Clinical associations of corneal neuromas with ocular surface diseases

Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or injury.The formation of corneal neuromas results from damage to corneal nerves,such as following corneal pathology or corneal or intraocular surge ries.Initially,denervated areas of sensory nerve fibers become invaded by sprouts of intact sensory nerve fibers,and later injured axons regenerate and new sprouts called neuromas develop.In recent years,analysis of corneal nerve abnormalities including corneal neuromas which can be identified using in vivo confocal microscopy,a non-invasive imaging technique with microscopic resolution,has been used to evaluate corneal neuropathy and ocular surface dysfunction.Corneal neuromas have been shown to be associated with clinical symptoms of discomfort and dryness of eyes,and are a promising surrogate biomarker for ocular surface diseases,such as neuropathic corneal pain,dry eye disease,diabetic corneal neuropathy,neurotrophic keratopathy,Sjogren's syndrome,bullous keratopathy,post-refra ctive surgery,and others.In this review,we have summarized the current literature on the association between these ocular surface diseases and the presentation of corneal microneuromas,as well as elaborated on their pathogenesis,visualization via in vivo confocal microscopy,and utility in monitoring treatment efficacy.As current quantitative analysis on neuromas mainly relies on manual annotation and quantification,which is user-dependent and labor-intensive,future direction includes the development of artificial intelligence software to identify and quantify these potential imaging biomarkers in a more automated and sensitive manner,allowing it to be applied in clinical settings more efficiently.Combining imaging and molecular biomarkers may also help elucidate the associations between corneal neuromas and ocular surface diseases.

Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease

· AIM: To determine the effect of topical 0.05% cyclosporine A (CsA) on corneal endothelium in patients with dry eye disease. · METHODS: Observational, prospective, case series study. Fifty-five eyes of 29 consecutive patients (9 males and 20 females; median age: 66.8 years, interquartile range: 61 -73.2 years) with moderate -severe dry eye disease were evaluated. All patients were treated with topical 0.05% CsA ophthalmic emulsion twice a day in addition to lubricant eyedrops 5 times a day. The follow- up period was 12 months. Before treatment and at 3 and 12 months post -treatment central corneal specular microscopy was performed. The endothelial cell density (ECD), coefficient of variation of cell size (CoV), and percentage of hexagonal cells (Hex %) were analyzed. ·RESULTS: The median ECDs pre-treatment and at 3 and 12 months post-treatment were 2 352.5/mm 2 (inter- quartile range, 2 178 -2548.5), 2 364/mm 2 (interquartile range, 2 174.25 -2 657.5), and 2 366 cells/mm 2 (inter - quartile range, 2 174.75-2 539.75), respectively (P=0.927, one way ANOVA). The median CoVs pre-treatment and at 3 and 12 months post -treatment were 34.5 (interquartile range, 30 -37), 35 (interquartile range, 30 -38), and 34 (interquartile range, 30.75-38.25), respectively (P=0.7193, one way ANOVA). The median Hex % values pre - treatment and at 3 and 12 months post -treatment were 53 (interquartile range, 47 -58), 54 (interquartile range, 45.75 -59), and 50.5 (interquartile range, 45.75 -58), respectively (P=0.824, one way ANOVA). · CONCLUSION: Treatment of patients with dry eye disease for 12 months with topical 0.05% CsA does not seem to cause substantial changes on corneal endothelium.

Prevalence and associated factors of corneal blindness in Ningxia in northwest China

AIM:To describe the prevalence and demographic characteristics of corneal blindness in an urban and rural region of Ningxia,located in the northwest part of China.METHODS:A stratified,randomized sampling procedure was employed in the study,including urban and rural area of all age group.Visual acuity,anterior segment and ocular fundus were checked.Related factor of corneal disease,including age,gender,education status,ethnic group,location and occupation,were identified according to uniform customized protocol.An eye was defined to be corneal blindness if the visual acuity was【20/400 due to a corneal disease.RESULTS:Three thousand individuals(1290 from urban area and 1710 from rural area)participated in the investigation,with a response rate of 80.380%.The prevalence of corneal blindness was 0.023%in both eyes and 0.733%in at least one eye.The blindness in at least one eye with varied causes was present in 106participants(3.533%)and in bilateral eyes in 34participants(1.133%).The corneal diseases accounted for 20.754%of blindness in at least one eye and 20.588%of bilateral blindness.The prevalence of corneal disease was higher in older and Han ethnic group,especially those who occupied in agriculture and outdoor work.People with corneal blindness were more likely to be older and lower education.Rural population were more likely to suffer from bilateral corneal blindness than the urban population in≥59-year group(χ2=6.716,P=0.019).Infectious,trauma and immune corneal disease were the three leading causes of corneal disease.Trauma cornealdisease was more likely leading to blindness in one eye.However,infectious and immune corneal diseases make more contribution to the bilateral corneal blindness.CONCLUSION:Corneal blindness is a significant burden of in Ningxia population,encompassing a variety of corneal infections and trauma;the majority of those were avoidable.Health promotion strategies and good hygienic conditions have to be developed.

