A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting

Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.

On the Motion of Controllable Mechanical Systems Having Variable Mass

The differential equations of motion of a comtlaint system with parameters and variable mass, of a system with variable mass and servo constraints and those for the control problem on the forced motion of constraint systems with variable mass are given respectively. Finally, an example is presented.

A new classification of seepage control mechanisms in geotechnical engineering

Seepage flow through soils,rocks and geotechnical structures has a great influence on their stabilities and performances,and seepage control is a critical technological issue in engineering practices.The physical mechanisms associated with various engineering measures for seepage control are investigated from a new perspective within the framework of continuum mechanics;and an equation-based classification of seepage control mechanisms is proposed according to their roles in the mathematical models for seepage flow,including control mechanisms by coupled processes,initial states,boundary conditions and hydraulic properties.The effects of each mechanism on seepage control are illustrated with examples in hydroelectric engineering and radioactive waste disposal,and hence the reasonability of classification is demonstrated.Advice on performance assessment and optimization design of the seepage control systems in geotechnical engineering is provided,and the suggested procedure would serve as a useful guidance for cost-effective control of seepage flow in various engineering practices.

Characteristics and control mechanisms of coalbed permeability change in various gas production stages

According to dimensionless analysis of the coalbed methane （CBM） production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM well production process into four stages, i.e., drai- nage stage, unstable gas production stage, stable gas pro- duction stage, and gas production decline stage. By the material balance method, the coal reservoir permeability change in different stages is quantitatively characterized. The characteristics and control mechanisms of change in coalbed permeability （CICP） during different production stages are concluded on five aspects, i.e., permeability trend variation, controlling mechanism, system energy, phase state compositions, and production performance. The study reveals that CICP is characterized by first decline, then recovery, and finally by increase and is controlled directly by effective stress and matrix shrinkage effects. Further, the duration and intensity of the matrix shrinkage effect are inherently controlled by adsorption and desorp- tion features.

Mei Adiabatic Invariants Induced by Perturbation of Mei Symmetry for Nonholonomic Controllable Mechanical Systems

Two types of Mei adiabatic invariants induced by perturbation of Mei symmetry for nonholonomic controllablemechanical systems are reported.Criterion and restriction equations determining Mei symmetry after beingdisturbed of the system are established.Form and existence condition of Mei adiabatic invariants are obtained.

Mei Symmetries and Lie Symmetries for Nonholonomic Controllable Mechanical Systems with Relativistic Rotational Variable Mass

The Mei symmetries and the Lie symmetries for nonholonomic controllable mechanical systems with relativistic rotational variable mass are studied. The differential equations of motion of the systems are established. The definition and criterion of the Mei symmetries and the Lie symmetries of the system are studied respectively. The necessary and sufficient condition under which the Mei symmetry is Lie symmetry is given. The condition under which the Mei symmetries can be led to a new kind of conserved quantity and the form of the conserved quantity are obtained. An example is given to illustrate the application of the results.

Perturbation to symmetries and Hojman adiabatic invariant for nonholonomic controllable mechanical systems with non-Chetaev type constraints

This paper studies the perturbation to symmetries and adiabatic invariant for nonholonomic controllable mechanical systems with non-Chetaev type constraints. It gives the exact invariants introduced by the Lie symmetries of the nonholonomic controllable mechanical system with non-Chetaev type constraints without perturbation. Based on the definition of high-order adiabatic invarlants of mechanical system, the perturbation of Lie symmetries for nonholonomic controllable mechanical system with non-Chetaev type constraints with the action of small disturbances is investigated, and a new type of adiabatic invariant of system are obtained. In the end of this paper, an example is given to illustrate the application of the results.

Noether-Form Invariance of Nonholonomic Controllable Mechanical Systems in Phase Space

In this paper,we study the Noether-form invariance of nonholonomic mechanical controllable systems inphase space.Equations of motion of the controllable mechanical systems in phase space are presented.The definitionand the criterion for this system are presented.A new conserved quantity and the Noether conserved quantity deducedfrom the Noether-form invariance are obtained.An example is given to illustrate the application of the results.

Control Strategies and Mechanisms for Active Control of Sound Transmission into a Vibro-acoustic Enclosure

An analytical study was presented on active control of sound transmission into a vibro-acoustic enclosure comprising two flexible plates. Two types of actuators were used, i.e. acoustic actuator and distributed lead zirconate titanate piezoelectric (PZT) actuator instead of point force actuator. Using the modal acoustic transfer impedance-mobility matrices, the excitation and interaction in the coupled sound transmission system can be described with clear physical significance. With the control system designed to globally reduce the sound field, different control system configurations were considered, including the structural actuator on the incident plate, actuator on the receiving plate, acoustic actuator on the cavity, and their combinations. The effectiveness and performance of the control strategy corresponding to each system configuration were compared and discussed. The role and control mechanism of each type of actuator were of particular interest. It was shown that the incident plate actuator is effective in controlling the cavity-dominated modes and the structural modes dominated by the incident plate and receiving plate. Two main control mechanisms are involved in this control configuration, i.e., modal suppressing and modal rearrangement. For control system configuration with only acoustic actuator in the enclosure, the mechanism involved in this arrangement is purely modal suppression. Desirable placements of structural actuators in terms of total potential energy reduction were also discussed.

