In the last decade, three dimensional discontinuous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a line...In the last decade, three dimensional discontinuous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a linear displacement function to describe the block movement and deformation, which would cause block expansion under rigid body rotation and thus limit its capability to model block deformation. In this paper, 3D DDA is coupled with tetrahedron finite elements to tackle these two problems. Tetrahedron is the simplest in the 3D domain and makes it easy to implement automatic discretization, even for complex topology shape. Furthermore, element faces will remain planar and element edges will remain straight after deformation for tetrahedron finite elements and polyhedral contact detection schemes can be used directly. The matrices of equilibrium equations for this coupled method are given in detail and an effective contact searching algorithm is suggested. Validation is conducted by comparing the results of the proposed coupled method with that of physical model tests using one of the most common failure modes, i.e., wedge failure. Most of the failure modes predicted by the coupled method agree with the physical model results except for 4 cases out of the total 65 cases. Finally, a complex rockslide example demonstrates the robustness and versatility of the coupled method.展开更多
A new kinetic model for commercial unit of toluene disproportionation and C9-armatiocs transalkylation is developed based on the reported reaction scheme.A time based catalyst deactivation function taking weight hourl...A new kinetic model for commercial unit of toluene disproportionation and C9-armatiocs transalkylation is developed based on the reported reaction scheme.A time based catalyst deactivation function taking weight hourly space velocity(WHSV)into account is incorporated into the model,which reasonably accounts for the loss in activity because of coke deposition on the surface of catalyst during long-term operation.The kinetic parameters are benchmarked with several sets of balanced plant data and estimated by the differential variable metric optimiza- tion method.Sets of plant data at different operating conditions are applied to make sure validation of the model and the results show a good agreement between the model predictions and plant observations.The simulation analysis of key variables such as temperature and WHSV affecting process performance is discussed in detail,giv- ing the guidance to select suitable operating conditions.展开更多
OBJECTIVE:This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders.DATA SOURCES:Online...OBJECTIVE:This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders.DATA SOURCES:Online literature retrieval was conducted using PubMed,ISI Web of Science,EMBASE,Medline and Cochrane Central Register of Controlled Trials databases from January1985 to May 2012.Key words were"transcranial magnetic stimulation","TMS","repetitive transcranial magnetic stimulation",and"hallucination".STUDY SELECTION:Selected studies were randomized controlled trials assessing therapeutic efficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders.Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders.Control groups received sham stimulation.MAIN OUTCOME MEASURES:The primary outcome was total scores of Auditory Hallucinations Rating Scale,Auditory Hallucination Subscale of Psychotic Symptom Rating Scale,Positive and Negative Symptom Scale-Auditory Hallucination item,and Hallucination Change Scale.Secondary outcomes included response rate,global mental state,adverse effects and cognitive function.RESULTS:Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened,with controls receiving sham stimulation.All data were completely effective,involving 398 patients.Overall mean weighted effect size for repetitive transcranial magnetic stimulation versus sham stimulation was statistically significant(MD=–0.42,95%CI:–0.64 to–0.20,P=0.000 2).Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation(OR=2.94,95%CI:1.39 to 6.24,P=0.005).No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms.Compared with sham stimulation,active repetitive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching.CONCLUSION:Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders.展开更多
Excellent vacuum performance ensures a high beam transmission efficiency of theneutral beam injector (NBI).The vacuum performance is mainly determined by the cryoperfor-mance of the cryopanel of the cryocondensation p...Excellent vacuum performance ensures a high beam transmission efficiency of theneutral beam injector (NBI).The vacuum performance is mainly determined by the cryoperfor-mance of the cryopanel of the cryocondensation pumps which are the main vacuum pumps of NBI.In order to optimize the cryoperformance,the requirements for the temperature distribution andthe heat load of tire cryopanel are analysed and the factors that affect the cryopanel's temperaturedistribution are studied.The results indicate that.tire temperature difference of the cryopanel canbe reduced by fabricating the eryopanel with high thermal conductivity material,increasing itsthickness and cutting the distance between the two upward cooling pipes.The results may beapplied to a cryopanel cooled by forced flow liquid helium.展开更多
This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach...This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach allows us to access the relative performance of transit system in absence of historical data and research to compare with. To explore the possibility of enhancing the performance, scenarios were created for relatively underperforming routes and long route problem by changing the most important input variable and output variables accordingly with regression model where it was relevant. Partial Least Squares (PLS) regression was used to determine the most influential input variables to the output variables. DEA was conducted to access the performance of all routes under these scenarios. Underperforming routes except the longest route under the first set of scenarios, emerge to be better performing efficiently without considerable negative deviation in effectiveness. The result of second set of scenarios for long route problem suggests that the longest route’s performance can be enhanced significantly upon proper route alignment. Scenarios development and evaluation can help lead transit companies to explore the strategies to facilitate operational performance enhancement.展开更多
