Macbeth is one of the four great tragedies penned by English playwright, William Shakespeare. Lady Macbeth, the primary tragic female character in the play, seems to be different from other typical female roles portra...Macbeth is one of the four great tragedies penned by English playwright, William Shakespeare. Lady Macbeth, the primary tragic female character in the play, seems to be different from other typical female roles portrayed by Shakespeare, and is often characterized by the world as vicious and ambitious. Being in a patriarchal society, Lady Macbeth awakens to female self-awareness and lust for power. She silently rebels against the oppression and constraints imposed by the society, ultimately paying the price of her life. By analyzing the process of Lady Macbeth’s subversion of the identity of the Other from the perspective of feminist criticism, this article offers a new interpretation of Lady Macbeth’s image and delves into the underlying causes of her tragedy. It suggests that it is often difficult for women to break free from the oppressive shackles of a patriarchal society in their pursuit for equality, freedom and power. The path to women’s liberation is long and arduous, which still requires unwavering efforts and perseverance from all.展开更多
This paper critically analyzes Roberto Guzman’s approach to teaching English, as outlined in his TED talk “Teaching English without Teaching English”. While Guzman focuses on inspirational teaching and open-ended d...This paper critically analyzes Roberto Guzman’s approach to teaching English, as outlined in his TED talk “Teaching English without Teaching English”. While Guzman focuses on inspirational teaching and open-ended discussion, the analysis highlights some shortcomings of his methods from three perspectives: 1) whether the approach aligns with socio-cultural theories, 2) whether it overlooks the importance of input assumptions, and 3) whether it can effectively improve students’ communicative competence. Through this analysis, the paper sheds light on the potential limitations of Guzman’s approach to teaching English and provides insights into how educators can design more effective language teaching methods.展开更多
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological thresholds.Mild hypog...Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological thresholds.Mild hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate intake.Severe hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left untreated.Individuals with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.展开更多
This study explores the application of Abrams’Fourfold Model in the classification of Western literary criticism.Abrams’framework categorizes literary criticism into four fundamental elements:text,author,world,and a...This study explores the application of Abrams’Fourfold Model in the classification of Western literary criticism.Abrams’framework categorizes literary criticism into four fundamental elements:text,author,world,and audience.The text is viewed as an independent entity with intrinsic artistic value,necessitating a detailed analysis of its structure,style,themes,and symbols.Author study delves into the creator’s life and socio-cultural context,often to uncover the work’s deeper meanings.Contextual study situates the work within its historical and social milieu,examining its reflection of or response to societal norms and events.Audience response analysis considers the diverse interpretations shaped by readers’backgrounds,emphasizing the reader’s role in constructing the work’s meaning.The study concludes that Abrams’Fourfold Model offers a comprehensive and flexible analytical tool,enabling critics to engage with literary works from multiple perspectives,thereby enriching the understanding of literary complexity and diversity.展开更多
As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct valu...As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct values in the future development of students.Influenced by traditional teaching ideas,students have many difficulties when learning this course,such as insufficient theoretical understanding,inadequate ability improvement,and not enough investment in course learning.In response to the above issues,this course focuses closely on the fundamental task of“cultivating virtue and nurturing people”,relying on modern information technology and introducing research methods of digital humanities.This course uses“7C”teaching mode under the“three-level integration”,in which“teaching”and“education”are carried out synchronously,and“teacher”and“student”are developed together,in order to greatly enhance students’learning participation and course satisfaction.展开更多
为了解决石化行业节能减排技术评估体系构建尚不完善的问题,聚焦石化行业节能减排技术,从技术性能、经济效益和环境保护3方面构建评价指标体系,通过CRITIC(criteria importance though intercrieria correlation)-云模型进行评价。结果...为了解决石化行业节能减排技术评估体系构建尚不完善的问题,聚焦石化行业节能减排技术,从技术性能、经济效益和环境保护3方面构建评价指标体系,通过CRITIC(criteria importance though intercrieria correlation)-云模型进行评价。结果表明:石化行业75%的节能减排技术综合评分在0.6以上,其中变频器调速节能技术、蒸汽系统运行优化与节能技术、大型高参数板壳式换热技术是标杆技术;石化行业节能减排技术在成熟度、适用性、减排成本以及减排潜力上的表现存在显著差异,其中多能互补型直流微电网及抽油机节能群控系统技术与多孔表面高通量管高效换热技术在经济效益和环境效益方面亟待改进;云模型评价显示,石化行业节能减排技术整体处于“可接受级”水平,并逐步向“可宣称级”水平迈进。研究结果从技术评价视角为石化行业锚定发展节能减排技术提供了评价依据,有助于助推“双碳”目标的达成。展开更多
In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic vi...In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.展开更多