Guidelines for the application of artificial intelligence in the diagnosis of anterior segment diseases(2023)

The landscape of ophthalmology has obser ved monumental shifts with the advent of artificial intelligence(AI)technologies.This article is devoted to elaborating on the nuanced application of AI in the diagnostic realm of anterior segment eye diseases,an area ripe with potential yet complex in its imaging characteristics.Historically,AI’s entrenchment in ophthalmology was predominantly rooted in the posterior segment.However,the evolution of machine learning paradigms,particularly with the advent of deep learning methodologies,has reframed the focus.When combined with the exponential surge in available electronic image data pertaining to the anterior segment,AI’s role in diagnosing corneal,conjunctival,lens,and eyelid pathologies has been solidified and has emerged from the realm of theoretical to practical.In light of this transformative potential,collaborations between the Ophthalmic Imaging and Intelligent Medicine Subcommittee of the China Medical Education Association and the Ophthalmology Committee of the International Translational Medicine Association have been instrumental.These eminent bodies mobilized a consortium of experts to dissect and assimilate advancements from both national and international quarters.Their mandate was not limited to AI’s application in anterior segment pathologies like the cornea,conjunctiva,lens,and eyelids,but also ventured into deciphering the existing impediments and envisioning future trajectories.After iterative deliberations,the consensus synthesized herein serves as a touchstone,assisting ophthalmologists in optimally integrating AI into their diagnostic decisions and bolstering clinical research.Through this guideline,we aspire to offer a comprehensive framework,ensuring that clinical decisions are not merely informed but transformed by AI.By building upon existing literature yet maintaining the highest standards of originality,this document stands as a testament to both innovation and academic integrity,in line with the ethos of renowned journals such as Ophthalmology.

Clinical Analysis of 30 Cases of Deep Lamellar Keratoplasty for the Treatment of Corneal Disease

purpose： to analyze clinical therapeutic effect of deep lamellar keratoplasty on treatment of corneal disease. Method： select 30 cases of corneal disease patients with a total of sick eyes, from 2012 January to 2013 January; all patients underwent deep lamellar keratoplasty, then observe and analyze visual acuity, corneal and occurrence of complications, to comprehensively assess the clinical therapeutic effect. Result： after receiving treatment of deep lamellar keratoplasty, of the 30 patients and 40 eyes, 31 corneal grafts are transparent; 9 corneal grafts are translucent; postoperative visual acuity： I0 eyes are 0.01-0.04; 13 eyes are 0.05~0.1; 14 eyes are 0.1-0.4; 3 eyes are above 0.5; 10 eyes have descemet micro-perforation or small perforation; 7 eyes have complications; these conditions are all controlled after active treatment. Conclusion： for patients with corneal disease, deep lamellar keratoplasty can not only achieve the similar transparency and visual rehabilitation as penetrating keratoplasty, but also reduce the incidence of adverse reactions and reject reaction after operation, to achieve the purpose of treatment and vision improvement; it has significant clinical effect, and greatly improve the quality of patients＇ life, so it is worthy of clinical application.