To attain the volumetric information of the optic radiation in normal human brains, we performed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to r...To attain the volumetric information of the optic radiation in normal human brains, we performed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are helpful in the study of optic radiation fiber tract information.展开更多
The qualities of petrology and paleobiology in Wuzhishan Section are studied. Several geo-chemical anomalies are recognized, such as: high rare earth element content, high pyrite content and Ni anomalies. It could be ...The qualities of petrology and paleobiology in Wuzhishan Section are studied. Several geo-chemical anomalies are recognized, such as: high rare earth element content, high pyrite content and Ni anomalies. It could be correlated with Nandong Section in Xiangzhou County and the F/F boundary could be determined according to Ni anomalies. The results of the study indicate that the geochemical anomaly plays an important role in stratigraphic correlation in non-fossil stratum.展开更多
Current research and ways of capturing mechanical energy are discussed in this paper.By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool,the amount of available work that can be produced f...Current research and ways of capturing mechanical energy are discussed in this paper.By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool,the amount of available work that can be produced from capturing the pressure energy has been calculated.Based on the comprehensive thermodynamic analysis,two systems have been proposed to capture pressure energy of natural gas to generate electricity.In this study,the expression of exergy is given which can be used in evaluating purposes.A problem with this multidisciplinary study is the complicated boundary condition.In conclusion,a technical prospect on recoverable natural gas pressure energy has been presented based on total energy system theory.展开更多
Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the...Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the whole range of the losses using a standard loss distribution. We tackle this modeling problem by proposing a three-component spliced regression model that can simultaneously model zeros, moderate and large losses and consider heterogeneous effects in mixture components. To apply our proposed model to Privacy Right Clearinghouse (PRC) data breach chronology, we segment geographical groups using unsupervised cluster analysis, and utilize a covariate-dependent probability to model zero losses, finite mixture distributions for moderate body and an extreme value distribution for large losses capturing the heavy-tailed nature of the loss data. Parameters and coefficients are estimated using the Expectation-Maximization (EM) algorithm. Combining with our frequency model (generalized linear mixed model) for data breaches, aggregate loss distributions are investigated and applications on cyber insurance pricing and risk management are discussed.展开更多
基金supported by the Key Project of Chinese National Programs for Fundamental Research and Development(2010CB731502)the National Natural Science Foundation of China(50978745)
文摘In the last decade, three dimensional discontinuous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a linear displacement function to describe the block movement and deformation, which would cause block expansion under rigid body rotation and thus limit its capability to model block deformation. In this paper, 3D DDA is coupled with tetrahedron finite elements to tackle these two problems. Tetrahedron is the simplest in the 3D domain and makes it easy to implement automatic discretization, even for complex topology shape. Furthermore, element faces will remain planar and element edges will remain straight after deformation for tetrahedron finite elements and polyhedral contact detection schemes can be used directly. The matrices of equilibrium equations for this coupled method are given in detail and an effective contact searching algorithm is suggested. Validation is conducted by comparing the results of the proposed coupled method with that of physical model tests using one of the most common failure modes, i.e., wedge failure. Most of the failure modes predicted by the coupled method agree with the physical model results except for 4 cases out of the total 65 cases. Finally, a complex rockslide example demonstrates the robustness and versatility of the coupled method.
基金Supported by the National'Creative Research Groups Science Foundation of China (No.60421002) and priority supported financially by "the New Century 151 Talent Project" of Zhejiang Province.
文摘A new kinetic model for commercial unit of toluene disproportionation and C9-armatiocs transalkylation is developed based on the reported reaction scheme.A time based catalyst deactivation function taking weight hourly space velocity(WHSV)into account is incorporated into the model,which reasonably accounts for the loss in activity because of coke deposition on the surface of catalyst during long-term operation.The kinetic parameters are benchmarked with several sets of balanced plant data and estimated by the differential variable metric optimiza- tion method.Sets of plant data at different operating conditions are applied to make sure validation of the model and the results show a good agreement between the model predictions and plant observations.The simulation analysis of key variables such as temperature and WHSV affecting process performance is discussed in detail,giv- ing the guidance to select suitable operating conditions.
