The activities of superoxide dismutase (SOD). glutathione peroxidase (GSH-PX) in blood and the content of melondialdehyde (MDA) in plasma of 30 Fatients (male 17, female 13) with coronary artery disease (CAD) were de...The activities of superoxide dismutase (SOD). glutathione peroxidase (GSH-PX) in blood and the content of melondialdehyde (MDA) in plasma of 30 Fatients (male 17, female 13) with coronary artery disease (CAD) were determined in this study. It was shown that SOD and GSH-PX activities were decreased and the content of MDA was increased in the Patients comparative with the healthy controls (P<0.001). Vitamin C, the free radical scavenger, was then administered intravenously with a daily dose of 2g for 2 weeks. The activities of SOD and GSB-PX were significantly elevated (P<0.01, and P<0.05, respectively). and the level of MDA was obviously declined (P<0.01). Thus,the lipid peroxidation is involved in the pathogenesis of CAD,and vitamin C possessing some effects to ameliorate the lipid peroxidation damage could be helpful in the treatment of CAE.展开更多
文摘The activities of superoxide dismutase (SOD). glutathione peroxidase (GSH-PX) in blood and the content of melondialdehyde (MDA) in plasma of 30 Fatients (male 17, female 13) with coronary artery disease (CAD) were determined in this study. It was shown that SOD and GSH-PX activities were decreased and the content of MDA was increased in the Patients comparative with the healthy controls (P<0.001). Vitamin C, the free radical scavenger, was then administered intravenously with a daily dose of 2g for 2 weeks. The activities of SOD and GSB-PX were significantly elevated (P<0.01, and P<0.05, respectively). and the level of MDA was obviously declined (P<0.01). Thus,the lipid peroxidation is involved in the pathogenesis of CAD,and vitamin C possessing some effects to ameliorate the lipid peroxidation damage could be helpful in the treatment of CAE.
