Kinetics for Describing the Creaming of Protein-Stabilized O/W Emulsions by Multiple Light Scattering

In the present work, new kinetics to describe the creaming stability of oil-in-water emulsions determined by backscattering measurements （BS） is proposed. The emulsions assayed exhibited a different backscattering profiles regarding creaming destabilization hyperbolic and sigmoid one. Hyperbolic behavior can be described by a second order kinetics, where k_h could be equaled to a rate constant that describes the creaming process and its values would indicate the stability of emulsions. While for the sigmoid BS pattern, kinetics with two terms, is adequate to describe the creaming process in contrast to kinetics previously reported in the literature. The kh value has the same meaning as before, and ks indicates the delaying effect on the creaming rate.

改进贝叶斯网络模型在起重作业人机交互差错风险分析中的应用

为量化分析起重作业人机交互差错风险,根据安全工效学原理及安全技术规范将起重作业人、机、环相关影响因素作为根节点,按照事故致因层次关联关系确定子节点,构建起重作业人机交互差错的3层级贝叶斯网络模型(Bayesian Network, BN);基于模糊集理论,采用认知可靠性与失误分析方法(Cognitive Reliability and Error Analysis Method, CREAM),厘定贝叶斯网络父节点失效概率以及中间节点条件概率;利用逆向推理仿真技术分析起重作业人机交互差错发生的因果链,探究起重伤害事故发生的人机交互差错风险。结果表明:起重作业人机交互差错最可能致因链为起重设备安全检查不到位→管理人员失误→人员操作失误→起重伤害事故发生;单因素失效条件下,起重作业人机交互差错风险概率呈线性增长趋势;在多因素失效条件下,一级节点因素失效概率愈大则人机交互差错效应愈显著,且呈现非线性增长态势。

基于组合赋权的压裂作业人因失误概率研究

压裂作业强度大,环境恶劣,长时间枯燥的作业容易诱发人因失误,造成事故,分析压裂现场人因可靠性对于提升压裂作业的安全和效率具有重要意义。在考虑压裂现场情境因素影响基础上,提出了一种组合赋权模糊人因可靠性分析方法,用以评估压裂现场人因失误概率。首先,通过对压裂现场的调研分析,结合压裂作业情境环境特点,基于认知可靠性与失误分析方法(CREAM)建立了适用于评估压裂作业的一级共同绩效条件CPC 8个,二级CPC因子评估指标36个。其次,根据实际工况中各CPC对人的绩效可靠性的影响程度不同,提出以差异系数法确定线性组合系数,基于序关系法与熵权法对各项评估指标进行主客观线性组合赋权。最后,利用本文方法分析四川某页岩气压裂作业现场人因失误概率,结果表明,较一般模糊CREAM方法,在不同情境环境下,随着情境环境水平的下降,组合赋权模糊CREAM方法对CPC评价数据敏感度更高,人因失误概率增加,并且变化速率加快,这与现场实际工况一致,为压裂现场的人因可靠性分析和人因失误概率量化结果优化提供了参考。

基于CREAM方法的海上风机安装人因可靠性评估

采用认知可靠性和差错分析法(Cognitive Reliability and Error Analysis Method,CREAM)对固定式海上风机安装作业的人因可靠性进行评估,并引入结构熵权法和马尔可夫方法对传统CREAM进行改进,实现人因差错概率、平均人为差错时间等人因可靠性指标的定量计算。在充分结合现实条件的情况下,考虑海上风机安装的天气、海浪和操作水平等环境和人为因素的影响,针对固定式海上风机安装作业的要求和特点,结合作业人员可靠性评估结果,从操作素质、组织管理、环境改善等方面提出发展建议。