Solvent extraction,a separation and purification technology,is crucial in critical metal metallurgy.Organic solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and ...Solvent extraction,a separation and purification technology,is crucial in critical metal metallurgy.Organic solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental safety.Neoteric solvents have been recognized as potential alternatives to these harmful organic solvents.In the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low cost.In this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically described.Subsequently,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively summarized.Finally,future opportunities and challenges of DESs were explored in the current research area.In conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.展开更多
This paper conducts an analysis of the protagonist,Leo Finckle,in The Magic Barrel from the perspective of ethical literary criticism.It explores Leo’s character traits,his ethical dilemmas and choices,and the moral ...This paper conducts an analysis of the protagonist,Leo Finckle,in The Magic Barrel from the perspective of ethical literary criticism.It explores Leo’s character traits,his ethical dilemmas and choices,and the moral and ethical implications within the context of the story.The study examines how Leo’s search for a wife and his encounters with various characters in the magic barrel setting reveal his inner struggles and the complex ethical landscape he navigates.It also analyzes the role of social and cultural factors in shaping Leo’s ethical perspectives and behaviors.Through this analysis,a deeper understanding of the text is achieved,highlighting the significance of ethical considerations in literature and the rich portrayal of the human condition presented through Leo Finckle’s experiences in The Magic Barrel.展开更多
BACKGROUND Acute hyperglycemia due to insulin resistance is common in critically ill patients,typically managed with insulin infusion.However,the occurrence of transient extreme insulin resistance(EIR)requiring except...BACKGROUND Acute hyperglycemia due to insulin resistance is common in critically ill patients,typically managed with insulin infusion.However,the occurrence of transient extreme insulin resistance(EIR)requiring exceptional high-dose insulin is rare.CASE SUMMARY We present the case of a 68-year-old woman with pneumonia who suffered an out-of-hospital cardiac arrest,subsequently developing transient EIR following a new episode of sepsis.Remarkably,insulin resistance rapidly reversed when the insulin infusion rate peaked at 960 units/hour(a total of 18224 units on that day),and it was promptly titrated down to zero upon achieving the target glucose level.CONCLUSION Exceptional high-dose insulin infusion may be required in critically ill patients with stress-related EIR,which is typically transient.Clinicians should be aware of the phenomenon and cautious to avoid hypoglycemia and fluid overload during the steep titration of high-dose insulin infusion.展开更多
Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic ...Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic illness or disability and their families.Advances in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing morbidity.For those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of life.At the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general hospitals.While there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive care.Many patients may encounter considerable challenges during this period.Difficulties may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric conditions.In addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health issues.These challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.展开更多
The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly recognised.Dietary strategies to modulate the GI microbiota during chronic diseases have demonstrated promis...The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly recognised.Dietary strategies to modulate the GI microbiota during chronic diseases have demonstrated promise.While changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain uncertain.Dietary fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI microbiota.The aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical illness.Randomised controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were identified.Studies show dietary fibres have an impact on faecal microbiota in health and disease.The fibre,inulin,has a marked and specific effect on increasing the abundance of faecal Bifidobacteria.Short chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient populations.Very few trials have evaluated the effect of dietary fibre on the GI microbiota during critical illness.More research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.展开更多
