Cu(DDC)_(2)纳米给药系统的抗肿瘤研究进展

二乙氨基硫代甲酸铜[copper diethyldithiocarbamate,Cu(DDC)_(2)]可通过多种机制诱导肿瘤细胞死亡,是一种潜在的抗肿瘤药物.但Cu(DDC)_(2)极低的水溶性使其应用受到很大限制.Cu(DDC)_(2)纳米给药系统在细胞和动物模型中显示出良好的抗肿瘤作用.文章基于近年来关于Cu(DDC)_(2)纳米给药系统的抗肿瘤研究进行总结和展望,为新型Cu(DDC)_(2)纳米给药系统的设计提供参考.

Shallow Convection Dataset Simulated by Three Different Large Eddy Models

Shallow convection plays an important role in transporting heat and moisture from the near-surface to higher altitudes,yet its parameterization in numerical models remains a great challenge,partly due to the lack of high-resolution observations.This study describes a large eddy simulation(LES)dataset for four shallow convection cases that differ primarily in inversion strength,which can be used as a surrogate for real data.To reduce the uncertainty in LES modeling,three different large eddy models were used,including SAM(System for Atmospheric Modeling),WRF(Weather Research and Forecasting model),and UCLA-LES.Results show that the different models generally exhibit similar behavior for each shallow convection case,despite some differences in the details of the convective structure.In addition to grid-averaged fields,conditionally sampled variables,such as in-cloud moisture and vertical velocity,are also provided,which are indispensable for calculation of the entrainment/detrainment rate.Considering the essentiality of the entraining/detraining process in the parameterization of cumulus convection,the dataset presented in this study is potentially useful for validation and improvement of the parameterization of shallow convection.

Mechanism of Thermally Radiative Prandtl Nanofluids and Double-Diffusive Convection in Tapered Channel on Peristaltic Flow with Viscous Dissipation and Induced Magnetic Field

The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and MATLAB.The velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.

2-D Modeling and Calculations of Stratospheric Ozone and Influences of Convection, Diffusion, and Time

An engineering system approach of 2-D cylindrical model of transient mass balance calculations of ozone and other concerned chemicals along with fourteen photolysis, ozone-generating and ozone-depleting chemical reaction equations was developed, validated, and used for studying the ozone concentrations, distribution and peak of the layer, ozone depletion and total ozone abundance in the stratosphere. The calculated ozone concentrations and profile at both the Equator and a 60˚N location were found to follow closely with the measured data. The calculated average ozone concentration was within 1% of the measured average, and the deviation of ozone profiles was within 14%. The monthly evolution of stratospheric ozone concentrations and distribution above the Equator was studied with results discussed in details. The influences of slow air movement in both altitudinal and radial directions on ozone concentrations and profile in the stratosphere were explored and discussed. Parametric studies of the influences of gas diffusivities of ozone DO3 and active atomic oxygen DO on ozone concentrations and distributions were also studied and delineated. Having both influences through physical diffusion and chemical reactions, the diffusivity (and diffusion) of atomic oxygen DO was found to be more sensitive and important than that of ozone DO3 on ozone concentrations and distribution. The 2-D ozone model present in this paper for stratospheric ozone and its layer and depletion is shown to be robust, convenient, efficient, and executable for analyzing the complex ozone phenomena in the stratosphere. .

Understanding the factors influencing cloud-core vertical accelerations during deep convection formation in the WRF model

本文将扰动气压利用一个线性诊断关系代替,重新推导了WRF模式框架地形追随坐标系下的垂直动量方程,建立了垂直加速与对流触发(DCI)影响因子(如温度,水汽等)的直接联系.研究发现,DCI过程与对流核垂直加速相关,三维副散,扰动位势在垂直方向的二阶非均匀性,扰动位温垂直梯度,比湿及其垂直梯度,水凝物拖曳,均是能够直接影响垂直加速和对流触发的物理因子,这些量与模式基本预报量相关,通过解析基本预报量对对流发展的直接影响,可能有助于理解模式对DCI过程预测失败的原因.