An Improved CREAM Model Based on DS Evidence Theory and DEMATEL

Cognitive Reliability and Error Analysis Method(CREAM)is widely used in human reliability analysis(HRA).It defines nine common performance conditions(CPCs),which represent the factors thatmay affect human reliability and are used to modify the cognitive failure probability(CFP).However,the levels of CPCs are usually determined by domain experts,whichmay be subjective and uncertain.What’smore,the classicCREAMassumes that the CPCs are independent,which is unrealistic.Ignoring the dependence among CPCs will result in repeated calculations of the influence of the CPCs on CFP and lead to unreasonable reliability evaluation.To address the issue of uncertain information modeling and processing,this paper introduces evidence theory to evaluate the CPC levels in specific scenarios.To address the issue of dependence modeling,the Decision-Making Trial and Evaluation Laboratory(DEMATEL)method is used to process the dependence among CPCs and calculate the relative weights of each CPC,thus modifying the multiplier of the CPCs.The detailed process of the proposed method is illustrated in this paper and the CFP estimated by the proposed method is more reasonable.

STPA和CREAM方法在飞行冲突调配人因差错研究中的应用

为了研究管制员飞行冲突调配的人因差错问题,进而有效评估管制员解决飞行冲突的可靠性,以保障空中交通的安全运行,提出系统理论过程分析(System Theoretic Process Analysis, STPA)与认知可靠性与失误分析方法(Cognitive Reliability and Error Analysis Method, CREAM)相结合的人因可靠性分析方法。首先,通过STPA方法构建系统控制模型,识别不安全控制行为(Unsafe Control Action, UCA)以及致因因素,找到管制员在调配飞行冲突过程中可能存在的差错行为;其次,基于CREAM扩展法对管制员的差错行为进行定量分析,得到管制员调配飞行冲突的人因失误概率。研究显示:使用该方法能够系统、全面地识别出管制员在调配飞行冲突过程中出现的差错行为,进而计算管制员飞行冲突调配的人因失误概率。实例分析表明该方法可以预测管制员在飞行冲突调配过程中的人因失误概率及可靠性,为管制员人因可靠性分析提供了新思路。

Enhancing Erectile Function and Alleviating Andropause Symptoms: Clinical Efficacy of a Human Stem Cell Conditioned Medium Cream

Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, along with endothelial dysfunction of the corpora cavernosa and impaired blood flow to the penis considered underlying factors. However, the current treatments are limited to Phosphodiesterase-5 (PDE5) inhibitors. ED is the primary symptom of andropathy. This study reports the clinical efficacy of human stem cell-conditioned medium cream for ED treatment. Ten men without underlying diseases suspected of andropause with ED (mean age 43.2 ± 4.4 y, Hb 15.2 ± 0.6 gm/dL, AST/ALT 30.2/37.9 ± 12.4/14.0, eGFR 82.7 ± 12.4 mL/min/1.73 m2) were targeted. The cream was applied twice daily to the genital and scrotal areas. The erectile hardness score (EHS), International Index of Erectile Function-5 (IIEF-5), and Aging Male Symptoms (AMS) scale were used to evaluate the participants before and 30 days after use, and the results were compared using paired t-tests. The post-use qualitative opinions were collected through interviews. Significant improvements were observed compared to baseline in the IIEF-5 (11.8 ± 4.6→17.2 ± 5.1, P < 0.001), and AMS (46.3 ± 6.7→37.6 ± 5.3, P < 0.001) scores post cream use. EHS did not show a statistically significant difference, but a trend towards improvement was observed. Qualitative feedback included increased morning erection, improved maintenance of erection during intercourse, and reduced post work fatigue. Human stem cell-conditioned medium contains endothelial growth factors that potentially contribute to the improvement of ED and andropause by enhancing corporal endothelial function. Future studies should include control groups to further investigate the efficacy of these treatments.

