Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro w...Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin releasing copper IUD (FICu IUD) on the PGI 2 was stronger than that on the TXA 2, the ratio of 6 keto PGF 1α /TXB 2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu IUD, and promote copper ion release. It was suggested that indomethacin released by FICu IUD could effectively reduce abnormal uterine bleeding.展开更多
探讨以益气化瘀立法的环血宁汤治疗宫内节育器 (IU D)所致子宫异常出血作用的机理。用消炎痛作对照 ,观察了环血宁汤对置带铜宫内节育器 (CUIUD)家兔子宫内膜形态学的影响。结果 :置 CU IU D模型组家兔子宫内膜上皮缺损明显 ,上皮下及...探讨以益气化瘀立法的环血宁汤治疗宫内节育器 (IU D)所致子宫异常出血作用的机理。用消炎痛作对照 ,观察了环血宁汤对置带铜宫内节育器 (CUIUD)家兔子宫内膜形态学的影响。结果 :置 CU IU D模型组家兔子宫内膜上皮缺损明显 ,上皮下及缺损处见大量炎性细胞浸润 ,子宫内膜微血管部分扩张、充血 ;环血宁汤治疗组家兔子宫内膜上皮轻度损伤 ,炎性细胞浸润程度较轻。消炎痛对照组家兔子宫内膜形态学变化与环血宁汤治疗组相似。结论 :环血宁汤对置 CU IU D家兔子宫内膜损伤有一定的修复作用 ,提示对子宫内膜的修复作用可能是环血宁汤治疗置 IU D后子宫异常出血的作用机制之一 ,亦说明益气化瘀法是治疗置 IU展开更多
The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive method.Here,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation funct...The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive method.Here,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation function,sensitivity to estrogen and progesterone,cell proliferation,and immune response of the endometrium.Studies on the morphology of endometrium indicate that the use of Cu-IUDs can affect the number and binding capacity of estrogen and progesterone receptors in the endometrium and reduce the response of the endometrium to estrogen and progesterone.The use of Cu-IUDs can also affect the proliferation of endometrial cells,suggesting that the aseptic inflammation caused by Cu-IUDs may differ from chronic infectious or noninfectious inflammation;this highlights that the use of Cu-IUDs provides protection against endometrial proliferative diseases.The use of Cu-IUDs increases local endometrial angiogenesis,bleeding tendency,and fibrinolytic activity,which can result in prolonged menstruation or abnormal uterine bleeding.Additionally,the use of Cu-IUDs can cause the infiltration of numerous lymphocytes,monocytes,macrophages,and other inflammatory cells around the endometrial gland and changes in endometrial immune function,immune cell function,and the number and type of immune molecules.Cu-IUD-induced decidual injury significantly increases the invasiveness of trophoblasts,further affecting the aberrant expression of their growth-,angiogenesis-,and invasion-related factors and improving the formation of the placenta.Moreover,the endometrial damage caused by Cu-IUD placement before embryo transfer can improve both clinical pregnancy and live birth rates;however,specific changes in the immune system after Cu-IUD use as well as its effects on future pregnancies require further investigation.展开更多
基金This project was supported by a grant from Hubei Science and Technology Com mittee(No.96 1P190 1)
文摘Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin releasing copper IUD (FICu IUD) on the PGI 2 was stronger than that on the TXA 2, the ratio of 6 keto PGF 1α /TXB 2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu IUD, and promote copper ion release. It was suggested that indomethacin released by FICu IUD could effectively reduce abnormal uterine bleeding.
文摘探讨以益气化瘀立法的环血宁汤治疗宫内节育器 (IU D)所致子宫异常出血作用的机理。用消炎痛作对照 ,观察了环血宁汤对置带铜宫内节育器 (CUIUD)家兔子宫内膜形态学的影响。结果 :置 CU IU D模型组家兔子宫内膜上皮缺损明显 ,上皮下及缺损处见大量炎性细胞浸润 ,子宫内膜微血管部分扩张、充血 ;环血宁汤治疗组家兔子宫内膜上皮轻度损伤 ,炎性细胞浸润程度较轻。消炎痛对照组家兔子宫内膜形态学变化与环血宁汤治疗组相似。结论 :环血宁汤对置 CU IU D家兔子宫内膜损伤有一定的修复作用 ,提示对子宫内膜的修复作用可能是环血宁汤治疗置 IU D后子宫异常出血的作用机制之一 ,亦说明益气化瘀法是治疗置 IU
文摘The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive method.Here,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation function,sensitivity to estrogen and progesterone,cell proliferation,and immune response of the endometrium.Studies on the morphology of endometrium indicate that the use of Cu-IUDs can affect the number and binding capacity of estrogen and progesterone receptors in the endometrium and reduce the response of the endometrium to estrogen and progesterone.The use of Cu-IUDs can also affect the proliferation of endometrial cells,suggesting that the aseptic inflammation caused by Cu-IUDs may differ from chronic infectious or noninfectious inflammation;this highlights that the use of Cu-IUDs provides protection against endometrial proliferative diseases.The use of Cu-IUDs increases local endometrial angiogenesis,bleeding tendency,and fibrinolytic activity,which can result in prolonged menstruation or abnormal uterine bleeding.Additionally,the use of Cu-IUDs can cause the infiltration of numerous lymphocytes,monocytes,macrophages,and other inflammatory cells around the endometrial gland and changes in endometrial immune function,immune cell function,and the number and type of immune molecules.Cu-IUD-induced decidual injury significantly increases the invasiveness of trophoblasts,further affecting the aberrant expression of their growth-,angiogenesis-,and invasion-related factors and improving the formation of the placenta.Moreover,the endometrial damage caused by Cu-IUD placement before embryo transfer can improve both clinical pregnancy and live birth rates;however,specific changes in the immune system after Cu-IUD use as well as its effects on future pregnancies require further investigation.