A teleconnection pattern of upper-tropospheric circulation anomalies over the Eurasian continent associated with the interannual variability of atmospheric convection over the tropical western North Pacific in July

热带西北太平洋大气对流的年际变化对东亚夏季气候有着显著影响,而且受到前冬ENSO的影响.然而,还有相当多的西北太平洋对流年际变化不能由前冬ENSO解释.本文表明,7月西北太平洋对流受到欧亚大陆对流层上层遥相关型的显著影响,且这一影响与前冬ENSO的影响程度相当.该遥相关型表现为位于欧洲的气旋式环流异常,中亚的反气旋式环流异常和东亚带状延伸的气旋式环流异常,并表现为7月对流层上层环流的第一主模态.基于本文的结果并结合前人的研究,作者认为这一遥相关型能通过亚洲急流出口区附近的罗斯贝波破碎引起西北太平洋对流异常.

建筑智能化DDC系统和安防系统有效融合软件设计探索

智能建筑已成为城市建设的新趋势,其中,建筑自动化集成控制系统(DDC)和安防系统是其重要组成部分。然而,传统的DDC和安防系统常常独立运作,系统融合的难度大,信息交流不畅。本研究针对以上问题,设计了一款基于智能建筑DDC系统和安防系统有效融合的软件。该软件以中控系统为基础,利用物联网技术,实现DDC系统和安防系统的数据共享、双向通信,达到了资源共享、互联互通和远程监控的目的。测试结果显示,该软件能够有效地实现DDC和安防系统的融合与优化,提升了建筑智能化的水平,并降低了运行成本。同时,软件操作界面友好,能够为建筑物业管理提供强大的支持。这样的研究成果对于促进智能建筑的研究与发展有着重要的理论和实践意义。

Control of the Dust Vertical Distribution over Western Africa by Convection and Scavenging

Saharan dust represents more than 50%of the total desert dust emitted around the globe and its radiative effect significantly affects the atmospheric circulation at a continental scale.Previous studies on dust vertical distribution and the Saharan Air Layer(SAL)showed some shortcomings that could be attributed to imperfect representation of the effects of deep convection and scavenging.The authors investigate here the role of deep convective transport and scavenging on the vertical distribution of mineral dust over Western Africa.Using multi-year(2006-2010)simulations performed with the variable-resolution(zoomed)version of the LMDZ climate model.Simulations are compared with aerosol amounts recorded by the Aerosol Robotic Network(AERONET)and with vertical profiles of the Cloud-Aerosol Lidar with Orthogonal Polarization(CALIOP)measurements.LMDZ allows a thorough examination of the respective roles of deep convective transport,convective and stratiform scavenging,boundary layer transport,and advection processes on the vertical mineral dust distribution over Western Africa.The comparison of simulated dust Aerosol Optical Depth(AOD)and distribution with measurements suggest that scavenging in deep convection and subsequent re-evaporation of dusty rainfall in the lower troposphere are critical processes for explaining the vertical distribution of desert dust.These processes play a key role in maintaining a well-defined dust layer with a sharp transition at the top of the SAL and in establishing the seasonal cycle of dust distribution.This vertical distribution is further reshaped offshore in the Inter-Tropical Convergence Zone(ITCZ)over the Atlantic Ocean by marine boundary layer turbulent and convective transport and wet deposition at the surface.

Numerical simulation for 2D double-diffusive convection(DDC) in rectangular enclosures based on a high resolution upwind compact streamfunction model Ⅰ: numerical method and code validation

A high resolution upwind compact streamfunction numerical algorithm for two-dimensional(2D)double-diffusive convection(DDC)is developed.The unsteady Navier-Stokes(N-S)equations in the streamfunction-velocity form and the scalar temperature and concentration equations are used.An optimized third-order upwind compact(UCD3 opt)scheme with a low dispersion error for the first derivatives is utilized to approximate the third derivatives of the streamfunction in the advection terms of the N-S equations and the first derivatives in the advection terms of the scalar temperature and concentration equations.The remaining first derivatives of the streamfunction(velocity),temperature,and concentration variables used in the governing equations are discretized by the fourth-order compact Pade(SCD4)schemes.With the temperature and concentration variables and their approximate values of the first derivatives obtained by the SCD4 schemes,the explicit fourth-order compact schemes are suggested to approximate the second derivatives of temperature and concentration in the diffusion terms of the energy and concentration equations.The discretization of the temporal term is executed with the second-order Crank-Nicolson(C-N)scheme.To assess the spatial behavior capability of the established numerical algorithm and verify the developed computer code,the DDC flow is numerically solved.The obtained results agree well with the benchmark solutions and some accurate results available in the literature,verifying the accuracy,effectiveness,and robustness of the provided algorithm.Finally,a preliminary application of the proposed method to the DDC is carried out.

