This paper introduced the development of Technical Safety Standards for Cosmetics(TSSC). It explained changes in TSSC in detail and put forward related suggestions for implementation.
To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSen...To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSens(DSens method)and Jurkat(TCPA method)were used as the test models and 9 of reference chemicals and 12 kinds of cosmetic products were used to confirm and assess the application capability in skin sensitization.The results showed that the DSens method was more sensitive to the reference chemicals compare to the TCPA method.All the results of cosmetic products showed a high consistency between these two assays and h-CLAT or in vivo assay.As the new screening method for skin sensitization evaluation of cosmetics,the in vitro alternative tests based on AOP have certain effectiveness.The reasonable combination strategy can bring a bright future for the development and application of animal alternative test in China.展开更多
In order to cooperate with the implementation of the relevant cosmetic safety and efficacy evaluation as regulated according to the Regulations on the Supervision and Administration of Cosmetics, the National Medical ...In order to cooperate with the implementation of the relevant cosmetic safety and efficacy evaluation as regulated according to the Regulations on the Supervision and Administration of Cosmetics, the National Medical Products Administration has successively promulgated The Technical Guide of Safety Assessment for Cosmetics and the Standard for Evaluation of Cosmetic Efficacy Claims. This paper comprehensively summarizes the requirements and methods for the evaluation of cosmetic safety and efficacy claims under the new regulations, and puts forward suggestions for relevant enterprises and practitioners, which provides useful guidance and reference for the cosmetic safety and efficacy claim evaluation.展开更多
Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Tra...Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Traditionally, safety evaluation of cosmetics uses animal tests. With the development of in vitro science and the 3R （Reduction, Replacement and Refinement） principle, three-dimensional reconstructed human epidermis （3D-RHE） models have been developed and widely applied in cosmetic safety evaluation. Reconstructed human skin models possess anatomy and metabolism biology similar to real human tissue. This paper reviews the current application of 3D-RHE models in the safety evaluation of skin irritation, eye irritation, phototoxicity and genotoxicity potential of cosmetic ingredients/formulas. The advantages and disadvantages of using skin models are also discussed, and comments and suggestions are given for its future development.展开更多
Regulations for the Supervision and Administration of Cosmetics was promulgated by the State Council on June 29,2020 and will take effect on January 1,2021.Compared with the previous Regulations on Health Supervision ...Regulations for the Supervision and Administration of Cosmetics was promulgated by the State Council on June 29,2020 and will take effect on January 1,2021.Compared with the previous Regulations on Health Supervision of Cosmetics,there are more items proposed for the safety of cosmetics.In this paper,the main changes of the safety supervision of cosmetics by comparing the“new”and“old”regulations were summarized with the potential influences on different groups(government,cosmetic enterprises and consumers)discussed.The important laws and regulations on cosmetic safety and risk assessment in China with recently added in vitro testing methods were summarized and the principal theory of cosmetic quantitative risk assessment was introduced.展开更多
It reviewed the backgrounds, contents and other aspects of several important cosmetic regulations issued recently, including the Filing of Non-special use Cosmetics in China, Integration of Whitening Cosmetics into Sp...It reviewed the backgrounds, contents and other aspects of several important cosmetic regulations issued recently, including the Filing of Non-special use Cosmetics in China, Integration of Whitening Cosmetics into Specialuse Cosmetics Administration, Inventory of Existing Cosmetic Ingredient in China, Safety and Technical Standards for Cosmetics, Guidance for Safety Risk Assessment of Cosmetics, and Cosmetic Production License Administration, to provide technical support for healthy and ordedy development of the cosmetic industry.展开更多
文摘This paper introduced the development of Technical Safety Standards for Cosmetics(TSSC). It explained changes in TSSC in detail and put forward related suggestions for implementation.
文摘To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSens(DSens method)and Jurkat(TCPA method)were used as the test models and 9 of reference chemicals and 12 kinds of cosmetic products were used to confirm and assess the application capability in skin sensitization.The results showed that the DSens method was more sensitive to the reference chemicals compare to the TCPA method.All the results of cosmetic products showed a high consistency between these two assays and h-CLAT or in vivo assay.As the new screening method for skin sensitization evaluation of cosmetics,the in vitro alternative tests based on AOP have certain effectiveness.The reasonable combination strategy can bring a bright future for the development and application of animal alternative test in China.
文摘In order to cooperate with the implementation of the relevant cosmetic safety and efficacy evaluation as regulated according to the Regulations on the Supervision and Administration of Cosmetics, the National Medical Products Administration has successively promulgated The Technical Guide of Safety Assessment for Cosmetics and the Standard for Evaluation of Cosmetic Efficacy Claims. This paper comprehensively summarizes the requirements and methods for the evaluation of cosmetic safety and efficacy claims under the new regulations, and puts forward suggestions for relevant enterprises and practitioners, which provides useful guidance and reference for the cosmetic safety and efficacy claim evaluation.
文摘Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Traditionally, safety evaluation of cosmetics uses animal tests. With the development of in vitro science and the 3R （Reduction, Replacement and Refinement） principle, three-dimensional reconstructed human epidermis （3D-RHE） models have been developed and widely applied in cosmetic safety evaluation. Reconstructed human skin models possess anatomy and metabolism biology similar to real human tissue. This paper reviews the current application of 3D-RHE models in the safety evaluation of skin irritation, eye irritation, phototoxicity and genotoxicity potential of cosmetic ingredients/formulas. The advantages and disadvantages of using skin models are also discussed, and comments and suggestions are given for its future development.
文摘Regulations for the Supervision and Administration of Cosmetics was promulgated by the State Council on June 29,2020 and will take effect on January 1,2021.Compared with the previous Regulations on Health Supervision of Cosmetics,there are more items proposed for the safety of cosmetics.In this paper,the main changes of the safety supervision of cosmetics by comparing the“new”and“old”regulations were summarized with the potential influences on different groups(government,cosmetic enterprises and consumers)discussed.The important laws and regulations on cosmetic safety and risk assessment in China with recently added in vitro testing methods were summarized and the principal theory of cosmetic quantitative risk assessment was introduced.
文摘It reviewed the backgrounds, contents and other aspects of several important cosmetic regulations issued recently, including the Filing of Non-special use Cosmetics in China, Integration of Whitening Cosmetics into Specialuse Cosmetics Administration, Inventory of Existing Cosmetic Ingredient in China, Safety and Technical Standards for Cosmetics, Guidance for Safety Risk Assessment of Cosmetics, and Cosmetic Production License Administration, to provide technical support for healthy and ordedy development of the cosmetic industry.