Enhancing Women's Well-being and Self-Confidence through Fragrance Cosmetics:Perceptions within Close and Broader Social Circles

Mental and physical stress can affect people's self-confidence and happiness.The primary objective of this study is to develop an active fragrance that has been proved to have a positive effect on happiness and self-confidence based on the latest research results of aroma components and fragrance innovation.The active fragrance is applied to the cream formula to study the emotions it brings to the user and extend the research scope of the active emotion to the close and extensive social circle of users to see whether it can perceive it.This study provides a reference cosmetic solution for emotional regulating active fragrance.

Supporting Skin Structure and Its Barrier Functions with Evidence-Based Skin Care Ingredients

The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.

基于CREAM和AHP的残疾人驾驶员人因可靠性分析

依据我国残疾人驾驶机动车辆现状,提出一种基于AHP的残疾人驾驶车辆人因可靠性分析方法。根据残疾人应对道路交通突发事件时需要执行的任务,改进CPC因子;针对人因可靠性分析法存在的片面性问题,采用层次分析法建立CPC因子网络层次结构,计算其权重,对残疾人驾驶员执行应对道路交通突发事件的任务的人因失误概率进行预测。研究结果表明,从方法的科学性性和可行性角度分析,改进后的CREAM方法研究该问题更具优势。

人因可靠性评价的改进加权BN-CREAM模型

传统认知可靠性与失误分析方法 (cognitive reliability and error analysis method,CREAM)存在诸多缺陷,导致适用面较窄,但仍具有较大的开发潜力。为提高方法评价的精度和扩展其适用性,提出一种改进加权的贝叶斯网络(Bayesian network,BN)与CREAM方法相结合的模型。该模型首先使用灰色关联法与决策实验室分析法获取在场景下因子的权重,再利用贝叶斯网络推理得到调整后的共同绩效条件因子节点概率分布;然后将加权后的因子进行抽样仿真,得到在该场景下人所处控制模式的概率分布。选用1 800 W定制种子电源的案例,通过分析评估结果,再对比其他方法,验证了模型的有效性和可行性。改进后模型的适用性更广,输出结果更客观,为人因可靠性评价指标体系的构建提供参考。

基于改进认知可靠性与失误分析方法的隧道驾驶人因可靠性分析模型

为有效预测驾驶人通过隧道时的人因失误概率,减少人为差错,提出一种基于改进认知可靠性与失误分析方法(cognitive reliability and error analysis,CREAM)的隧道驾驶人因可靠性分析模型。结合隧道驾驶任务的特点,调整共用绩效条件(common performance condition,CPC),给出评估细则。使用模糊数将CPC因子的绩效效应值从确定值转换为概率值,以降低主观因素对评价结果的影响。考虑CPC因子间的相互影响关系,给出调整规则。最后建立基于贝叶斯网络的改进CREAM模型,确定控制模式。对隧道驾驶实例进行分析,计算驾驶人完成隧道驾驶任务的人因失误概率。结果表明,该模型可以准确计算隧道驾驶任务中的人误概率,且灵敏性比CREAM基本法更高,可为隧道交通人因可靠性分析提供支持。

基于CREAM的管线打开作业人因失误事故研究

为提升管线打开作业的人因可靠性,深入探讨管线打开作业人因失误事故发生的根原因,基于认知可靠性和失误分析方法(CREAM),建立了管线打开作业人因失误模型,将失误模式划分为疏忽、擅自、错误、违反,建立了涵盖环境、人、信息、组织、危险源、技术6个方面的前因分类表和后果—前因追溯表,追溯分析人因失误的根原因,并运用扩展法对人因失误的发生概率进行定量预测。将模型应用于管线打开作业人因失误事故实例分析,结果显示:追溯到事故发生的根原因与员工个性缺陷、管理问题、安全意识欠缺等方面相关;获得3个人因失误事件的人因失误概率值分别为0.006、0.04、0.006;并提出了有针对性的建议、措施。

Textural and functional analysis of sorghum flour cookies as ice cream inclusions

