networked systems with unknown nonlinear dynamics. Sensor-to-observer signal transmission is facilitated over networks that has communication constraints.These transmissions are carried out over an unreliable communication channel. In order to enhance the utilization rate of measurement data, a buffer-aided strategy is novelly employed to store historical measurements when communication networks are inaccessible. Using the neural network technique, a novel observer-based controller is introduced to address effects of signal transmission behaviors and unknown nonlinear dynamics.Through the application of stochastic analysis and Lyapunov stability, a joint framework is constructed for analyzing resultant system performance under the introduced controller. Subsequently, existence conditions for the desired output-feedback controller are delineated. The required parameters for the observerbased controller are then determined by resolving some specific matrix inequalities. Finally, a simulation example is showcased to confirm method efficacy.
基金supported by the National Natural Science Foundation of China(Grant No.51677058)。
文摘To address the impact of wind-power fluctuations on the stability of power systems,we propose a comprehensive approach that integrates multiple strategies and methods to enhance the efficiency and reliability of a system.First,we employ a strategy that restricts long-and short-term power output deviations to smoothen wind power fluctuations in real time.Second,we adopt the sliding window instantaneous complete ensemble empirical mode decomposition with adaptive noise(SW-ICEEMDAN)strategy to achieve real-time decomposition of the energy storage power,facilitating internal power distribution within the hybrid energy storage system.Finally,we introduce a rule-based multi-fuzzy control strategy for the secondary adjustment of the initial power allocation commands for different energy storage components.Through simulation validation,we demonstrate that the proposed comprehensive control strategy can smoothen wind power fluctuations in real time and decompose energy storage power.Compared with traditional empirical mode decomposition(EMD),ensemble empirical mode decomposition(EEMD),and complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)decomposition strategies,the configuration of the energy storage system under the SW-ICEEMDAN control strategy is more optimal.Additionally,the state-of-charge of energy storage components fluctuates within a reasonable range,enhancing the stability of the power system and ensuring the secure operation of the energy storage system.
基金supported by the National Key R&D Program of China(No.2021YFB2700800)the GHfund B(No.202302024490).
文摘The traffic within data centers exhibits bursts and unpredictable patterns.This rapid growth in network traffic has two consequences:it surpasses the inherent capacity of the network’s link bandwidth and creates an imbalanced network load.Consequently,persistent overload situations eventually result in network congestion.The Software Defined Network(SDN)technology is employed in data centers as a network architecture to enhance performance.This paper introduces an adaptive congestion control strategy,named DA-DCTCP,for SDN-based Data Centers.It incorporates Explicit Congestion Notification(ECN)and Round-Trip Time(RTT)to establish congestion awareness and an ECN marking model.To mitigate incorrect congestion caused by abrupt flows,an appropriate ECN marking is selected based on the queue length and its growth slope,and the congestion window(CWND)is adjusted by calculating RTT.Simultaneously,the marking threshold for queue length is continuously adapted using the current queue length of the switch as a parameter to accommodate changes in data centers.The evaluation conducted through Mininet simulations demonstrates that DA-DCTCP yields advantages in terms of throughput,flow completion time(FCT),latency,and resistance against packet loss.These benefits contribute to reducing data center congestion,enhancing the stability of data transmission,and improving throughput.
文摘With the gradual acceleration of the urbanization process,the construction industry has been developing rapidly.As the key link to ensure the quality and safety of the project,construction management and construction quality control are of great significance to enhance the competitiveness of construction enterprises and realize sustainable development.In this paper,the effective strategy of construction management and the effective strategy of construction quality control will be discussed in depth,aiming at providing useful management and quality control strategies for construction enterprises.
基金supported by the National Natural Science Foundation of China (Grant No.12388101)the Science Challenge Project+1 种基金the Anhui NARI Jiyuan Electric Power Grid Technology Co.Ltd.through the Joint Laboratory of USTC-NARIthe advanced computing resources provided by the Supercomputing Center of the USTC
文摘Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical applications.In this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind farms.To reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake interaction.Meanwhile,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single agent.Optimized results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.
