Stress is a major risk factor for the development of mental illness,such as major depression disorder (MDD)[1].Despite decades of progress,including findings that stressinduced depression corresponds with numerous mor...Stress is a major risk factor for the development of mental illness,such as major depression disorder (MDD)[1].Despite decades of progress,including findings that stressinduced depression corresponds with numerous morphological and functional neuronal changes within brain structures associated with cognition and mood,such as the medial prefrontal cortex (mPFC)[1-3],a thorough understanding of how stress induces the core symptoms of depression,such as hopelessness,is still lacking.In an exciting new paper in mice,Yin et al.show that astrocyteneuronal metabolic coupling in the mPFC is critically involved in the stress-induced passive coping response in mice [4].展开更多
文摘Stress is a major risk factor for the development of mental illness,such as major depression disorder (MDD)[1].Despite decades of progress,including findings that stressinduced depression corresponds with numerous morphological and functional neuronal changes within brain structures associated with cognition and mood,such as the medial prefrontal cortex (mPFC)[1-3],a thorough understanding of how stress induces the core symptoms of depression,such as hopelessness,is still lacking.In an exciting new paper in mice,Yin et al.show that astrocyteneuronal metabolic coupling in the mPFC is critically involved in the stress-induced passive coping response in mice [4].
