Critical Behavior of the Energy Gap and Its Relation with the Berry Phase Close to the Excited State Quantum Phase Transition in the Lipkin Model

In our previous work [Phys. Rev. A 85 （2012） 044102], we studied the Berry phase of the ground state and exited states in the Lipkin model. In this work, using the Hellmann-Feynman theorem, we derive the relation between the energy gap and the Berry phase closed to the excited state quantum phase transition （ESQPT） in the Lipkin model. It is found that the energy gap is approximately linearly dependent on the Berry phase being closed to the ESQPT for large N. As a result, the critical behavior of the energy gap is similar to that of the Berry phase. In addition, we also perform a semiclassical qualitative analysis about the critical behavior of the energy gap.

Drying Technology and Formation Process of Naomai Xingshen Capsules

[Objectives]To optimize the drying technology and formation process of Naomai Xingshen Capsules.[Methods]The yield of paste powder and moisture content as evaluation indicators were taken as indicators,the relative density of feed liquid,inlet air temperature and dosage of excipients were selected as investigation factors,the orthogonal experiment method was used to optimize the spray drying process.The moisture absorption rate and angle of repose were taken as evaluation indicators,the types of forming excipient were screened,and the critical relative humidity was determined.[Results]The optimum spray drying process was that the relative density of liquid medicine was 1.05(60℃),the air inlet temperature was 200℃,and the dosage of excipients was 2%.The effect of using dextrin as a forming excipient was better,and the relative humidity of the production environment should be controlled below 65%.[Conclusions]The optimized process is stable,feasible,scientific and reasonable,and can be used for large-scale industrial production.

Study on the Forming Process of Yi Medicine Tongfeng Granules

[Objectives]To optimize the forming process of Yi medicine Tongfeng Granules.[Methods]The forming process of Yi medicine Tongfeng Granules was optimized,with paste density,ethanol volume fraction,and type and proportion of excipient as influencing factors,and granule formability,solubility,moisture absorption,and angle of repose as evaluation indicators.Critical relative humidity(CRH)was investigated to select optimal storage conditions.[Results]Maltodextrin was selected as the excipient,and the best process parameters was the ratio of drug to excipient at 1∶2(g/g),under which the forming rate,solubility,moisture absorption rate,and angle of repose were 81.38%,98.90%,8.81%,and 27.5°,respectively.The critical relative humidity was 72%.[Conclusions]The forming process adopted is reasonable and feasible,and can provide a reference for large-scale production of Yi medicine Tongfeng Granules.

Effects of glucocorticoids on traumatic brain injury related critical illness-related corticosteroid insufficiency

Background Traumatic brain injury （TBI） is a heterogeneous condition that can lead to critical LLLness-related corticosteroid insufficiency （CIRCI） causing a high mortality and morbidity.Glucocorticoids were widely used in the clinical management of TBI,but their benefit has been challenged in some studies and their efficacy,especially for treating CIRCI in TBI patients,remains unclear.Methods We conducted a meta-analysis of published data to determine if the controversy is related to clinical dosing and timing of glucocorticoids （GCs） application.We analyzed published reports in four databases （MEDLINE,EMBASE,the Cochrane Controlled Trials Register,and CBMdisc）.The published data were stratified into not only low-and high-dose GCs group but also short-and long-term GCs group to compare their effectiveness in improving TBI outcomes.Results We totally identified 16 reports.For low-dose patients,the pooled relative risks （RRs） for two clinical outcomes of death or a combination of death and severe disability were 0.95 （95% confidence interval （CI）：0.80 to 1.13） and 0.95 （95% CI：0.83 to 1.09）,respectively.The risks for infection and gastrointestinal bleeding were 0.85 （95% CI：0.50 to 1.45） and 0.64 （95% Cl：0.15 to 2.70）,respectively.For high-dose group,the pooled RR of death is 1.14 （95% Cl：1.06 to 1.21）.The pooled RRs for infection and gastrointestinal bleeding for the high-dose patients were 1.04 （95% CI：0.93 to 1.15） and 1.26 （95% CI：0.92 to 1.75）,respectively.For long-term use group,the pooled RRs for two clinical outcomes of death or a combination of death and severe disability were 0.98 （95% CI：0.87 to 1.12） and 1.00 （95% CI：0.90 to 1.11）,respectively.The risks for infection and gastrointestinal bleeding were 0.88 （95% CI：0.71 to 1.11） and 0.96 （95% CI：0.35 to 2.66）,respectively.For short-term use group,the pooled RR of death is 1.15 （95% CI：1.07 to 1.23）,and importantly the effects on infections were beneficial in terms of TBI patients suffering from CIRCI.Conclusions This meta-analysis suggests an increased risk of death for TBI patients on a high dose and short term of glucocorticoids compared with those on a low dose and long term,for whom a trend towards clinical improvement is evident.In addition,stress-does of GCs further decrease the pneumonia incidence in TBI patients suffering from CIRCI.A large-scale multicenter randomized controlled trial is warranted for testing （1） the efficacy of stress-dose GCs treatment in the sub-acute phase of TBI （4-21 days after initial trauma）,when CIRCI is most likely to occur; （2） the hypothesis that stress-dose GCs could boost patients＇ stress function and ensure survival.

Effect of Ag substitution on structural,magnetic and magnetocaloric properties of Pr_(0.6)Sr_(0.4–x)Ag_xMnO_3 manganites

A systematic investigation on the structural, magnetic and magnetocaloric properties of Pr_（0.6）Sr_（0.4-x）Ag_xMnO_3（x=0.05 and 0.1） manganites was reported. Rietveld refinements of the X-ray diffraction patterns confirmed that all samples were single phase and crystallized in the orthorhombic structure with Pnma space group. Magnetic measurements in a magnetic applied field of 0.01T revealed that the ferromagnetic-paramagnetic transition temperature T_C decreased from about 293 to 290 K with increasing silver content from x=0.05 to 0.1. The reported magnetocaloric entropy change and relative cooling power for both samples were considerably remarkable with a △S_（max） value of 1.9 J/（kg·K）and maximum RCP values of 100 J/kg, under a magnetic field change（？μ0H） equal to 1.8T. The analysis of the universal curves gave an evidence of a second order magnetic transition for the studied samples. The magnetic field influence on both the magnetic entropy change and the relative cooling power was also studied and discussed.