The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of...The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of coronary heart disease with blood biochemical indexes,such as blood lipid metabolism,inflammatory factors,coagulation-fibrinolysis system,blood rheology and vascular endothelial function,which was hoped to provide a guidance on the clinical combined application of TCM syndrome differentiation and biochemical indexes of coronary heart disease,so as to promote the objectification and standardization of TCM syndrome differentiation.展开更多
Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators ...Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators to conventional coronary heart disease(CHD)risk prediction.Methods Data of TCM indicators(tongue,facial,and pulse diagnostics)and clinical parame-ters from patients diagnosed with CHD at the Cardiology Department of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,from October 3,2023 to March 15,2024,were collected.Important variables were identified using importance screen-ing and correlation analysis with CHD risk factors and laboratory markers.Six machine learn-ing models including logistic regression(LR),decision tree(DT),support vector machine(SVM),k-nearest neighbors(KNN),random forest(RF),and gradient boosting(GB),were ap-plied to evaluate the risk of coronary artery obstruction by combining clinical and TCM data of CHD.Model performance was assessed using metrics such as accuracy,precision,and re-call,with reliability validated through ten-fold cross-validation.Results A total of 288 patients were included in the study.Fifteen clinical risk factors,includ-ing body mass index(BMI),myoglobin,and alcohol consumption history,were incorporated into the diagnostic models.The KNN model showed good performance when combining clin-ical data with tongue and facial data.The SVM model performed well when clinical data was combined with pulse data.Among all the models,the KNN model with 10-fold cross-valida-tion,which integrates the three types of TCM diagnostic data(tongue,face,and pulse)with clinical data,performs the best(accuracy:0.837,precision:0.814,and recall:0.809).Conclusion Incorporating TCM diagnostic data can enhance the accuracy of coronary artery obstruction risk assessment.The KNN prediction model that integrate tongue,facial,and pulse data performs the best and can be recommended as a clinical decision support tool.展开更多
Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AH...Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AHA stage of acute coronary syndrome (ACS), to provide an objective evidence for TCM Syndrome typing on ACS Methods: Ninety patients of ACS with their TCM Syndrome typing and CAG successfully conducted were enrolled in this study. They were classified into 3 Syndrome types, the blood stasis type (type I ), the phlegm stagnant with blood stasis type (type II ),and the endogenous collateral Wind type (type III) The scores of the number and severity of the stenosis branch of CA and ACC/AHA lesion stage in different Syndrome types were calculated respectively and analysed statistically by Ridit analysis. Results: The number of stenosed branches increased gradually with the Syndrome type changing from I -II-III, compared the type III with the other two types(P<0. 01). The severity of stenosis in type I and II were similar, but that of Type III, much aggravated was significantly different from that in the former two (P<0. 01) . The ACC/AHA stage of coronary lesion tended to be more complex as the Syndrome type changed, patients of TCM type I and II had mostly lesion of stage A or Bl , while lesion in majority of patients of type III belonged to stage B2 or C, comparison between the three types showed significant difference (P<0.01). Conclusion: Most ACS patients of TCM Syndrome type III with tri-branch, severe stenosed coronary arteries, belong to the complex ACC/AHA stage of B2 and C.展开更多
Objective: To explore the patterns of Syndrome Differentiation (SD) of coronary heart disease (CHD) patients in peri-operative stage of coronary artery bypass graft (CABG).Methods: One week after operation, thirty-sev...Objective: To explore the patterns of Syndrome Differentiation (SD) of coronary heart disease (CHD) patients in peri-operative stage of coronary artery bypass graft (CABG).Methods: One week after operation, thirty-seven CHD patients, who received CABG of internal mammary artery or great saphena vein under conventional general anesthesia with low or middle temperature extracorporeal circulation were differentiated as various syndromes, with the pre- or post-operational EKG, color Doppler echocardiography were done during and after operation. The hemodynamic parameters were monitored.Results: In the CHD patients, 64.9% were differentiated as Qi-Yin deficiency, 67.6% were complicated with phlegm syndrome and 62.2% with blood stasis, suggesting that Qi-deficiency, phlegm and stasis are the basic pathogenetic factors in patients with CABG. Moreover, the peri-operative syndrome was correlated with the condition of coronary artery lesion, heart and lung functions before operation, and the extracorporeal circulation time during the operation.Conclusion: TCM SD conducting in peri-operative stage might be useful in exploring the patterns of syndrome alteration which provided a basis for preventing peri-operative complications and elevating success rate of operation.展开更多
基金General Project of National Natural Science Foundation of China(No.81774260)。
文摘The researches on the correlation between TCM syndromes of coronary heart disease and blood biochemical indexes from Jan.2011 to Jul.2020 were reviewed,in order to explore the association of different TCM syndromes of coronary heart disease with blood biochemical indexes,such as blood lipid metabolism,inflammatory factors,coagulation-fibrinolysis system,blood rheology and vascular endothelial function,which was hoped to provide a guidance on the clinical combined application of TCM syndrome differentiation and biochemical indexes of coronary heart disease,so as to promote the objectification and standardization of TCM syndrome differentiation.