The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser facility.The spatial-temporal evolution of X-ray emis...The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser facility.The spatial-temporal evolution of X-ray emission is observed using an X-ray streak camera,electron and ion temperatures are measured by X-ray spectroscopy,and hot-electron production is characterized by monochromatic X-ray imaging.Transmission of a femtosecond laser probe pulse through foams is observed in the near and far fields.In spite of large differences in pore size and foam structure,the velocity of ionization front propagation is quite similar for all the foams studied and is slower than that in a homogeneous material of the same average density.The ion temperature in the plasma behind the ionization front is a few times higher than the electron temperature.Hot-electron production in plastic foams with small pores is strongly suppressed compared with that in solid targets,whereas in foams produced by additive manufacturing,it is significantly increased to the level observed in bare copper foil targets.展开更多
This paper presents a novel multi-criteria decision-making(MCDM)model for selecting optimal locations for a solar-wind hybrid energy plant in Vietnam.The study employs the Criteria Importance Through Intercriteria Cor...This paper presents a novel multi-criteria decision-making(MCDM)model for selecting optimal locations for a solar-wind hybrid energy plant in Vietnam.The study employs the Criteria Importance Through Intercriteria Correlation(CRITIC)and Combined Compromise Solution(CoCoSo)methods to address the challenge of evaluating potential sites based on a range of economic,technical,environmental,and social criteria.By integrating CRITIC for criteria weighting and CoCoSo for ranking alternatives,the study underscores the importance of objective,data-driven approaches in the strategic planning and implementation of sustainable energy projects.The results identifyHamThuanNamDistrict inBinhThuan Province(DA4)as themost suitable site for the solar-wind hybrid energy plant,with a performance score of 2.0919.Phan Thiet City(DA3)and Ninh Phuoc District(DA6)rank second and third,with scores of 2.0655 and 1.8723,respectively.Sensitivity analysis confirms the robustness of the model,showing stable rankings under various scenarios.展开更多
文摘Macbeth is one of the four great tragedies penned by English playwright, William Shakespeare. Lady Macbeth, the primary tragic female character in the play, seems to be different from other typical female roles portrayed by Shakespeare, and is often characterized by the world as vicious and ambitious. Being in a patriarchal society, Lady Macbeth awakens to female self-awareness and lust for power. She silently rebels against the oppression and constraints imposed by the society, ultimately paying the price of her life. By analyzing the process of Lady Macbeth’s subversion of the identity of the Other from the perspective of feminist criticism, this article offers a new interpretation of Lady Macbeth’s image and delves into the underlying causes of her tragedy. It suggests that it is often difficult for women to break free from the oppressive shackles of a patriarchal society in their pursuit for equality, freedom and power. The path to women’s liberation is long and arduous, which still requires unwavering efforts and perseverance from all.
文摘This paper critically analyzes Roberto Guzman’s approach to teaching English, as outlined in his TED talk “Teaching English without Teaching English”. While Guzman focuses on inspirational teaching and open-ended discussion, the analysis highlights some shortcomings of his methods from three perspectives: 1) whether the approach aligns with socio-cultural theories, 2) whether it overlooks the importance of input assumptions, and 3) whether it can effectively improve students’ communicative competence. Through this analysis, the paper sheds light on the potential limitations of Guzman’s approach to teaching English and provides insights into how educators can design more effective language teaching methods.
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
基金generously supported by the faculty startup funds from Auburn University at Montgomery (to SSVPS)。
文摘Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological thresholds.Mild hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate intake.Severe hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left untreated.Individuals with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.
基金The paper was supported by Henan Province Teaching Reform and Practice Project(Project Fund No.135)-Research on the Reform of Literary Theory Courses for English Majors in Universities.
文摘This study explores the application of Abrams’Fourfold Model in the classification of Western literary criticism.Abrams’framework categorizes literary criticism into four fundamental elements:text,author,world,and audience.The text is viewed as an independent entity with intrinsic artistic value,necessitating a detailed analysis of its structure,style,themes,and symbols.Author study delves into the creator’s life and socio-cultural context,often to uncover the work’s deeper meanings.Contextual study situates the work within its historical and social milieu,examining its reflection of or response to societal norms and events.Audience response analysis considers the diverse interpretations shaped by readers’backgrounds,emphasizing the reader’s role in constructing the work’s meaning.The study concludes that Abrams’Fourfold Model offers a comprehensive and flexible analytical tool,enabling critics to engage with literary works from multiple perspectives,thereby enriching the understanding of literary complexity and diversity.
基金supported by Henan Province Teaching Reform and Practice Project(Project Fund No.135)—Research on the Reform of Literary Theory Courses for English Majors in Universities.