Mei Symmetry and Hojman Conserved Quantity of Nonholonomic Controllable Mechanical System

A non-Noether conserved quantity, i.e., Hojman conserved quantity, constructed by using Mei symmetry for the nonholonomic controllable mechanical system, is presented. Under general infinitesimal transformations, the determining equations of the special Mei symmetry, the constrained restriction equations, the additional restriction equations, and the definitions of the weak Mei symmetry and the strong Mei symmetry of the nonholonomic controllable mechanical system are given. The condition under which Mei symmetry is a Lie symmetry is obtained. The form of the Hojman conserved quantity of the corresponding holonomic mechanical system, the weak Hojman conserved quantity and the strong Hojman conserved quantity of the nonholonomie controllable mechanical system are obtained. An example is given to illustrate the application of the results.

Weak Noether symmetry for a nonholonomic controllable mechanical system

This paper discusses the weak Noether symmetry for a nonholonomic controllable mechanical system of Chetaev type, and presents expressions of three kinds of conserved quantities obtained by using weak Noether symmetry. Finally, the application of these new results is illustrated by an example.

RELATIVISTIC VARIATION PRINCIPLES AND EQUATION OF MOTION FOR VARIABLE MASS CONTROLLABLE MECHANICAL SYSTEM

With classical variable mass and relativistic variable mass cases being considered.the relativistic D' Alembert principles of Lagrange form Nielsen form and Appell. form for variable mass controllable mechanical system are given the relativistic Chaplygin equation. Nielsen equation and Appell equation .for variable mass controllable mechanical system in quasi-coordinates and generalized- coordinates are obtained, and the equations of motion of relativistic controllable mechanical system for holonomic system and constant mass system are diseussed

INTELLIGENT CAD OF CRANE TRAVELLING MECHANISMS

Based on common characteristics in crane design, a new procedure of intelligent CAD for crane travelling mechanisms is proposed. The CAD used for crane travelling mechanisms is usually involved in choosing electrical motors.gear reducers,brakes and couplings, arranging travelling wheels and equilibrium beams.checking temperature increase of motors and slippage of driving wheels,estimating the time used for starting and stopping the cranes, drawing up the travelling mechanism.and so on. By enhancing the CAD, the related expert system and overall intelligent con trol are further developed here in treated as individual module. Accordingly,the intelligent CAD is constructed by combing the CAD with the two modules.

Mechanism of gas pressure action during the initial failure of coal containing gas and its application for an outburst inoculation

Faced with the continuous occurrence of coal and gas outburst(hereinafter referred to as“outburst”)disasters,as a main controlling factor in the evolution process of an outburst,for gas pressure,it is still unclear about the phased characteristics of the coupling process with in situ stress,which induce coal damage and instability.Therefore,in the work based on the mining stress paths induced by typical outburst accidents,the gradual and sudden change of three-dimensional stress is taken as the background for the mechanical reconstruction of the disaster process.Then the true triaxial physical experiments are conducted on the damage and instability of coal containing gas under multiple stress paths.Finally,the response characterization between coal damage and gas pressure has been clarified,revealing the mechanism of action of gas pressure during the initial failure of coals.And the main controlling mechanism during the outburst process is elucidated in the coupling process of in situ stress with gas pressure.The results show that during the process of stress loading and unloading,the original gas pressure enters the processes of strengthening and weakening the action ability successively.And the strengthening effect continues to the period of large-scale destruction of coals.The mechanical process of gas pressure during the initial failure of coals can be divided into three stages:the enhancement of strengthening action ability,the decrease of strengthening action ability,and the weakening action ability.The entire process is implemented by changing the dominant action of in situ stress into the dominant action of gas pressure.The failure strength of coals is not only affected by its original mechanical strength,but also by the stress loading and unloading paths,showing a particularly significant effect.Three stages can be divided during outburst inoculation process.That is,firstly,the coals suffer from initial damage through the dominant action of in situ stress with synergy of gas pressure;secondly,the coals with spallation of structural division are generated through the dominant action of gas pressure with synergy of in situ stress,accompanied by further fragmentation;and finally,the fractured coals suffer from fragmentation and pulverization with the gas pressure action.Accordingly,the final broken coals are ejected out with the gas action,initiating an outburst.The research results can provide a new perspective for deepening the understanding of coal and gas outburst mechanism,laying a theoretical foundation for the innovation of outburst prevention and control technologies.