A Rational Design of Metal–Organic Framework Nanozyme with High‑Performance Copper Active Centers for Alleviating Chemical Corneal Burns

Metal–organic frameworks(MOFs)have attracted significant research interest in biomimetic catalysis.However,the modulation of the activity of MOFs by precisely tuning the coordination of metal nodes is still a significant challenge.Inspired by metalloenzymes with well-defined coordination structures,a series of MOFs containing halogen-coordinated copper nodes(Cu-X MOFs,X=Cl,Br,I)are employed to elucidate their structure–activity relationship.Intriguingly,experimental and theoretical results strongly support that precisely tuning the coordination of halogen atoms directly regulates the enzyme-like activities of Cu-X MOFs by influencing the spatial configuration and electronic structure of the Cu active center.The optimal Cu–Cl MOF exhibits excellent superoxide dismutase-like activity with a specific activity one order of magnitude higher than the reported Cu-based nanozymes.More importantly,by performing enzyme-mimicking catalysis,the Cu–Cl MOF nanozyme can significantly scavenge reactive oxygen species and alleviate oxidative stress,thus effectively relieving ocular chemical burns.Mechanistically,the antioxidant and antiapoptotic properties of Cu–Cl MOF are achieved by regulating the NRF2 and JNK or P38 MAPK pathways.Our work provides a novel way to refine MOF nanozymes by directly engineering the coordination microenvironment and,more significantly,demonstrating their potential therapeutic effect in ophthalmic disease.

Induced pluripotent stem cells as a potential therapeutic source for corneal epithelial stem cells

Corneal blindness caused by limbal stem cell deficiency(LSCD) is one of the most common debilitating eye disorders. Thus far, the most effective treatment for LSCD is corneal transplantation, which is often hindered by the shortage of donors. Pluripotent stem cell technology including embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs) have opened new avenues for treating this disease. iPSCs-derived corneal epithelial cells provide an autologous and unlimited source of cells for the treatment of LSCD. On the other hand, iPSCs of LSCD patients can be used for iPSCs-corneal disease model and new drug discovery. However, prior to clinical trial, the efficacy and safety of these cells in patients with LSCD should be proved. Here we focused on the current status of iPSCs-derived corneal epithelial cells used for cell therapy as well as for corneal disease modeling. The challenges and potential of iPSCs-derived corneal epithelial cells as a choice for clinical treatment in corneal disease were also discussed.

Cryopreserved limbal lamellar keratoplasty for peripheral corneal and limbal reconstruction

This study aimed to evaluate the outcomes and described the recovery process of cryopreserved limbal lamellar keratoplasty（CLLK） for peripheral corneal and limbal diseases. Thirteen eyes of 12 patients with a mean age of 41±23.9 y were included. The average follow-up was 12.1±5.6 mo. Stable ocular surface was achieved in all eyes at last follow-up. Epithelialization originated from both recipient and graft in 9 eyes. We conclude that CLLK compensates for the shortage of donor corneas and cryopreserved limbal grafts provide epithelialization sources in ocular surface reconstruction.

不同严重程度干眼患者角膜地形图的可重复性观察

目的观察不同严重程度干眼患者的角膜地形图测量结果的可重复性。方法回顾性收集2023年8月至12月就诊于航天中心医院眼科门诊的干眼患者53例作为观察组,将其按照严重程度分为轻度干眼组(n=16)、中度干眼组(n=21)、重度干眼组(n=16),另选取无干眼症状及干眼症相关病史的健康者20名作为对照组。所有患者进行检查,完成常规干眼检查[泪膜破裂时间(TBUT)、泪膜脂质层厚度(LLT)、非接触泪膜破裂时间(NIKBUT)、角膜荧光素染色(cCFS)、Schirmer试验、眼表疾病指数(OSDI)评分],并在30 min内使用进行3次角膜地形图测量,双眼均计入统计。测量结果运用计算组内相关系数(ICC)进行比较,观察两组角膜地形图测量结果中平坦曲率(K1)、轴位1、陡峭曲率(K2)、轴位2、最大角膜曲率(Kmax)、上下方平均屈光度差值(IS)、平面e、斜面e、8 mm凹陷指数、角膜表面非对称性指数(SAI)可重复性。结果观察组的TBUT、LLT、NIKBUT、Schirmer试验均低于对照组,CFS、OSDI评分均高于对照组,差异均有统计学意义(P<0.05)。重症干眼患者K2、其所对应轴位及Kmax可重复性较差,差异均无统计学意义(P>0.05);重症干眼患者K1、轴位1、IS、平面e、斜面e、8 mm凹陷指数、SAI各项可重复性较好,差异均有统计学意义(P<0.05)。结论轻、中度干眼患者所有CCs可重复性较好,重度干眼患者的角膜地形图测量结果可重复性差。白内障术前干眼治疗可提高晶体测量的准确性,特别是对屈光性白内障手术晶体的测算更有意义。

