The liver represents a frontline immune organ that is constantly exposed to a variety of gut-derived antigens as a result of its unique location and blood supply, With a predominant role in innate immunity, the liver ...The liver represents a frontline immune organ that is constantly exposed to a variety of gut-derived antigens as a result of its unique location and blood supply, With a predominant role in innate immunity, the liver is enriched with various innate immune cells, among which natural killer （NK） cells play important roles in host defense and in maintaining immune balance, Hepatic NK cells were first described as ＇pit cells＇ in the rat liver in the 1970s, Recent studies of NK cells in mouse and human livers have shown that two distinct NK cell subsets, liver-resident NK cells and conventional NK （cNK） cells, are present in this organ, Here, we review liver NK cell subsets in different species, revisiting rat hepatic pit ceils and highlighting recent progress related to resident NK cells in mouse and human livers, and also discuss the dual roles of NK cells in liver immunity,展开更多
Nature killer(NK) cells are important lymphocytes of the innate immune system,well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells.Current studies have revealed ...Nature killer(NK) cells are important lymphocytes of the innate immune system,well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells.Current studies have revealed that NK cells are not a homogeneous population,but instead consist of distinct subsets with diverse characteristics.As an organ with predominant innate immunity,the liver is enriched with NK cells,among which two distinct NK cell subsets have recently been identified:conventional NK(cNK)cells and tissue-resident NK(trNK) cells.Liver trNK cells are markedly different from cNK cells in many aspects,representing a new lineage of innate lymphoid cell(ILC) family.Here,we summarize the phenotypic and functional features of liver trNK cells,and review current knowledge regarding developmental pathway of liver trNK cells.We also overview recent advances in human liver trNK cells and discuss the striking shared hallmarks of trNK cells in different tissues.展开更多
基金This work was supported by the Ministry of Science ＆ Technology of China （973 Basic Science Project #2013CB944902）, the Natural Science Foundation of China （#81361120388, #31300727, and #81571522）, and the Key Program of the Chinese Academy of Sciences （KJZD-EW-L10 -003）.
文摘The liver represents a frontline immune organ that is constantly exposed to a variety of gut-derived antigens as a result of its unique location and blood supply, With a predominant role in innate immunity, the liver is enriched with various innate immune cells, among which natural killer （NK） cells play important roles in host defense and in maintaining immune balance, Hepatic NK cells were first described as ＇pit cells＇ in the rat liver in the 1970s, Recent studies of NK cells in mouse and human livers have shown that two distinct NK cell subsets, liver-resident NK cells and conventional NK （cNK） cells, are present in this organ, Here, we review liver NK cell subsets in different species, revisiting rat hepatic pit ceils and highlighting recent progress related to resident NK cells in mouse and human livers, and also discuss the dual roles of NK cells in liver immunity,
基金supported by the Ministry of Science&Technology of China(2013CB944902)the Natural Science Foundation of China(81361120388,81571522,31300727,91542114,91442112)
文摘Nature killer(NK) cells are important lymphocytes of the innate immune system,well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells.Current studies have revealed that NK cells are not a homogeneous population,but instead consist of distinct subsets with diverse characteristics.As an organ with predominant innate immunity,the liver is enriched with NK cells,among which two distinct NK cell subsets have recently been identified:conventional NK(cNK)cells and tissue-resident NK(trNK) cells.Liver trNK cells are markedly different from cNK cells in many aspects,representing a new lineage of innate lymphoid cell(ILC) family.Here,we summarize the phenotypic and functional features of liver trNK cells,and review current knowledge regarding developmental pathway of liver trNK cells.We also overview recent advances in human liver trNK cells and discuss the striking shared hallmarks of trNK cells in different tissues.