基于嵌入式DDC控制器的通信楼宇自控系统设计

楼宇自控系统是在楼宇建筑中综合监管机电设备的智能系统。因建筑内机电设备多且分散,无法在局部网络共享通信数据而导致控制效果不佳。为此,设计了基于嵌入式DDC控制器的通信楼宇自控系统。以江森自控MSEA系列产品架构为系统总体结构,设计用户管理操作站。利用SQL标准数据库扩展数据管理服务器,向整个楼宇设备发送命令。使用网络控制引擎,负责监控安装在其现场总线上设备嵌入式DDC控制器。通过嵌入式DDC控制器在局部网络上分享数据,实时监测整个网络。将系统负荷和扰动视为恒定,分析开机过程中室内温度与时间的关系,充分考虑系统滞后问题,设计机电设备最佳启停节能控制方案。采用PID算法控制升温到保温过渡时期温度。测试结果表明,该系统能耗最大值为1250 kW·h,温度最大值为26.0℃,与实际数据一致,说明使用该系统能够达到节能、控温的目的。

Simulation of inclined dendrites under natural convection by KKS phase field model based on CUDA

In this work,Al-4.5wt.%Cu was selected as the research object,and a phase field-lattice Boltzmann method(PF-LBM)model based on compute unified device architecture(CUDA)was established to solve the problem of low serial computing efficiency of a traditional CPU and achieve significant acceleration.This model was used to explore the evolution of dendrite growth under natural convection.Through the study of the tip velocities,it is found that the growth of the dendrite arms at the bottom is inhibited while the growth of the dendrite arms at the top is promoted by natural convection.In addition,research on the inclined dendrite under natural convection was conducted.It is observed that there is a deviation between the actual growth direction and the preferred angle of the inclined dendrite.With the increase of the preferred angle of the seed,the difference between the actual growth direction and the initial preferred angle of the inclined dendrite shows a trend of increasing at first and then decreasing.In the simulation area,the relative deflection directions of the primary dendrite arms in the top right corner and the bottom left corner of the same dendrite are almost counterclockwise,while the relative deflection directions of the other two primary dendrite arms are clockwise.

Numerical Assessment of Nanofluid Natural Convection Using Local RBF Method Coupled with an Artificial Compressibility Model

In this paper,natural heat convection inside square and equilateral triangular cavities was studied using a meshless method based on collocation local radial basis function(RBF).The nanofluids used were Cu-water or Al_(2)O_(3)-water mixture with nanoparticle volume fractions range of 0≤φ≤0.2.A system of continuity,momentum,and energy partial differential equations was used in modeling the flow and temperature behavior of the fluids.Partial derivatives in the governing equations were approximated using the RBF method.The artificial compressibility model was implemented to overcome the pressure velocity coupling problem that occurs in such equations.Themain goal of this work was to present a simple and efficient method to deal with complex geometries for a variety of problem conditions.To assess the accuracy of the proposed method,several test cases of natural convection in square and triangular cavities were selected.For Rayleigh numbers ranging from 103 to 105,a validation test of natural convection of Cu-water in a square cavity was used.The numerical investigation was then extended to Rayleigh number 106,as well as Al_(2)O_(3)-water nanofluid with a volume fraction range of 0≤φ≤0.2.In a second investigation,the same nanofluids were used in a triangular cavitywith varying volume fractions to test the proposed meshless approach on non-rectangular geometries.The numerical results appear to be in agreement with those from earlier investigations.Furthermore,the suggested meshless method was found to be stable and accurate,demonstrating that it may be a viable alternative for solving natural heat transfer equations of nanofluids in enclosures with irregular geometries.

