Cranberry extract(CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid(Aβ) toxicity in C. elegans model of Alzheimer's disease(AD). In order to better apply CBE as an anti-AD a...Cranberry extract(CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid(Aβ) toxicity in C. elegans model of Alzheimer's disease(AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβtoxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβtoxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.展开更多
基金supported by the Creative Inquiry Fund at Clemson University to Y.D.China National Science and Technology Major Projects for Key New Drugs Innovation(No.2012ZX09103301-018)
文摘Cranberry extract(CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid(Aβ) toxicity in C. elegans model of Alzheimer's disease(AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβtoxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβtoxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