文摘As a core compulsory course for English majors majoring in teacher education,Literary Theory and Criticism plays an important role in enhancing text understanding,cultivating critical thinking,and shaping correct values in the future development of students.Influenced by traditional teaching ideas,students have many difficulties when learning this course,such as insufficient theoretical understanding,inadequate ability improvement,and not enough investment in course learning.In response to the above issues,this course focuses closely on the fundamental task of“cultivating virtue and nurturing people”,relying on modern information technology and introducing research methods of digital humanities.This course uses“7C”teaching mode under the“three-level integration”,in which“teaching”and“education”are carried out synchronously,and“teacher”and“student”are developed together,in order to greatly enhance students’learning participation and course satisfaction.
文摘为了解决石化行业节能减排技术评估体系构建尚不完善的问题,聚焦石化行业节能减排技术,从技术性能、经济效益和环境保护3方面构建评价指标体系,通过CRITIC(criteria importance though intercrieria correlation)-云模型进行评价。结果表明:石化行业75%的节能减排技术综合评分在0.6以上,其中变频器调速节能技术、蒸汽系统运行优化与节能技术、大型高参数板壳式换热技术是标杆技术;石化行业节能减排技术在成熟度、适用性、减排成本以及减排潜力上的表现存在显著差异,其中多能互补型直流微电网及抽油机节能群控系统技术与多孔表面高通量管高效换热技术在经济效益和环境效益方面亟待改进;云模型评价显示,石化行业节能减排技术整体处于“可接受级”水平,并逐步向“可宣称级”水平迈进。研究结果从技术评价视角为石化行业锚定发展节能减排技术提供了评价依据,有助于助推“双碳”目标的达成。
文摘In 2014,Huang Kaihong,a professor at School of Foreign Languages and Cultures,Southwest University of Science and Technology,interviewed the Doctoral advisor Professor Nie Zhenzhao during the period of his academic visiting to Central China Normal University.As early as in 2005,Huang Kaihong conducted an interview with Professor Nie Zhenzhao on the topic of the general introduction of ethical literary criticism.So around 11 years later,the second interview mainly covers not only the ethical literary criticism theory,but the game theory and the relationship between them as well.Professor Nie thinks whether the game theory can be applied to literature research is still under discussion.The theory of ethical literary criticism is a kind of methodology based on science and it can get the attention of literary critics at home and abroad,which is because it fits the practical needs of literary criticism,draws the literary criticism away from only emphasizing criticism genres and the research of criticism terms,and pays attention to the true nature of the literary text in literature research.After consulting Professor Nie Zhenzhao about some related questions from the perspective of game theory.Huang Kaihong gets some significant information concerning literature research and understands the latest core terms and the concrete application method of ethical literary criticism,especially the relationship between the instructing and aesthetic functions of literature.
基金financially supported by the Original Exploration Project of the National Natural Science Foundation of China(No.52150079)the National Natural Science Foundation of China(Nos.U22A20130,U2004215,and 51974280)+1 种基金the Natural Science Foundation of Henan Province of China(No.232300421196)the Project of Zhongyuan Critical Metals Laboratory of China(Nos.GJJSGFYQ202304,GJJSGFJQ202306,GJJSGFYQ202323,GJJSGFYQ202308,and GJJSGFYQ202307)。
文摘Solvent extraction,a separation and purification technology,is crucial in critical metal metallurgy.Organic solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental safety.Neoteric solvents have been recognized as potential alternatives to these harmful organic solvents.In the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low cost.In this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically described.Subsequently,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively summarized.Finally,future opportunities and challenges of DESs were explored in the current research area.In conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.
基金USST Construction Project of English-Taught Courses for International Students in 2024USST Teaching Achievement Award(Postgraduate)Cultivation Project in 2024Key Course Construction Project in Universities of Shanghai in 2024.
文摘This paper conducts an analysis of the protagonist,Leo Finckle,in The Magic Barrel from the perspective of ethical literary criticism.It explores Leo’s character traits,his ethical dilemmas and choices,and the moral and ethical implications within the context of the story.The study examines how Leo’s search for a wife and his encounters with various characters in the magic barrel setting reveal his inner struggles and the complex ethical landscape he navigates.It also analyzes the role of social and cultural factors in shaping Leo’s ethical perspectives and behaviors.Through this analysis,a deeper understanding of the text is achieved,highlighting the significance of ethical considerations in literature and the rich portrayal of the human condition presented through Leo Finckle’s experiences in The Magic Barrel.
