This paper describes the direct oxidation of pyridines to pyridine-N-oxides by means of 30% H2O2 in aq media in the presence of Na2WO4.2H(2)O as catalyst instead of with per-acids or 30% H2O2 in acetic acid. Good yiel...This paper describes the direct oxidation of pyridines to pyridine-N-oxides by means of 30% H2O2 in aq media in the presence of Na2WO4.2H(2)O as catalyst instead of with per-acids or 30% H2O2 in acetic acid. Good yields were obtained.展开更多
1,5-Bismethylene cyclooctane derivatives were synthesized by the palladium catalyzed annulation reaction of 2-methylene propane-1,3-diol diacetate with compounds containing active methylene groups in the presence of BSA.
The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleo...The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleophiles in the presence of base to give the title compounds.展开更多
2-Fluoroalkyl-4-hydroxy-quinolines were easily obtained from the reactions of 2-(F-alkyl)acetates with aromatic amines in the presence of Et_3N,followed by cyclization of the intermediates with PPA.
Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good ...Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good yields through a radical process.展开更多
A convenient method for the asymmetric synthesis of 1-amino- alkylphosphonic acids was described.It involved the diastereoselctive alkylation of bicyclic chloromethylphosphonamide derived from(S)-2-ani- linomethylpyrr...A convenient method for the asymmetric synthesis of 1-amino- alkylphosphonic acids was described.It involved the diastereoselctive alkylation of bicyclic chloromethylphosphonamide derived from(S)-2-ani- linomethylpyrrolidine followed by subsequent conversions leading to amino compounds by Staudinger method.Acid hydrolysis afforded the target molecule in good yield.展开更多
The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formati...The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formation of 2-perfluoroalkyl-2,5-dimethyl-2H-pyrrole (3) as a major product in good yield.展开更多
A simple and general method for the synthesis of bi(acyl)disulfides is reported.Sulfur is allowed to react with sodium hydroxide to give sodium disulfide at 65℃ under PTC,which can react with acyl halides to afford b...A simple and general method for the synthesis of bi(acyl)disulfides is reported.Sulfur is allowed to react with sodium hydroxide to give sodium disulfide at 65℃ under PTC,which can react with acyl halides to afford bi(acyl)disulfides in good to excellent isolated yields.The effects of solvents and phase transfer catalysts are discussed.展开更多
文摘This paper describes the direct oxidation of pyridines to pyridine-N-oxides by means of 30% H2O2 in aq media in the presence of Na2WO4.2H(2)O as catalyst instead of with per-acids or 30% H2O2 in acetic acid. Good yields were obtained.
文摘1,5-Bismethylene cyclooctane derivatives were synthesized by the palladium catalyzed annulation reaction of 2-methylene propane-1,3-diol diacetate with compounds containing active methylene groups in the presence of BSA.
文摘The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleophiles in the presence of base to give the title compounds.
基金This work was partially supported by the National Natural Science Foundation of China.
文摘2-Fluoroalkyl-4-hydroxy-quinolines were easily obtained from the reactions of 2-(F-alkyl)acetates with aromatic amines in the presence of Et_3N,followed by cyclization of the intermediates with PPA.
文摘Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good yields through a radical process.
文摘A convenient method for the asymmetric synthesis of 1-amino- alkylphosphonic acids was described.It involved the diastereoselctive alkylation of bicyclic chloromethylphosphonamide derived from(S)-2-ani- linomethylpyrrolidine followed by subsequent conversions leading to amino compounds by Staudinger method.Acid hydrolysis afforded the target molecule in good yield.
文摘The reaction between 2,5-Dimethylpyrrole (1) and R_FI (2)(R_F: a, Cl(CF_2)_4; b, Cl(CF_2)_6; c, Cl(CF_2)_8; d, n-C_6F_(13); e, n-C_8F_(17)) in the presence of Na_2S_2O_4-NaHCO_3 in acetonitrile resulted in the formation of 2-perfluoroalkyl-2,5-dimethyl-2H-pyrrole (3) as a major product in good yield.
文摘A simple and general method for the synthesis of bi(acyl)disulfides is reported.Sulfur is allowed to react with sodium hydroxide to give sodium disulfide at 65℃ under PTC,which can react with acyl halides to afford bi(acyl)disulfides in good to excellent isolated yields.The effects of solvents and phase transfer catalysts are discussed.