基金National Natural Science Foundation of China(82104738)High-Level Key Discipline Construction Project in Traditional Chinese Medicine Diagnostics by the National Administration of Traditional Chinese Medicine(ZYYZDXK-2023069)Clinical Research Project in the Health Industry by Shanghai Municipal Health Commission(20244Y0129).
文摘Objective To develop an integrated risk model for coronary artery occlusion based on data of both traditional Chinese medicine(TCM)and western medicine data,and to evaluate the contribution of TCM-specific indicators to conventional coronary heart disease(CHD)risk prediction.Methods Data of TCM indicators(tongue,facial,and pulse diagnostics)and clinical parame-ters from patients diagnosed with CHD at the Cardiology Department of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,from October 3,2023 to March 15,2024,were collected.Important variables were identified using importance screen-ing and correlation analysis with CHD risk factors and laboratory markers.Six machine learn-ing models including logistic regression(LR),decision tree(DT),support vector machine(SVM),k-nearest neighbors(KNN),random forest(RF),and gradient boosting(GB),were ap-plied to evaluate the risk of coronary artery obstruction by combining clinical and TCM data of CHD.Model performance was assessed using metrics such as accuracy,precision,and re-call,with reliability validated through ten-fold cross-validation.Results A total of 288 patients were included in the study.Fifteen clinical risk factors,includ-ing body mass index(BMI),myoglobin,and alcohol consumption history,were incorporated into the diagnostic models.The KNN model showed good performance when combining clin-ical data with tongue and facial data.The SVM model performed well when clinical data was combined with pulse data.Among all the models,the KNN model with 10-fold cross-valida-tion,which integrates the three types of TCM diagnostic data(tongue,face,and pulse)with clinical data,performs the best(accuracy:0.837,precision:0.814,and recall:0.809).Conclusion Incorporating TCM diagnostic data can enhance the accuracy of coronary artery obstruction risk assessment.The KNN prediction model that integrate tongue,facial,and pulse data performs the best and can be recommended as a clinical decision support tool.
文摘Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AHA stage of acute coronary syndrome (ACS), to provide an objective evidence for TCM Syndrome typing on ACS Methods: Ninety patients of ACS with their TCM Syndrome typing and CAG successfully conducted were enrolled in this study. They were classified into 3 Syndrome types, the blood stasis type (type I ), the phlegm stagnant with blood stasis type (type II ),and the endogenous collateral Wind type (type III) The scores of the number and severity of the stenosis branch of CA and ACC/AHA lesion stage in different Syndrome types were calculated respectively and analysed statistically by Ridit analysis. Results: The number of stenosed branches increased gradually with the Syndrome type changing from I -II-III, compared the type III with the other two types(P<0. 01). The severity of stenosis in type I and II were similar, but that of Type III, much aggravated was significantly different from that in the former two (P<0. 01) . The ACC/AHA stage of coronary lesion tended to be more complex as the Syndrome type changed, patients of TCM type I and II had mostly lesion of stage A or Bl , while lesion in majority of patients of type III belonged to stage B2 or C, comparison between the three types showed significant difference (P<0.01). Conclusion: Most ACS patients of TCM Syndrome type III with tri-branch, severe stenosed coronary arteries, belong to the complex ACC/AHA stage of B2 and C.
文摘Objective: To explore the patterns of Syndrome Differentiation (SD) of coronary heart disease (CHD) patients in peri-operative stage of coronary artery bypass graft (CABG).Methods: One week after operation, thirty-seven CHD patients, who received CABG of internal mammary artery or great saphena vein under conventional general anesthesia with low or middle temperature extracorporeal circulation were differentiated as various syndromes, with the pre- or post-operational EKG, color Doppler echocardiography were done during and after operation. The hemodynamic parameters were monitored.Results: In the CHD patients, 64.9% were differentiated as Qi-Yin deficiency, 67.6% were complicated with phlegm syndrome and 62.2% with blood stasis, suggesting that Qi-deficiency, phlegm and stasis are the basic pathogenetic factors in patients with CABG. Moreover, the peri-operative syndrome was correlated with the condition of coronary artery lesion, heart and lung functions before operation, and the extracorporeal circulation time during the operation.Conclusion: TCM SD conducting in peri-operative stage might be useful in exploring the patterns of syndrome alteration which provided a basis for preventing peri-operative complications and elevating success rate of operation.