文摘BACKGROUND Acute hyperglycemia due to insulin resistance is common in critically ill patients,typically managed with insulin infusion.However,the occurrence of transient extreme insulin resistance(EIR)requiring exceptional high-dose insulin is rare.CASE SUMMARY We present the case of a 68-year-old woman with pneumonia who suffered an out-of-hospital cardiac arrest,subsequently developing transient EIR following a new episode of sepsis.Remarkably,insulin resistance rapidly reversed when the insulin infusion rate peaked at 960 units/hour(a total of 18224 units on that day),and it was promptly titrated down to zero upon achieving the target glucose level.CONCLUSION Exceptional high-dose insulin infusion may be required in critically ill patients with stress-related EIR,which is typically transient.Clinicians should be aware of the phenomenon and cautious to avoid hypoglycemia and fluid overload during the steep titration of high-dose insulin infusion.
文摘Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic illness or disability and their families.Advances in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing morbidity.For those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of life.At the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general hospitals.While there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive care.Many patients may encounter considerable challenges during this period.Difficulties may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric conditions.In addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health issues.These challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.
文摘The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly recognised.Dietary strategies to modulate the GI microbiota during chronic diseases have demonstrated promise.While changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain uncertain.Dietary fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI microbiota.The aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical illness.Randomised controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were identified.Studies show dietary fibres have an impact on faecal microbiota in health and disease.The fibre,inulin,has a marked and specific effect on increasing the abundance of faecal Bifidobacteria.Short chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient populations.Very few trials have evaluated the effect of dietary fibre on the GI microbiota during critical illness.More research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.
基金supported by the Center of Advanced Applied Sciences(CAAS)Project No.(CZ.02.1.01/0.0/0.0/16019/0000778)from the European Regional Development FundIt was also supported in part by the Czech Technical University in Prague Project No.SGS22/184/OHK4/3T/14+1 种基金We acknowledge partial funding via EUROfusion Enabling Research Project No.AWP24-ENR-03-CEA-02“Foams as a pathway to energy from high gain direct drive ignition,”within the framework of the EUROfusion Consortium,funded by the European Union via the Euratom Research and Training Program(Grant Agreement No.101052200-EUROfusion)The views and opinions expressed are,however,those of the authors only and do not necessarily reflect those of the European Union or the European Commission.Our thanks also go to the Czech Ministry of Education,Youth and Sports(CMEYS)for funding the operation of the PALS facility(Grant No.LM2023068).
文摘The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser facility.The spatial-temporal evolution of X-ray emission is observed using an X-ray streak camera,electron and ion temperatures are measured by X-ray spectroscopy,and hot-electron production is characterized by monochromatic X-ray imaging.Transmission of a femtosecond laser probe pulse through foams is observed in the near and far fields.In spite of large differences in pore size and foam structure,the velocity of ionization front propagation is quite similar for all the foams studied and is slower than that in a homogeneous material of the same average density.The ion temperature in the plasma behind the ionization front is a few times higher than the electron temperature.Hot-electron production in plastic foams with small pores is strongly suppressed compared with that in solid targets,whereas in foams produced by additive manufacturing,it is significantly increased to the level observed in bare copper foil targets.
文摘This paper presents a novel multi-criteria decision-making(MCDM)model for selecting optimal locations for a solar-wind hybrid energy plant in Vietnam.The study employs the Criteria Importance Through Intercriteria Correlation(CRITIC)and Combined Compromise Solution(CoCoSo)methods to address the challenge of evaluating potential sites based on a range of economic,technical,environmental,and social criteria.By integrating CRITIC for criteria weighting and CoCoSo for ranking alternatives,the study underscores the importance of objective,data-driven approaches in the strategic planning and implementation of sustainable energy projects.The results identifyHamThuanNamDistrict inBinhThuan Province(DA4)as themost suitable site for the solar-wind hybrid energy plant,with a performance score of 2.0919.Phan Thiet City(DA3)and Ninh Phuoc District(DA6)rank second and third,with scores of 2.0655 and 1.8723,respectively.Sensitivity analysis confirms the robustness of the model,showing stable rankings under various scenarios.