后弹力层角膜内皮移植术患者围手术期护理

目的总结后弹力层角膜内皮移植术(DMEK)患者围手术期护理经验。方法对18例(18眼)内皮功能失代偿患者实施DMEK,给予充分的围手术期护理及改善术后并发症的专科护理。结果18例患者手术顺利,住院时间6~12(8.17±1.82)d。14例在术后2 h出现高眼压,经放掉部分前房气体解除瞳孔阻滞,利用体位护理后眼压均下降;发生部分脱位5例(27.8%),通过再次前房注气后移植片均能完全复位。术后随访3个月,随访期间移植片在位,贴附良好,无排斥反应,无内皮功能失代偿,14例患者术后1个月矫正视力大于0.5,4例患者术后1个月矫正视力在0.2~0.5。结论对DMEK患者加强围手术期护理,重视术后体位控制以及对于高眼压的处理,对于确保手术效果至关重要。

杞菊地黄丸联合睑板腺按摩挤压治疗睑板腺功能障碍性干眼症的效果观察

目的探讨杞菊地黄丸联合睑板腺按摩挤压治疗睑板腺功能障碍(MGD)性干眼症的效果及对主观症状、泪液炎性因子、生活质量的影响。方法选取2022年1月至2023年7月收治的MGD性干眼症患者84例,采用随机数字表法分为观察组、对照组各42例。2组均予以常规治疗,对照组在此基础上予以联合睑板腺按摩,观察组在对照组基础上予以杞菊地黄丸,均治疗8周。比较2组临床疗效,治疗前后主观症状评分、睑板开口状态评分、睑板腺分泌物性状评分、基础泪液分泌试验(SIT)、角膜荧光染色评分(FLS)、泪膜破裂时间、泪液白细胞介素-10(IL-10)、泪液白细胞介素-13(IL-13)及成纤维细胞生长因子受体2(FGFR2)表达水平及生活质量,记录2组不良反应发生率。结果2组均有2例脱落。观察组治疗总有效率[90.00%(36/40)]高于对照组[72.50%(29/40)],差异有统计学意义(P<0.05);治疗4及8周,观察组SIT、泪膜破裂时间长于对照组,主观症状评分、睑板腺功能评分、FLS低于对照组(P<0.01);治疗4及8周,观察组泪液IL-10、FGFR2表达水平高于对照组,IL-13表达水平低于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。治疗8周及12周,观察组生活质量测定量表简表评分高于对照组(P<0.05)。结论杞菊地黄丸联合睑板腺按摩挤压治疗MGD性干眼症安全有效,可抑制炎症反应,改善临床症状及患者生活质量。

2型糖尿病患者眼表变化及影响因素分析

目的探讨2型糖尿病患者眼表功能的变化及影响因素分析。方法回顾性病例对照研究。收集2022年9月至2023年9月在我院确诊的2型糖尿病患者61例(122只眼)为病例组,年龄(61.44±7.14)岁;同年龄段健康人群为对照组61例(122只眼),年龄(64.52±6.93)岁。所有受试者均采用Keratograph 5M眼表综合分析仪检测平均泪膜破裂时间(ATBUT)、泪河高度(TMH)及上下睑板腺缺失评分,泪液分泌检测滤纸条行基础泪液分泌检查(sIt),荧光素钠眼科检测试纸行角膜染色检查(FL),眼表疾病指数量表(OSDI)主观评分。2型糖尿病患者记录糖尿病病程,并行糖化血红蛋白(HbA1c)检查。根据患者年龄及HbA1c进行分组,分析不同分组条件下以上指标有无差异。结果病例组与对照组的ATBUT、TMH、上下睑板腺缺失评分、sIt、FL、OSDI评分组间比较差异有统计学意义(P<0.05);在2型糖尿病患者中,HbA1c≥7.5%患者的ATBUT、sIt、TMH、FL、上下睑板腺缺失评分与HbA1c<7.5%的患者之间存在差异,差异均有统计学意义(P<0.05);以ATBUT为因变量进行回归分析发现HbA1c(P<0.001)、睑板腺缺失评分(P=0.014)对ATBUT具有影响,HbA1c值每增加1%,ATBUT减小1.635 s,而睑板腺缺失评分每增加1分,ATBUT减少0.747 s。结论与同年龄段健康人群相比,2型糖尿病患者易出现ATBUT缩短、泪液分泌量下降、泪河高度降低、睑板腺缺失增加、角膜荧光素染色评分增高,且血糖控制水平与泪膜破裂时间密切相关。

