Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products

Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons（Schwab and Strittmatter,2014）.

Counteracting effects on ENSO induced by ocean chlorophyll interannual variability and tropical instability wave-scale perturbations in the tropical Pacific

Large perturbations in chlorophyll(Chl)are observed to coexist at interannual and tropical instability wave(TIW)scales in the tropical Pacific;at present,their combined effects on El Ni?o-Southern Oscillation(ENSO)through ocean biologyinduced heating(OBH)feedbacks are not understood well.Here,a hybrid coupled model(HCM)for the atmosphere and ocean physics-biogeochemistry(AOPB)in the tropical Pacific is adopted to quantify how ENSO can be modulated by Chl perturbations at interannual and TIW scales,individually or collectively,respectively.The HCM-based sensitivity experiments demonstrate a counteracting effect on ENSO:the bio-climate feedback due to large-scale Chl interannual variability acts to damp ENSO through its impact on upper-ocean stratification and vertical mixing,whereas that due to TIW-scale Chl perturbations tends to amplify ENSO.Because ENSO simulations are sensitively dependent on the ways Chl effects are represented at these different scales,it is necessary to adequately take into account these related differential Chl effects in climate modeling.A bias source for ENSO simulations is illustrated that is related with the Chl effects in the tropical Pacific,adding in a new insight into interactions between the climate system and ocean ecosystem on different scales in the region.These results reveal a level of complexity of ENSO modulations resulting from Chl effects at interannual and TIW scales,which are associated with ocean biogeochemical processes and their interactions with physical processes in the tropical Pacific.

Characteristics of photosensitization of Pheophorbide a in liposomal media

Pheophorbide a (PPa), a decomposition product of chlorophyll a, is a photosensitizer. The photosensiti-zation mechanisms (Type Ⅰ and Type Ⅱ) of PPa in simple buffer solutions and in buffer solutions containing double-layered DPPC liposomes have been studied using techniques of ESR, spin-trapping, spin-counteraction and laser flash photolysis . The results showed that adding DPPC liposomes to the buffer solution caused an increase of efficiency of generating 1O2 and PPa - by photoactivating PPa. The increase could be ascribed to the disaggregation of hydrophobic PPa caused by the addition of liposomes and the protective effect of liposomal media on the triplet state of PPa. It is concluded that the photosensitization of PPa in liposomal systems is different from that in simple aqueous solutions, and shows higher efficacy. The results will be useful to elucidating the mechanisms of photodynamic therapy of cancer.

Improving the Stability of theMultiple-Relaxation-Time Lattice Boltzmann Method by a Viscosity Counteracting Approach

Numerical instability may occur when simulating high Reynolds number flows by the lattice Boltzmann method(LBM).The multiple-relaxation-time(MRT)model of the LBM can improve the accuracy and stability,but is still subject to numerical instability when simulating flows with large single-grid Reynolds number(Reynolds number/grid number).The viscosity counteracting approach proposed recently is a method of enhancing the stability of the LBM.However,its effectiveness was only verified in the single-relaxation-time model of the LBM(SRT-LBM).This paper aims to propose the viscosity counteracting approach for the multiple-relaxationtime model(MRT-LBM)and analyze its numerical characteristics.The verification is conducted by simulating some benchmark cases:the two-dimensional(2D)lid-driven cavity flow,Poiseuille flow,Taylor-Green vortex flow and Couette flow,and threedimensional(3D)rectangular jet.Qualitative and Quantitative comparisons show that the viscosity counteracting approach for the MRT-LBMhas better accuracy and stability than that for the SRT-LBM.