The crystal structure of \[Cu(Im)_ 4 \](teph) (Im=imidazole,teph=terephthalate) has been determined by X-ray crystallography. It crystallizes in the triclinic system,space group P ī with cell dimensions of a =0.8035...The crystal structure of \[Cu(Im)_ 4 \](teph) (Im=imidazole,teph=terephthalate) has been determined by X-ray crystallography. It crystallizes in the triclinic system,space group P ī with cell dimensions of a =0.80356(16) nm, b = 0.84269(17) nm,c =0.88967(18) nm,α =76.90(3)°,β =68.95(3)°,γ =75.94(3)°,and Z =1. Its structure of the title compound is composed of discrete monomeric molecule of \[Cu(Im)_ 4 \]-(teph). The copper(II) ions have a square plane geometry with the CuN_ 4 chromophore.展开更多
The structures of [Cu(S_2CN(CH_2)_4)_2] (1) and [Zn_2(S_2CN-(CH_2)_4)_4] (2) have been determined by X-ray crystallography analysis. They are all isomorphous and triclinic, space group of P1, with Z=1. The lattice p...The structures of [Cu(S_2CN(CH_2)_4)_2] (1) and [Zn_2(S_2CN-(CH_2)_4)_4] (2) have been determined by X-ray crystallography analysis. They are all isomorphous and triclinic, space group of P1, with Z=1. The lattice parameters of compound 1 is: a=0.63483(2) nm, b=0.74972(3) nm, c=0.78390(1) nm, α=75.912(2)°, β=78.634(2)° and γ=86.845(2)°; compound 2: a=0.78707(6) nm, b=0.79823(6) nm, c=1.23246(9) nm, α=74.813(2)°, β=73.048(2)° and γ=88.036(2)°. The copper atom is located on a crystallographic inversion center and zinc atom lies across centers of symmetry. The Cu(II) ion has a square-planar geometry while Zn(II) has a distorted tetrahedral geometry. The thermal gravity (TG) data indicate that no structural transitions in the two compounds were abserved and the decomposition products can adsorb gas. Also they all have a high thermal stability.展开更多
A new Cu（II） coordination polymer, [Cu2（mip）2（bmix）], （bmix = 1,4-bis（2-methyl- imidazole-l-ylmethyl）benzene, HEmip = 5-methylisophthalic acid）, has been hydrothermally synthesized and characterized by eleme...A new Cu（II） coordination polymer, [Cu2（mip）2（bmix）], （bmix = 1,4-bis（2-methyl- imidazole-l-ylmethyl）benzene, HEmip = 5-methylisophthalic acid）, has been hydrothermally synthesized and characterized by elemental analyses, IR, TGA and single-crystal X-ray diffraction. The title compound belongs to the triclinic system, space group P1 with a -- 9.435（5）, b = 12.241（6）, c = 13.666（6） A, β = 94.396（8）°, V= 1565.5（13） A3, Z= 2, C34H30Cu2N4Os, Mr = 749.70, Dc = 1.590 g/cm3,/l = 1.419 mm-1 and F（000） = 768. The title metal-organic coordination polymer exhibits the first two-fold interpenetrated pcu topological structure assembled by two types of dinuclear copper（Ⅱ） dusters and a flexible bis（imidazole）-based ligand. In addition, the fluorescence and catalytic performances of the complex for the degradation of Congo red azo dye in Fenton-like process were presented.展开更多
Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution.The active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)...Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution.The active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer treatment.Both in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side effects.This research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.展开更多
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 2 75 0 2 0 )andtheNaturalScienceFoundationofShandongProvince (No .Z2 0 0 2B0 2 )
文摘The crystal structure of \[Cu(Im)_ 4 \](teph) (Im=imidazole,teph=terephthalate) has been determined by X-ray crystallography. It crystallizes in the triclinic system,space group P ī with cell dimensions of a =0.80356(16) nm, b = 0.84269(17) nm,c =0.88967(18) nm,α =76.90(3)°,β =68.95(3)°,γ =75.94(3)°,and Z =1. Its structure of the title compound is composed of discrete monomeric molecule of \[Cu(Im)_ 4 \]-(teph). The copper(II) ions have a square plane geometry with the CuN_ 4 chromophore.
基金ProjectsupportedbytheKeyProjectofEducationalAdministrationofShandongProvince (No .J0 1C0 5 )andtheOutstandingAdult YoungScien tificResearchEncouragingFoundationofShandongProvince (No .O1BS18)
文摘The structures of [Cu(S_2CN(CH_2)_4)_2] (1) and [Zn_2(S_2CN-(CH_2)_4)_4] (2) have been determined by X-ray crystallography analysis. They are all isomorphous and triclinic, space group of P1, with Z=1. The lattice parameters of compound 1 is: a=0.63483(2) nm, b=0.74972(3) nm, c=0.78390(1) nm, α=75.912(2)°, β=78.634(2)° and γ=86.845(2)°; compound 2: a=0.78707(6) nm, b=0.79823(6) nm, c=1.23246(9) nm, α=74.813(2)°, β=73.048(2)° and γ=88.036(2)°. The copper atom is located on a crystallographic inversion center and zinc atom lies across centers of symmetry. The Cu(II) ion has a square-planar geometry while Zn(II) has a distorted tetrahedral geometry. The thermal gravity (TG) data indicate that no structural transitions in the two compounds were abserved and the decomposition products can adsorb gas. Also they all have a high thermal stability.
基金supported by the Excellent Youth Fund of Hebei Province Department of Education(Y2012010)
文摘A new Cu（II） coordination polymer, [Cu2（mip）2（bmix）], （bmix = 1,4-bis（2-methyl- imidazole-l-ylmethyl）benzene, HEmip = 5-methylisophthalic acid）, has been hydrothermally synthesized and characterized by elemental analyses, IR, TGA and single-crystal X-ray diffraction. The title compound belongs to the triclinic system, space group P1 with a -- 9.435（5）, b = 12.241（6）, c = 13.666（6） A, β = 94.396（8）°, V= 1565.5（13） A3, Z= 2, C34H30Cu2N4Os, Mr = 749.70, Dc = 1.590 g/cm3,/l = 1.419 mm-1 and F（000） = 768. The title metal-organic coordination polymer exhibits the first two-fold interpenetrated pcu topological structure assembled by two types of dinuclear copper（Ⅱ） dusters and a flexible bis（imidazole）-based ligand. In addition, the fluorescence and catalytic performances of the complex for the degradation of Congo red azo dye in Fenton-like process were presented.
基金the National Natural Science Foundation of China(Grant Nos.81774125 and 81973671)the Natural Science Foundation of Shandong Province(Grant No.ZR2019BB071)+1 种基金the Major Innovation and Technology Engineering Project of Shandong Province(Grant No.2019JZZY011106)the Science and Technology Innovation Fund for College Students of Weifang Medical University,and the Weifang Medical University-Sponsored Visiting Schola Research.
文摘Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient solution.The active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer treatment.Both in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side effects.This research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.
