Bacterial infection is a major threat to public health.Nanotechnology offers a solu-tion by combining nanomaterials with antibacterial agents.The development of an effective nanocomposite against drug-resistant bacter...Bacterial infection is a major threat to public health.Nanotechnology offers a solu-tion by combining nanomaterials with antibacterial agents.The development of an effective nanocomposite against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)is highly important yet challenging.Here,an anti-MRSA core–shell structure is designed,containing antibacterial zeolitic imidazolate framework-8(ZIF-8)as the core and bactericidal benzalkonium chloride(BAC)templated rough-surface mesostructured silica nanocomposite(RMSN)as the shell.The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions,effective disruption of the bacterial membrane,generation of oxidative damage of bacterial DNA,leakage of intracellular components,andfinally bacte-rial death.Furthermore,the synergistic antibacterial mechanisms lead to enhanced biofilm elimination performance.In addition,the ZIF-8@RMSN-modified band-aid effectively combats MRSA infection in vivo.This work has provided a promising nanocomposite against MRSA-related infections.展开更多
基金National Natural Science Foundation of China,Grant/Award Number:32171414Natural Science Foundation of Shanghai,Grant/Award Number:23ZR1419500Nature Science Foundation of Chongqing,Grant/Award Number:CSTB2022NSCQ-MSX0461。
文摘Bacterial infection is a major threat to public health.Nanotechnology offers a solu-tion by combining nanomaterials with antibacterial agents.The development of an effective nanocomposite against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)is highly important yet challenging.Here,an anti-MRSA core–shell structure is designed,containing antibacterial zeolitic imidazolate framework-8(ZIF-8)as the core and bactericidal benzalkonium chloride(BAC)templated rough-surface mesostructured silica nanocomposite(RMSN)as the shell.The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions,effective disruption of the bacterial membrane,generation of oxidative damage of bacterial DNA,leakage of intracellular components,andfinally bacte-rial death.Furthermore,the synergistic antibacterial mechanisms lead to enhanced biofilm elimination performance.In addition,the ZIF-8@RMSN-modified band-aid effectively combats MRSA infection in vivo.This work has provided a promising nanocomposite against MRSA-related infections.