基于Web of Science的巩膜镜研究态势文献计量分析

目的通过文献计量方法分析Web of Science数据库中巩膜镜的研究现状。方法检索2013年1月至2022年12月Web of Science核心合集数据库收录的巩膜镜相关文献,采用CiteSpace工具对文献进行可视化分析,对文献发文量、国家及机构分布、核心作者信息、刊文期刊分布及关键词聚类等方面进行综合分析。结果共检索到340篇文献,相关文献分别刊载在54种期刊,平均每种期刊约6.3篇,涉及301位作者;该研究领域覆盖35个国家或地区,共256个研究机构;学科发展主要集中在美国、印度、西班牙、澳大利亚,主要研究领域为巩膜镜(巩膜接触镜)、眼表疾病、角膜水肿、小型巩膜接触镜等方面。近10年来,巩膜镜的研究热点变化趋势为从最初的巩膜接触镜与眼表疾病相结合的研究,到后续的眼表人工置换研究,再到角膜间隙及形状方面的研究。2013—2021年主要关注的主题为眼表疾病、巩膜接触镜及角膜水肿,而在2021年后,眼表疾病和角膜移植术的相关研究有衰落趋势。2013年1月至2022年12月巩膜镜相关的突现词主要包括:第1阶段为巩膜接触镜、移植、抗宿主病、假体装置等研究;第2阶段为眼表生态系统人工置换、不规则角膜等研究;第3阶段为角膜间隙、特有形状等研究。光学相干断层扫描和角膜地形图是巩膜镜研究和验配的常用检查。结论目前巩膜镜主要应用于干眼、角膜扩张、角膜炎、角膜移植(特别是穿透角膜移植术后)和屈光不正;眼表人工置换、角膜间隙及形状是近年的研究热点。

角膜淋巴管生成的内源性调控因素及新生淋巴管相关眼表疾病研究进展

正常角膜无血管和淋巴管。角膜感染、化学烧伤、移植排斥反应等病理性刺激可破坏促淋巴管生成因素与抗淋巴管生成因素间的平衡,致使淋巴管从角膜缘向角膜中央延伸。角膜新生淋巴管的形成与多种调控因素及细胞信号通路密切相关,深入研究并阐明角膜淋巴管生成的机制将为角膜移植排斥反应、炎症性疾病、干眼症和肿瘤转移等相关领域的研究开辟新的方向。本文综述了角膜淋巴管生成的内源性调控因素及新生淋巴管相关眼表疾病的治疗策略。

眼部移植物抗宿主病患者的角结膜特征

目的探讨眼部移植物抗宿主病患者角结膜特征。方法选取2022年10月至2023年8月期间,就诊安徽医科大学第一附属医院血液科,合并眼部移植物抗宿主病患者28例,分析其不同眼表不同区域角膜荧光素钠染色以及结膜充血分数。结果眼部移植物抗宿主病患者其鼻下象限角膜染色分数显著高于颞下象限[2.000(1.0,2.0)vs 1.000(1.0,1.0),Z=-2.132,P=0.033]及鼻上象限[2.000(1.0,2.0)vs 0.000(0.0,1.0),Z=-3.650,P<0.001],颞下象限角膜染色分数显著高于颞上象限[1.000(1.0,1.0)vs 1.000(0.0,1.0),Z=-1.995,P=0.045],颞侧结膜充血分数高于颞侧近角膜部[0.600(0.4,1.0)vs 0.250(0.2,0.6),Z=-3.967,P<0.001],鼻侧结膜充血分数高于鼻侧近角膜部[0.850(0.4,1.4)vs 0.400(0.2,0.7),Z=-2.827,P=0.005],鼻侧结膜充血分数高于颞侧[0.850(0.4,1.4)vs 0.600(0.4,1.0),Z=-0.699,P=0.485]。结论下方角膜染色分数较上方更显著,鼻下方角膜荧光素钠染色较颞下方更显著,球结膜充血程度较近角膜缘处结膜更显著,鼻侧结膜充血程度较颞侧更显著。

