The present situation of cosmetic raw materials has been introduced,mainly including the measures of risk analysis and quality control for cosmetic raw materials.Through the inspection of cosmetic raw materials,the fo...The present situation of cosmetic raw materials has been introduced,mainly including the measures of risk analysis and quality control for cosmetic raw materials.Through the inspection of cosmetic raw materials,the formulation design and development,and the incoming management,the departments in the enterprise have worked together to achieve the risk analysis and quality control of cosmetic raw materials,to ensure the quality and safety of cosmetics.展开更多
Via the use of Mimedisc~? as a scaffold, the normal human dermal fibroblasts were first seeding into the scaffold to form a dermal equivalent after three weeks, and then seeding normal human epidermal keratinocytes on...Via the use of Mimedisc~? as a scaffold, the normal human dermal fibroblasts were first seeding into the scaffold to form a dermal equivalent after three weeks, and then seeding normal human epidermal keratinocytes on it, followed by immersion and air-liquid interphase culture stage, to finally form a 3 D sponge matrix skin model which has a very similar structure of normal human skin(NHS). The results of Masson staining, and immunohistochemistry(IHC), immunofluorescence(IF) staininccg show that this skin model has a very similar structure and key protein expression of NHS. Meanwhile, this model was used as a tool to investigate the effect of Himalaya cedar extract on Dermal-Epidermal Junction(DEJ) in vitro. Results show that the Himalayan cedar extract can significantly increase the thickness of the epidermis, thus increase the barrier capacity of the skin to resist external environment. Further, this Himalaya cedar extract can promote the expressions of Laminin 5 and Collagen VII of DEJ. The expressions of the Laminin 5 and Collagen VII increased 20% and 47% respectively.So the Himalaya cedar extract displays the potential to be applied in development of anti-aging cosmetics.展开更多
Taking the qualified bovine placenta as the research object,a series of pure physical separation and extraction processes such as tissue fragmentation,ultrasound,freeze-thawed,centrifugation and filtration were used t...Taking the qualified bovine placenta as the research object,a series of pure physical separation and extraction processes such as tissue fragmentation,ultrasound,freeze-thawed,centrifugation and filtration were used to prepare the bovine placental bioactive proteins.The results of protein concentration showed that bovine placental bioactive proteins prepared in this study could reach(11.33±2.09)mg/mL under optimal experimental condition.The determination of specific components showed that there were abundant exosome like vesicles in the product with particle size ranging from 30 to 150 nm,pie structure under transmission electron microscope and expressing CD9,CD63 and TSG101 by western blot detection.The results of cell efficacy evaluation showed that bovine placental bioactive proteins could significantly promote the proliferation of human skin fibroblasts and had anti-inflammatory effect via down-regulating IL-6 and TNF-αexpressionin RAW264.7 cells.展开更多
With the increasing incidence of hair loss and especially among younger population in recent years,the demand for diversified products on anti-hair loss solutions is growing and the market of cosmetic products expandi...With the increasing incidence of hair loss and especially among younger population in recent years,the demand for diversified products on anti-hair loss solutions is growing and the market of cosmetic products expanding accordingly.Worldwide attention is being paid to the research and development of anti-hair loss actives,while there is no unified standard for the efficacy evaluation and testing methods of anti-hair loss cosmetics.Therefore,it is critical to establish standardized methodology for assessing the effectiveness of anti-hair loss actives and their cosmetic products.In this review,an overview of the human hair follicle structure,the hair follicle cycle,and the biological pathways and signaling mechanisms involved in hair growth are summarized.This provides the fundamental understanding of human hair growth for reviewing anti-hair loss actives and cosmetic hair loss products,and respective methods and techniques applied for evaluating their efficacy.Additionally,changes in the normal hair cycle,and corresponding cosmetic strategies to slow down and reduce hair loss have been provided.This review aims to provide recommendations for evaluating the effectiveness of anti-hair loss actives on the mechanisms involved in the hair follicle growth cycle,and so provide criteria for new technology development and scientific research for cosmetic products.展开更多
文摘The present situation of cosmetic raw materials has been introduced,mainly including the measures of risk analysis and quality control for cosmetic raw materials.Through the inspection of cosmetic raw materials,the formulation design and development,and the incoming management,the departments in the enterprise have worked together to achieve the risk analysis and quality control of cosmetic raw materials,to ensure the quality and safety of cosmetics.
文摘Via the use of Mimedisc~? as a scaffold, the normal human dermal fibroblasts were first seeding into the scaffold to form a dermal equivalent after three weeks, and then seeding normal human epidermal keratinocytes on it, followed by immersion and air-liquid interphase culture stage, to finally form a 3 D sponge matrix skin model which has a very similar structure of normal human skin(NHS). The results of Masson staining, and immunohistochemistry(IHC), immunofluorescence(IF) staininccg show that this skin model has a very similar structure and key protein expression of NHS. Meanwhile, this model was used as a tool to investigate the effect of Himalaya cedar extract on Dermal-Epidermal Junction(DEJ) in vitro. Results show that the Himalayan cedar extract can significantly increase the thickness of the epidermis, thus increase the barrier capacity of the skin to resist external environment. Further, this Himalaya cedar extract can promote the expressions of Laminin 5 and Collagen VII of DEJ. The expressions of the Laminin 5 and Collagen VII increased 20% and 47% respectively.So the Himalaya cedar extract displays the potential to be applied in development of anti-aging cosmetics.
文摘Taking the qualified bovine placenta as the research object,a series of pure physical separation and extraction processes such as tissue fragmentation,ultrasound,freeze-thawed,centrifugation and filtration were used to prepare the bovine placental bioactive proteins.The results of protein concentration showed that bovine placental bioactive proteins prepared in this study could reach(11.33±2.09)mg/mL under optimal experimental condition.The determination of specific components showed that there were abundant exosome like vesicles in the product with particle size ranging from 30 to 150 nm,pie structure under transmission electron microscope and expressing CD9,CD63 and TSG101 by western blot detection.The results of cell efficacy evaluation showed that bovine placental bioactive proteins could significantly promote the proliferation of human skin fibroblasts and had anti-inflammatory effect via down-regulating IL-6 and TNF-αexpressionin RAW264.7 cells.
文摘With the increasing incidence of hair loss and especially among younger population in recent years,the demand for diversified products on anti-hair loss solutions is growing and the market of cosmetic products expanding accordingly.Worldwide attention is being paid to the research and development of anti-hair loss actives,while there is no unified standard for the efficacy evaluation and testing methods of anti-hair loss cosmetics.Therefore,it is critical to establish standardized methodology for assessing the effectiveness of anti-hair loss actives and their cosmetic products.In this review,an overview of the human hair follicle structure,the hair follicle cycle,and the biological pathways and signaling mechanisms involved in hair growth are summarized.This provides the fundamental understanding of human hair growth for reviewing anti-hair loss actives and cosmetic hair loss products,and respective methods and techniques applied for evaluating their efficacy.Additionally,changes in the normal hair cycle,and corresponding cosmetic strategies to slow down and reduce hair loss have been provided.This review aims to provide recommendations for evaluating the effectiveness of anti-hair loss actives on the mechanisms involved in the hair follicle growth cycle,and so provide criteria for new technology development and scientific research for cosmetic products.