Flour serves as one of the primary ingredients of cookies,which affects dough properties,physical changes during baking,and post-baking cookie properties.Two gluten-free cookie formulations were developed with the goal of use as inclusions in frozen desserts.Blonde and chocolate cookies were made with sorghum flour or all-purpose wheat flour and then evaluated for physical and chemical properties.To determine functionality in a frozen state,texture analysis was conducted on cookies at−30℃,−17°C,and 20℃,replicating various ice cream storage temperatures.To simulate the process effect of incorporating the product into a frozen dessert,cookies were crumbled mechanically,and the crumbles were separated based on size.When evaluating cookies,no significant differences(P<0.05)were observed in width(W),thickness(T),spread,and W/T ratio for flour source within formula.Blonde cookies had lower moisture contents than chocolate cookies;further,blonde cookies made from sorghum flour had less moisture than those made with wheat flour.As the cookie temperature decreased from 20℃to−17℃,cookie hardness increased,with flour type having no effect.Within formula,cookies had similar instrumental color parameters.However,blonde cookies made from sorghum flour produced more smaller-sized pieces than those made from wheat flour.The results of this study demonstrate that sorghum flour cookies have desirable properties for use as inclusions in ice cream and other frozen desserts.

Comprehensive treatment of deep frostbite of multiple fingers after trauma:A case report

BACKGROUND Frostbite is becoming increasingly common in urban environments,and severe cases can lead to tissue loss.The treatment goal is to preserve tissue and function;the sooner appropriate treatment is administered,the more tissue can be saved.However,not every patient with deep frostbite seeks medical care promptly.CASE SUMMARY We report the case of a 73-year-old male patient who was lost in the wilderness for 2 d due to trauma and confusion.He experienced deep frostbite on multiple fingers.Treatment should not be discontinued for patients with deep frostbite who present after the optimum treatment timing.Bullae that no longer form(bloody)blisters within 24 h of aspiration should be removed.Mucopolysaccharide polysulfate cream has clinical value in frostbite treatment.The patient was transferred to Chinese Academy of Medical Sciences and Peking Union Medical College Hospital 12 h after being rescued.The patient had contraindications for thrombolysis,the most effective treatment,due to intracranial hemorrhage and presenting past the optimum treatment timing.We devised a comprehensive treatment plan,which involved delayed use vasodilators and high-pressure oxygen therapy at day 49 post-injury.We experimented with mucopolysaccharide polysulfate cream to treat the frostbite.The aim of the treatment was to safeguard as much tissue as possible.In the end,the fingers that suffered from frostbite were able to be partially preserved.CONCLUSION The case indicated that patients with severe frostbite who missed the optimal treatment time and had contraindications for thrombolysis could still partially preserve the affected limbs through comprehensive treatment.

Effect of Soursop Puree and Gum Arabic on the Sensory Properties of Non-Dairy Coconut Milk-Based Ice Cream

Coconut (Cocos nucifera) milk-based ice cream is one of the innovative non-dairy milk products gaining popularity among consumers. The objective was to develop coconut milk-based ice cream incorporated with soursop (Annona muricata) fruit puree and gum Arabic from Acacia senegal var. kerensis, conduct a sensory evaluation using descriptive tests by trained panelists (n = 9) then evaluate for consumer acceptability by semi trained panelists (n = 30). A seven-point hedonic scale for colour, taste, flavour, texture and overall acceptability was used. The data obtained was subjected to analysis of variance (ANOVA) and the means were separated to determine their significance differences. Principal Component Analysis (PCA) was done for factor reduction to make it easy for the multi-dimensional descriptive data to be interpreted. PCA results indicated that unit increase in soursop and gum Arabic in the ice cream led to 83.1% increase in starchy taste, 78.3% increase in consistency and 73.6% decrease in coconut aroma. For consumer acceptability test, the obtained results showed that, soursop puree addition at successive levels led to a statistically significant effect (p < 0.05) on colour, flavour, texture, taste and overall acceptability while of gum Arabic incorporation was not significant (p > 0.05) for all attributes. The effect due to interaction between gum Arabic and soursop puree at the different levels however was significant for colour, flavour and texture but not significant for taste and overall acceptability. Our results therefore point to a potential application of soursop fruit and gum Arabic as alternative ingredients in the manufacture of a non-dairy ice cream with desirable sensory properties that would expand the variety of options consumers can choose from.

