Background:The study aimed to assess the efficacy and safety of dinoprostone vaginal insert in labor induction following optimization of standard operating procedure(SOP)and to discover independent predictors of vagin...Background:The study aimed to assess the efficacy and safety of dinoprostone vaginal insert in labor induction following optimization of standard operating procedure(SOP)and to discover independent predictors of vaginal delivery.Methods:This study comprised 551 pregnant women who required cervical ripening with dinoprostone before induction of labor.Using univariate and multivariate analyses,independent predictors of vaginal delivery were identified.Results:443 of the 551 women(80.4%)gave birth vaginally.Vaginal delivery was predicted by maternal age(24-30 vs.<24,P<0.001;30-35 vs.<24,P=0.03),gestational age(P=0.005),birth weight(P<0.001),parity(P=0.001),pre-pregnancy BMI(P<0.001),premature rupture of membranes(P=0.001),meconium-stained amniotic fluid(P<0.001),fundal height(P<0.001)and the Bishop score(P<0.001).None of the women exhibited severe postpartum hemorrhage.Conclusions:The maternal age,gestational age,birth weight,parity,body mass index,premature membrane rupture,amniotic fluid contamination,fundal height,and the Bishop score were independent predictors of vaginal delivery.These may guide the clinical use of dinoprostone for induction of labor.展开更多
目的探讨地诺前列酮栓用于不同宫颈条件孕产妇引产的疗效和安全性。方法将广东省珠江三角洲地区10家医院2010年1月至2014年12月收治的798例使用地诺前列酮栓进行孕晚期引产的病例作为研究组,选取同期496例单纯使用缩宫素引产的病例作为...目的探讨地诺前列酮栓用于不同宫颈条件孕产妇引产的疗效和安全性。方法将广东省珠江三角洲地区10家医院2010年1月至2014年12月收治的798例使用地诺前列酮栓进行孕晚期引产的病例作为研究组,选取同期496例单纯使用缩宫素引产的病例作为对照组。根据宫颈Bishop评分及是否为初产妇进行分层分析,研究地诺前列酮栓用于不同宫颈条件下的孕产妇引产的疗效及安全性。结果研究组宫颈Bishop评分4~6分的经产妇用药后24 h经阴道分娩率高于对照组(81.82%vs.66.04%),两组比较差异有统计学意义(P=0.013);研究组宫颈Bishop评分4~6分的初产妇宫缩过频、过强发生率高于对照组(4.65%vs.0.99%),两组比较差异有统计学意义(P=0.009)。余不良反应各组比较差异无统计学意义。新生儿出生后1、5 min Apgar评分<7分发生率各组比较差异无统计学意义。结论孕晚期地诺前列酮栓引产的临床疗效及安全性与缩宫素相似,是一种安全有效的引产方法。展开更多
文摘Background:The study aimed to assess the efficacy and safety of dinoprostone vaginal insert in labor induction following optimization of standard operating procedure(SOP)and to discover independent predictors of vaginal delivery.Methods:This study comprised 551 pregnant women who required cervical ripening with dinoprostone before induction of labor.Using univariate and multivariate analyses,independent predictors of vaginal delivery were identified.Results:443 of the 551 women(80.4%)gave birth vaginally.Vaginal delivery was predicted by maternal age(24-30 vs.<24,P<0.001;30-35 vs.<24,P=0.03),gestational age(P=0.005),birth weight(P<0.001),parity(P=0.001),pre-pregnancy BMI(P<0.001),premature rupture of membranes(P=0.001),meconium-stained amniotic fluid(P<0.001),fundal height(P<0.001)and the Bishop score(P<0.001).None of the women exhibited severe postpartum hemorrhage.Conclusions:The maternal age,gestational age,birth weight,parity,body mass index,premature membrane rupture,amniotic fluid contamination,fundal height,and the Bishop score were independent predictors of vaginal delivery.These may guide the clinical use of dinoprostone for induction of labor.
文摘目的探讨地诺前列酮栓用于不同宫颈条件孕产妇引产的疗效和安全性。方法将广东省珠江三角洲地区10家医院2010年1月至2014年12月收治的798例使用地诺前列酮栓进行孕晚期引产的病例作为研究组,选取同期496例单纯使用缩宫素引产的病例作为对照组。根据宫颈Bishop评分及是否为初产妇进行分层分析,研究地诺前列酮栓用于不同宫颈条件下的孕产妇引产的疗效及安全性。结果研究组宫颈Bishop评分4~6分的经产妇用药后24 h经阴道分娩率高于对照组(81.82%vs.66.04%),两组比较差异有统计学意义(P=0.013);研究组宫颈Bishop评分4~6分的初产妇宫缩过频、过强发生率高于对照组(4.65%vs.0.99%),两组比较差异有统计学意义(P=0.009)。余不良反应各组比较差异无统计学意义。新生儿出生后1、5 min Apgar评分<7分发生率各组比较差异无统计学意义。结论孕晚期地诺前列酮栓引产的临床疗效及安全性与缩宫素相似,是一种安全有效的引产方法。