文摘As government agencies continue to tighten emissions regulations due to the continued increase in greenhouse gas production, automotive industries are seeking to produce increasingly efficient vehicle technology. Hybrid electric vehicles (HEVs) have been introduced to mitigate problems while improving fuel economy. HEVs have led to the demand of creating more advanced controls software to consider multiple components for propulsive power in a vehicle. A large section in the software development process is the implementation of an optimal energy management strategy meant to improve the overall fuel efficiency of the vehicle. Optimal strategies can be implemented when driving conditions are known a prior. The Equivalent Consumption Minimization Strategy (ECMS) is an optimal control strategy that uses an equivalence factor to equate electrical to mechanical power when performing torque split determination between the internal combustion engine and electric motor for propulsive and regenerative torque. This equivalence factor is determined from offline vehicle simulations using a sensitivity analysis to provide optimal fuel economy results while maintaining predetermined high voltage battery state of charge (SOC) constraints. When the control hierarchy is modified or different driving styles are applied, the analysis must be redone to update the equivalence factor. The goal of this work is to implement a fuzzy logic controller that dynamically updates the equivalence factor to improve fuel economy, maintain a strict charge sustaining window of operation for the high voltage battery, and reduce computational time required during algorithm development. The adaptive algorithm is validated against global optimum fuel economy and charge sustaining results from a sensitivity analysis performed for multiple drive cycles. Results show a maximum fuel economy improvement of 9.82% when using a mild driving style and a 95% success rate when maintaining an ending SOC within 5% of the desired SOC regardless of starting SOC.
基金Supported by the National Natural Science Foundation of China(52074344)。
文摘Based on the tectonic genesis and seismic data of fault-controlled fractured-vuggy reservoirs,the typical fractured-vuggy structure features were analyzed.A 3D large-scale visual physical model of“tree-like”fractured-vuggy structure was designed and made.The experiments of bottom-water flooding and multi-media synergistic oil displacement after bottom-water flooding were conducted with different production rates and different well-reservoir configuration relationships.The formation mechanisms and distribution rules of residual oil during bottom-water flooding under such fractured-vuggy structure were revealed.The producing characteristics of residual oil under different production methods after bottom-water flooding were discovered.The results show that the remaining oil in"tree-like"fractured-vuggy structure after bottom-water flooding mainly include the remaining oil of non-well controlled fault zones and the attic remaining oil at the top of well controlled fault zones.There exists obvious water channeling of bottom-water along the fault at high production rate,but intermittent drainage can effectively weaken the interference effect between fault zones to inhibit water channeling.Compared with the vertical well,horizontal well can reduce the difference in flow conductivity between fault zones and show better resistance to water channeling.The closer the horizontal well locates to the upper part of the“canopy”,the higher the oil recovery is at the bottom-water flooding stage.However,comprehensive consideration of the bottom-water flooding and subsequent gas injection development,the total recovery is higher when the horizontal well locates in the middle part of the“canopy”and drills through a large number of fault zones.After bottom water flooding,the effect of gas huff and puff is better than that of gas flooding,and the effect of gas huff and puff with large slug is better than that of small slug.Because such development method can effectively develop the remaining oil of non-well controlled fault zones and the attic remaining oil at the top of well controlled fault zones transversely connected with oil wells,thus greatly improving the oil recovery.
基金supported by the Science and Technology Project of State Grid Shanxi Electric Power Research Institute:Research on Data-Driven New Power System Operation Simulation and Multi Agent Control Strategy(52053022000F).
文摘Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve the expected economy.This paper constructs an operating simulation model of the park power grid operation considering demand response and proposes a multi-time scale operating simulation method that combines day-ahead optimization and model predictive control(MPC).In the day-ahead stage,an operating simulation plan that comprehensively considers the user’s side comfort and operating costs is proposed with a long-term time scale of 15 min.In order to cope with power fluctuations of photovoltaic,wind turbine and conventional load,MPC is used to track and roll correct the day-ahead operating simulation plan in the intra-day stage to meet the actual operating operation status of the park.Finally,the validity and economy of the operating simulation strategy are verified through the analysis of arithmetic examples.
基金supported by National Natural Science Foundation of China(Project No.52077079).