Common Emulsifier Combination Skin Feeling Research and Recommendation

Emulsifier is an important component of emulsified skin care BASE(matrix),and the common influencing factors affecting the skin feel of BASE are:emollient,thickeners,and emulsifier.The choice of emulsifier is crucial to the skin feel of cosmetics.In this paper,12 classical emulsifiers were selected and 13 combinations of them were made.Thirteen creams were designed using the same formulation structure,their physicochemical indexes were determined,and their skin feel was tested and evaluated using five expert panel scores,with the test site being the hand.Physicochemical parameters included pH and viscosity.Skin feel indicators include:stickiness,silkiness,whiteheads,greasiness at the end of application,absorption,softness after use,etc.The BASE formulations of the creams were tested and evaluated by five experts.Recommendations were also made for the selection of emulsifier combinations in the design of cream BASE formulations.

Topical Application of Synbiotic Bacillus Preparations Positively Affects Skin (Micro) Biology

Alteration in skin microbiome profile is involved in many skin conditions, therefore, microbiome modulation is a reasonable target for skin health. Probiotic skincare was suggested, and leave-on synbiotic skincare preparation, blending bacillus spores, as probiotic active ingredient, and inulin sugar, as prebiotic booster, is evaluated, using microarray, 16S gene sequencing, and clinical skin analyses. Topical application of leave-on synbiotic skincare on skin model activates a profound effect on skin biology, expressed in the transcriptome level, with higher than 10% affected genes. The significance of the synbiotic preparation on skin biology was assured, indicating the involvement of major biological pathways. Blending probiotic with Polygonum aviculare plant extract, had triggered a distinct gene expression alteration, demonstrating the sensitivity of skin responses to different active substances. A synbiotic skincare application, had successfully introduced live and active Bacillus probiotics on human skin, detectable days after application was finalized. Following synbiotic application, the microbial content of several microorganisms, related to skin pathologies, was reduced, while the content of bacillus species, representing a healthier microbiome status, was increased, suggesting that frequent application may lead to overall healthier skin microbiome. Acne vulgaris involves unbalanced skin microbiome, with expansion of Cutibacterium acnes. The efficacy of a synbiotic skin cream was assessed to improve acne symptoms, including IGA dermatologist acne severity score, the number of counted acne lesions, measured skin oiliness and skin redness, visual appearance of skin-pores, skin smoothness and softness, and Acne Quality of Life Index.

基于CREAM追溯法的变电运行人因失效分析

文章以GREAM追溯法为基础对人为因素给电力系统造成的影响进行研究分析,构建变电站运行人为故障模型,创建真正适用于变电运行人因失效事故分析的方法,以期为电力系统中变电运行安全保障体系的整体构建提供理论支持。

地铁盾构施工人因可靠性分析的加权模糊CREAM模型

针对地铁盾构施工风险评估中人因可靠性分析(HRA)问题,构建了一种加权模糊CREAM模型.首先,利用复相关性分析和证据理论确定共同绩效条件因子(CPC)的合理权重.其次,基于现行规范编制CPC评价细则,利用统计方法得到了CPC水平隶属函数.在此基础上,提出将离散基本控制模式图连续化的方法,建立了地铁盾构施工人因失误概率(HEP)点估计值预测模型,通过4条公理验证了模型的合理性和可靠性.结果表明:加权模糊CREAM模型将权重引入到CPC效应值计算和HEP推理中,能更好地反映不同CPC因子对人行为绩效的影响,可为地铁盾构施工HRA提供定量评估数据.