Tight regulation of gene expression is orchestrated by enhancers.Through recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor bindin...Tight regulation of gene expression is orchestrated by enhancers.Through recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks,but they rather display sign atures of active transcription,showingdistinct degrees oftranscription unit organization.Thereby,a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential functions.In this review,we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers,as well as enhancer-produced long non-coding RNA transcripts,may modulate or define the functional regulatory potential ofthe cognate enhancer.In addition,we summarize supporting evidence that RNA processing ofthe enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity,which contributes to the control and final outcome of enhancer-targeted gene expression.展开更多
文摘Tight regulation of gene expression is orchestrated by enhancers.Through recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks,but they rather display sign atures of active transcription,showingdistinct degrees oftranscription unit organization.Thereby,a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential functions.In this review,we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers,as well as enhancer-produced long non-coding RNA transcripts,may modulate or define the functional regulatory potential ofthe cognate enhancer.In addition,we summarize supporting evidence that RNA processing ofthe enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity,which contributes to the control and final outcome of enhancer-targeted gene expression.