Polarization characteristics and controllability mechanism of passive scattering elements

Polarization feature is one of the important features of radar targets,which has been used in many fields.In this paper,the grid models of some typical foreign moving targets are constructed on the simulation platform,such as glider,cruiser,fixed wing aircraft,and rotorcraft.The electromagnetic scattering characteristics of the moving platforms under the incidence of circular polarization waves are calculated.The typical polarization characteristics which the orthogonal and in-phase components have in the echoes are analyzed and proved.Based on the polarization scattering matrix(PSM)theory,from the point of view of the physical reproduction,the technical status quo that the existing technical approaches are difficult to realize the passive simulation of polarization characteristic of the target is summarized.To solve this problem,combined with the vector synthesis law,the realization mechanism of controllable polarization characteristic of target echoes is proposed,the analytical expressions of polarization control matrix and polarization ratio are deduced,and the controllability of polarization ratio feature in the case of circular polarization is verified by simulation calculation.

Development,sand control mechanism and hydrocarbon accumulation of beach-bar sandstone in a saline lake basin:A case from the Neogene of southwestern Qaidam Basin,NW China

Based on the data of field outcrops,drilling cores,casting thin sections,well logging interpretation,oil/gas shows during drilling,and oil/gas testing results,and combined with modern salt-lake sediments in the Qinghai Lake,the Neogene saline lake beach-bars in southwestern Qaidam Basin are studied from the perspective of sedimentary characteristics,development patterns,sand control factors,and hydrocarbon accumulation characteristics.Beach-bar sand bodies are widely developed in the Neogene saline lake basin,and they are lithologically fine sandstone and siltstone,with wavy bedding,low-angle cross bedding,and lenticular-vein bedding.In view of spatial-temporal distribution,the beach-bar sand bodies are stacked in multiple stages vertically,migratory laterally,and extensive and continuous in NW-SE trending pattern in the plane.The stacking area of the Neogene beach-bar sandstone is predicted to be 3000 km^(2).The water salinity affects the sedimentation rate and offshore distance of beach-bar sandstone,and the debris input from the source area affects the scale and enrichment of beach-bar sandstone.The ancient landform controls the morphology and stacking style of beach-bar sandstone,and the northwest monsoon driving effect controls the long-axis extension direction of beach-bar sandstone.The beach-bars have a reservoir-forming feature of“one reservoir in one sand body”,with thick beach-bar sand bodies controlling the effective reservoir distribution and oil-source faults controlling the oil/gas migration and accumulation direction.Three favorable exploration target zones in Zhahaquan,Yingdong-eastern Wunan and Huatugou areas are proposed based on the analysis of reservoir-forming elements.

Research of Strapdown Integrated Navigation System Based on Rota­tion Control Technology

To realize high-precision Single-axial Rotating FOG-SINS,a low-power,low-cost,middle-precision rotating control mechanism design for single-axial rotating navigation system is put forward.Through theory analysis,design and experimental verification,the rotating control mechanism has good control precision and high reliability,which meets the demands for developing middle&high-precision FOG-SINS.

Active control of structural sound radiation in an acoustic enclosure consisting of flexible structure

The active control of structural sound radiation in an acoustic enclosure is studied by using distributed point force actuators as the secondary control force, and the control mechanisms for the radiated noise in the cavity are analyzed. A rectangular enclosure involving two simply supported flexible plates is created for this investigation. The characteristics of the primary and secondary sound field and the structural-acoustic coupled system are analyzed, and the optimal control objective for reducing the sound pressure level （SPL） in the cavity is derived. The response of the SPL in the cavity is analyzed and compared when the secondary point force actuators with different locations and parameters are applied to the two flexible plates. The results indicate that the noise in the cavity can be better controlled when some point force actuators are applied to two flexible plates for cooperative control rather than the point force actuators being only applied to the excited flexible plate.

Control technology for floor heave of Jurassic soft rock in the Erdos Basin of China: A case study

The deformation of soft rock roadway caused by floor heave is a major challenge for coal mines in China western mining areas. To achieve security and stability of soft rock roadway, this work considered the headgate at panel 11505 of the Yushujing Coal Mine as background. First, based on the limit equilibrium method and slip line field theory,a model of floor heave was established, the mechanism of floor heave control was analyzed, and an optimized support method was proposed. Then, the displacement, stress and failure zones around the surrounding rock with the original and optimized support were studied by FLAC. Finally, the serviceability of the support method was verified by field application. The results showed that the main deformation form of soft rock roadway is floor heave, and 0.5 m is relatively reasonable thicknesses of the inverted arch. The extrusion failure zone and shear failure zone were mainly affected by tensile and shear failure, respectively. The modification of floor and the effective support are key points. The failure zone was consistent between numerical simulation and theoretical calculation. The maximum convergences of floor heave determined by numerical simulation and field measurement were 220 mm and 240 mm, respectively, which were reduced by 55% and 60% compared with the original support, and the convergence between sidewalls decreased considerably. The optimized support method controls the floor heave well.