一种基于资源优化的DDC设计及实现

数字接收系统中,对输入的射频信号直接中频采样后进行数字下变频(Digital Down Converter,DDC),有效减少了硬件模拟设备的数量,提高了系统的可靠性和稳定性。针对高速数字下变频存在的采样率高、资源消耗高等难点,利用滤波器系数的对称性特点设计了一种在不降低处理速度的前提下,减少现场可编程门阵列(Field ProgrammableGate Array,FPGA)内部处理单元个数,实现功耗降低的有限冲击响应(Finite Impulse Response,FIR)滤波器,并在FPGA中得到了实现。实验结果表明,该方法性能优异,可大幅节省资源,具有较高的工程实用价值。

BOUNDEDNESS OF A CHEMOTAXIS-CONVECTION MODEL DESCRIBING TUMOR-INDUCED ANGIOGENESIS

This paper is concerned with the parabolic-parabolic-elliptic system■in a bounded domainΩ?Rnwith a smooth boundary,where the parametersχ,ζ1,ζ2are positive constants and m≥1.Based on the coupled energy estimates,the boundedness of the global classical solution is established in any dimensions(n≥1)provided that m>1.

Evaluation of the Predicted Particle Properties (P3) Microphysics Scheme in Simulations of Stratiform Clouds with Embedded Convection

To evaluate the ability of the Predicted Particle Properties(P3)scheme in the Weather Research and Forecasting(WRF)model,we simulated a stratiform rainfall event over northern China on 22 May 2017.WRF simulations with two P3 versions,P3-nc and P3-2ice,were evaluated against rain gauge,radar,and aircraft observations.A series of sensitivity experiments were conducted with different collection efficiencies between ice and cloud droplets.The comparison of the precipitation evolution between P3-nc and P3-2ice suggested that both P3 versions overpredicted surface precipitation along the Taihang Mountains but underpredicted precipitation in the localized region on the leeward side.P3-2ice had slightly lower peak precipitation rates and smaller total precipitation amounts than P3-nc,which were closer to the observations.P3-2ice also more realistically reproduced the overall reflectivity structures than P3-nc.A comparison of ice concentrations with observations indicated that P3-nc underestimated aggregation,whereas P3-2ice produced more active aggregation from the self-collection of ice and ice-ice collisions between categories.Efficient aggregation in P3-2ice resulted in lower ice concentrations at heights between 4 and 6 km,which was closer to the observations.In this case,the total precipitation and precipitation pattern were not sensitive to riming.Riming was important in reproducing the location and strength of the embedded convective region through its impact on ice mass flux above the melting level.

Experimentation of a Forced Convection Solar Dryer for Drying Sweet Potatoes at the Higher Institute of Technology of Mamou-Guinea

This study was carried out at the Mamou Higher Institute of Technology during the period from March 10 to April 15, 2022, with the aim of designing and testing a solar dryer with forced convection by drying potatoes. The dryer was designed using local materials. Its main geometric parameters are: 1) height of the drying chamber (90 cm), 2) length of the drying chamber (50 cm), 3) width of the drying chamber (43 cm), 4) surface of the racks (0.1806 m2), 5) surface of the heat accumulator (0.2537 m2). The experiment focused on the vacuum test of the dryer for two days and that of the drying of the sweet potato for three days from 8:30 a.m. to 5:30 p.m. The average vacuum test temperature values of the three environments are respectively accumulator (43°C), dryer chamber (41°C) and ambient environment (34°C). Four kilograms (4 kg) of boiled sweet potato were dried. The average temperatures in the accumulator and in the drying chamber during the three days of drying are respectively 33°C and 39°C. The final mass of the dried product is 1.2 kg, with a quantity of water extracted of 2 liters or 63% of the initial mass of the product. The average drying rate is 0.074 kg/h. The drying kinetics showed a decreasing rate in the absence of the heating period and the constant rate period.

