The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator(OPO)radiation.Experiments were performed to determine the corneal damage thresholds of New ...The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator(OPO)radiation.Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743 nm for ex-posurédurations of 0.1 s,1.0 s and 10.0 s.Through slit-lamp biomicroscope and histopathology,corneal injury characteristics were revealed.The damage thresholds were 3.73 J/cm^(2),7.91 J/cm^(2)and 31.1 J/cm^(2),respectively,for exposure durations of 0.1 s,1.0 s and 10.0 s.The damage data was correlated by an empirical equation:Radiant exposure at the threshold=9.72×exposure duration,^(0.46)where the units of radiant exposure and exposure duration were J/cm^(2)and second.At near-threshold level,corneal injuries at 1 h post-exposure mainly involved the epithelium,and the epithelium damages repaired at 24-h post-exposure.There are sufficient safety margins be-tween the damage thresholds and the maximum permitted exposures from current international laser safety standard IEC 60825-1.展开更多
基金This study was supported by the National Natural Science Foundation of China(NSFC)(61575221).
文摘The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator(OPO)radiation.Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743 nm for ex-posurédurations of 0.1 s,1.0 s and 10.0 s.Through slit-lamp biomicroscope and histopathology,corneal injury characteristics were revealed.The damage thresholds were 3.73 J/cm^(2),7.91 J/cm^(2)and 31.1 J/cm^(2),respectively,for exposure durations of 0.1 s,1.0 s and 10.0 s.The damage data was correlated by an empirical equation:Radiant exposure at the threshold=9.72×exposure duration,^(0.46)where the units of radiant exposure and exposure duration were J/cm^(2)and second.At near-threshold level,corneal injuries at 1 h post-exposure mainly involved the epithelium,and the epithelium damages repaired at 24-h post-exposure.There are sufficient safety margins be-tween the damage thresholds and the maximum permitted exposures from current international laser safety standard IEC 60825-1.