文摘The merits of compressed air energy storage(CAES)include large power generation capacity,long service life,and environmental safety.When a CAES plant is switched to the grid-connected mode and participates in grid regulation,using the traditional control mode with low accuracy can result in excess grid-connected impulse current and junction voltage.This occurs because the CAES output voltage does not match the frequency,amplitude,and phase of the power grid voltage.Therefore,an adaptive linear active disturbance-rejection control(A-LADRC)strategy was proposed.Based on the LADRC strategy,which is more accurate than the traditional proportional integral controller,the proposed controller is enhanced to allow adaptive adjustment of bandwidth parameters,resulting in improved accuracy and response speed.The problem of large impulse current when CAES is switched to the grid-connected mode is addressed,and the frequency fluctuation is reduced.Finally,the effectiveness of the proposed strategy in reducing the impact of CAES on the grid connection was verified using a hardware-in-the-loop simulation platform.The influence of the k value in the adaptive-adjustment formula on the A-LADRC was analyzed through simulation.The anti-interference performance of the control was verified by increasing and decreasing the load during the presynchronization process.
基金funded by Jilin Province Science and Technology Development Plan Projects(20230508157RC)the National Natural Science Foundation of China(U2066208).
文摘To ensure frequency stability in power systems with high wind penetration,the doubly-fed induction generator(DFIG)is often used with the frequency fast response control(FFRC)to participate in frequency response.However,a certain output power suppression amount(OPSA)is generated during frequency support,resulting in the frequency modulation(FM)capability of DFIG not being fully utilised,and the system’s unbalanced power will be increased during speed recovery,resulting in a second frequency drop(SFD)in the system.Firstly,the frequency response characteristics of the power system with DFIG containing FFRC are analysed.Then,based on the analysis of the generation mechanism of OPSA and SFD,a combined wind-storage FM control strategy is proposed to improve the system’s frequency response characteristics.This strategy reduces the effect of OPSA and improves the FM capability of DFIG by designing the fuzzy logic of the coefficients of FFRC according to the system frequency index in the frequency support stage.During the speed recovery stage,the energy storage(ES)active power reference value is calculated according to the change of DFIG rotor speed,and the ES output power is dynamically adjusted to reduce the SFD.Finally,taking the IEEE 39-bus test system as an example,real-time digital simulation verification was conducted based on the RTLAB OP5707 simulation platform.The simulation results showthat theproposedmethodcan improve theFMcapabilityofDFIG,reduce the SFDunder thepremise of guaranteeing the rapid rotor speed recovery,and avoid the overshooting phenomenon so that the systemfrequency can be quickly restored to a stable state.
基金National Natural Science Foundation of China(32201491)Young Elite Scientists Sponsorship Program by CAST(2023QNRC001)The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University,Arar,KSA for funding this research work through the project number“NBU-FPEJ-2024-1101-02”.
文摘Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.
基金funded by the National Natural Science Foundation of China(52067013),and the Provincial Natural Science Foundation of Gansu(20JR5RA395).
文摘In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To address this issue,the application of a virtual synchronous generator(VSG)in grid-connected inverters control is referenced and proposes a control strategy called the analogous virtual synchronous generator(AVSG)control strategy for the interface DC/DC converter of the battery in the microgrid.Besides,a flexible parameter adaptive control method is introduced to further enhance the inertial behavior of the AVSG control.Firstly,a theoretical analysis is conducted on the various components of the DC microgrid,the structure of analogous virtual synchronous generator,and the control structure’s main parameters related to the DC microgrid’s inertial behavior.Secondly,the voltage change rate tracking coefficient is introduced to adjust the change of the virtual capacitance and damping coefficient flexibility,which further strengthens the inertia trend of the DC microgrid.Additionally,a small-signal modeling approach is used to analyze the approximate range of the AVSG’s main parameters ensuring system stability.Finally,conduct a simulation analysis by building the model of the DC microgrid system with photovoltaic(PV)and battery energy storage(BES)in MATLAB/Simulink.Simulation results from different scenarios have verified that the AVSG control introduces fixed inertia and damping into the droop control of the battery,resulting in a certain level of inertia enhancement.Furthermore,the additional adaptive control strategy built upon the AVSG control provides better and flexible inertial support for the DC microgrid,further enhances the stability of the DC bus voltage,and has a more positive impact on the battery performance.