Experimentation of a Forced Convection Solar Dryer for Drying Sweet Potatoes at the Higher Institute of Technology of Mamou-Guinea

This study was carried out at the Mamou Higher Institute of Technology during the period from March 10 to April 15, 2022, with the aim of designing and testing a solar dryer with forced convection by drying potatoes. The dryer was designed using local materials. Its main geometric parameters are: 1) height of the drying chamber (90 cm), 2) length of the drying chamber (50 cm), 3) width of the drying chamber (43 cm), 4) surface of the racks (0.1806 m2), 5) surface of the heat accumulator (0.2537 m2). The experiment focused on the vacuum test of the dryer for two days and that of the drying of the sweet potato for three days from 8:30 a.m. to 5:30 p.m. The average vacuum test temperature values of the three environments are respectively accumulator (43°C), dryer chamber (41°C) and ambient environment (34°C). Four kilograms (4 kg) of boiled sweet potato were dried. The average temperatures in the accumulator and in the drying chamber during the three days of drying are respectively 33°C and 39°C. The final mass of the dried product is 1.2 kg, with a quantity of water extracted of 2 liters or 63% of the initial mass of the product. The average drying rate is 0.074 kg/h. The drying kinetics showed a decreasing rate in the absence of the heating period and the constant rate period.

Modeling of Mixed Convection in a Lid Driven Wavy Enclosure with Two Square Blocks Placed at Different Positions

The purpose of this paper is to investigate the simulation of mixed convection in a lid-driven wavy enclosure with blocks positioned at various positions. This study also examined the impact of the longitudinal position of the heated block on heat transfer enhancement. The Galerkin weighted residual finite element method is employed to computationally solve the governing equations of Navier-Stokes, thermal energy, and mass conservation. The enclosure consists of two square heated blocks strategically placed at different heights—firstly, one set is closer to the bottom surface;secondly, one set is nearer to the middle area and finally, one set is closer to the upper undulating surface of the enclosure. The wavy top wall’s thermal insulation, along with active heating of the bottom wall and blocks, generates a dynamic convective atmosphere. In addition, the left wall ascends as the right wall falls, causing the flow formed by the lid. The study investigates the impact of the Richardson number on many factors, such as streamlines, isotherms, dimensionless temperature, velocity profiles, and average Nusselt numbers. These impacts are depicted through graphical illustrations. In all instances, two counter-rotating eddies were generated within the cage. Higher rotating speed consistently leads to improved performance, irrespective of other characteristics. Furthermore, an ideal amalgamation of the regulating factors would lead to increased heat transmission.

Influence of the Inclination Angle on Mixed Convection and Heat Transfer in a“T”Shaped Double Enclosure

The effect of the tilt angle on mixed convection and related heat transfer in a“T”shaped double enclosure with four heated obstacles on the bottom surface is numerically investigated.The considered obstacles are constantly kept at a relatively high(fixed)temperature,while the cavity’s upper wall is cooled.The finite volume approach is used to solve the mass,momentum,and energy equations with the SIMPLEC algorithm being exploited to deal with the pressure-velocity coupling.Emphasis is put on the influence of the tilt angle on the solution symmetry,flow structure,and heat exchange through the walls.The following parameters and related ranges are considered:Rayleigh number 104≤Ra≤5.105,tilt angle 0°≤φ≤90°,Reynolds number 100≤Re≤1000,Prandtl number Pr=0.72,block height B=0.5,opening width C=0.15,and distance between blocks D=0.5.The results reveal different branches of solutions on varying Re andφ.They also show that the symmetry of the solution regarding the P_(2)axis is retained for all cases with no tilt and for values of Re between 100 and 1000.

Simulation of Natural Convection Flow with Magneto-Hydrodynamics in a Wavy Top Enclosure with a Semi-Circular Heater

Natural convection flow in enclosure has different applications such as room ventilation, heat exchangers, the cooling system of a building etc. The Finite-Element method based on the Galerkin weighted residual approach is used to solve two-dimensional governing mass, momentum and energy-equations for natural convection flow in the presence of a magnetic field on a roof top with semi-circular heater. In the enclosure the horizontal lower wall was heated, the vertical two walls were adiabatic, inside the semi-circular heater, the wavy top wall cooled. The parameters Rayleigh number, Hartmann number and Prandtl number are considered. The effects of the Hartmann number and Rayleigh number on the streamlines, isotherms, velocity profiles and average Nusselt number are examined graphically. The local Nusselt number and the average Nusselt number of the heated portion of the enclosure with the semi-circular heater are presented in this paper. Finally, for the validation of the existing work, the current results are compared with published results and the auspicious agreement is achieved.