角膜共聚焦显微镜在帕金森病患者伴不同程度自主神经功能障碍的研究

目的采用角膜共聚焦显微镜(CCM)来研究帕金森病(PD)患者伴不同严重程度自主神经功能障碍的角膜神经纤维的特点。方法招募帕金森病患者70例,健康对照31例,对所有入组患者进行CCM检测,同时根据自主神经症状结局量表(SCOPA-AUT)评分将PD分为轻度和中重度自主神经功能障碍两组,并比较这两组和健康对照组的CCM参数和临床数据。应用受试者工作特征(ROC)曲线分析量化CCM参数诊断PD伴不同严重程度自主神经功能障碍的诊断效能。结果轻度自主神经功能障碍的PD患者和中重度自主神经功能障碍的患者的CNFD和CNFL显著低于健康对照组(P<0.05)。此外,使用ROC曲线分析发现,CCM参数中CNFD在鉴别PD伴中重度自主神经功能障碍和健康人群时的诊断价值更高,其曲线下面积(AUC)为0.8224。结论CCM可以作为一种有效、客观的检测手段来研究PD伴不同严重程度自主神经功能障碍的角膜神经纤维的特点,补充了目前应用CCM技术对PD伴小纤维神经病变(SFN)的研究。

医务人员SARS感染情况分析

目的 :了解医务人员在SARS患者的诊疗工作中的感染情况和防护措施的效果。方法 :采用回顾性调查方法观察加强防护前后医务人员的发病情况 ,资料分析采用EPI统计软件。结果 :北京大学第一医院在 2 0 0 3年 3月 15日至 2 0 0 3年 5月 18日期间共收治确诊SARS患者 2 2 4例 ,疑似患者 72例。发现SARS患者后迅速采取防护措施。 72 0位医务人员参加防治SARS的工作 ;其中 18/ 74 0 (2 .4 3% )例医务人员感染SARS ,以急诊室发病率最高 ;不同专业人员发病率不同 ,以护工发病率最高 ,加强防护后医务人员感染率迅速下降。医务人员SARS感染占整个收治SARS患者的 7.2 0 % ,显著低于全国平均水平。结论 :我院采取的防护措施是科学。

重症急性胰腺炎合并深部真菌感染的预防和治疗

目的 探讨重症急性胰腺炎 (SAP)合并深部真菌感染的预防和治疗措施。方法 将 1998年 7月～ 2 0 0 2年 6月收治的 70例SAP病人随机分 3组 :大蒜素预防组、氟康唑 (小剂量 )预防组、对照组 ,比较各组的真菌感染发生率 ,治疗后真菌清除率及死亡率。结果 大蒜素组真菌感染率明显低于对照组 (16%∶3 0 % ,P <0 .0 5 )及氟康唑组 (9%∶3 0 % ,P <0 .0 1)。真菌感染发生后 ,采用治疗剂量的氟康唑和两性霉素B对大蒜素组、对照组的真菌感染病人有效 ,而对氟康唑组真菌感染病人无效。结论 预防性应用大蒜素、小剂量氟康唑均可明显降低SAP的深部真菌感染发生率。真菌感染发生后 ,如氟康唑治疗无效 ,应及时改用两性霉素B。

急性下肢动脉缺血的手术治疗和术后并发症的防治:附32例报告

目的探讨急性下肢动脉缺血的有效治疗措施及并发症的防治方法。方法回顾性分析32例急性下肢动脉缺血患者的诊治经验。4例行非手术治疗,28例行急诊手术,其中25例行股动脉切开Fogarty导管取栓术(7例同时行血管成型术),3例取栓后行截肢术。结果非手术组死亡1例,手术组无死亡病例。3例截肢,28例肢体得以保存。结论急诊股动脉切开取栓术为治疗急性下肢动脉缺血的首选治疗方案。该方法有助于降低病死率和截肢率。

穿透性角膜移植432例流行病学报告

目的调查报告穿透性角膜移植（ｐｅｎｅｔｒａｔｉｎｇｋｅｒａｔｏｐｌａｓｔｙ，ＰＫ）病人流行病学状况。方法根据ＰＫ适应证标准选择４３２例病人手术治疗，并行回顾性分析。分析ＰＫ病人流行病学状况。结果目前ＰＫ术适应证仍以感染性角膜病为主，约占６３．４％，其中病毒性角膜病约占４０．５％。年龄分布以中年组为主。职业以工人、农民等体力劳动者为主。结论ＰＫ术是治疗角膜疾病的一种有效手术方法。各种疾病的手术时机及手术方式值得进一步探讨，以期达到最佳治疗效果。