基金University-level self-study project:Construction cost control research of finished house based on BIM-5D(Project No.2023xzky06)。
文摘Building Information Modeling(BIM)technology can not only achieve project refinement management of the construction process based on a 3D model but also form a BIM-5D model based on the fusion of progress data and cost data to achieve the dynamic control of the whole process of project cost.This paper discusses the application of BIM-5D in the cost control of finished house construction,aiming to provide technical reference for China’s finished house project units,so that they can master how to realize the construction of cost control system based on BIM,the monitoring of the key coefficients of the cost,corrective action,to ensure that the project cost deviation is within the controllable range,and to make an effective guarantee for the economic benefits of the project construction.
基金The National Natural Science Foundation of China,Grant/Award Number:52178080Major Research Project of the Hospital Management Research Institute of the National Health Commission,Grant/Award Number:GY2023011National Institute of Hospital Administration Management of China,Grant/Award Number:GY2023049。
文摘Remarkable progress has been made in infection prevention and control(IPC)in many countries,but some gaps emerged in the context of the coronavirus disease 2019(COVID-19)pandemic.Core capabilities such as standard clinical precautions and tracing the source of infection were the focus of IPC in medical institutions during the pandemic.Therefore,the core competences of IPC professionals during the pandemic,and how these contributed to successful prevention and control of the epidemic,should be studied.To investigate,using a systematic review and cluster analysis,fundamental improvements in the competences of infection control and prevention professionals that may be emphasized in light of the COVID-19 pandemic.We searched the PubMed,Embase,Cochrane Library,Web of Science,CNKI,WanFang Data,and CBM databases for original articles exploring core competencies of IPC professionals during the COVID-19 pandemic(from January 1,2020 to February 7,2023).Weiciyun software was used for data extraction and the Donohue formula was followed to distinguish high-frequency technical terms.Cluster analysis was performed using the within-group linkage method and squared Euclidean distance as the metric to determine the priority competencies for development.We identified 46 studies with 29 high-frequency technical terms.The most common term was“infection prevention and control training”(184 times,17.3%),followed by“hand hygiene”(172 times,16.2%).“Infection prevention and control in clinical practice”was the most-reported core competency(367 times,34.5%),followed by“microbiology and surveillance”(292 times,27.5%).Cluster analysis showed two key areas of competence:Category 1(program management and leadership,patient safety and occupational health,education and microbiology and surveillance)and Category 2(IPC in clinical practice).During the COVID-19 pandemic,IPC program management and leadership,microbiology and surveillance,education,patient safety,and occupational health were the most important focus of development and should be given due consideration by IPC professionals.
文摘BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes.
基金supported by the Lanzhou Jiaotong University-Southwest Jiaotong University Joint Innovation Fund(LH2024027).
文摘The virtual synchronous generator(VSG)technology has been proposed to address the problem of system frequency and active power oscillation caused by grid-connected new energy power sources.However,the traditional voltage-current double-closed-loop control used in VSG has the disadvantages of poor disturbance immunity and insufficient dynamic response.In light of the issues above,a virtual synchronous generator voltage outer-loop control strategy based on improved linear autonomous disturbance rejection control(ILADRC)is put forth for consideration.Firstly,an improved first-order linear self-immunity control structure is established for the characteristics of the voltage outer loop;then,the effects of two key control parameters-observer bandwidthω_(0)and controller bandwidthω_(c)on the control system are analyzed,and the key parameters of ILADRC are optimally tuned online using improved gray wolf optimizer-radial basis function(IGWO-RBF)neural network.A simulationmodel is developed using MATLAB to simulate,analyze,and compare the method introduced in this paper.Simulations are performed with the traditional control strategy for comparison,and the results demonstrate that the proposed control method offers superior anti-interference performance.It effectively addresses power and frequency oscillation issues and enhances the stability of the VSG during grid-connected operation.
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS)the National Natural Science Foundation of China,No.31970970(to JSR)Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
文摘Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.