基金financially sponsored by the Special Funding of Henan Health Science and Technology Innovation Talent Project,No.4173(2010-2015)Xinxiang Medical University of High-Level Personnel of Scientific Research Projects,No.08BSKYQD-004the Key Projects of Science and Technology Research of Department of Education in Henan,No.13A320869
文摘OBJECTIVE:This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders.DATA SOURCES:Online literature retrieval was conducted using PubMed,ISI Web of Science,EMBASE,Medline and Cochrane Central Register of Controlled Trials databases from January1985 to May 2012.Key words were"transcranial magnetic stimulation","TMS","repetitive transcranial magnetic stimulation",and"hallucination".STUDY SELECTION:Selected studies were randomized controlled trials assessing therapeutic efficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders.Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders.Control groups received sham stimulation.MAIN OUTCOME MEASURES:The primary outcome was total scores of Auditory Hallucinations Rating Scale,Auditory Hallucination Subscale of Psychotic Symptom Rating Scale,Positive and Negative Symptom Scale-Auditory Hallucination item,and Hallucination Change Scale.Secondary outcomes included response rate,global mental state,adverse effects and cognitive function.RESULTS:Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened,with controls receiving sham stimulation.All data were completely effective,involving 398 patients.Overall mean weighted effect size for repetitive transcranial magnetic stimulation versus sham stimulation was statistically significant(MD=–0.42,95%CI:–0.64 to–0.20,P=0.000 2).Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation(OR=2.94,95%CI:1.39 to 6.24,P=0.005).No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms.Compared with sham stimulation,active repetitive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching.CONCLUSION:Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders.
基金National Natural Science Foundation of China(No.10575105)
文摘Excellent vacuum performance ensures a high beam transmission efficiency of theneutral beam injector (NBI).The vacuum performance is mainly determined by the cryoperfor-mance of the cryopanel of the cryocondensation pumps which are the main vacuum pumps of NBI.In order to optimize the cryoperformance,the requirements for the temperature distribution andthe heat load of tire cryopanel are analysed and the factors that affect the cryopanel's temperaturedistribution are studied.The results indicate that.tire temperature difference of the cryopanel canbe reduced by fabricating the eryopanel with high thermal conductivity material,increasing itsthickness and cutting the distance between the two upward cooling pipes.The results may beapplied to a cryopanel cooled by forced flow liquid helium.
文摘This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach allows us to access the relative performance of transit system in absence of historical data and research to compare with. To explore the possibility of enhancing the performance, scenarios were created for relatively underperforming routes and long route problem by changing the most important input variable and output variables accordingly with regression model where it was relevant. Partial Least Squares (PLS) regression was used to determine the most influential input variables to the output variables. DEA was conducted to access the performance of all routes under these scenarios. Underperforming routes except the longest route under the first set of scenarios, emerge to be better performing efficiently without considerable negative deviation in effectiveness. The result of second set of scenarios for long route problem suggests that the longest route’s performance can be enhanced significantly upon proper route alignment. Scenarios development and evaluation can help lead transit companies to explore the strategies to facilitate operational performance enhancement.
文摘To attain the volumetric information of the optic radiation in normal human brains, we performed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are helpful in the study of optic radiation fiber tract information.
文摘The qualities of petrology and paleobiology in Wuzhishan Section are studied. Several geo-chemical anomalies are recognized, such as: high rare earth element content, high pyrite content and Ni anomalies. It could be correlated with Nandong Section in Xiangzhou County and the F/F boundary could be determined according to Ni anomalies. The results of the study indicate that the geochemical anomaly plays an important role in stratigraphic correlation in non-fossil stratum.
基金Supported by Tianjin Institute of Urban Construction(03046)
文摘Current research and ways of capturing mechanical energy are discussed in this paper.By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool,the amount of available work that can be produced from capturing the pressure energy has been calculated.Based on the comprehensive thermodynamic analysis,two systems have been proposed to capture pressure energy of natural gas to generate electricity.In this study,the expression of exergy is given which can be used in evaluating purposes.A problem with this multidisciplinary study is the complicated boundary condition.In conclusion,a technical prospect on recoverable natural gas pressure energy has been presented based on total energy system theory.
文摘Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the whole range of the losses using a standard loss distribution. We tackle this modeling problem by proposing a three-component spliced regression model that can simultaneously model zeros, moderate and large losses and consider heterogeneous effects in mixture components. To apply our proposed model to Privacy Right Clearinghouse (PRC) data breach chronology, we segment geographical groups using unsupervised cluster analysis, and utilize a covariate-dependent probability to model zero losses, finite mixture distributions for moderate body and an extreme value distribution for large losses capturing the heavy-tailed nature of the loss data. Parameters and coefficients are estimated using the Expectation-Maximization (EM) algorithm. Combining with our frequency model (generalized linear mixed model) for data breaches, aggregate loss distributions are investigated and applications on cyber insurance pricing and risk management are discussed.